Abstract: A kit for preparing a nucleic acid sample for analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) is provided, the kit comprising: a lyophilized enzyme composition comprising: micrococcal nuclease; nuclease P1; and bacterial alkaline phosphatase (BAP); and a digestion buffer. Also provided are enzyme compositions and methods of use for rapid, efficient preparation of a nucleic acid sample for analysis by LC-MS/MS, without the need for denaturation of the sample.

Abstract: Multi-mode management systems are disclosed. Such systems include a first controller and a second controller. The first controller can be configured to control a power system. The second controller can have two modes. The second controller can be configured to, when in a first mode, estimate a state of the power system by monitoring communications between the first controller and the power system, and in response to satisfaction of a first condition, switch to the second mode. The second controller can be configured to, when in the second mode, disable communication between the first controller and the power system and control the power system based on the estimated state of the power system.

Abstract: Technology is disclosed for proactively enriching content of electronic communications through predicting user intents. User-composed content within an electronic communication is observed and used to predict one or more intents each associated with a task related to the communication and to be completed in creating the communication. Task-queries may be generated based on the detected intents and entities extracted from the user-composed content, contextual information, or other information related to the user, such as a user-knowledge database. User selection of a suggested task-query automatically executes the task-query, and the results are provided to the user. Each result may include an action involving adding content to or supplementing the content of the electronic communication. A conversational digital assistant may further be invoked to interact with the user to confirm and/or modify suggested task-queries and results of selected task-queries.

Abstract: The present disclosure relates to the use of X-ray detector cassettes that may be abutted or overlapped to form a detector assembly suitable for imaging objects that are too large to image using a single X-ray detector cassette. Such a detector assembly may be customized in terms of the size and/or shape of the field-of-view (FOV). In certain embodiments the radiation-sensitive electronics (e.g., readout electronics) are positioned to the side of the X-ray detecting components (e.g., scintillator, TFT array, and so forth), allowing the cassette to be thin relative to other detector devices and allowing the electronics to remain outside the X-ray beam path.

Abstract: A fixture for supporting an article (e.g., a guitar such as a Stratocaster® guitar body) and controlling the position of the article relative to a print head to allow a contoured portion of a surface of the article to be printed by the print head. The fixture may include a pivot axis about which the article is pivotal. A cam surface may be engaged by the article and/or a bracket of the fixture to which the article is affixed to prescribe the controlled movement of the article based on relative movement between the article and the print head. In turn, both planar and contoured portions of the guitar surface may be printed during a single print operation.

Abstract: Techniques are disclosed for digitizing a framework for clinical development. In one example, A computing device comprising a memory configured to store a regulatory database, and one or more processors may be configured to perform the techniques. The one or more processors may retrieve, from the regulatory database, a template based on a governance process, receive, via a user interface, input from a user, parameterize the template based on the governance process with the user input to create a parameterized template, and store the parameterized template in a database.

Abstract: A computing device comprising a processor is configured to perform the techniques of this disclosure. The processor may duplicate a first node of a tree data structure to create a duplicate node, and create an inbound edge of the duplicate node to a parent node of the first node and an outbound edge to at least one child node of the first node. The processor may receive an update to the at least one child node of the first node. In response to determining that the at least one child node has multiple parent nodes, the processor may duplicate the at least one child node to create a duplicate child node, create an outbound edge of the duplicate node to the duplicate child node, delete the outbound edge of the duplicate node to the at least one child node, and perform the update to the at least one child node.

Abstract: Techniques are disclosed for digitizing a framework for clinical development. In one example, a computing device comprising a memory configured to store a study and a processor may be configured to perform the techniques. The processor may receive, from a user, an input specifying a plurality of trial elements for the study, and receive, from the user, an input arranging the plurality of trial elements into a tree data structure. The processor may also determine, based on the tree data structure of the plurality of trial elements, one or more trial arms for the study, each trial arm of the one or more trial arms comprising a single path between at least one trial element of the plurality of trial elements to at least one other trial element of the plurality of trial elements. The processor may further output, for display, the one or more trial arms for the study.

Abstract: A wellbore completion system includes an expandable liner hanger with a post-setting fluid flow path. The system includes an expandable liner hanger that can be expanded by a running tool prior to a completion operation in a wellbore. The system also includes a circulating sleeve that can be manipulated by the running tool. The circulating sleeve can provide a return path for fluid internal to the expandable liner hanger for the completion operation that is performed subsequent to releasing the running tool from the expandable liner hanger.

