Abstract: A dispensing unit includes an outer front wall, two outer side walls, a housing for holding a pile of a continuous length of accordion-like folded web of towels of tissue paper or nonwoven including bundles, the outer front wall having an access opening to the pile, a dispensing opening for the web of towels and a feeding mechanism including a member for controlling the dispensing of the web of towels, a drive unit and a braking arrangement for the web of towels. A unit of consumable articles includes the pile of bundles with connecting elements therebetween, which are inserted through the access opening into the housing in the dispensing unit and added to the bottom of the pile. The web of towels is dispensed from the upper part of the pile by a feeding mechanism, which positions the web of towels in a starting mode in the dispensing opening.

Abstract: A dispenser for rolls of flexible sheet material, each of the rolls having spindle elements extending axially outwardly beyond the ends thereof, wherein a first roll is located in a dispensing position. Alternatively, a second roll may be located in a reserve position. The dispenser further includes a stub roll position arranged to receive a first roll exhausted to a predetermined extent. Retaining elements are arranged on both sides of the stub roll position to support the spindle elements inserted into each end of a roll, wherein the retaining elements arranged for simultaneous release of the spindle elements when the dispenser is opened.

Abstract: A dispensing unit includes an outer front wall, two outer side walls, a housing for holding a pile of a continuous length of accordion-like folded web of towels of tissue paper or nonwoven including bundles, the outer front wall having an access opening to the pile, a dispensing opening for the web of towels and a feeding mechanism including a member for controlling the dispensing of the web of towels, a drive unit and a braking arrangement for the web of towels. A unit of consumable articles includes the pile of bundles with connecting elements therebetween, which are inserted through the access opening into the housing in the dispensing unit and added to the bottom of the pile. The web of towels is dispensed from the upper part of the pile by a feeding mechanism, which positions the web of towels in a starting mode in the dispensing opening.

Abstract: A method of producing basic starting material for the manufacture of fastener tabs intended for joining the side portions of the front and rear parts of an absorbent article. The method includes stretching a first sheet of elastic material in a first direction; applying a second and third sheet of material onto respective opposite sides of the first sheet; fastening the three material sheets together in at least two mutually separated zones that extend parallel with each other in one direction perpendicular to the first direction; dividing the first sheet in each region between two zones along a line lying therebetween, whereby the first sheet contracts to a non-stretched state, and thereafter fastening the sheets together in each region between two zones. The invention also relates to an arrangement for carrying out the method, to starting material for producing fastener tabs, and to such a tab.

Abstract: An end plug to be inserted axially into the centre of an end of a paper roll, and provided with a holding element for hold/guiding the end of the paper roll in correct position in a dispenser, the holding element being movable between a transport position, where the whole of the holding element is accommodated within the interior of an outer sleeve of the end plug, and an active position where a part of the holding element protrudes outwardly from an outer end of the outer sleeve, the outer sleeve includes a conical wall, whose base end defines the outer axial end of the outer sleeve, the holding element includes two opposite slide elements guided in diametrically opposite spoke elements projecting inwards in a radial direction in relation to the inner wall of the conical wall of the outer sleeve.

Abstract: The present invention relates to N-containing heterocyclic compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2, JAK3 or TYK2 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

Abstract: A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein A represents a variety of six membered nitrogen containing heterocyclic rings, Q is a bond, halogen, C1-4 alkyl, O, S, SO2, CO or CS and X1, X2, X3 and X4 are optionally substituted by 9 specific substituents or one can be nitrogen. Compositions comprising a carrier and at least one compound of formula (I) are also provided. Further provided are methods of treating tyrosine kinase-associated disease states by administering a compound of formula (I) and methods of suppressing the immune system of a subject by administering a compound of formula (I).

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: An absorbent article having a liquid-permeable cover sheet, a liquid-impermeable cover sheet, and an absorption body arranged between the cover sheets. The article defines a longitudinal direction, a front portion in the longitudinal direction, and a rear portion in the longitudinal direction. The upper cover sheet, together with an underlying wadding material, defines a laminate which, at least in the rear portion, is designed with at least one through-slit which defines an opening for passage of bodily excretions through the slit, and the slit is surrounded by binding areas which, together with a resilient action of the wadding material, define a raised area on the surface of the article.

Abstract: An end plug to be inserted axially into the centre of an end of a roll of paper, includes a holding element adapted to hold and/or guide the end of the roll of paper in correct position in a dispenser. The end plug includes an outer sleeve having an outer end and an inner end and the holding element is connected to the sleeve by elements allowing the holding element to be axially moved from a first position to a second position, in which the holding element protrude outwardly from the outer end of the sleeve, the holding element being releasably held in the first position when moved thereto. A roll of tissue paper including such an end plug and a dispenser provided with such a roll are also disclosed.

