Abstract: Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.

Abstract: A stylus pen that can be used as an input device to a digitizer associated with a computer screen on a computing device, such as a computer, mobile device, tablet, etc. The stylus pen can include an end cap that has multiple pressure thresholds for implementing different user-input commands. To detect the pressure being applied to the end cap, the cap is movable relative to a stylus pen body so as to move a plunger in proximity or contact with a mechanical switch. The mechanical switch is a single-action switch that is converted to a dual-action switch by using the electrical conductivity of the switch to detect an electrical coupling between a plunger and the switch. The electrical coupling can be in the form of a capacitive coupling or a direct electrical connection. Further pressure can be detected through actuation of the mechanical switch.

Abstract: The coating can have a low-sweetness perception. During manufacturing and processing, the coating maintains a flowability to allow a glaze state of the coating to be applied to a food. Upon cooling, the glaze state of the coating forms a glass state that provides a low-sweetness impact which facilitates application of savory taste perceptions.

Abstract: The coating can have a low-sweetness perception. During manufacturing and processing, the coating maintains a flowability to allow a glaze state of the coating to be applied to a food. Upon cooling, the glaze state of the coating forms a glass state that provides a low-sweetness impact which facilitates application of savory taste perceptions.

Abstract: A suspension system for a work vehicle includes an axle bar, an inner control member, an outer control member, and a slide housing. The axle bar extends through the inner control member, the outer control member, and the slide housing. The axle bar is non-rotatably coupled to the slide housing and is configured to pivot with the slide housing and relative to the inner control member and the outer control member.

Abstract: A sealing system includes a shaft seal plate, a seal guide having a tab, and a shaft seal coupled to the seal guide. A guide slot is formed in the shaft seal plate, and the tab extends into the guide slot. The shaft seal is configured to form and substantially maintain a seal at an axle bar as the axle bar rotates and pivots. The seal guide is configured to translate relative to the shaft seal plate as the axle bar pivots, and the tab is configured to block a rotation of the seal guide and the shaft seal relative to the shaft seal plate as the axle bar rotates.

Abstract: A vehicle including a chassis and a planetary gear assembly supported by the chassis. The planetary gear assembly includes a planetary carrier having a carrier locking feature, at least one planetary gear, at least one pin supporting the at least one planetary gear and including at least one pin locking feature, and at least one thrust washer coupled to and supported by the at least one pin. The at least one thrust washer includes a first locking member engaging with the carrier locking feature, which prevents the at least one thrust washer from rotating, and a second locking member engaging with the at least one pin locking feature such that the at least one thrust washer prevents the at least one pin from rotating and axially sliding.

Abstract: An agricultural vehicle including a front axle assembly having an axle beam with a slot, a wheel assembly including a steering knuckle coupled to a wheel flange assembly, and a steering sensor pin assembly is provided. The steering sensor pin assembly includes a steering sensor pin having a first end and a second end opposite the first end having a flat face, and a kingpin connected to the steering knuckle. The kingpin has a top surface, a bottom surface, and a hole from the top surface to the bottom surface. The hole is aligned with the slot in the axle beam, and the steering sensor pin is positioned in the hole for coupling the kingpin to the axle beam via the flat face of the steering sensor pin being coupled to the slot.

Abstract: Disclosed are methods of making a genetically modified immune cell for modifying a tumor microenvironment (TME) and methods of modifying a tumor microenvironment (TME). In some embodiments, the method can include delivering a first vector to an immune cell, wherein the first vector comprises a nucleic acid encoding a protein that induces T-cell proliferation, promotes persistence and activation of endogenous or adoptively transferred NK or T cells and/or induces production of an interleukin, an interferon, a PD-1 checkpoint binding protein, HMGB1, MyD88, a cytokine or a chemokine. Methods of modulating the suppression of the immune response in a tumor microenvironment, minimizing the proliferation of tumor and suppressive cells, and increasing the efficiency of an anti-cancer therapy, anti-infection therapy, antibacterial therapy, anti-viral therapy, or anti-tumoral therapy are also provided.