Abstract: Vertical shaft crushers and control systems therefor are disclosed. In some embodiments a rotor of the crusher is reversible and/or autogenous. In some embodiments a crushing chamber of the crusher includes at least one anvil and at least one rock shelf chamber.

Abstract: A media depository is described. The media depository comprises: a media item validation module; a diverter for routing a received media item via either a storage path or a return path; an escrow for temporarily holding received media items; and a printer located between the diverter and the escrow so that the printer can print on any media items transported via the return path.

Abstract: This application discloses a system that may comprise at least a portion of a supply network. The system may further comprise a load controller that controls current flow with a current level of I1 into a load network that provides power to one or more loads from the at least a portion of the supply network according to a preprogrammed load curve. The system may also comprise a protection system that isolates the at least a portion of the supply network from the load controller in response to detecting a current pattern that is inconsistent with the preprogrammed load curve.

Abstract: The present disclosure relates to the use of X-ray detector cassettes that may be abutted or overlapped to form a detector assembly suitable for imaging objects that are too large to image using a single X-ray detector cassette. Such a detector assembly may be customized in terms of the size and/or shape of the field-of-view (FOV). In certain embodiments the radiation-sensitive electronics (e.g., readout electronics) are positioned to the side of the X-ray detecting components (e.g., scintillator, TFT array, and so forth), allowing the cassette to be thin relative to other detector devices and allowing the electronics to remain outside the X-ray beam path.

Abstract: A community DC power distribution system is provided including a community node comprising a voltage source, a first switch, and a second switch; and a power distribution loop. The power distribution loop can include power distribution lines. First power distribution lines can be grounded through first sensor resistors and electrically connected to the first switch, first local nodes, and a third switch. Second power distribution lines can be grounded through second sensor resistors and electrically connected to the second switch, second local nodes, and the third switch. The community node can be configured to provide power (i) to the first local nodes via the first power distribution lines and the first switch when the first switch is in a closed state; and (ii) to the second local nodes via the second power distribution lines and the second switch when the second switch is in a closed state.

Abstract: The present disclosure provides composite structures and methods of use for delivering explosive proppant particles to a subterranean formation. The composite structure may comprise one or more packagings disposed about a plurality of explosive proppant particles. The explosive proppant may be become exposed and triggered to create micro-seismic events, which may be used to determine the subterranean formation geometry or other properties in the formation.

Abstract: Technology is disclosed for proactively enriching content of electronic communications through predicting user intents. User-composed content within an electronic communication is observed and used to predict one or more intents each associated with a task related to the communication and to be completed in creating the communication. Task-queries may be generated based on the detected intents and entities extracted from the user-composed content, contextual information, or other information related to the user, such as a user-knowledge database. User selection of a suggested task-query automatically executes the task-query, and the results are provided to the user. Each result may include an action involving adding content to or supplementing the content of the electronic communication. A conversational digital assistant may further be invoked to interact with the user to confirm and/or modify suggested task-queries and results of selected task-queries.

Abstract: This application discloses a system that may comprise at least a portion of a supply network. The system may further comprise a load controller that controls current flow with a current level of I1 into a load network that provides power to one or more loads from the at least a portion of the supply network according to a preprogrammed load curve. The system may also comprise a protection system that isolates the at least a portion of the supply network from the load controller in response to detecting a current pattern that is inconsistent with the preprogrammed load curve.

Abstract: A downhole inspection system includes a neutron imaging device operable to generate data for detecting potential wellbore anomalies and an electromagnetic imaging device operable to generate data for detecting potential wellbore eccentricity. The neutron imaging device includes a neutron generator operable to emit neutrons, and a neutron detector fixed relative to the neutron generation unit and operable to detect backscattered neutrons from a surrounding environment. The electromagnetic imaging device includes at least one transmitter for generating electromagnetic pulse, and at least one receiver for detecting returning electromagnetic pulse. Correlation of the neutron imaging data with the electromagnetic imaging data provides additional data regarding the potential wellbore anomalies.

Abstract: Example implementations related to hyperconverged loads. In an example, a set of system characteristics is defined for a hyperconverged system. A plurality of components of an arbitrary workload running on a computing system are then separately modeled. The modeling converts the plurality of components into a plurality of respective hyperconverged loads. The plurality of respective hyperconverged loads are then allocated among a set of hyperconverged nodes that satisfies the set of system characteristics.