Patents by Inventor Michael Powell

Michael Powell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION
    Publication number: 20140004181
    Abstract: The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
    Type: Application
    Filed: September 6, 2013
    Publication date: January 2, 2014
    Applicant: Morehouse School of Medicine
    Inventors: Vincent Craig BOND, Michael Powell, Ming Bo Huang, Syed Ali
  • COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES
    Publication number: 20140005117
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
    Type: Application
    Filed: August 30, 2013
    Publication date: January 2, 2014
    Applicant: Morehouse School of Medicine
    Inventors: Vincent Craig BOND, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger
  • Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles
    Patent number: 8563506
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: October 22, 2013
    Assignee: Morehouse School of Medicine
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger
  • Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles
    Patent number: 8551943
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: October 8, 2013
    Assignee: Morehouse School of Medicine
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger
  • Compositions and methods for treating cancer by inhibiting the secretion of microparticles
    Patent number: 8476237
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. Also disclosed are polynucleotides encoding the peptides, expression vectors carrying the polynucleotides and methods for treating tumors using the novel peptides.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: July 2, 2013
    Assignee: Morehouse School of Medicine
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger
  • COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION
    Publication number: 20130156801
    Abstract: The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
    Type: Application
    Filed: December 15, 2011
    Publication date: June 20, 2013
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Vincent Craig BOND, Michael POWELL, Ming Bo HUANG, Syed ALI
  • Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles
    Patent number: 8431530
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: April 30, 2013
    Assignee: Morehouse School of Medicine
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger
  • ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20130089525
    Abstract: The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
    Type: Application
    Filed: October 7, 2011
    Publication date: April 11, 2013
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Martin Neville Shelton
  • COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES
    Publication number: 20130018002
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
    Type: Application
    Filed: September 17, 2012
    Publication date: January 17, 2013
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger
  • COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES
    Publication number: 20130018003
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
    Type: Application
    Filed: September 17, 2012
    Publication date: January 17, 2013
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger
  • Diagnosis and treatment of human dormancy-related sequellae
    Patent number: 8343488
    Abstract: New methods for diagnosis and treatment of human dormancy syndrome-related sequellae are provided. Human dormancy syndrome (HDS) is characterized by elevated serum ratio of rT3/fT3 compared to a population of normal subjects. HDS includes fibromyalgia, chronic fatigue, cancer, autoimmune disease, obesity and related dormancy conditions. Dormancy and HDS-related sequellae are imposed on humans by infection with lipopolysaccharide (LPS; or endotoxin)-producing organisms, especially those that are intracellular and those that create antigens that stimulate the TLR pathways. In such instances, the elimination or neutralization of the LPS signal along with the infectious source is required to impact the sequellae of HDS. Treatment includes use of novel and non-obvious doses of antibiotics, optionally including agents that decrease the adverse effects of endotoxin.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: January 1, 2013
    Inventor: Michael Powell
  • Power management techniques for buffering and playback of audio broadcast data
    Patent number: 8346203
    Abstract: Various techniques that relate to prolonging the battery life on a portable electronic device during the buffering and playback of audio broadcast data are provided. In accordance with disclosed embodiments, upon detecting a low power state, the device may implement one or more low power actions, including starting, continuing, or stopping one or more audio broadcast functions, such as buffering or playing back audio broadcast data, to reduce overall power consumption, and thus prolong battery life. In one embodiment, a user may specify one or more low power actions that are to be implemented during a low power state by configuring user settings stored on the device. In another embodiment, the device, upon detecting a low power state, may prompt the user to make a selection from a listing of selectable low power action options and perform the selected low power action.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: January 1, 2013
    Assignee: Apple Inc.
    Inventors: Aram Lindahl, Richard Michael Powell, Joseph M. Williams
  • Cigar Punch and Holder
    Publication number: 20120266901
    Abstract: A combination cigar piercing and support device having a handle attached to an elongated member extending to a point at a distal end. The member preferably has a triangular or square cross section to form an exterior circumference of the member which when engaged to and supporting a lit cigar, will prevent spinning thereof which might place the hot ember proximate to the smoker's face. The elongated member additionally provides a tool to form draw passages through the cigar and to clean clogged cigars for easier smoking.
