Abstract: The present invention discloses a type-G crystal form of fenolamine, a preparation method thereof, and a composition and use thereof. In particular, disclosed is a type-G crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-G fenolamine crystal form in solid state; a method for preparing the solid of type-G crystal form; and use of the solid of the type-G fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).

Abstract: There is provided a nanopore sensor including cis and trans fluidic reservoirs. A nanopore is provided in a support structure separating the cis and trans reservoirs. The nanopore has an inlet in fluidic connection with the cis fluidic reservoir and an outlet in fluidic connection with the trans fluidic reservoir. The cis fluidic reservoir has a fluidic access resistance, RC, the trans fluidic reservoir has a fluidic access resistance, RT, and the nanopore has a fluidic resistance, RP. RP is of the same order of magnitude as RT and both RP and RT are at least an order of magnitude greater than RC. An electrical transduction element is disposed at a nanopore sensor site that exposes the transduction element to the trans reservoir. An electrical circuit is connected to the electrical transduction element for producing an electrical signal indicative of changes in electrical potential local to the trans reservoir.

Abstract: Provided herein are compositions, systems, and methods for treating wounds with the combination of statins and cholesterol to help prevent and reduce scar formation.

Abstract: There is provided a multi-channel nanopore sensor having a plurality of independent nanopore sensors. Each independent nanopore sensor includes a nanopore disposed in a support structure. A fluidic connection is between a first fluidic reservoir, common to all of the independent nanopore sensors, and an inlet to the nanopore, with a first ionic solution of a first ionic concentration disposed in the first fluidic reservoir. A fluidic connection is between a second fluidic reservoir, common to all of the independent nanopore sensors, and an outlet from the nanopore, with a second ionic solution of a second ionic concentration, different than the first ionic concentration, disposed in the second fluidic reservoir. An electrical transduction element, disposed in contact with that ionic solution having a lower ionic concentration, is arranged at a site that produces an electrical signal indicative of electrical potential local to that ionic solution having a lower ionic concentration.

Abstract: Storage virtualization techniques allow files and directories to be stored remotely, for example, by a cloud storage provider, but in a manner that appears to a user or application running on a local computing device as if the files are stored locally—even though the data of those files and directories may not be resident on the local computing device. That is, the contents of files and directories that may exist in the cloud look and behave as if they were stored locally on a computing device. The level of hydration of placeholders may be monitored and operations may be performed to reduce the impact of excessive hydration on the resources of the computing device.

Abstract: The present invention discloses a type-B crystal form of fenolamine, a preparation method thereof, and a composition and use thereof, more particularly a type-B crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-B fenolamine crystal form in solid state; a method for preparing the solid of type-B crystal form; and use of the solid of the type-B fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).

Abstract: Techniques are disclosed for managing applications. Responsive to receiving a request for access to a first application, metadata is retrieved that is written to the local drive of the computing device. Responsive to the metadata indicating that the first application is not written to the local drive of the computing device, a download request is transmitted to an application provider. A download package for application is received that includes one or more application files that are operable to execute the application when stored on the computing device without executing an installation process.

Abstract: A compressed sensing based object imaging system and an imaging method thereof. The object imaging system comprises a light source generation unit (11), a filter unit (12), an image generation unit (13), an image acquisition unit (14), and an image reconstruction unit (15). The light source generation unit (11) generates experimental laser; the filter unit (12) filters high frequency scattered light and forms parallel light; the image generation unit (13) generates an experimental image in which an object image (16) and a specific measurement matrix (17) are superimposed; the image acquisition unit (14) performs compression sampling on the generated experimental image; and the image reconstruction unit (15) reconstructs sampling data to restore the object image (16).

Abstract: Storage virtualization techniques allow directories to be stored remotely, for example, by a cloud storage provider, but in a manner that appears to a user or application running on a local computing device as if the directories are stored locally—even though the data of those directories may not be resident on the local computing device. That is, the contents of directories that may exist in the cloud look and behave as if they were stored locally on a computing device.

Abstract: The present invention discloses a type-B crystal form of fenolamine, a preparation method thereof, and a composition and use thereof, more particularly a type-B crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-B fenolamine crystal form in solid state; a method for preparing the solid of type-B crystal form; and use of the solid of the type-B fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).

Abstract: Techniques are disclosed for managing applications. Responsive to receiving a request for access to a first application, metadata is retrieved that is written to the local drive of the computing device. Responsive to the metadata indicating that the first application is not written to the local drive of the computing device, a download request is transmitted to an application provider. A download package for application is received that includes one or more application files that are operable to execute the application when stored on the computing device without executing an installation process.

