Abstract: A flooring element suitable for connection to other elements in a flooring system. The flooring element comprises a body, a female connector and a retainer. The body defines a connector surface that is horizontal when in use. The female connector comprises a connector recess which is suitable for receiving a male connector and also which defines a connector opening in the connector surface. The retainer is connectable to the body such that, while it is connected to the body, the retainer is movable between and open position and a closed position. When in the closed position, the retainer is arranged to restrict movement of the male connector to guard against the male connector exiting the connector recess through the connector opening. When in the open position, the retainer does not restrict movement of the male connector thereby permitting the male connector to exit the connector recess through the connector opening.

Abstract: A system for identifying industrial ergonomics risk root-causes and providing risk control actions, comprising: a computing device configured to obtain textual information describing a series of tasks of a job and forces being exerted during the series of tasks; and a computing server system configured to receive and process the textual information to generate a set of textual entry to correspond to a unique identifier of the job, identify nouns and verbs in the set of textual entry via natural language processing techniques, perform dependency parsing and part-of-speech tagging to associate each identified verb in the set of textual entry with a root noun in order to identify action-object pairs and unpaired actions, determine ergonomic risk root-causes based at least upon the action-object pairs and the unpaired actions in the set of textual entry, and provide ergonomic risk control recommendations to mitigate the ergonomic risk root-causes.

Abstract: Tools and other devices incorporating cutting chains are disclosed. In some examples, a knife comprises a chain of cutting links positioned along a chain path around a saw bar having a rail, wherein each of the cutting links comprises a groove such that the cutting links straddle the rail of the saw bar. In some examples, a knife comprises a chain of cutting links and a plurality of motors for driving the chain of cutting links. In some examples, a knife comprises a chain of cutting links driven along a blunt edge of the knife. In other examples, the tool is an axe, hatchet, or other device.

Abstract: Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e. g., such for inducing sedation and/or anesthesia.

Abstract: A sealing arrangement for use in a patient interface device. The sealing arrangement includes a nasal pillow having a sealing surface structured to sealingly engage a surface of the patient at or about the airway. A first magnetic material is disposed in or the nasal pillow. A carrier member is positioned across a nose of the patient. Finally, a second magnetic material is positioned in or on carrier member. The first magnetic material and the second magnetic material magnetically interact in a manner that the sealing surface of the flexible member toward the surface of the patient responsive to the flexible member being disposed at or about the airway and the second magnetic material is disposed at a corresponding position to interact with the first magnetic material.

Abstract: The present teachings provide for a hand-held robotic system for use with a saw blade or other surgical tool. The hand-held robotic system also includes an instrument with a hand-held portion, a blade support coupled to the hand-held portion by a plurality of actuators, the actuators configured to move the blade support or tool support in a plurality of degrees of freedom relative to the hand-held portion. The system includes a localizer and a control system coupled to the localizer and the plurality of actuators. The control system is configured to control each of the plurality of actuators and/or the tool drive motor.

Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.

Abstract: Provided herein are compositions of engineered guide RNAs relating to providing or engineering a structural target to attract adenosine deaminase acting on RNA (ADAR) editing to a desired site and methods of use thereof. Further provided herein are compositions and methods relating to recombinant adenosine deaminase acting on RNA (ADAR) split guide RNAs (adar-sgRNA). In certain embodiments, the adar-sgRNA composition comprises two guides-one guide with an ADAR recruiting domain and a second guide with a 5? and/or 3? RNA targeting domain for forming a trimolecular complex at a mismatch site that serves to recruit ADAR. Binding of the two adar-split gRNAs to the target RNA forms a trimolecular complex which recruits ADAR enzymes to deaminate one or more mismatched adenosine residues in the adar-split gRNA RNA targeting domain: target RNA duplex. In certain embodiments, such compositions and methods will be useful for modifying a coding sequence of a desired protein.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: This invention relates to aqueous plant treatment compositions that improve the environmental experience of the consumer and industrial grower while contributing to the health of plants. Compositions of the invention include mixtures of naturally sourced fragrances, plant sourced micronutrients, naturally derived oils; surfactants; emulsifying agents, and odor sequestering agents. Compositions are combined as solutions or suspensions that may be disposed onto soil; plant foliage, or onto dried cellulosic particles to reduce or eliminate the malodors of plant treatment or nourishment, such as from organic fertilizers or from pesticides, while imparting a pleasant post treatment fragrance.