    Type: Application
    Filed: April 19, 2011
    Publication date: October 25, 2012
    Inventors: Michael Powell, Terry Tarasen
  • FASTENER RETAINER
    Publication number: 20120237314
    Abstract: A fastener retainer is provided capable of retaining a fastener to a part prior to and during assembly. A first portion engages a fastener flange while leaving a fastener head exposed for assembly tool access. A second portion has flanges that engage the edges of the part.
    Type: Application
    Filed: May 23, 2012
    Publication date: September 20, 2012
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Larry A. Walton, Baden Michael Powell, Gurdeep Singh, Mohammad A. Khorrami
  • DETECTION OF AUTOANTIBODIES REACTIVE WITH PANCREATIC ISLET CELL ANTIGENIC MOLECULES AND/OR INSULIN
    Publication number: 20120225955
    Abstract: A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising `antigenic molecule of fist source!-`analyte auto antibody!-`antigenic molecule of second source! The antigenic molecule of first source is immobilised to a solid phase, the second is labeled.
    Type: Application
    Filed: March 5, 2012
    Publication date: September 6, 2012
    Applicant: RSR Limited
    Inventors: Bernard Rees SMITH, Jadwiga Furmaniak, Michael Powell
  • Fastener retainer
    Patent number: 8202030
    Abstract: A fastener retainer is provided capable of retaining a fastener to a part prior to and during assembly. A first portion engages a fastener flange while leaving a fastener head exposed for assembly tool access. A second portion has flanges that engage the edges of the part.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: June 19, 2012
    Assignee: GM Global Technology Operations LLC
    Inventors: Larry A. Walton, Baden Michael Powell, Gurdeep Singh, Mohammad A Khorrami
  • Adaptable assembly fixture apparatus
    Patent number: 8177047
    Abstract: An apparatus for transporting a first workpiece assembly, the apparatus includes a pallet, a universal fixture and an adaptable fixture. The pallet has a rectangular base and support members fixed to opposite edges of the base. The universal fixture has a frame, a first and second support arms and three workpiece mounts. The support arms are fixed to opposite sides of the frame and are rotatably supported in the support members of the pallet. The adaptable fixture has a frame, three fixture mounts and three workpiece mounts. The fixture mounts are disposed on the bottom surface of the frame and aligned with the workpiece mounts of the universal fixture. The workpiece mounts of the adaptable fixture are disposed on the top surface of the frame and aligned with a first, second and third locator of a workpiece assembly.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: May 15, 2012
    Assignee: GM Global Technology Operations LLC
    Inventors: Fredrick R. Poskie, Baden Michael Powell, Leonid Basin
  • ADAPTABLE ASSEMBLY FIXTURE APPARATUS
    Publication number: 20120061208
    Abstract: An apparatus for transporting a first workpiece assembly, the apparatus includes a pallet, a universal fixture and an adaptable fixture. The pallet has a rectangular base and support members fixed to opposite edges of the base. The universal fixture has a frame, a first and second support arms and three workpiece mounts. The support arms are fixed to opposite sides of the frame and are rotatably supported in the support members of the pallet. The adaptable fixture has a frame, three fixture mounts and three workpiece mounts. The fixture mounts are disposed on the bottom surface of the frame and aligned with the workpiece mounts of the universal fixture. The workpiece mounts of the adaptable fixture are disposed on the top surface of the frame and aligned with a first, second and third locator of a workpiece assembly.
    Type: Application
    Filed: September 13, 2010
    Publication date: March 15, 2012
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS, INC.
    Inventors: Fredrick R. Poskie, Baden Michael Powell, Leonid Basin
  • TRANSPORTING AND INSTALLING FLEXIBLE PIPE
    Publication number: 20120061504
    Abstract: A method and apparatus are disclosed for transporting and/or unloading and/or installing a flexible pipe. The apparatus comprises at least one support member for supporting a reel member carrying a wound flexible pipe and a plurality of reel rim guide elements for locating the reel member at a desired location with respect to the support member.
    Type: Application
    Filed: May 19, 2010
    Publication date: March 15, 2012
    Inventor: Michael Powell
  • Detection of autoantibodies reactive with pancreatic islet cell antigenic molecules and/or insulin
    Patent number: 8129132
    Abstract: A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: March 6, 2012
    Assignee: RSR Limited
    Inventors: Bernard Rees Smith, Jadwiga Furmaniak, Michael Powell