Abstract: A network diversity resolution system comprising: a diversity assessment tool, the diversity assessment tool including a path finding module and a sampling module that communicate with an input/output device; the path finding module communicates with an enterprise data warehouse; the path finding module configured to search through a network inventory stored in the enterprise data warehouse, the path finding module constructing a representation to identify at least two representative paths between a selected first end point and a second end point; wherein the at least two representative paths meets at least a capacity requirement between the first end point and the second end point; and wherein the sampling module generates at least one circuit reassignment plan based on the at least two representative paths, wherein the sampling module provides a score for each of the at least one circuit reassignment plan, wherein the score is based on at least one of a machine preference, path length, and number of changes

Abstract: Approaches, techniques, and mechanisms are disclosed for automatically inserting supplemental items into documents. According to an embodiment, a first request is received, comprising document information that identifies a particular document. A target repeated structure type, to which a group of items in the particular document conform, is identified within the particular document. Based on the target repeated structure type, a template is generated. A new content item is generated by applying descriptive metadata that describes the new content item to the template. The new content item conforms to the target repeated structure type. The new content item is inserted in the particular document at an insertion point before or after a particular content item that conforms to the target repeated structure type.

Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.

Abstract: Described herein is a reversible aptamer selection technology for production-scale isolation of label-free cells (e.g., CD8+ T cells). Provided herein are methods for isolating a cell of interest from a biological sample by contacting the biological sample with an aptamer that specifically binds a cell surface marker specific for the cell of interest; separating the aptamer-bound cells from cells not bound to the aptamer; and recovering a cell of interest by disrupting binding of the aptamer to the cell surface marker.

Abstract: A cartridge comprising a generally cylindrical cartridge main body with a proximal edge portion having a circumferential inner surface and a proximal opening surrounded by a circumferential edge, a piston slidable received therein, and a ring-formed code member attached to the circumferential edge portion and comprising an axially extending mounting portion in engagement with the edge portion circumferential inner surface, a flange portion having a distally facing mounting surface in engagement with the circumferential edge and a proximally facing stop surface, and a drive opening allowing a piston rod to engage the piston proximal surface, wherein the flange portion radially extends within the circumferential boundaries of the cartridge main body.

Abstract: The present disclosure relates to devices, methods, and computer-readable medium for providing recommendations for alternate resources to use for cloud services. The devices, methods, and computer-readable medium may receive a resource allocation request for a new resource of a computing system and may predict an occurrence of a capacity related allocation for the resource allocation request. The devices, methods, and computer-readable medium may identify alternate resources to use for the resource allocation request and may provide recommendations with the alternate resources.

Abstract: The present invention concerns a drug delivery device (1) comprising: a housing (2) extending along a main axis, a torsion spring (5) comprising a first spring end (4) arranged stationarily with respect to the housing (2) and a second spring end (6) capable of rotation about the main axis, a rotatable shaft (80) extending along the main axis, the rotatable shaft (80) having a non-self-locking thread (81) and being axially fixed with respect to the housing (2), a spring end retainer (82) to which the second spring end (6) is attached, the spring end retainer (82) being rotationally fixed relative to the rotatable shaft (80), and a nut member (45) engaged with the non-self-locking thread (81), the nut member (45) being axially movable by translation relative to the housing (2) to thereby travel the non-self-locking thread (81) between a first position in which the torsion spring (5) is in a relaxed state and a second position in which the torsion spring (5) is in a strained state.

Abstract: A seed sampling system is provided comprising an automated seed loading assembly operable to singulate seeds from a plurality of seeds or enable loading of individually stored seeds and an automated seed sampling assembly comprising at least one sampling module operable to remove tissue samples from one of the singulated seeds. The system also includes an automated seed transport assembly comprising at least one retention member operable to transfer the singulated seeds from at least one elevator unit of the seed loading assembly to the at least one sampling module of the seed sampling assembly. In connection therewith, the at least one sampling module includes multiple sampling locations, each associated with a sampler, where the at least one sampling module is operable to remove tissue samples from seeds at one of sampling locations while another one of the sampling locations is cleaned to remove residual seed tissue therefrom.

Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.

Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.

Abstract: The present invention provides a drug delivery device with a dose counting mechanism and an end-of-content identification.

Abstract: Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.

Abstract: The coating can have a low-sweetness perception. During manufacturing and processing, the coating maintains a flowability to allow a glaze state of the coating to be applied to a food. Upon cooling, the glaze state of the coating forms a glass state that provides a low-sweetness impact which facilitates application of savory taste perceptions.

Abstract: The present invention provides a power unit (1) for a drug delivery device as well as methods for providing and mounting the power unit (1) in the drug delivery device. The power unit (1) comprises a first interface member (30) extending along a reference axis and comprising a hollow body (31) and a first engagement structure (35), a second interface member (10) comprising a tubular structure (11) extending at least partially through the hollow body (31) and having a skirt (12), and a second engagement structure (14) configured for releasable engagement with the first engagement structure (35), and a torsion spring (20) comprising a first end portion (23) being attached to the first interface member (30) and a second end portion (22) being attached to the second interface member (10), the torsion spring (20) being pre-strained to induce a relative rotational motion between the first interface member (30) and the second interface member (10).

Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.

Abstract: A suspension system for a work vehicle includes an axle bar, an inner control member, an outer control member, and a slide housing. The axle bar extends through the inner control member, the outer control member, and the slide housing. The axle bar is non-rotatably coupled to the slide housing and is configured to pivot with the slide housing and relative to the inner control member and the outer control member.

Abstract: Approaches, techniques, and mechanisms are disclosed for automatically inserting supplemental items into documents. According to an embodiment, a first request is received, comprising document information that identifies a particular document. A target repeated structure type, to which a group of items in the particular document conform, is identified within the particular document. Based on the target repeated structure type, a template is generated. A new content item is generated by applying descriptive metadata that describes the new content item to the template. The new content item conforms to the target repeated structure type. The new content item is inserted in the particular document at an insertion point before or after a particular content item that conforms to the target repeated structure type.

Abstract: A vehicle including a chassis and a planetary gear assembly supported by the chassis. The planetary gear assembly includes a planetary carrier having a carrier locking feature, at least one planetary gear, at least one pin supporting the at least one planetary gear and including at least one pin locking feature, and at least one thrust washer coupled to and supported by the at least one pin. The at least one thrust washer includes a first locking member engaging with the carrier locking feature, which prevents the at least one thrust washer from rotating, and a second locking member engaging with the at least one pin locking feature such that the at least one thrust washer prevents the at least one pin from rotating and axially sliding.

Abstract: An agricultural vehicle including a front axle assembly having an axle beam with a slot, a wheel assembly including a steering knuckle coupled to a wheel flange assembly, and a steering sensor pin assembly is provided. The steering sensor pin assembly includes a steering sensor pin having a first end and a second end opposite the first end having a flat face, and a kingpin connected to the steering knuckle. The kingpin has a top surface, a bottom surface, and a hole from the top surface to the bottom surface. The hole is aligned with the slot in the axle beam, and the steering sensor pin is positioned in the hole for coupling the kingpin to the axle beam via the flat face of the steering sensor pin being coupled to the slot.

Abstract: A vehicle traffic sensor for detecting and monitoring vehicular targets is presented. The sensor employs a planar design resulting in a reduced profile sensor. The sensor includes a multi-layer radio frequency board with RF components on one of the sides and both isolation and planar array antennas on the opposing side. The antennas are preferably tapered planar array antennas which include one transmit antenna and one receive antenna. The sensor also includes at least one logic or signal processing board populated with components on a first side and a ground plane on a second side positioned toward the RF componentry of the RF board to form an RF shield. The boards are housed within a housing that is permeable, at least on the side through which the antenna structures propagate.