Abstract: Techniques are disclosed for managing applications. Responsive to receiving a request for access to a first application, metadata is retrieved that is written to the virtual machine. Responsive to the metadata indicating that the first application is not written to the virtual machine, a download request is transmitted to a remote host. A download package for application is received that includes one or more application files that are operable to execute the application when stored at the virtual machine without executing an installation process.

Abstract: A system to enable a user to generate copies of files at a client device and to cause a file hosting platform to generate backups of these copies in a cloud database without transferring file content data for these files between the client device and the cloud database. When a user copies a file from a first folder on a client device to a second folder on the client device, the system may determine that the file content data for this file is already present in the cloud database. Then, rather than uploading the file content data to the cloud database from the client device, the system may cause a file hosting platform to access the file content data directly from the cloud database to perform a file copy operation.

Abstract: Methods, systems, and computer storage media for providing a set of common flat files in a composite image that can be mounted as a container (i.e. composite container) to support isolation and interoperation of computing resources. Container management is provided for a container management system based on a composite image file system engine that executes composite operations to support resource isolation and operating system (OS) virtualization functionality. In particular, a layout manager operates with a composite engine interface to support generating composite images with optimized configurations (i.e., pre-alignment and pre-computed hashes of for executable files). In operation, a plurality of files for generating a composite image are accessed.

Abstract: Methods, systems, and computer storage media for providing a set of common flat files in a composite image that can be mounted as a container (i.e., composite container) to support isolation and interoperation of computing resources. Container management is provided for a container management system based on a composite image file system engine that executes composite operations to support resource isolation and operating system (OS) virtualization functionality. In particular, a container engine interface supports creating, mounting, and providing access to and from composite images or composite containers. In operation, a plurality of files for generating a composite image are accessed. The composite image for the plurality of files is generated. The composite image includes a set of common flat files. The composite image is communicated to cause mounting of the composite image, where mounting the composite image is based on a metadata file from the set of common flat files.

Abstract: Methods, systems, and computer storage media for providing a set of common flat files in a composite image that can be mounted as a container (i.e. composite container) to support isolation and interoperation of computing resources. Container management is provided for a container management system based on a composite image file system engine that executes composite operations. In particular, a remote sharing manager operates with a composite engine interface to support generating composite images configured for split layer memory sharing, split layer direct access memory sharing, and dynamic base images. In operation, a plurality of files and a selection of a remote sharing configuration for generating a composite image are accessed. The composite image for the plurality of files and the remoting sharing configuration is generated. The composite image is communicated to cause sharing of the composite image, sharing of the composite image is based on the remote sharing configuration.

Abstract: In a method for sensing translocation of a molecule through a nanopore, a molecule in a first fluidic solution in a first fluidic reservoir that is in direct fluidic connection with the nanopore is directed to a nanopore inlet and translocated through the nanopore to a nanopore outlet and through a fluidic passage that is in direct fluidic connection with the nanopore outlet, to a second fluidic solution in a second fluidic reservoir disposed in direct fluidic connection with the fluidic passage. The fluidic passage has at least one fluidic section in which a length of the fluidic section is greater than a width of the fluidic section. Translocation of the molecule through the nanopore is sensed by measuring the electrical potential local to the fluidic passage during the translocation of the molecule.

Abstract: A first fluidic solution having a first ionic concentration is provided in a first fluidic reservoir in direct fluidic connection with a nanopore. A second fluidic solution, having a second ionic concentration, is provided in a second fluidic reservoir disposed in fluidic connection with the nanopore through a fluidic passage having at least one fluidic section in which the section length is greater than the section width. The electrical potential local to the fluidic passage is measured, and the resistance of both the fluidic passage the nanopore are determined based on the fluidic passage electrical potential. The fluidic passage resistance is compared with the nanopore resistance and at least one of the first and second ionic concentrations is adjusted based on the comparison. The measuring, determining, comparing, and adjusting steps are conducted until the fluidic passage resistance is between about 0.1 times and about 10 times the nanopore resistance.

Abstract: Storage virtualization techniques allow directories to be stored remotely, for example, by a cloud storage provider, but in a manner that appears to a user or application running on a local computing device as if the directories are stored locally—even though the data of those directories may not be resident on the local computing device. That is, the contents of directories that may exist in the cloud look and behave as if they were stored locally on a computing device.

Abstract: Systems, methods, and apparatuses are disclosed for file synchronizing service status monitoring and error handling. A client device includes a local file system access manager that includes a status interface. The status interface is configured to receive a status message from a client-side sync manager of the client device. The client-side sync manager that communicates with a server-side sync manager at a server to synchronize data objects between file systems of the client device and server. The status message corresponds to a state of the client-side sync manager during a multi-stage start-up process for the client-side sync manager. A status caller in an application of the client device can retrieve the status message from the status interface. The status message can also be provided to a user interface for display to a user of the client device, and/or to a telemetry server for use in improving the file synchronizing service.