Abstract: A rotatable downhole cutting tool configured for enhanced drive consistency in low power circumstances. The tool is equipped with a hydraulic axial drive actuator suitable for use in wireline deployment. The actuator itself includes a reciprocating piston with a ball screw that threadably interfaces a ball nut for dampening the axial drive imparted by the piston. As such, even though hydraulically driven at generally well under about 10 horsepower, bounce in the axial drive is substantially eliminated.

Abstract: A method (50) and an assembly (10) for milling an obstruction disposed within a wellbore (W) includes a milling module (12) having a motor (22) rotating a milling bit (14), a first electronics cartridge (26) for controlling the motor based upon a motor torque value, a tractor module (16, 18) for engaging with the wellbore and providing a push force against the wellbore to urge the milling assembly in a direction of the milling bit, and a second electronics cartridge (28) for controlling a push force value of tractor module. The method involves rotating the milling bit (54) and engaging the tractor module with the wellbore (56), and adjusting, iteratively, the operation (58) based on a calculated torque value and a calculated push force value to maintain the calculated values at around a target torque value and below a push force limit value (66, 70).

Abstract: Approaches, techniques, and mechanisms are disclosed for third-party tracking of user data. Instructions provided in association with a first document cause a client at which the first document is viewed to load a second document in a tracking document container associated with the first document. The second document belongs to a third-party domain that is different than a first domain to which the first document belongs. Instructions provided in association with the second document cause the client to retrieve a particular identifier from a local storage area for the third-party domain at the client. The instructions provided in association with the second document further cause the client to send a message to a server comprising the particular identifier.

Abstract: A wireless earphone system (1) comprising a first earphone (2) and a second earphone (3). The first earphone (2) comprises a first earphone transceiver (6) of a first type and a second earphone transceiver (7) of a second type, and the second earphone (3) comprises a third earphone transceiver (7) of the first type. A first wireless link (5) can be established between the first earphone transceiver (6) and the third earphone transceiver (8), and a second wireless link (9) can be established between the second earphone transceiver (7) and an audio rendering transceiver (25) of the second type of an audio rendering device (4). The first earphone device (2) is adapted to send a link status signal (12) via the second wireless link (9) to the audio rendering device (4).

Abstract: A stylus pen is disclosed that can be used as an input device to a digitizer associated with a computer screen on a computing device, such as a computer, mobile device, tablet, etc. The stylus pen can include a voltage boost circuit that generates a stylus output signal on an antenna output. The voltage boost circuit has a charging portion and a discharging portion. Both portions have transistors that are activated and deactivated through pulsed control signals. However, a pulse duration for each control signal is separately controllable through different RC-based circuits. Additionally, the voltage boost circuit provides power savings by draining the output voltage signal to a positive voltage rail, rather than ground.

Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.

Abstract: Disclosed are methods of making a genetically modified immune cell for modifying a tumor microenvironment (TME) and methods of modifying a tumor microenvironment (TME). In some embodiments, the method can include delivering a first vector to an immune cell, wherein the first vector comprises a nucleic acid encoding a protein that induces T-cell proliferation, promotes persistence and activation of endogenous or adoptively transferred NK or T cells and/or induces production of an interleukin, an interferon, a PD-1 checkpoint binding protein, HMGB1, MyD88, a cytokine or a chemokine. Methods of modulating the suppression of the immune response in a tumor microenvironment, minimizing the proliferation of tumor and suppressive cells, and increasing the efficiency of an anti-cancer therapy, anti-infection therapy, antibacterial therapy, anti-viral therapy, or anti-tumoral therapy are also provided.

Abstract: A stylus pen is disclosed that can be used as an input device to a digitizer associated with a computer screen on a computing device, such as a computer, mobile device, tablet, etc. The stylus pen can include a voltage boost circuit that generates a stylus output signal on an antenna output. The voltage boost circuit has a charging portion and a discharging portion. Both portions have transistors that are activated and deactivated through pulsed control signals. However, a pulse duration for each control signal is separately controllable through different RC-based circuits. Additionally, the voltage boost circuit provides power savings by draining the output voltage signal to a positive voltage rail, rather than ground.

Abstract: The description relates to enhancing user experience with devices, such as host and peripheral devices. One example relates to devices that can automatically power down when packaged for shipping and power up when opened by the user. Another example allows automatic, secure pairing between sets of host and peripheral devices without any affirmative user actions.

