Abstract: A spherical reamer comprises a cutting element having a support member and at least one circumference cutting member built on it. The cutting member can be characterized by edge configuration, geometric parameters or further by positional parameters, respectively. All variations of the parameters above lead various types of the cutting elements and methods of including self- assembling and/or “One Size Cutting Element for Assembling Several Size of Reamers” in order to assembling either reusable or disposable reamer.

Abstract: Systems, methods, and apparatuses are disclosed for file synchronizing service status monitoring and error handling. A client device includes a local file system access manager that includes a status interface. The status interface is configured to receive a status message from a client-side sync manager of the client device. The client-side sync manager that communicates with a server-side sync manager at a server to synchronize data objects between file systems of the client device and server. The status message corresponds to a state of the client-side sync manager during a multi-stage start-up process for the client-side sync manager. A status caller in an application of the client device can retrieve the status message from the status interface. The status message can also be provided to a user interface for display to a user of the client device, and/or to a telemetry server for use in improving the file synchronizing service.

Abstract: A method of preparing liposomal statins includes preparing a lipid solution including phosphatidylcholine, cholesterol, vitamin-E and an organic solvent and removing the solvent, forming a lipid cake. The lipid cake may then be hydrated with a first aqueous media. The hydrated cake may be mixed in a mixer and subjected to one or more freeze/thaw cycles and then extruded to form liposomes. A cryo-protective agent may be added to the liposomes and the liposomes may be lyophilized to provide a powder. A statin is added to the organic lipid solution or to the first aqueous media used for hydrating the lipid cake.

Abstract: There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic solution of a first ionic concentration. The molecule is caused to translocate through the nanopore from the inlet of the nanopore to an outlet of the nanopore and into a second ionic solution of a second ionic concentration that is different than the first ionic concentration. An electrical potential, local to that ionic solution, of the first and second ionic solutions, which has a lower ionic concentration, is measured while the molecule is caused to translocate through the nanopore.

Abstract: Methods and apparatus for preparing at least a hemispherical surface with a desired dimension have been disclosed. The method includes at least two steps: a primary cutting mode for mostly reaming a lower portion of the target site, which enveloped area from the pole to intermediate latitude and a finishing cutting mode for reaming either an upper portion or an entire area of the site by less number of times of rotation, respectively. The intermediate latitude locates between the pole and the equator of hemisphere.

Abstract: A system to enable a user to generate copies of files at a client device and to cause a file hosting platform to generate backups of these copies in a cloud database without transferring file content data for these files between the client device and the cloud database. When a user copies a file from a first folder on a client device to a second folder on the client device, the system may determine that the file content data for this file is already present in the cloud database. Then, rather than uploading the file content data to the cloud database from the client device, the system may cause a file hosting platform to access the file content data directly from the cloud database to perform a file copy operation.

Abstract: An earphone, comprising a rear housing, a front housing, and a loudspeaker unit which divides a cavity formed by the rear housing and the front housing into a front and rear acoustic cavities; wherein the earphone further comprises a sound adjusting element; the front housing is provided with a sound outlet hole and mode posts, and the sound adjusting element is provided with a sound adjusting hole corresponding to the sound outlet hole and a mode adjustment groove corresponding to the mode posts; when the sound adjusting element rotates, the mode adjustment groove may be limited by different mode posts, thus adjusting the volume of the front acoustic cavity and the area of a sound hole for the front acoustic cavity. Use of the above-described invention enables the middle and high frequency responses of the earphone to be adjusted and enables a single earphone to provide different sound characteristics.

Abstract: The present invention relates in a first aspect to a method of preparing a crystalline lanthanum-carboxylate coordination polymer and the crystalline lanthanum-carboxylate coordination polymer obtained or obtainable by the method. In another aspect of the present invention, also provides a method of detecting a target nucleic acid sequence in a sample.

Abstract: An earphone, comprising an earphone housing and a loudspeaker unit accommodated in the earphone housing, the loudspeaker unit dividing a cavity formed by the earphone housing into an earphone front sound cavity and an earphone rear sound cavity; wherein the earphone further comprises a tuning mechanism; wherein a rear sound cavity audio hole is provided on the loudspeaker unit rear sound cavity, and the loudspeaker unit rear sound cavity is in communication with the earphone rear sound cavity through the rear sound cavity audio hole; the tuning mechanism is provided between the rear sound cavity audio hole and the housing, and the tuning mechanism is used to adjust the size of the rear sound cavity audio hole of the loudspeaker unit. The present application allows for individual adjustment of the sound quality of the earphone in accordance with a middle and low frequency requirements of different users.

Abstract: Provided herein are compositions, systems, and methods for treating wounds with the combination of statins and cholesterol to help prevent and reduce scar formation.

Abstract: The subject disclosure is directed towards partially recalling file ranges of deduplicated files based on tracking dirty (write modified) ranges (user writes) in a way that eliminates or minimizes reading and writing already-optimized adjacent data. The granularity of the ranges does not depend on any file-system granularity for tracking ranges. In one aspect, lazy flushing of tracking data that preserves data-integrity and crash-consistency is provided. In one aspect, also described is supporting granular partial recall on an open file while a data deduplication system is optimizing that file.

Abstract: The present invention relates in a first aspect to a method of preparing a crystalline lanthanum-carboxylate coordination polymer and the crystalline lanthanum-carboxylate coordination polymer obtained or obtainable by the method. In another aspect of the present invention, also provides a method of detecting a target nucleic acid sequence in a sample.

