Patents by Inventor Michael Simpson

Michael Simpson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180208565
    Abstract: The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.
    Type: Application
    Filed: July 20, 2016
    Publication date: July 26, 2018
    Applicant: WisTa Laboratories Ltd.
    Inventors: John Mervyn David STOREY, Christopher Paul LARCH, Steven John KEMP, Scott CLUNAS, Sarah Louise NICOLL, Helen Sarah GIBBARD, Michael SIMPSON, James Peter SINCLAIR, Colin MARSHALL
  • Publication number: 20180080899
    Abstract: A method of making an electroanalytical measurement including providing a glass-fused working electrode that includes a tungsten rod and a glass coating fused to the rod to form a leak-proof seal, which defines a fixed working electrode area; inserting the electrode into a molten salt such that the fixed working electrode area is completely submerged and a portion of the glass coating is in contact with the molten salt; applying a potential to the molten salt; measuring current as a function of potential; and quantifying a concentration of an analyte.
    Type: Application
    Filed: September 21, 2017
    Publication date: March 22, 2018
    Inventors: Michael Simpson, Devin Rappleye, Kevin Teaford
  • Patent number: 9907804
    Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: March 6, 2018
    Assignee: WISTA LABORATORIES LTD.
    Inventors: Colin Marshall, Scott Clunas, John Mervyn David Storey, James Peter Sinclair, Thomas Craven Baddeley, Ahtsham Ishaq, Michael Simpson, Craig Williamson, Barry Alan Wood, Claude Michel Wischik, Charles Robert Harrington, Janet Elizabeth Rickard, David Horsley, Yin Sze Loh, Karrar Ahmad Khan, Christopher Paul Larch
  • Patent number: 9826778
    Abstract: A sleeve (1) for holding a plurality of elongate elements (9) positioned in end-to-end relationship is disclosed. The sleeve has an elongate body (2) with opposite ends (10,11) and a space (3) defined therebetween to receive the elongate elements (9). The elongate body has an opening (4) between the ends (10,11) that is configured to enable a user to contact elongate elements (9) received in the sleeve (1) through the opening (4) and push them along, and out of one end of the sleeve (1).
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: November 28, 2017
    Assignee: BRITISH AMERICAN TOBACCO (INVESTMENTS) LIMITED
    Inventors: Michael Simpson, Richard Young, John Richardson
  • Publication number: 20170294242
    Abstract: A method for in-situ measuring of a liquidus temperature of a supply of the molten salt, includes withdrawing a sample of the molten salt from the supply, placing it into a sample container, and cooling the sample of the molten salt from a first temperature above the liquidus temperature of the molten salt to a second temperature at which at least a portion of the sample of the molten salt solidifies. The method includes taking a plurality of temperature measurements of the sample of the molten salt during cooling of the sample and determining the liquidus temperature of the molten salt from the measurements. The sample of the molten salt is heated from the second temperature to the first temperature and returned to the supply of the molten salt.
    Type: Application
    Filed: November 3, 2016
    Publication date: October 12, 2017
    Inventors: Michael Simpson, Andrew McCall Dodson
  • Publication number: 20170294241
    Abstract: A molten salt reactor comprising a reactor vessel and a molten salt contained within the reactor vessel. There is a corrosion reduction unit configured to process the molten salt to maintain an oxidation reduction ratio, (E(o)/E(r)), in the molten salt at a substantially constant level, wherein E(o) is an element (E) at a higher oxidation state (o) and E(r) is the element (E) at a lower oxidation state (r).
    Type: Application
    Filed: November 3, 2016
    Publication date: October 12, 2017
    Inventors: Andrew McCall Dodson, Michael Simpson, William Wangard, Edward Pheil
  • Patent number: 9565874
    Abstract: A smoking article comprises a first part and a second part movable relative to the first part. A control mechanism comprises a first control surface on one of the first part or second part; and a second control surface on the other of the first and second parts. The second control surface is configured to engage with the first control surface to control relative rotation between the first part and second part.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: February 14, 2017
    Assignees: BRITISH AMERICAN TOBACCO (INVESTMENTS) LIMITED, BRITISH AMERICAN TOBACCO JAPAN, LTD.