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: A dispenser for rolls of flexible sheet material, each of the rolls having spindle elements extending axially outwardly beyond the ends thereof, wherein a first roll is located in a dispensing position. Alternatively, a second roll may be located in a reserve position. The dispenser further includes a stub roll position arranged to receive a first roll exhausted to a predetermined extent. Retaining elements are arranged on both sides of the stub roll position to support the spindle elements inserted into each end of a roll, wherein the retaining elements arranged for simultaneous release of the spindle elements when the dispenser is opened.

Abstract: Supply package and apparatus for dispensing sheet material comprising a housing (82) arranged for receiving a supply of sheet material (1), a feed mechanism (2) for advancing said sheet material through a discharge opening (100) of said housing (82), a motor (3) for driving said feed mechanism (2) and a controller (4) for powering the motor (3) to drive the feed mechanism.

Abstract: Starting from an elastic material web and an absorbent product web, the method includes removing a first material piece from the elastic material web to provide a second material piece with an aperture and applying the first piece to a first portion of the absorbent product web. The second piece is supplied to a second application station and a section of the second piece is stretched and applied to a second portion of the absorbent product web. In this way an absorbent product with elastic waist portions is manufactured efficiently and with a minimum of waste.

Abstract: A method of producing basic starting material for the manufacture of fastener tabs (31) intended for joining the side portions of the front and rear parts of an absorbent article that includes a front part, a rear part and an intermediate crotch part, so as to give the article a pants-like configuration According to the invention the method comprises the steps of stretching a first sheet (1) of elastic material in a first direction (T); applying a second and a third sheet of material (9, 10) onto respective opposite sides of the first sheet; fastening the three material sheets together in at least two mutually separated zones (14, 15) that extend parallel with each other in one direction (M) perpendicular to said first direction; dividing the first sheet (1) in each region between two zones (14, 15) along a line that lies between said zones, wherewith the first sheet in each region (16) between two zones (14, 15) contracts to a non-stretched state, and thereafter fastening the sheets together in each regio

Abstract: A process for producing a web (1) of paper, cardboard or other fibrous material using a device (28) for applying starch is characterised in that the dry content of the web (1) of fibrous material is of less than 70% while the starch becomes adhesive, and in that the web (1) of fibrous material is heated to a temperature which is sufficient for causing the starch to become adhesive.

Abstract: A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein A represents a variety of six membered nitrogen containing heterocyclic rings, Q is a bond, halogen, C1-4 alkyl, O, S, SO2, CO or CS and X1, X2, X3 and X4 are optionally substituted by 9 specific substituents or one can be nitrogen. Compositions comprising a carrier and at least one compound of formula (I) are also provided. Further provided are methods of treating tyrosine kinase-associated disease states by administering a compound of formula (I) and methods of suppressing the immune system of a subject by administering a compound of formula (I).

Abstract: This invention relates to a method for detecting a tear in a fibrous web (3) in a drying section (2) of a machine (1) for producing the fibrous web (3), whereby the fibrous web (3) is passed through the drying section (2) by way of at least one dryer fabric (5). The tear is detected by at least one web tear detection device (8) and a cut-off apparatus (9) for the fibrous web (3) is activated by the web tear detection device (8). Use is made of a dryer fabric (5) with at least one characteristic color pattern (10) which is reliably detected by the web tear detection device (8) in the event of a tear in the fibrous web (3). In addition the present invention relates to a dryer fabric (5) for a drying section (2) of a machine (1) for producing a fibrous web (3).

Abstract: Method and machine for producing a fiber web having a mass per unit area of less than 125 g/m2. The method includes applying a fluid application medium to the fibrous web. The fluid application medium being a liquid having a solids concentration of 15% or more. The machine for producing a fiber web includes a press section having at least one press nip and at least one application device structured and arranged to apply a liquid medium to one side of the fiber web at least one of immediately before the at least one press nip and in the at least one press nip. This abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Abstract: A method of manufacturing an absorbent article, and an absorbent article, in the form of a pants-type diaper or a sanitary panty, starting from a flat blank which includes an elongated absorbent body enclosed between two casing sheets which at opposing front and rear end parts of the absorbent body have side parts which extend laterally beyond the body on both sides thereof. The method includes the step of folding the blank around a transverse axis so that the end edges of the side parts lie edge-to-edge. At least one folded band of flexible material is placed between each pair of front and rear side parts which lie opposite one another in the folded state of the blank, and the free ends of the bands are fastened to adjacent side parts.