Patents by Inventor Nader Najafi
Nader Najafi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8744544Abstract: A system for monitoring a charge-based physiological parameter within an internal organ of a living body, and a sensor adapted to be implanted in the living body and an organ therein. The sensor includes sensing elements adapted to sense the charge-based physiological parameter within the organ, and the sensing elements include at least first and second sensing elements that are electrically conductive, aligned, spaced apart and exposed at the exterior of the sensor. The sensor further includes a device for passing an alternating current from the first to the second sensing elements through an ionic solution contacting the sensing elements. The sensor also includes a device for generating a signal corresponding to the impedance of the ionic solution based on the alternating current.Type: GrantFiled: October 17, 2008Date of Patent: June 3, 2014Assignee: Integrated Sensing Systems, Inc.Inventors: Nader Najafi, Douglas Ray Sparks
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Patent number: 8715300Abstract: A delivery system and method for placing a medical implant, such as for diagnosing, monitoring and/or treating cardiovascular diseases. The delivery system includes a hollow catheter, an anchor coupled to the catheter, and an implant secured within the anchor. The anchor has a base portion with first and second longitudinal ends and a cage therebetween. The anchor further has flexible arms, flexible legs, features for securing the medical implant within the cage of the base portion, and a coupler portion connected to and spaced apart from the second longitudinal end of the base portion. Surfaces of the arms and legs are adapted to clamp the anchor to a wall. The system further includes a pusher wire adapted to cause the anchor to acquire a stowed configuration in which the legs axially extend from the base portion, permitting the anchor to be retrieved after its deployment.Type: GrantFiled: June 30, 2011Date of Patent: May 6, 2014Assignee: Integrated Sensing Systems, Inc.Inventors: Nader Najafi, David Joseph Goetzinger, Catherine Hook Morgan, Jacek Ryszard Baranowski
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Patent number: 8695418Abstract: Fluidic systems and methods of determining properties of fluids flowing therein. The fluidic systems and methods make use of a micromachined device that determines at least one property of the fluid within the system. The micromachined device includes a base structure on a substrate and a tube structure extending from the base structure and spaced apart from a surface of the substrate. The tube structure has at least one pair of geometrically parallel tube portions substantially lying in a plane, and at least one continuous internal passage defined at least in part within the parallel tube portions. A drive element induces vibrational movement of the tube structure in the plane of the tube structure and induces resonant vibrational movements in the tube portions in the plane of the tube structure. A sensing element senses deflections of each tube portion in the plane of the tube structure.Type: GrantFiled: April 25, 2011Date of Patent: April 15, 2014Assignee: Integrated Sensing Systems, Inc.Inventors: Douglas Ray Sparks, Michael W. Putty, Nader Najafi, Richard Thayre Smith
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Patent number: 8696693Abstract: An anchor for a medical implant, methods of manufacturing the anchor, and procedures for placing a medical implant, such as for diagnosing, monitoring and/or treating cardiovascular diseases. The anchor has a base portion with first and second longitudinal ends and a cage therebetween. The anchor further has flexible arms, flexible legs, features for securing the medical implant within the cage of the base portion, and a coupler portion connected to and spaced apart from the second longitudinal end of the base portion. The anchor is adapted to have a deployed configuration in which the arms and legs radially project away from the base portion, the arms axially project toward the second longitudinal end of the base portion, and the legs axially project toward the first longitudinal end of the base portion. Convex surfaces of the arms and legs are adapted to clamp the anchor to a wall.Type: GrantFiled: December 6, 2010Date of Patent: April 15, 2014Assignee: Integrated Sensing Systems, Inc.Inventors: Nader Najafi, David Joseph Goetzinger, Catherine Hook Morgan, Jacek Ryszard Baranowski
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Publication number: 20140044900Abstract: A micromachined tube (microtube) suitable for microfluidic devices. The microtube is formed by isotropically etching a surface of a first substrate to define therein a channel having an arcuate cross-sectional profile, and forming a substrate structure by bonding the first substrate to a second substrate so that the second substrate overlies and encloses the channel to define a passage having a cross-sectional profile of which at least half is arcuate. The substrate structure is thinned to define the microtube and walls thereof that surround the passage.Type: ApplicationFiled: October 8, 2013Publication date: February 13, 2014Applicant: Integrated Sensing Systems, Inc.Inventors: Douglas Ray Sparks, Nader Najafi
