Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A vacuum cleaner including a vacuum motor configured to draw an air flow through an air flow path of the vacuum cleaner; a dirt separator having dirt, receptacle; a display screen; and a controller configured to control images displayed on the screen. The dirt receptacle has a closed configuration in which it can receive dirt separated from the air flow, and an open configuration in which dirt contained in the dirt receptacle can be emptied therefrom. The controller is configured to display video instructions on the screen.

Abstract: Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Abstract: A respiratory interface system for use in delivering a flow of a positive pressure breathing gas to an airway of a patient that includes a patient interface device with a tubing assembly structured to be disposed on the head of the patient, a mask having a sealing element structured to sealingly engage about the airway of the patient, and an adaptor. The adapter includes a flange portion that extends generally radially outward from a central aperture and a hollow male connector extending from the flange portion and coupled with a correspondingly-shaped female connector of the tubing assembly or the mask. The mask is coupled to the tubing assembly via the adaptor, and the tubing assembly, the mask, and the adapter define a pathway structured to conduct the flow of the positive pressure breathing gas to the airway of the patient.

Abstract: Computer-implemented methods, computer-readable storage media storing instructions and computer systems for labeling significant locations based on contextual data can be implemented to perform operations that include determining a location of a computing device, and determining a label for the determined location based on contextual data associated with the significant location. The location can be a significant location that has meaning to a user of the device.

Abstract: A coupling arrangement for use in an air delivery circuit includes a first connector tube defining a first passage therethrough and a second connector tube defining a second passage therethrough. The second connector tube telescopically receives a portion of the first connector tube within the second passage. A release mechanism includes wedges coupled to the first or second connector tube. The first and second connector tubes have a number of corresponding features that latch the first connector tube within the second passage of the second connector tube when the first connector tube is axially inserted along the longitudinal axis a predetermined distance. Actuation of the wedges radially toward the longitudinal axis causes axial movement among the first connector tube and the second connector tube a second predetermined distance that is sufficient to unlatch the corresponding features.

Abstract: A heat exchanger assembly including an elongated tubular heat exchanger enclosure defining an interior chamber. A tube sheet is positioned within the interior chamber of the heat exchanger enclosure separating the interior chamber into a shell side and a channel side. The interior portion is configured to removably receive a tube bundle positioned within the shell side of the interior chamber. An annular sleeve member is positioned within the channel side of the interior chamber of the heat exchanger enclosure. An annular elastic torsion member is positioned within the channel side of the interior chamber of the heat exchanger such that the sleeve member is positioned between the tube sheet and the elastic torsion member. The elastic torsion member has an inner circumference deflectable relative to its outer circumference for torsioning the elastic torsion member.

Abstract: Disclosed is a method for the treatment of a subject having an HIV infection or inhibiting neddylation using a neddylation inhibiting enzyme, neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8)-activating enzyme E1 (NAE1).

Abstract: An air supply arrangement for air flow plates (5) of electrochemical cells (3) within a fuel cell stack (1). Each air flow plate (5) has a gas exchange volume (19). A common air supply pipe (11) supplies air to the air flow plates (5). There is an air supply region (35) and a separate air distribution conduit (15) for each air flow plate (5). Each air distribution conduit (15) provides an air header volume (43) and has an inlet and an outlet. The common air supply pipe (11) is connected to each air supply region (35) and each air supply region (35) is connected to the inlet of each air distribution conduit (15). The outlet of each air distribution conduit (15) is connected to a gas exchange volume (19) and each gas exchange volume (19) extends across the width of the associated air flow plate (5).

Abstract: An electrochemical cell (3) for use in a fuel cell stack (1) comprising a resilient electrical conduction member sub-assembly (10, 16) having a first flow plate (5, 9), a second flow plate (6, 8) and a bipolar plate (11, 22). A fluid chamber (17, 19) is created by the first flow plate (5, 9), the second flow plate (6, 8), the bipolar plate (11, 22) and an electrode (13, 18) and has an inflow duct (59, 63) and an outflow duct (61, 65). A resilient electrical conduction member (15, 20) is located within the fluid chamber (17, 19) so that in use, a fluid can flow between the inflow duct (59, 61) and the outflow duct (61, 65). The resilient electrical conduction member (15, 20) is in electrically conductive contact with the bipolar plate (11, 22) and with the electrode (13, 18) via a plurality of electrical contacts (51) and the resilient electrical conduction member (15, 20) is compressed between the bipolar plate (11, 22) and the electrode (13, 18).

Abstract: The present invention is directed to an electrodepositable coating composition comprising an electrodepositable binder comprising an ionic salt group-containing film-forming polymer comprising active hydrogen functional groups, and a blocked polyisocyanate curing agent; a solubilized bismuth catalyst; and a guanidine; wherein the electrodepositable coating composition has a weight ratio of bismuth metal from the solubilized bismuth catalyst to guanidine of from 1.00:0.071 to 1.0:2.1 and/or a molar ratio of bismuth metal to guanidine of from 1.0:0.25 to 1.0:3.0. Also disclosed are methods of treating electrodepositable coating compositions, methods for making electrodepositable coating compositions, systems for coating a metal substrate, coatings, coated substrates, and methods of coating a substrate.

Abstract: Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

Abstract: A method for determining improved control parameters of a number of wind turbines of a wind park is provided. The method considers the impact of individual turbine manufacturing tolerances on the turbine performance, thereby avoiding under-utilization of those wind turbines. The method includes the steps of: receiving, by an interface, one or more actual manufacturing tolerances of characteristic values for each of the number of wind turbines; determining, by a processing unit, for each of the number of wind turbines a power versus wind speed map which is calculated from a given turbine model with the one or more actual manufacturing tolerances of the respective wind turbines as input parameters; and deriving, by the processing unit, the control parameters for each of the number of wind turbines from their associated power versus wind speed map.

Abstract: A peripheral device, for use with a host, comprises one or more compute elements a security module and at least one encryption unit. The security module is configured to form a trusted execution environment on the peripheral device for processing sensitive data using sensitive code. The sensitive data and sensitive code are provided by a trusted computing entity which is in communication with the host computing device. The at least one encryption unit is configured to encrypt and decrypt data transferred between the trusted execution environment and the trusted computing entity via the host computing device. The security module is configured to compute and send an attestation to the trusted computing entity to attest that the sensitive code is in the trusted execution environment.

Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.

Abstract: A system for identifying industrial ergonomics risk root-causes and providing risk control actions, comprising: a computing device configured to obtain video signals of a worker performing a job at a workplace; and a computing server system configured to receive and process the video signals to determine joint locations of the worker, calculate joint angles for each body region of the worker based on the joint locations, calculate, based on the joint angles, a risk score for each body region of the worker in a plurality of risk categories, calculate a risk rating for each body region of the worker based on the risk score, determine ergonomic risk root-causes for each body region of the worker based on the risk rating, and provide ergonomic risk control recommendations to mitigate the ergonomic risk root-causes.

Abstract: A joist assembly system that is structured for dynamic retrieval of components, dynamic and precise positioning and location of retrieved components, assembly of the components to form a joist, and delivery of the assembled joist. The joist assembly system has a plurality of material handling systems, a plurality of welding systems, and a rigging table system. The material handling systems are structured to load and position the components such as chords and webs onto the rigging table. The rigging table in turn supports the chords or webs. Subsequently, the plurality of welding systems weld the webs to the chords to form the joist.

Abstract: A jug for a juicer has sealing features so that its contents may be isolated from the environment when it is not being filled or when used for pouring.