Abstract: Disclosed in the present invention are a primer-probe combination and a kit for vaginal microecosystem detection, wherein the primer-probe combination comprises primers and probes for target gene detection against Lactobacillus crispatus (LC), Lactobacillus gasseri (LG), Lactobacillus jensenii (LJ), Lactobacillus iners (LI), Gardnerella vaginalis (GV), Candida albicans (CA) and Trichomonas vaginalis (TV), and the probes are used for melting curve analysis. The kit comprises the primer-probe combination. The combination of specific primers and probes enables effective amplification of specific target genes of the above different microorganisms and melting curve analysis performed on the amplified products thereof, making detection of the above seven microorganisms in a single tube possible, thus achieving the advantages of high specificity, short time consuming, high sensitivity, comprehensive coverage of detection sites, etc.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a machine learning model on training data. In one aspect, one of the methods include: obtaining a training data set comprising a plurality of training inputs; obtaining data defining an original search space of a plurality of candidate data augmentation policies; generating, from the original search space, a compact search space that has one or more global hyperparameters; and training the machine learning model on the training data using one or more final data augmentation policies generated from the compact search space.

Abstract: A quantum dot composite structure and a method for forming the same are provided. The quantum dot composite structure includes: a glass particle including a glass matrix and a plurality of quantum dots located in the glass matrix, wherein at least one of the plurality of quantum dots includes an exposed surface in the glass matrix; and an inorganic protective layer disposed on the glass particle and covering the exposed surface.

Abstract: The embodiments of the disclosure provide a method for evaluating a health condition indicator of a subject, a host, and a computer readable storage medium. The method includes: obtaining a reference heart rate of the subject and determining a heart rate indicator of the subject according to the reference heart rate; determining a fitness indicator of the subject based on physiological information of the subject; determining an age indicator of the subject based on an age of the subject; and determining the health condition indicator of the subject at least based on the heart rate indicator, the fitness indicator, and the age indicator.

Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: The present disclosure provides a fixed-position defect doping method for a micro-nanostructure based on a self-alignment process, including: S1, sequentially forming a sacrificial layer and a photoresist layer on a surface of a crystal substrate; S2, performing a lithography on the photoresist layer to form a mask hole according to a micro-nano pattern; S3, performing an isotropic etching on the sacrificial layer through the mask hole, and amplifying the micro-nano pattern to the sacrificial layer; S4, performing an ion implantation doping on an exposed crystal surface below the mask hole; S5, removing the photoresist layer, and depositing a mask material; S6, removing the sacrificial layer, and transferring a micro-nano amplified pattern in the sacrificial layer to a mask material pattern; and S7, etching an exposed crystal surface, and removing the mask material on the surface and forming a specific defect by annealing.

Abstract: The present disclosure relates to window display methods and electronic devices. In one example window display method, an electronic device displays a first window and a second window, where a screen direction of the electronic device is a first direction, the screen direction is one of a portrait direction, a landscape direction, a reverse portrait direction, and a reverse landscape direction, and a display direction of the first window is the first direction. When detecting that the screen direction of the electronic device changes from the first direction to a second direction, the electronic device keeps a display direction of the second window unchanged, and rotates the first window, so that the display direction of the first window is the second direction.

Abstract: There is provided a display substrate, including: a base; light-emitting units on a side of the base; a flat light-shielding functional layer, including a black matrix and a first planarization layer, on a side of the light-emitting units away from the base, light outgoing openings being provided in the black matrix and being in one-to-one correspondence with the light-emitting units, and the first planarization layer at least filling the light outgoing openings; and a color filter layer, including color filter patterns in one-to-one correspondence with the light outgoing openings, on a side of the flat light-shielding functional layer away from the base, an orthographic projection of each color filter pattern on the base covering an orthographic projection of the light outgoing opening corresponding to the color filter pattern on the base. A method for manufacturing a display substrate, a display panel and a display apparatus are further provided.

Abstract: A module comprises a tray, a mechanical switch, and a linkage system. The tray is configured to receive a circuit board thereon. The mechanical switch is mounted to the tray and movable between an unsecured position and a secured position. The linkage system is mechanically coupled to the mechanical switch, and moves between an unsecured configuration and a secured configuration in response to the mechanical switch moving between the unsecured position and the secured position. When the module is coupled to a computing device and the linkage system is in the secured configuration, the linkage system engages the computing device, such that the module is locked to the computing device. When the module is coupled to the computing device and the linkage system is in the unsecured configuration, the linkage system is disengaged from the computing device, such that the module is unlocked from the computing device.

Abstract: The invention relates to a method for microbial remediation of underground water petroleum hydrocarbon contamination by regulating soil buffer capability, which comprises detecting the soil particle size of contaminated site soil, dividing the contaminated site soil into coarse-grained soil and fine-grained soil; dividing the contaminated site soil into high buffer capacity soil and low buffer capacity soil; and adjusting the composition and ratio of a biostimulant solution added to the contaminated site soil based on the classification of the contaminated site soil. The detecting step includes classifying soil with a particle size between 0.075 mm and 60 mm and a mass greater than or equal to 50% of the total mass as coarse-grained soil; and classifying soil with a particle size not greater than 0.075 mm and a mass greater than or equal to 50% as fine-grained soil.