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Patent number: 8585910Abstract: A process for producing a micromachined tube (microtube) suitable for microfluidic devices. The process entails isotropically etching a surface of a first substrate to define therein a channel having an arcuate cross-sectional profile, and forming a substrate structure by bonding the first substrate to a second substrate so that the second substrate overlies and encloses the channel to define a passage having a cross-sectional profile of which at least half is arcuate. The substrate structure can optionally then be thinned to define a microtube and walls thereof that surround the passage.Type: GrantFiled: March 3, 2009Date of Patent: November 19, 2013Assignee: Integrated Sensing Systems Inc.Inventors: Douglas Ray Sparks, Nader Najafi
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Patent number: 8512252Abstract: A delivery method and system for noninvasively monitoring cardiac physiologic parameters used to evaluate patients with cardiovascular conditions. The system includes an implantable sensing device configured for chronic implantation in a cavity of the cardiovascular system, such as the heart, pulmonary artery (PA), etc. The method involves introducing the sensing device through a cardiovascular cavity that is upstream in the vasculature from the cavity where implantation is intended and has a larger diameter than the intended cavity, and thereafter blood flow through the cardiovascular system delivers the device to the intended cavity. The device is sized and configured so as to secure itself within the intended cavity when the device moves through the cavity to a point where the diameter narrows sufficiently to secure the device and so as to be oriented once secured to sense a pressure either within, upstream (wedge), or downstream (distal) of the cavity.Type: GrantFiled: November 1, 2005Date of Patent: August 20, 2013Assignee: Integrated Sensing Systems Inc.Inventors: Achiau Ludomirsky, David Goetzinger, Catherine Morgan, Nader Najafi
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Publication number: 20130144379Abstract: In some embodiments, a cardiac monitoring system includes multiple sensors configured for implantation in a cardiovascular system of a user. Each sensor includes a sensing unit configured to be disposed in sensory communication with the location for measuring a biological parameter in the at least one heart chamber. The sensing unit is also configured to generate a sensory signal associated with the biological parameter. Each sensor also includes a wireless transceiver configured to receive the sensory signal from the sensing unit. The wireless transceiver is further configured to wirelessly transmit the sensory signal to an external processing device disposed outside a body of the user. The external processing device monitors, based on the sensory signal received from at least two sensors from the plurality of sensors, cardiac health associated with at least one of an implanted device or a surgery.Type: ApplicationFiled: June 8, 2012Publication date: June 6, 2013Applicant: Integrated Sensing Systems, Inc.Inventors: Nader Najafi, Jacek Rysard Baranowski, David Joseph Goetzinger
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Patent number: 8408073Abstract: A microfluidic device and sensing method that utilize a resonating tube configured to have sufficient sensitivity to be capable of sensing the volume of a gas present as bubbles in a liquid or the flow rate and/or density of a gas or gas mixture flowing through the tube. The tube has a freestanding tube portion supported above a surface of a substrate so as to be capable of vibrating in a plane normal to the surface of the substrate. As a gas-containing fluid flows through an internal passage of the tube, a drive signal vibrates the freestanding tube portion at a resonant frequency thereof. Coriolis-induced deflections of the freestanding tube portion are sensed relative to the substrate to produce an output corresponding to the sensed deflections, and the drive signal and/or the output are assessed to determine the volume, density and/or flow rate of the gas of the gas-containing fluid.Type: GrantFiled: October 11, 2011Date of Patent: April 2, 2013Assignee: Integrated Sensing Systems Inc.Inventors: Douglas Ray Sparks, Richard Thayre Smith, Nader Najafi
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Patent number: 8412332Abstract: An implantable system and method for deep brain stimulation (DBS) treatments. The implantable system is sufficiently small and self-contained to enable implantation of the entire system within the brain, or optionally within the brain and the surrounding tissue. The system comprises an implantable inductor on which a voltage is induced when subjected to an electromagnetic field, and an implantable device comprising a housing, stimulating elements at an exterior surface of the housing, and electronics within the housing and electrically connected to the implantable inductor. The electronics produces a brain-stimulating current from the voltage induced on the implantable inductor and then delivers the brain-stimulating current to the stimulating elements. Deep brain stimulation is performed by subjecting the inductor to an electromagnetic field to induce a voltage on the inductor that powers the electronics to produce and deliver the brain-stimulating current to the stimulating elements.Type: GrantFiled: October 20, 2008Date of Patent: April 2, 2013Assignee: Integrated Sensing Systems, Inc.Inventors: Sonbol Massoud-Ansari, Nader Najafi