Abstract: Disclosed are compositions and methods relating to genetically modified cells for the long-term expression of an antigen of interest.

Abstract: Powered patient support apparatuses—such as beds, cots, stretchers, or the like—include a plurality of user controls that allow a caregiver to control the steering and/or driving of one or more powered wheels from multiple different locations around the patient support apparatus (e.g. head end, foot end, and/or the sides). The control is carried out by force sensors that detect both an orientation of the applied forces and a magnitude of the applied forces. Translational and/or rotational movement is effectuated, depending upon the magnitude and direction of the forces, as well as the physical location of the applied force relative to a reference point on the support apparatus, such as the center. One or more object sensors may also be included in the support apparatus to assist in steering and/or navigating.

Abstract: Compositions suitable for use as biodegradable coatings, comprising mixtures of naturally sourced waxes and naturally sourced crosslinkable agents. Compositions may be used to impart water resistance to a substrate, to control the release time of soil nutrients, to reduce environmental damage, and to protect seed or crop damage from high local concentrations of salts. Compositions are preferably prepared as aliphatic alcohol and thereafter may be disposed about an agronomically important substrate core or a fibrous substrate, at temperatures below about 90° C. to impart water resistance or extend the storage time.

Abstract: A coupling arrangement for use in securing a patient interface to the head of a patient. The fastening arrangement includes a first component having a source of a magnetic field and a second component having a mating component attracted to the source by the magnetic field. One or both of the source and/or a portion of the first component is moveable among: a shielded positioning wherein the source is shielded such that the maximum strength of the magnetic field outside of the first component is less than a predetermined value, and an unshielded positioning wherein the source is unshielded such that the maximum strength of the magnetic field outside of the first component is greater than or equal to the predetermined value.

Abstract: Techniques for low power gunshot detection are disclosed. Infrared information is collected using a gunshot sensor device. The infrared information is collected using mid-infrared band sensing to provide motion detection. Additional infrared information is buffered using the gunshot sensor device. The additional infrared information is collected using near-infrared band sensing. The buffering is enabled by the motion detection. Acoustic information is collected using the gunshot sensor device. The collecting acoustic information is enabled by the motion detection. A gunshot is detected using the gunshot sensor device. The detecting is based on the additional infrared information and the acoustic information. The detecting includes monitoring the acoustic information to identify a high-intensity gunshot sound and correlating the high-intensity gunshot sound to the infrared information that was buffered.

Abstract: The disclosure provides for a bottom hole assembly that comprises a stator solenoid winding transmitter assembly operable to generate a magnetic field. The stator solenoid winding transmitter assembly comprises a coil comprising a plurality of windings and a sleeve, wherein the coil is disposed within the sleeve. The bottom hole assembly further comprises a solenoid control assembly disposed adjacent to the stator solenoid winding transmitter assembly, wherein the solenoid control assembly is communicatively coupled to a controller and electrically connected to the coil and a mud motor comprising a rotor and a stator, wherein the stator solenoid winding transmitter assembly is disposed around the mud motor.

Abstract: Provided herein are compositions and methods relating to providing or engineering a structural target to attract ADAT editing to a desired site. Further provided herein are compositions and methods relating to recombinant adenosine deaminase acting on tRNA (ADAT) guide tRNAs (adat-gtRNA). In certain embodiments, such compositions and methods will be useful for modifying a coding sequence of a desired protein. Also provided are methods of treating a disease or disorder associated with loss of wild-type protein expression.

Abstract: An apparatus includes an introducer defining an inner volume, a catheter, and a guide member. The having a proximal end portion and a distal end portion, with the catheter defining a lumen extending through the proximal end portion and the distal end portion of the catheter, and with the catheter configured to move between a first position, in which the catheter is disposed within the introducer, and a second position, in which at least the distal end portion of the catheter is distal to the introducer. The guide member is coupled to the introducer, with the guide member defining a lumen. A portion of the catheter is received within the lumen of the guide member when the catheter is in the first position, and the distal end portion of the catheter is distal to the guide member when the catheter is in the second position.