Abstract: The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.

Abstract: A method of making an electroanalytical measurement including providing a glass-fused working electrode that includes a tungsten rod and a glass coating fused to the rod to form a leak-proof seal, which defines a fixed working electrode area; inserting the electrode into a molten salt such that the fixed working electrode area is completely submerged and a portion of the glass coating is in contact with the molten salt; applying a potential to the molten salt; measuring current as a function of potential; and quantifying a concentration of an analyte.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: A sleeve (1) for holding a plurality of elongate elements (9) positioned in end-to-end relationship is disclosed. The sleeve has an elongate body (2) with opposite ends (10,11) and a space (3) defined therebetween to receive the elongate elements (9). The elongate body has an opening (4) between the ends (10,11) that is configured to enable a user to contact elongate elements (9) received in the sleeve (1) through the opening (4) and push them along, and out of one end of the sleeve (1).

Abstract: A method for in-situ measuring of a liquidus temperature of a supply of the molten salt, includes withdrawing a sample of the molten salt from the supply, placing it into a sample container, and cooling the sample of the molten salt from a first temperature above the liquidus temperature of the molten salt to a second temperature at which at least a portion of the sample of the molten salt solidifies. The method includes taking a plurality of temperature measurements of the sample of the molten salt during cooling of the sample and determining the liquidus temperature of the molten salt from the measurements. The sample of the molten salt is heated from the second temperature to the first temperature and returned to the supply of the molten salt.

Abstract: A molten salt reactor comprising a reactor vessel and a molten salt contained within the reactor vessel. There is a corrosion reduction unit configured to process the molten salt to maintain an oxidation reduction ratio, (E(o)/E(r)), in the molten salt at a substantially constant level, wherein E(o) is an element (E) at a higher oxidation state (o) and E(r) is the element (E) at a lower oxidation state (r).

Abstract: A smoking article comprises a first part and a second part movable relative to the first part. A control mechanism comprises a first control surface on one of the first part or second part; and a second control surface on the other of the first and second parts. The second control surface is configured to engage with the first control surface to control relative rotation between the first part and second part.

Abstract: A speech-based system includes an audio device in a user premises and a network-based service that supports use of the audio device by multiple applications. The audio device may be directed to play audio content such as music, audio books, etc. The audio device may also be directed to interact with a user through speech. The network-based service monitors event messages received from the audio device to determine which of the multiple applications currently has speech focus. When receiving speech from a user, the service first offers the corresponding meaning to the application, if any, that currently has primary speech focus. If there is no application that currently has primary speech focus, or if the application having primary speech focus is not able to respond to the meaning, the service then offers the user meaning to the application that currently has secondary speech focus.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: A speech-based system includes an audio device in a user premises and a network-based service that supports use of the audio device by multiple applications. The audio device may be directed to play audio content such as music, audio books, etc. The audio device may also be directed to interact with a user through speech. The network-based service monitors event messages received from the audio device to determine which of the multiple applications currently has speech focus. When receiving speech from a user, the service first offers the corresponding meaning to the application, if any, that currently has primary speech focus. If there is no application that currently has primary speech focus, or if the application having primary speech focus is not able to respond to the meaning, the service then offers the user meaning to the application that currently has secondary speech focus.

Abstract: The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.

Abstract: Systems and methods for optimizing the performance of a vehicle under normal operating conditions. A vehicle system adjusts one or more vehicle operating parameters in a closed-loop in response to data received from sensors. A portable vehicle communication interface module is selectively attached to the vehicle without inhibiting normal operation of the vehicle. When connected to the vehicle, the vehicle communication interface module records the adjustments made by the vehicle system in closed-loop operation. These recorded values are then used to update calibration information that the vehicle system uses as default values.

Abstract: A sleeve (1) for holding a plurality of elongate elements (9) positioned in end-to-end relationship is disclosed. The sleeve has an elongate body (2) with opposite ends (10,11) and a space (3) defined therebetween to receive the elongate elements (9). The elongate body has an opening (4) between the ends (10,11) that is configured to enable a user to contact elongate elements (9) received in the sleeve (1) through the opening (4) and push them along, and out of one end of the sleeve (1).

Abstract: A smoking article filter (20) comprises a recess (25) to receive a filter insert unit (30). The filter insert unit (30) is secured to the filter (20) once inserted. The filter (20) and the filter insert unit (30) may comprise additives such as flavourants, colourants or sorbents.

Abstract: A method, non-transitory computer readable medium, and apparatus for recommending one or more cross-media marketing campaign strategies are disclosed. For example, the method collects information about a business, applies a weighting table to the information about the business, wherein the weighting table comprises a pre-defined value for each one of a plurality of cross-media marketing campaign strategies based upon a plurality of different industries and a plurality of different business operations, calculates, via a processor, a total score for each one of the plurality of cross-media marketing campaign strategies for an industry and a business operation determined based upon the information about the business that is collected and recommends one or more cross-media marketing campaign strategies based upon the total score of each one of the plurality of cross-media marketing campaign strategies.

Abstract: A smoking article comprises a first part and a second part movable relative to the first part. A control mechanism comprises a first control surface on one of the first part or second part; and a second control surface on the other of the first and second parts. The second control surface is configured to engage with the first control surface to control relative rotation between the first part and second part.

Abstract: The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.

Abstract: In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).

Abstract: In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).

Abstract: Systems and methods for optimizing the performance of a vehicle under normal operating conditions. A vehicle system adjusts one or more vehicle operating parameters in a closed-loop in response to data received from sensors. A portable vehicle communication interface module is selectively attached to the vehicle without inhibiting normal operation of the vehicle. When connected to the vehicle, the vehicle communication interface module records the adjustments made by the vehicle system in closed-loop operation. These recorded values are then used to update calibration information that the vehicle system uses as default values.