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Patent number: 8343068Abstract: An anchor for an implantable sensing device, a sensor unit formed by the anchor and sensing device, and a surgical procedure for implanting the sensor unit for monitoring a physiological parameter within a cavity of a living body, such as an intracranial physiological property. The anchor includes a shank portion and a head portion. The shank portion defines a distal end of the anchor and has a bore defining an opening at the distal end. The head portion defines a proximal end of the anchor and has a larger cross-sectional dimension than the shank portion. The sensor unit comprises the anchor and the sensing device placed and secured within the bore of the anchor so that a sensing element of the sensing device is exposed for sensing the physiological parameter within the cavity.Type: GrantFiled: May 25, 2010Date of Patent: January 1, 2013Assignee: Integrated Sensing Systems Inc.Inventors: Nader Najafi, Catherine Hook Morgan, David Joseph Goetzinger, Sonbol Massoud-Ansari
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Patent number: 8322346Abstract: A minimally-invasive surgical procedure for monitoring a physiological parameter within an internal organ of a living body. The procedure entails making a first incision in the body to enable access to the organ. An endoscopic instrument is then inserted through the first incision and a second incision is made therewith through an external wall of the organ and into the internal cavity thereof. A sensing unit is placed in the second incision such that the second incision is occluded by the unit and a proximal end of the unit is outside the organ. The unit includes a sensing device having a sensing element adapted to sense the physiological parameter within the organ, and an anchor to which the sensing device is secured. The first incision is closed, after which a readout device outside the body telemetrically communicates with the sensing device to obtain a reading of the physiological parameter.Type: GrantFiled: June 25, 2008Date of Patent: December 4, 2012Assignee: Integrated Sensing Systems, Inc.Inventors: Nader Najafi, Catherine Hook Morgan
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Publication number: 20120260718Abstract: A microfluidic device and sensing method that utilize a resonating tube configured to have sufficient sensitivity to be capable of sensing the volume of a gas present as bubbles in a liquid or the flow rate and/or density of a gas or gas mixture flowing through the tube. The tube has a freestanding tube portion supported above a surface of a substrate so as to be capable of vibrating in a plane normal to the surface of the substrate. As a gas-containing fluid flows through an internal passage of the tube, a drive signal vibrates the freestanding tube portion at a resonant frequency thereof. Coriolis-induced deflections of the freestanding tube portion are sensed relative to the substrate to produce an output corresponding to the sensed deflections, and the drive signal and/or the output are assessed to determine the volume, density and/or flow rate of the gas of the gas-containing fluid.Type: ApplicationFiled: October 11, 2011Publication date: October 18, 2012Applicant: INTEGRATED SENSING SYSTEMS INC.Inventors: Douglas Ray Sparks, Richard Thayre Smith, Nader Najafi
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Patent number: 8272274Abstract: A microelectromechanical system (MEMS) device and a method for operating the device to determine at least one property of a fluid. The device includes a base on a substrate and a tube structure extending from the base and spaced apart from a surface of the substrate. The tube structure includes at least one tube portion and more preferably at least a pair of parallel tube portions substantially lying in a plane, at least one continuous internal passage defined at least in part within the parallel tube portions, and an inlet and outlet of the internal passage fluidically connected to the base. A drive element is operable to induce vibrational movement in the tube structure in a plane of the tube structure and induce resonant vibrational movements in the tube portions. A sensing element senses the deflections of the tube portions when the tube structure is vibrated with the drive element.Type: GrantFiled: February 11, 2009Date of Patent: September 25, 2012Assignee: Integrated Sensing Systems Inc.Inventors: Douglas Ray Sparks, Michael W. Putty, Richard Thayre Smith, Nader Najafi
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Patent number: 8267863Abstract: A system and surgical procedure for monitoring physiological parameters within an internal organ of a living body. The procedure entails making a first incision to expose the organ and a second incision through an external wall of the organ and into an internal cavity. A sensing unit is placed in the second incision such that a proximal end thereof remains outside the organ. The unit includes a sensing device having a sensing element for sensing the physiological parameter within the organ, and an anchor to which the sensing device is secured. The unit occludes the second incision and a distal end of the unit does not extend more than one centimeter into the cavity. The anchor is then secured to the wall of the organ, after which the first incision is closed and a readout device telemetrically communicates with the sensing device to obtain a reading of the physiological parameter.Type: GrantFiled: April 29, 2008Date of Patent: September 18, 2012Assignee: Integrated Sensing Systems, Inc.Inventors: Nader Najafi, Sonbol Massoud-Ansari, Catherine Hook Morgan
