Abstract: The present disclosure relates, in some embodiments, to an apparatus for conducting a capillary electrophoresis assay. The apparatus can comprise a capillary array comprising an anode end and a cathode end, the capillary array provided in a housing further comprising a reservoir configured to house a separation medium and an anode buffer. The system can also comprise an injection mechanism configured to deliver sample to the cathode end of the capillary array, and a temperature control zone, wherein the temperature control zone is configured to control the temperature of the interior of the housing.

Abstract: Method and apparatus for signal detection in dynamic channels with high carrier frequency offset are provided. A coherent detector and a non-coherent detector are operated in parallel on a block of samples of an input signal to determine respective time offset candidates of the input signal. The time offset candidate obtained from the non-coherent detector is used to determine a frequency offset candidate of the input signal.

Abstract: Exemplary embodiments of rotary pulsers are provided that include a stator and a rotor rotationally disposed adjacent to the stator. The rotary pulsers can include a regulator mechanism and a pump. Based on a parameter or condition associated with the rotary pulser, the regulator mechanism can adjust a parameter of the pump to control rotation of the rotor. Exemplary embodiments are also directed to methods of regulating a rotary pulser.

Abstract: An improved device and system for power transmission. A power transmission device comprises a primary winding magnetically coupled to a resonant secondary which comprises a plurality of magnetic resonators, each magnetic resonator comprising a magnetic winding. The magnetic resonators are connected in series and arranged so that the magnetic axis of each magnetic resonator is coupled to the primary winding. In operation, a power source supplies alternating current at an operating frequency to the primary of a power transmission device used as a transmitter. A load is coupled to the primary of a power transmission device used as a receiver. Collectors may be coupled to either or both of the transmit or receive device. A return line may be coupled to either or both of the transmit or receive device.

Abstract: A device and system for power transmission. A power transmission system comprises an RF power source coupled to one or more emitters producing a field which transfers power to one or more sinks. A sink comprises one or more collectors coupled to a resonator, which couples RF power from the collectors and resonator to harvesting electronics which convert the RF power to direct current to power a load. Emitters coupled to the source produce a field which is harvested by the sink and converted to DC for a load. Emitters and collectors may be capacitively coupled, or coupled through a conductive path. Coupling may include a ground path. Charge mobility elements may be used with emitters and/or collectors.

Abstract: An external service application discovery process that connects a host with an external application server running a service application allowing a user of a client computing device to work with a file via a web browser. The host brokers the functionality of an external application server and serves as the platform where interactions between the client computing device and the external application server occur. An open interface protocol, which is a shared communication protocol, allows the host to communicate instructions from the client computing device to the external application server. Through the external service application discovery process, the external application server describes functionality provided by the service application to the host.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: A measuring device for measuring a signal with a first component signal and at least one second component signal comprises a high-frequency processing device, which is embodied to mix the signal in order to form an intermediate-frequency signal and to digitize the latter in order to form a digital composite signal. The measuring device further comprises a digital mixer, which is embodied to generate a first digital composite test signal and a second digital composite test signal subject to a displacement of the frequency of the digital composite signal. Moreover, the measuring device comprises a digital filter, which is embodied to filter the first digital composite test signal in order to form a first digital test signal and to filter the second digital composite test signal in order to form a second digital test signal.

Abstract: Methods for treating or preventing neointima stenosis are disclosed. The methods generally involve the use of a TGF? inhibitor, a SMAD2 inhibitor, an FGF Receptor agonist, a Let-7 agonist, or a combination thereof, to inhibit endothelial-to-mesenchymal transition (Endo-MT) of vascular endothelial cells into smooth muscle cells (SMC) at sites of endothelial damage. The disclosed methods can therefore be used to prevent or inhibit neointimal stenosis or restenosis, e.g., after angioplasty, vascular graft, or stent. Also disclosed are methods for increasing the patency of biodegradable, synthetic vascular grafts using a composition that inhibits Endo-MT. A cell-free tissue engineered vascular graft (TEVG) produced by this method is also disclosed.

