Patents by Inventor Muraleedharan G. Nair

Muraleedharan G. Nair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7141253
    Abstract: Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: November 28, 2006
    Assignee: Board of Trustees of Michigan State University
    Inventors: Muraleedharan G. Nair, Bolleddula Jayaprakasam
  • Patent number: 7132403
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: November 7, 2006
    Assignees: Board of Trustees of Michigan State University, Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Patent number: 7000348
    Abstract: A method and compositions for increasing ectomycorrhizal colonization of the roots of trees using an alkali metal formononetinate, formononetin or mixtures thereof is described. The method enhances the growth of healthy and impaired trees.
    Type: Grant
    Filed: January 6, 2004
    Date of Patent: February 21, 2006
    Assignee: Vamtech, LLC
    Inventors: Michael P. Amaranthus, Muraleedharan G. Nair, Taylor C. Reid
  • Patent number: 6903076
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: June 7, 2005
    Assignees: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Patent number: 6875746
    Abstract: Anthraquinones are described which have anticancer or antitumor activity and which are useful for inhibiting cancer cells and cells comprising tumors in vitro or in vivo. Preferably, the anthraquinones have the chemical formula: wherein R1 is selected from the group consisting of hydrogen, alkyl, and substituted alkyl; R2 is a group containing 1-12 carbons selected from the group consisting of alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate and combinations thereof; and R3 is a group containing 1 to 12 carbons selected from the group consisting of methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, and combinations thereof.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: April 5, 2005
    Assignee: Board of Trustees of Michigan State University
    Inventors: Muraleedharan G. Nair, Robert H. Cichewicz, Navindra P. Seeram, Yanjun Zhang
  • Patent number: 6838443
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: January 4, 2005
    Assignees: Board of Trustees of Michigan State University, The Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20040258781
    Abstract: Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.
    Type: Application
    Filed: July 8, 2004
    Publication date: December 23, 2004
    Applicant: Board of Trustees of Michigan State University
    Inventors: Muraleedharan G. Nair, Bolleddula Jayaprakasam
  • Patent number: 6818234
    Abstract: The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: November 16, 2004
    Assignees: Access Business Group International LLC, Michigan State University
    Inventors: Muraleedharan G. Nair, Haibo Wang, David L. Dewitt, David W. Krempin, Dipak K. Mody, Yong Qian, David G. Groh, Audra J. Davies, Mary A. Murray, Robin Dykhouse, Marc Lemay
  • Publication number: 20040200139
    Abstract: A method and compositions for increasing ectomycorrhizal colonization of the roots of trees using an alkali metal formononetinate, formononetin or mixtures thereof is described. The method enhances the growth of healthy and impaired trees.
    Type: Application
    Filed: January 6, 2004
    Publication date: October 14, 2004
    Applicant: Vamtech, L.L.C.
    Inventors: Michael P. Amaranthus, Muraleedharan G. Nair, Taylor C. Reid
  • Patent number: 6800615
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: October 5, 2004
    Assignees: Board of Trustees of Michigan State University, The Regent of the University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20040161523
    Abstract: A method for isolating a mixture of anthocyanins, bioflavonoids and phenolics from an edible berry using adsorbent resins which are regenerable for reuse is described. The mixture with a consumable carrier is particularly useful in foods and as a dietary supplement or nutraceutical product.
    Type: Application
    Filed: February 11, 2004
    Publication date: August 19, 2004
    Applicant: Michigan State University
    Inventor: Muraleedharan G. Nair
  • Publication number: 20040152645
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo.
    Type: Application
    Filed: January 20, 2004
    Publication date: August 5, 2004
    Applicants: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20040132672
    Abstract: A method for inhibiting stomach or colon cancer cells in a mammal using a composition comprising an anthocyanidin. The method involves using the composition in an amount and for a time to inhibit the cancer cells. The composition can include other anticancer agents.
    Type: Application
    Filed: December 1, 2003
    Publication date: July 8, 2004
    Applicant: Board of Trustees of Michigan State University
    Inventors: Muraleedharan G. Nair, Yanjun Zhang, Shaiju K. Vareed
  • Publication number: 20040116361
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo.
    Type: Application
    Filed: November 26, 2003
    Publication date: June 17, 2004
    Applicants: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20040106686
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo.
    Type: Application
    Filed: November 26, 2003
    Publication date: June 3, 2004
    Applicants: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20040096524
    Abstract: Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.
    Type: Application
    Filed: November 14, 2002
    Publication date: May 20, 2004
    Applicant: Michigan State University
    Inventors: Muraleedharan G. Nair, Bolleddula Jayaprakasam
  • Patent number: 6676978
    Abstract: A method for isolating a mixture of anthocyanins, bioflavonoids and phenolics from an edible berry using adsorbent resins which are regenerable for reuse is described. The mixture with a consumable carrier is particularly useful in foods and as a dietary supplement or nutraceutical product.
    Type: Grant
    Filed: October 3, 2000
    Date of Patent: January 13, 2004
    Assignee: Board of Trustees of Michigan State University
    Inventor: Muraleedharan G. Nair
  • Publication number: 20030229032
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo.
    Type: Application
    Filed: December 12, 2002
    Publication date: December 11, 2003
    Applicants: Board of Trustees of MICHIGAN STATE UNIVERSITY, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Patent number: 6656914
    Abstract: A method for inhibiting a tumor in a mammal using a composition comprising an anthocyanin or cyanidin from a berry is described. The method involves using the composition in an amount and for a time to inhibit the tumor. The composition can include other antitumor agents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: December 2, 2003
    Assignee: Board of Trustees of Michigan State University
    Inventors: Muraleedharan G. Nair, Leslie D. Bourquin, Navindra P. Seeram, Soo-Young Kang
  • Patent number: 6623743
    Abstract: A method for providing nutraceutical or phytoceutical benefits to a mammal, particularly a human, using cherry derivatives is described. A method for inhibiting oxidation in a living biological material is also described. A composition of anthocyanins, bioflavonoids, phenolics or mixtures thereof from cherries is used in the methods.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: September 23, 2003
    Assignee: Board of Trustees of Michigan State University
    Inventors: Muraleedharan G. Nair, Haibo Wang, Gale M. Strasburg, Alden M. Booren, James I. Gray