Abstract: Hematopoietic stem/progenitor cells (HSPC) and/or non-T effector cells are genetically modified to express (i) an extracellular component including a ligand binding domain that binds a cellular marker preferentially expressed on an unwanted cell; and (ii) an intracellular component comprising an effector domain. Among other uses, the modified cells can be administered to patients to target unwanted cancer cells without the need for immunological matching before administration.

Abstract: Approaches, techniques, and mechanisms are disclosed for automatically inserting supplemental items into documents. According to an embodiment, a first request is received, comprising document information that identifies a particular document. A target repeated structure type, to which a group of items in the particular document conform, is identified within the particular document. Based on the target repeated structure type, a template is generated. A new content item is generated by applying descriptive metadata that describes the new content item to the template. The new content item conforms to the target repeated structure type. The new content item is inserted in the particular document at an insertion point before or after a particular content item that conforms to the target repeated structure type.

Abstract: A network diversity resolution system comprising: a diversity assessment tool, the diversity assessment tool including a path finding module and a sampling module that communicate with an input/output device; the path finding module communicates with an enterprise data warehouse; the path finding module configured to search through a network inventory stored in the enterprise data warehouse, the path finding module constructing a representation to identify at least two representative paths between a selected first end point and a second end point; wherein the at least two representative paths meets at least a capacity requirement between the first end point and the second end point; and wherein the sampling module generates at least one circuit reassignment plan based on the at least two representative paths, wherein the sampling module provides a score for each of the at least one circuit reassignment plan, wherein the score is based on at least one of a machine preference, path length, and number of changes

Abstract: A drug delivery device comprising a housing, a piston rod, a transmission member, a helical torsion drive spring coupled to the transmission member and the housing, and a drive member in engagement with the piston rod and adapted to be rotated by the transmission member to thereby move the piston rod distally during expelling. The device further comprises dose setting means allowing a user to simultaneously set a dose and strain the drive spring correspondingly. The drive spring comprises a plurality of wire windings and is formed from a wire having a rectangular cross section wound on edge with the height larger than the thickness. The spring is operated such that the tilt angle for at least a portion of the rectangular wire will increase when the drive spring is strained from an initial strained state to a fully strained state, this resulting in a corresponding non-linear spring characteristic.

Abstract: Approaches, techniques, and mechanisms are disclosed for automatically inserting supplemental items into documents. According to an embodiment, a first request is received, comprising document information that identifies a particular document. A target repeated structure type, to which a group of items in the particular document conform, is identified within the particular document. Based on the target repeated structure type, a template is generated. A new content item is generated by applying descriptive metadata that describes the new content item to the template. The new content item conforms to the target repeated structure type. The new content item is inserted in the particular document at an insertion point before or after a particular content item that conforms to the target repeated structure type.

Abstract: Approaches, techniques, and mechanisms are disclosed for third-party tracking of user data. Instructions provided in association with a first document cause a client at which the first document is viewed to load a second document in a tracking document container associated with the first document. The second document belongs to a third-party domain that is different than a first domain to which the first document belongs. Instructions provided in association with the second document cause the client to retrieve a particular identifier from a local storage area for the third-party domain at the client. The instructions provided in association with the second document further cause the client to send a message to a server comprising the particular identifier.

Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.

Abstract: Provided are methods for preventing or ameliorating toxicity caused by or due to a therapy, such as an immunotherapy or a cell therapy, by pre-emptive or early administration toxicity-targeting agent(s). In some embodiments, the therapy is a cell therapy in which the cells generally express recombinant receptors such as chimeric receptors, e.g., chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the methods, including the timing of the administration of the agents or treatments for toxicity, provide various advantages, such as lower toxicity while maintaining persistence and efficacy of the administered cells.

Abstract: The description relates to enhancing user experience with devices, such as host and peripheral devices. One example relates to devices that can automatically power down when packaged for shipping and power up when opened by the user. Another example allows automatic, secure pairing between sets of host and peripheral devices without any affirmative user actions.

Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.

Abstract: An apparatus for debris removal. The apparatus includes a debris storage housing. The debris storage housing has a velocity tube located therein. The velocity tube has a hole formed therethrough. A diverter is located on the velocity tube adjacent the hole.