Abstract: A package of folded sheet products includes a stack of the sheet products, and a package wrapper, which surrounds the stack and holds the stack together. The stack includes a start sheet product at a start end of the stack, and an end sheet product at an opposite end of the stack. The package wrapper (3) includes a first end portion (12) and a second end portion (13), which end portions (11, 12) are mutually joined by where the end portions (11, 12) are overlapping and with the first end portion (12) arranged outside the second end portion (13). The second end portion (13) of the package wrapper (3) is free from direct attachment to the stack, and the first end portion (12) of the package wrapper (3) is joined with the start sheet product (4) by second attachment means (22).

Abstract: An apparatus for dispensing sheet material pertains to a housing arranged for receiving a supply of sheet material, a feed mechanism for advancing said sheet material through a discharge opening of said housing, a motor for driving said feed mechanism and a controller for powering the motor to drive the feed mechanism.

Abstract: An end plug to be inserted axially into the centre of an end of a roll of paper, includes a holding element adapted to hold and/or guide the end of the roll of paper in correct position in a dispenser. The end plug includes an outer sleeve having an outer end and an inner end and the holding element is connected to the sleeve by elements allowing the holding element to be axially moved from a first position to a second position, in which the holding element protrude outwardly from the outer end of the sleeve, the holding element being releasably held in the first position when moved thereto. A roll of tissue paper including such an end plug and a dispenser provided with such a roll are also disclosed.

Abstract: An apparatus for dispensing sheet material pertains to a housing (82) arranged for receiving a supply of sheet material (1), a feed mechanism (2) for advancing said sheet material through a discharge opening (100) of said housing (82), a motor (3) for driving said feed mechanism (2) and a controller (4) for powering the motor (3) to drive the feed mechanism.

Abstract: The present invention relates to N-containing heterocyclic compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2, JAK3 or TYK2 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

Abstract: An end plug to be inserted axially into the center of an end of a roll of paper, includes a holding element adapted to hold and/or guide the end of the roll of paper in correct position in a dispenser. The end plug includes an outer sleeve having an outer end and an inner end and the holding element is connected to the sleeve by elements allowing the holding element to be axially moved from a first position to a second position, in which the holding element protrude outwardly from the outer end of the sleeve, the holding element being releasably held in the first position when moved thereto. A roll of tissue paper including such an end plug and a dispenser provided with such a roll are also disclosed.

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: A package of folded sheet products includes a stack of the sheet products, and a package wrapper, which surrounds the stack and holds the stack together. The stack includes a start sheet product at a start end of the stack, and an end sheet product at an opposite end of the stack. The package wrapper (3) includes a first end portion (12) and a second end portion (13), which end portions (11, 12) are mutually joined by where the end portions (11, 12) are overlapping and with the first end portion (12) arranged outside the second end portion (13). The second end portion (13) of the package wrapper (3) is free from direct attachment to the stack, and the first end portion (12) of the package wrapper (3) is joined with the start sheet product (4) by second attachment means (22).

Abstract: A dispenser for hygienic articles such as wipes, towels, toilet paper or soap, includes a dispenser housing for containing the articles, and a fastener for fastening the dispenser to a fastening surface. The fastener includes a suction unit disposed on the outside of the dispenser facing the fastening surface. The fastener further comprise operating device by which the suction unit is operable so as to establish or release a sub-atmospheric pressure between the suction unit and the fastening surface. Access to the operating device is provided from inside the dispenser.

Abstract: A dispenser for dispensing flexible sheet material includes a roll of material, the roll of material having a core. One end portion of the flexible sheet material is adhered to the core by a pickup glue. The dispenser includes a sensor for sensing the pickup glue of the roll of material and a control unit for triggering at least one action of the dispenser in response to the detection of the pickup glue.

Abstract: A stack of a plurality of cellulose-containing absorbent towels for a dispenser is provided. The towels are separable upon dispensing. The stack is compressed to a predetermined density dependent on material choice.

Abstract: A support device includes a base member having a first side adapted to face a flat surface and a second side opposite to the first side, and a cover member adapted to cover at least partially the base member. The base member is adapted to be attached to the flat surface by a fastening system. The fastening system includes a first surface adapted for the application of a stretch releasable adhesive strip on the first side of the base member. The base member has a through opening extending through the base member from the second side to the first side. The through opening is arranged adjacent to the first surface and is adapted for pulling the stretch releasable adhesive strip at least partially therethrough. The cover member in a first position covers the through opening and in a second position exposes the through opening.

Abstract: A solution for detecting level of a consumable tissue product (201, 301) in a tissue dispenser (103, 106) located in a washroom. This is provided in a number of aspects such as a tissue dispenser, a method, system, and a sensor unit utilizing two sensor elements (420, 430), each arranged to measure light reflected from a reflection field located on the tissue product, reflected directly from the tissue product, or measure the absence of the tissue product. Data from the sensor elements are wirelessly transmitted to a server (901) for further handling, such as for instance notification to a janitor in charge of service of the washroom.

Abstract: A dispenser for dispensing flexible sheet material includes a roll of material, the roll of material having a core. One end portion of the flexible sheet material is adhered to the core by a pickup glue. The dispenser includes a sensor for sensing the pickup glue of the roll of material and a control unit for triggering at least one action of the dispenser in response to the detection of the pickup glue.

Abstract: Supply package and apparatus for dispensing sheet material comprising a housing (82) arranged for receiving a supply of sheet material (1), a feed mechanism (2) for advancing said sheet material through a discharge opening (100) of said housing (82), a motor (3) for driving said feed mechanism (2) and a controller (4) for powering the motor (3) to drive the feed mechanism.

Abstract: The present invention relates to N-containing heterocyclic compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2, JAK3 or TYK2 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

Abstract: A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein A represents a variety of six membered nitrogen containing heterocyclic rings, Q is a bond, halogen, C1-4 alkyl, O, S, SO2, CO or CS and X1, X2, X3 and X4 are optionally substituted by 9 specific substituents or one can be nitrogen. Compositions comprising a carrier and at least one compound of formula (I) are also provided. Further provided are methods of treating tyrosine kinase-associated disease states by administering a compound of formula (I) and methods of suppressing the immune system of a subject by administering a compound of formula (I).

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating tyrosine kinase-associated disease states in a subject using a compound of formula (I) is also described.