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Publication number: 20120157961Abstract: A device and method capable of sensing the presence of biochem agents, and preferably also capable of delivering precise amounts of one or more antidotes to treat a victim exposed to the agents. The device includes a freestanding tube portion having an internal passage containing a substance selective to a chemical or biological agent so that matter accumulates within the freestanding tube portion when a fluid drawn through the tube portion contains the agent. When vibrated at resonance, the resonant frequency of the tube portion is indicative of the accumulation of matter and thereby the presence of the agent to which the substance is selective. The device then preferably delivers precise amounts of one or more appropriate antidotes to treat the victim. The device is a sufficiently small and lightweight unit to permit being carried by an individual.Type: ApplicationFiled: February 15, 2008Publication date: June 21, 2012Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Douglas Ray Sparks, Nader Najafi
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Publication number: 20120022507Abstract: A delivery system and method for placing a medical implant, such as for diagnosing, monitoring and/or treating cardiovascular diseases. The delivery system includes a hollow catheter, an anchor coupled to the catheter, and an implant secured within the anchor. The anchor has a base portion with first and second longitudinal ends and a cage therebetween. The anchor further has flexible arms, flexible legs, features for securing the medical implant within the cage of the base portion, and a coupler portion connected to and spaced apart from the second longitudinal end of the base portion. Surfaces of the arms and legs are adapted to clamp the anchor to a wall. The system further includes a pusher wire adapted to cause the anchor to acquire a stowed configuration in which the legs axially extend from the base portion, permitting the anchor to be retrieved after its deployment.Type: ApplicationFiled: June 30, 2011Publication date: January 26, 2012Applicant: INTEGRATED SENSING SYSTEMS INC.Inventors: Nader Najafi, David Joseph Goetzinger, Catherine Hook Morgan, Jacek Ryszard Baranowski
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Publication number: 20110303229Abstract: An anchor for a medical implant, methods of manufacturing the anchor, and procedures for placing a medical implant, such as for diagnosing, monitoring and/or treating cardiovascular diseases. The anchor has a base portion with first and second longitudinal ends and a cage therebetween. The anchor further has flexible arms, flexible legs, features for securing the medical implant within the cage of the base portion, and a coupler portion connected to and spaced apart from the second longitudinal end of the base portion. The anchor is adapted to have a deployed configuration in which the arms and legs radially project away from the base portion, the arms axially project toward the second longitudinal end of the base portion, and the legs axially project toward the first longitudinal end of the base portion. Convex surfaces of the arms and legs are adapted to clamp the anchor to a wall.Type: ApplicationFiled: December 6, 2010Publication date: December 15, 2011Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Nader Najafi, David Joseph Goetzinger, Catherine Hook Morgan, Jacke Ryszard Baranworki
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Patent number: 8016798Abstract: A fluid delivery system capable of delivering a precise amount of fluid, such as a fluid required for medical treatment. The delivery system makes use of an inline sensing unit that includes a housing comprising an inlet for receiving a fluid from a fluid source, an outlet for discharging the fluid from the housing, and at least one cavity between the inlet and the outlet. A sensing element and electronic circuitry are disposed within the at least one cavity. The electronic circuitry is adapted to produce an electrical output based on at least one response of the sensing element. The sensing unit is further equipped with a communication element for providing communication between the electronic circuitry and an electronic device remote from the housing.Type: GrantFiled: March 9, 2004Date of Patent: September 13, 2011Assignee: Integrated Sensing Systems, Inc.Inventors: Douglas Ray Sparks, Nader Najafi
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Publication number: 20110214512Abstract: Fluidic systems and methods of determining properties of fluids flowing therein. The fluidic systems and methods make use of a micromachined device that determines at least one property of the fluid within the system. The micromachined device includes a base structure on a substrate and a tube structure extending from the base structure and spaced apart from a surface of the substrate. The tube structure has at least one pair of geometrically parallel tube portions substantially lying in a plane, and at least one continuous internal passage defined at least in part within the parallel tube portions. A drive element induces vibrational movement of the tube structure in the plane of the tube structure and induces resonant vibrational movements in the tube portions in the plane of the tube structure. A sensing element senses deflections of each tube portion in the plane of the tube structure.Type: ApplicationFiled: April 25, 2011Publication date: September 8, 2011Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Douglas Ray Sparks, Michael W. Putty, Nader Najafi, Richard Thayre Smith