Abstract: Methods for treating or preventing neointima stenosis are disclosed. The methods generally involve the use of a TGF? inhibitor, a SMAD2 inhibitor, an FGF Receptor agonist, a Let-7 agonist, or a combination thereof, to inhibit endothelial-to-mesenchymal transition (Endo-MT) of vascular endothelial cells into smooth muscle cells (SMC) at sites of endothelial damage. The disclosed methods can therefore be used to prevent or inhibit neointimal stenosis or restenosis, e.g., after angioplasty, vascular graft, or stent. Also disclosed are methods for increasing the patency of biodegradable, synthetic vascular grafts using a composition that inhibits Endo-MT. A cell-free tissue engineered vascular graft (TEVG) produced by this method is also disclosed.

Abstract: An improved device and system for power transmission. A power transmission device comprises a primary winding magnetically coupled to a resonant secondary which comprises a plurality of magnetic resonators, each magnetic resonator comprising a magnetic winding. The magnetic resonators are connected in series and arranged so that the magnetic axis of each magnetic resonator is coupled to the primary winding. In operation, a power source supplies alternating current at an operating frequency to the primary of a power transmission device used as a transmitter. A load is coupled to the primary of a power transmission device used as a receiver. Collectors may be coupled to either or both of the transmit or receive device. A return line may be coupled to either or both of the transmit or receive device.

Abstract: The invention relates to a carriage cart, which comprises a chassis frame with a front end and a rear end; a pair of front wheels mounted on the front end of the chassis frame; a pair of rear wheels mounted on the rear end of the chassis frame. The carriage cart according to example embodiments of the present invention may improve the performance of obstacle overcoming for robotic system.

Abstract: The invention relates to a device which includes two longitudinal deflecting surfaces or two pluralities of longitudinal deflecting surfaces, which are symmetrical on either side of the plane formed by the roll and yaw axes of the device and substantially in line with the roll axis and parallel to same, an air flow generator including at least one axial fan suctioning ambient air by means of at least one propeller faired in a flow path and, downstream of said propeller, an air distributor-diffuser, consisting of two adjacent semi-distributors each defining a curved duct directing the air to an outlet opening and toward the longitudinal deflecting surface or plurality of longitudinal deflecting surfaces.

Abstract: Systems, methods and computer-readable media are provided for enabling and/or managing contribution of paid time off. A system including one or more units configured for determining the value of paid time off as currency; and one or more units configured for conducting a transaction wherein paid time off is designated for contribution, and the determined value of the paid time off is designated for payment to one or more organizations is provided. Corresponding methods and computer-readable media are also provided.

Abstract: An electronic health record system includes a query translation engine in communication with a user interaction module to transform query phrases from the user interaction module into formalized database queries of the extracted data from a data organization module.

Abstract: A method of generating a clinically supplemented risk score using data from an electronic health record system can include collecting data from a plurality of electronic health records; parsing the data into defined fields; comparing the parsed data to at least one look-up table to generate an inferred diagnostic condition; comparing the inferred diagnostic condition to a documented diagnostic condition; mapping the inferred diagnostic condition to at least one condition category; refining the at least one mapped inferred diagnostic condition into a hierarchy to generate a hierarchal mapped conditioned category; and determining via a processor, a risk score in response to the inferred diagnostic condition for the patient in response to the hierarchal mapped conditioned category, the risk score representing an expected total cost of care for the patient relative to the average per-patient cost of care over an entire population.

Abstract: A document accessible on a network may be opened by multiple users. A user may use a thin client application to access the document, wherein an image of the document and XML data including comments and locations of the comments in the document. Hint icons are displayed in the document where comments are anchored. Upon selection of a hint, an HTML comments pane may be displayed to a side of the document, exposing comments and replies to comments currently stored in the document. The comments pane may be scrolled to the comment associated with the selected hint. Additionally, highlighting may be provided over elements in the document associated with a selected comment. Comments may be added via the comments pane and saved to the document on the network. Comments and comment location data may be communicated to other clients, allowing for collaborative communication via a thin client application.

Abstract: Aspects of the present disclosure are directed to methods and systems dynamic trust federation. In one aspect, a computer implemented method may include a security token that enables sign-on into a group applications based on applicable trust criteria. In one aspect, when a user interacts with one application in the group, the trust is elevated through the application internal authentication application program interface (API). The trust may be included in the security token to make available to other applications in the group. Applications can be in multiple groups with variable level of authentication based on location and other transactions variables.