Abstract: A method of preparing a crystalline copper-based coordination polymer comprises preparing a mixture of copper ions and a first quaternized carboxylate pyridyl ligand; adding a second polypyridyl ligand; and forming crystals of a copper-based coordination polymer therefrom. The crystalline copper-based coordination polymer is suitable for providing a sensing platform for detecting the presence of one or more target nucleic acid sequences such as viral RNA, in particular Dengue virus and/or Zika virus RNA with high selectivity and high specificity. A method of detecting at least a first target nucleic acid sequence, in particular from a viral RNA, in particular it is Flavivirus RNA, in a sample is also provided. Further provided is a kit including the crystalline copper-based coordination polymer and an oligonucleotide probe.

Abstract: A file system executing on a computing device may store a placeholder for a file on secondary storage of the computing device. The placeholder may comprise a sparse data stream containing none or some of the data of the file and information which enables the remotely stored data of the file to be retrieved from the network. As some or all of the data for the file is being stored remotely, the computing device may rely on a storage virtualization provider to create metadata for the file. Thus, the file system executing on the computing device may receive, from the storage virtualization provider, a request to store metadata associated with the file. In response to this request, the file system may store the metadata as a Binary Large Object (BLOB) in a secondary data stream of the placeholder for the file.

Abstract: A solid state molecular sensor having an aperture extending through a thickness of a sensing material is configured with a continuous electrically-conducting path extending in the sensing material around the aperture. A supply reservoir is connected to provide a molecular species, having a molecular length, from the supply reservoir to an input port of the aperture. A collection reservoir is connected to collect the molecular species from an output port of the aperture after translocation of the molecular species from the supply reservoir through the sensing aperture. The sensing aperture has a length between the input and output ports, in the sensing material, that is substantially no greater than the molecular length of the molecular species from the supply reservoir. An electrical connection to the sensing material measures a change in an electrical characteristic of the sensing material during the molecular species translocation through the aperture.

Abstract: A method of preparing a crystalline zwitterionic zinc(II)-carboxylate compound includes the steps of preparing a mixture of zinc(II) ions and a first pyridyl ligand having three carboxylic acid moieties; subjecting the mixture to conditions under which a precipitate is formed; separating the precipitate; adding a solvent and optionally a second pyridyl ligand to the separated precipitate; subjecting the obtained mixture to conditions under which crystals of the zwitterionic zinc(II)-carboxylate compound are formed; and separating the crystals of the zwitterionic zinc(II)-carboxylate compound. Preferably but not exclusively, the crystalline zwitterionic zinc(II)-carboxylate compound essentially consists of at least one 1D coordination polymer.

Abstract: An earphone, comprising an earphone housing and a loudspeaker unit accommodated in the earphone housing, the loudspeaker unit dividing a cavity formed by the earphone housing into an earphone front sound cavity and an earphone rear sound cavity; wherein the earphone further comprises a tuning mechanism; wherein a rear sound cavity audio hole is provided on the loudspeaker unit rear sound cavity, and the loudspeaker unit rear sound cavity is in communication with the earphone rear sound cavity through the rear sound cavity audio hole; the tuning mechanism is provided between the rear sound cavity audio hole and the housing, and the tuning mechanism is used to adjust the size of the rear sound cavity audio hole of the loudspeaker unit. The present application allows for individual adjustment of the sound quality of the earphone in accordance with a middle and low frequency requirements of different users.

Abstract: An earphone, comprising a rear housing, a front housing, and a loudspeaker unit which divides a cavity formed by the rear housing and the front housing into a front and rear acoustic cavities; wherein the earphone further comprises a sound adjusting element; the front housing is provided with a sound outlet hole and mode posts, and the sound adjusting element is provided with a sound adjusting hole corresponding to the sound outlet hole and a mode adjustment groove corresponding to the mode posts; when the sound adjusting element rotates, the mode adjustment groove may be limited by different mode posts, thus adjusting the volume of the front acoustic cavity and the area of a sound hole for the front acoustic cavity. Use of the above-described invention enables the middle and high frequency responses of the earphone to be adjusted and enables a single earphone to provide different sound characteristics.

Abstract: Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown are provided. In one disclosed arrangement a plurality of apertures are formed. The membrane comprises a first surface area portion on one side of the membrane and a second surface area portion on the other side of the membrane. Each of a plurality of target regions comprises a recess or a fluidic passage opening out into the first or second surface area portion. The method comprises contacting all of the first surface area portion of the membrane with a first bath comprising ionic solution and all of the second surface area portion with a second bath comprising ionic solution. A voltage is applied across the membrane via first and second electrodes in respective contact with the first and second baths comprising ionic solutions to form an aperture at each of a plurality of the target regions in the membrane.

Abstract: A method of preparing a crystalline zwitterionic zinc(II)-carboxylate compound includes the steps of preparing a mixture of zinc(II) ions and a first pyridyl ligand having three carboxylic acid moieties; subjecting the mixture to conditions under which a precipitate is formed; separating the precipitate; adding a solvent and optionally a second pyridyl ligand to the separated precipitate; subjecting the obtained mixture to conditions under which crystals of the zwitterionic zinc(II)-carboxylate compound are formed; and separating the crystals of the zwitterionic zinc(II)-carboxylate compound. Preferably but not exclusively, the crystalline zwitterionic zinc(II)-carboxylate compound essentially consists of at least one 1D coordination polymer.