    Inventors: Karl Kaljura, Kevin Blick, David Paton, Michael Simpson
  • Patent number: 9552816
    Abstract: A speech-based system includes an audio device in a user premises and a network-based service that supports use of the audio device by multiple applications. The audio device may be directed to play audio content such as music, audio books, etc. The audio device may also be directed to interact with a user through speech. The network-based service monitors event messages received from the audio device to determine which of the multiple applications currently has speech focus. When receiving speech from a user, the service first offers the corresponding meaning to the application, if any, that currently has primary speech focus. If there is no application that currently has primary speech focus, or if the application having primary speech focus is not able to respond to the meaning, the service then offers the user meaning to the application that currently has secondary speech focus.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 24, 2017
    Assignee: Amazon Technologies, Inc.
    Inventors: Peter Spalding VanLund, Kurt Wesley Piersol, James David Meyers, Jacob Michael Simpson, Vikram Kumar Gundeti, David Robert Thomas, Andrew Christopher Miles
  • Publication number: 20160237048
    Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.
    Type: Application
    Filed: February 29, 2016
    Publication date: August 18, 2016
    Applicant: WisTa Laboratories Ltd.
    Inventors: COLIN MARSHALL, Scott Clunas, John Mervyn David Storey, James Peter Sinclair, Thomas Craven Baddeley, Ahtsham Ishaq, Michael Simpson, Craig Williamson, Barry Alan Wood, Claude Michel Wischik, Charles Robert Harrington, Janet Elizabeth Rickard, David Horsley, Yin Sze Loh, Karrar Ahmad Khan, Christopher Paul Larch
  • Publication number: 20160180853
    Abstract: A speech-based system includes an audio device in a user premises and a network-based service that supports use of the audio device by multiple applications. The audio device may be directed to play audio content such as music, audio books, etc. The audio device may also be directed to interact with a user through speech. The network-based service monitors event messages received from the audio device to determine which of the multiple applications currently has speech focus. When receiving speech from a user, the service first offers the corresponding meaning to the application, if any, that currently has primary speech focus. If there is no application that currently has primary speech focus, or if the application having primary speech focus is not able to respond to the meaning, the service then offers the user meaning to the application that currently has secondary speech focus.
    Type: Application
    Filed: December 19, 2014
    Publication date: June 23, 2016
    Inventors: Peter Spalding VanLund, Kurt Wesley Piersol, James David Meyers, Jacob Michael Simpson, Vikram Kumar Gundeti, David Robert Thomas, Andrew Christopher Miles
  • Patent number: 9283230
    Abstract: The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: March 15, 2016
    Assignee: WisTa Laboratories Ltd.
    Inventors: Scott Clunas, John Mervyn David Storey, James Peter Sinclair, Thomas Craven Baddeley, Ahtsham Ishaq, Michael Simpson, Craig Williamson, Barry Alan Wood, Claude Michel Wischik, Charles Robert Harrington, Janet Elizabeth Rickard, David Horsley, Yin Sze Loh, Colin Marshall, Karrar Ahmad Khan
  • Patent number: 9115663
    Abstract: Systems and methods for optimizing the performance of a vehicle under normal operating conditions. A vehicle system adjusts one or more vehicle operating parameters in a closed-loop in response to data received from sensors. A portable vehicle communication interface module is selectively attached to the vehicle without inhibiting normal operation of the vehicle. When connected to the vehicle, the vehicle communication interface module records the adjustments made by the vehicle system in closed-loop operation. These recorded values are then used to update calibration information that the vehicle system uses as default values.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: August 25, 2015
    Assignee: Harley-Davidson Motor Company Group, LLC
    Inventors: Tony Nicosia, Edward A. Ramberger, Charles Zellner, David Klosterman, John Chapin, Karl Lingerfelt, Michael Simpson, Andrew Stampor
  • Publication number: 20150189914
    Abstract: A sleeve (1) for holding a plurality of elongate elements (9) positioned in end-to-end relationship is disclosed. The sleeve has an elongate body (2) with opposite ends (10,11) and a space (3) defined therebetween to receive the elongate elements (9). The elongate body has an opening (4) between the ends (10,11) that is configured to enable a user to contact elongate elements (9) received in the sleeve (1) through the opening (4) and push them along, and out of one end of the sleeve (1).