Abstract: A non-immunogenic selection epitope may be generated by removing certain amino acid sequences of the protein. For example, a gene encoding a truncated human epidermal growth factor receptor polypeptide (EGFRt) that lacks the membrane distal EGF-binding domain and the cytoplasmic signaling tail, but retains an extracellular epitope recognized by an anti-EGFR antibody is provided. Cells may be genetically modified to express EGFRt and then purified without the immunoactivity that would accompany the use of full-length EGFR immunoactivity. Through flow cytometric analysis, EGFRt was successfully utilized as an in vivo tracking marker for genetically modified human T cell engraftment in mice. Furthermore, EGFRt was demonstrated to have cellular depletion potential through cetuximab mediated antibody dependent cellular cytotoxicity (ADCC) pathways.

Abstract: The invention is a dish rack for accommodating oversized containers in an automated dish machine. The rack includes a generally porous base surrounded by upstanding sidewalls and at least a pair of notches in one sidewall or opposing sidewalls configured for receiving an edge of the an oversized container. One form of the invention includes a wire framework having a base and one or more stanchions that extend generally upwardly from the base. The notches and wire framework are configured for supporting an oversized container at an angled position within an automated dish machine to inhibit spray from being directed out of the dish machine.

Abstract: A stylus pen that can be used as an input device to a digitizer associated with a computer screen on a computing device, such as a computer, mobile device, tablet, etc. The stylus pen can include an end cap that has multiple pressure thresholds for implementing different user-input commands. To detect the pressure being applied to the end cap, the cap is movable relative to a stylus pen body so as to move a plunger in proximity or contact with a mechanical switch. The mechanical switch is a single-action switch that is converted to a dual-action switch by using the electrical conductivity of the switch to detect an electrical coupling between a plunger and the switch. The electrical coupling can be in the form of a capacitive coupling or a direct electrical connection. Further pressure can be detected through actuation of the mechanical switch.

Abstract: A nozzle assembly including a nozzle. The nozzle has an elongated body. The elongated body has a nozzle end at one end and a connection portion at another end. A joint section is connected with the connection portion. The joint section allows the nozzle to move axially and radially when an axial force is applied to the nozzle end.

Abstract: A computer system has access to a database storing collaboration data for at least one collaboration having a collaboration space. The collaboration data includes data structures identifying objects displayable by a display client on a display wall and associating locations in the collaboration space with the objects. The system includes logic configured to identify available display walls, each available wall having an identification code; logic to detect user input identifying a collaboration and an identification code for one of the free display walls; and logic to enable delivery of collaboration data for the identified collaboration to a display client for the identified display wall.

Abstract: Approaches, techniques, and mechanisms are disclosed for automatically inserting supplemental items into documents. According to an embodiment, a first request is received, comprising document information that identifies a particular document. A target repeated structure type, to which a group of items in the particular document conform, is identified within the particular document. Based on the target repeated structure type, a template is generated. A new content item is generated by applying descriptive metadata that describes the new content item to the template. The new content item conforms to the target repeated structure type. The new content item is inserted in the particular document at an insertion point before or after a particular content item that conforms to the target repeated structure type.

Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.

Abstract: Hematopoeitic stem/progenitor cells (HSPC) and/or non-T effector cells are genetically modified to express (i) an extracellular component including a ligand binding domain that binds a cellular marker preferentially expressed on an unwanted cell; and (ii) an intracellular component comprising an effector domain. Among other uses, the modified cells can be administered to patients to target unwanted cancer cells without the need for immunological matching before administration.

Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.

Abstract: A nozzle assembly including a nozzle. The nozzle has an elongated body. The elongated body has a nozzle end at one end and a connection portion at another end. A joint section is connected with the connection portion. The joint section allows the nozzle to move axially and radially when an axial force is applied to the nozzle end.

Abstract: An apparatus for measuring at least one of downhole position and velocity. The apparatus includes a body. A roller is connected with the body, and a plurality of sensors is connected with the body. The plurality of sensors can acquire roller data and wellbore data. The roller data and wellbore data can be used to determine at least one of the velocity and position of the apparatus. The apparatus can also have an electronic module that is in communication with the plurality of of sensors.