Abstract: A stacked integrated circuit (IC) device and a method are disclosed. The stacked IC device includes a first semiconductor element. The first substrate includes a dielectric block in the first substrate; and a plurality of first conductive features formed in first inter-metal dielectric layers over the first substrate. The stacked IC device also includes a second semiconductor element bonded on the first semiconductor element. The second semiconductor element includes a second substrate and a plurality of second conductive features formed in second inter-metal dielectric layers over the second substrate. The stacked IC device also includes a conductive deep-interconnection-plug coupled between the first conductive features and the second conductive features. The conductive deep-interconnection-plug is isolated by dielectric block, the first inter-metal-dielectric layers and the second inter-metal-dielectric layers.

Abstract: An example computing system includes an I/O module that is securable to the computer chassis. The I/O module includes a gear rack. In additional implementations, the computing system includes a fastening assembly which has a fastener configured to receive an external rotational force from a user. In other implementations, the fastening assembly includes a thread mechanism having first and second portions. The first portion of the thread mechanism are rotatably fixed to the fastener. In other implementations, the fastening assembly includes a gear rotatably fixed to the second portion of the thread mechanism, the gear being configured to engage a gear rack coupled to the I/O module. Upon receiving the external rotational force, the thread mechanism also causes (a) the gear to rotate and (b), in turn, linear movement of the gear rack to (c) secure or unsecure the I/O module relative to the computer chassis.

Abstract: An example computing system includes an I/O module that is securable to the computer chassis. The I/O module includes a gear rack. In additional implementations, the computing system includes a fastening assembly which has a fastener configured to receive an external rotational force from a user. In other implementations, the fastening assembly includes a thread mechanism having first and second portions. The first portion of the thread mechanism are rotatably fixed to the fastener. In other implementations, the fastening assembly includes a gear rotatably fixed to the second portion of the thread mechanism, the gear being configured to engage a gear rack coupled to the I/O module. Upon receiving the external rotational force, the thread mechanism also causes (a) the gear to rotate and (b), in turn, linear movement of the gear rack to (c) secure or unsecure the I/O module relative to the computer chassis.

Abstract: The present invention discloses a method and system for evaluating road safety based on multi-dimensional influencing factors, and relates to the field of road safety technologies. Based on historical traffic data and corresponding safety influencing factors, safety evaluation models in different dimensions are respectively constructed, and road safety risk exposure is classified flexibly. The safety evaluation models in macro and micro dimensions are linked by using a constraint function, and influence mechanisms of the safety influencing factors are determined respectively. Specifically, a safety evaluation model is constructed and obtained for each sub-region in a limited region range. The safety evaluation model is applied to obtain influencing factors of safety of each traffic road in the sub-region, and safety evaluation is performed on the sub-region.

Abstract: The present invention discloses a combination of DNA methylation markers and the use thereof, primers, probes and a kit for early detection of ovarian cancer, wherein the combination of DNA methylation markers comprises at least one methylated fragment of each of four genes, including PCDHB18P, CDO1, HOXA9 and LYPD5. The detection primers and kit obtained for the methylated regions of the target genes can significantly improve the sensitivity of ovarian cancer detection, and meanwhile maintain a high specificity for normal ovarian cells and benign ovarian tumors. The detection primers and probes detect patients with possible gynecological malignant tumors early through molecular epigenetic methods using methylation detection technology, and the result is very accurate, and can provide clinicians with auxiliary diagnostic reference for early prophylactic treatment.

Abstract: A device to detect unauthorized opening of a casing is disposed in the upper or lower casing of an apparatus. The device includes a base plate with vibrator, carrier, and sensor on the lower case, and receiving grooves. Balls of a lesser number than the number of receiving grooves are installed in the grooves in a predetermined arrangement by the manufacturer. A waveguide element and magnet, fixed on the upper casing, is in contact with the balls, and when the waveguide is vibrated, the number and locations of the balls govern the form of a setting signal derived therefrom at the factory. If the upper casing is separated from the lower casing, the waveguide element separates from the carrier, the magnetic element gathers the balls, the predetermined arrangement being thereby lost, when tested by an authorized repair engineer.

Abstract: An expansion bay for a computer device for easy insertion and extension of an expansion component is disclosed. The expansion bay has two facing side walls, a bottom panel joining the facing side walls, and a closed end. A front cross member joins the side walls to define a front open end. A pair of springs are located the closed end that force the expansion component away from the closed end. A pair of rotating levers are mounted on the front cross member near each of the side walls. Each of the rotating levers has a pin that engages a groove on the expansion component that is inserted through the open front end. The levers are rotated via the pins engaging the grooves when the expansion component is moved into and out of open front end.

Abstract: A computing system includes a chassis, a circuit board including at least one electronic component, a mounting bracket secured to the chassis, a support bracket pivotably coupled to the mounting bracket, and a cold plate coupled to the support bracket. The support bracket is pivotable between a first configuration and a second configuration. The cold plate is in contact with the at least one electronic component in the first configuration, and the cold plate is removed from contact with the at least one electronic component in the second configuration.

Abstract: Disclosed are a transition metal-doped carbon microsphere, a preparation method therefor and an application thereof. The transition metal-doped carbon sphere has a uniform solid porous structure, and the transition metal is uniformly distributed inside the carbon sphere. The preparation method comprises that a carbon microsphere uniformly doped with manganese, vanadium, molybdenum and tungsten is prepared by means of a one-step hydrothermal method, is mixed with potassium oxalate, and is roasted in a protective atmosphere to obtain an activated metal-doped carbon sphere. The doped transition metal elements remain uniformly dispersed after being roasted, and do not agglomerate. The transition metal-doped carbon microsphere obtained has the following characteristics: it exhibits good adsorption properties for heavy metal ions Cr(VI), with the maximum adsorption amount being 660.