    Type: Application
    Filed: May 24, 2013
    Publication date: July 9, 2015
    Applicant: British American Tobacco (Investments) Limited
    Inventors: Michael Simpson, Richard Young, John Richardson
  • Publication number: 20140332014
    Abstract: A smoking article filter (20) comprises a recess (25) to receive a filter insert unit (30). The filter insert unit (30) is secured to the filter (20) once inserted. The filter (20) and the filter insert unit (30) may comprise additives such as flavourants, colourants or sorbents.
    Type: Application
    Filed: June 27, 2012
    Publication date: November 13, 2014
    Applicant: BRITISH AMERICAN TOBACCO (INVESTMENTS) LIMITED
    Inventors: Graham Penrose, Michael Malthouse, David Wake, Gary Fulcher, Michael Simpson, Aaron Brookbank, Gordon Grierson, Jon Hindley, John Sampson, Rabya Khan-Dar, Karl Kaljura, Nelson Ong, John Richardson, John Major, Richard Young
  • Publication number: 20140089083
    Abstract: A method, non-transitory computer readable medium, and apparatus for recommending one or more cross-media marketing campaign strategies are disclosed. For example, the method collects information about a business, applies a weighting table to the information about the business, wherein the weighting table comprises a pre-defined value for each one of a plurality of cross-media marketing campaign strategies based upon a plurality of different industries and a plurality of different business operations, calculates, via a processor, a total score for each one of the plurality of cross-media marketing campaign strategies for an industry and a business operation determined based upon the information about the business that is collected and recommends one or more cross-media marketing campaign strategies based upon the total score of each one of the plurality of cross-media marketing campaign strategies.
    Type: Application
    Filed: September 25, 2012
    Publication date: March 27, 2014
    Applicant: Xerox Corporation
    Inventors: Michael E. FARRELL, Stephen Michael Simpson, Warren Kleiman, Jack T. Latone, Derrick Kazuo Doi
  • Publication number: 20140076338
    Abstract: A smoking article comprises a first part and a second part movable relative to the first part. A control mechanism comprises a first control surface on one of the first part or second part; and a second control surface on the other of the first and second parts. The second control surface is configured to engage with the first control surface to control relative rotation between the first part and second part.
    Type: Application
    Filed: March 9, 2012
    Publication date: March 20, 2014
    Applicants: BRITISH AMERICAN TOBACCO JAPAN, LTD., BRITISH AMERICAN TOBACCO (INVESTMENTS) LIMITED
    Inventors: Karl Kaljura, Kevin Blick, David Paton, Michael Simpson
  • Publication number: 20130315992
    Abstract: The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.
    Type: Application
    Filed: August 15, 2011
    Publication date: November 28, 2013
    Inventors: Scott Clunas, John Mervyn David Storey, James Peter Sinclair, Thomas Craven Baddeley, Ahtsham Ishaq, Michael Simpson, Craig Williamson, Barry Alan Wood, Claude Michel Wischik, Charles Robert Harrington, Janet Elizabeth Rickard, David Horsley, Yin Sze Loh, Colin Marshall, Karrar Ahmad Khan
  • Patent number: 8562675
    Abstract: In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: October 22, 2013
    Assignee: Novartis AG
    Inventors: Xin Hong, Mutlu Karakelle, Xiaoxiao Zhang, Michael Simpson, Myoung Choi, Yan Zhang
  • Publication number: 20120290085
    Abstract: In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).
    Type: Application
    Filed: July 30, 2012
    Publication date: November 15, 2012
    Inventors: Xin Hong, Mutlu Karakelle, Xiaoxiao Zhang, Michael Simpson, Myoung Choi, Yan Zhang
  • Publication number: 20120259533
    Abstract: Systems and methods for optimizing the performance of a vehicle under normal operating conditions. A vehicle system adjusts one or more vehicle operating parameters in a closed-loop in response to data received from sensors. A portable vehicle communication interface module is selectively attached to the vehicle without inhibiting normal operation of the vehicle. When connected to the vehicle, the vehicle communication interface module records the adjustments made by the vehicle system in closed-loop operation. These recorded values are then used to update calibration information that the vehicle system uses as default values.
    Type: Application
    Filed: June 20, 2012
    Publication date: October 11, 2012
    Applicant: HARLEY-DAVIDSON MOTOR COMPANY GROUP, LLC
    Inventors: Tony Nicosia, Edward A. Ramberger, David Klosterman, Charles Zellner, Andrew Stampor, Michael Simpson, John Chapin, Karl Lingerfelt