Abstract: The present invention provides new processes for the preparation of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds which are useful, for example, for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-?. The invention can provide improved and/or efficient processes for the commercial production of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds, including, but not limited to, unsubstituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione.

Abstract: A noise cancelling headphone includes a headphone body, a audio player and a central processing unit. The headphone body includes a headband, a first speaker unit and a second speaker unit. The elongated headband is bent and shaped to fittedly and adjustably wear on a user's head, wherein the headband has a first and a second end portion. The first speaker unit and the second speaker unit are attached on the first and the second end portion of the headband respectively. The audio player is provided on the headphone body, and is arranged to read a predetermined kind of audio signals. The central processing unit is received in the headphone body, and is arranged to process the audio signals outputted from the audio player and drive the first speaker unit and the second speaker unit to generate corresponding audible sound.

Abstract: This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid of the nanopore. Next, an individual tagged nucleotide of the tagged nucleotides can be incorporated into a growing strand complementary to a single stranded nucleic acid molecule derived from the nucleic acid sample. With the aid of the nanopore, a tag associated with the individual tagged nucleotide can be detected upon incorporation of the individual tagged nucleotide. The tag can be detected with the aid of the nanopore when the tag is released from the nucleotide.

Abstract: An image navigation integrated dental implant system includes a control unit for storing and transmitting data streams, a scan module electrically connected to the control unit for scanning and taking the pictures of the soft tissue and hard tissue of the parenchyma of the oral cavity of a patient and the related external skin color and transmitting the obtained data to the control unit, a design module electrically connected to the control unit for receiving the oral cavity data from the control unit and using the data to design a oral cavity simulation diagram, and a navigator module electrically connected to the control unit for receiving the oral cavity data and photographing the oral cavity and then providing a picture to guide the dentist to perform the dental implant surgery.

Abstract: A light guide type pain reliever includes a handle including a barrel accommodating a battery, a rear end cap and a front end cap respectively capped on two opposite ends of the barrel, a pushbutton mounted in the rear end cap and a switching connector mounted in the rear end cap and electrically connected to the battery and drivable by the pushbutton to switching on/off the battery, a holder shell connected to the front end cap and electrically coupled to the battery and having electrically connected thereto a vibrator and a light-emitting device, an adapter connected to the holder shell, and a light guide plate connected to adapter guiding out light rays emitted by the light-emitting device.

Abstract: A handheld pain reliever includes a hollow handle, a presser bar having an end piece extended from a rear end of a connection rod thereof inserted into the handle and a presser ring provided with protruding portions connected to a front end of the connection rod at an angle, a vibrator mounted inside the handle for vibrating the presser bar, a rechargeable battery mounted inside the handle adjacent to provide the necessary working voltage to the vibrator, and an on/off switch mounted at the handle and operable to switch on/off the vibrator.

Abstract: A bone powder filling tool includes a handle connectable to a rotary dental instrument, and a bone powder propelling bit located one end of the handle. The bone powder propelling bit has opposing top end portion and bottom end portion, bone powder transferring grooves spirally extending around the periphery thereof from the top end portion to the bottom end portion, and bone powder propelling threads extending around the periphery thereof at different elevations for rapidly and uniformly propelling bone powder into the space between the sinus floor and the cortical bone to increase the thickness of the cortical bone in favor of the process of the subsequent tooth implanting, helping the doctor in charge of the operation save operating time and physical strength.

Abstract: The present disclosure provides devices, systems and methods for sequencing nucleic acid molecules. Nucleic acid molecules can be sequenced with a high accuracy (e.g., greater than 97% in a single pass) using a chip comprising an array of independently addressable nanopore sensors at a density of at least about 500 sites per 1 mm2. An individual nanopore sensor can include a nanopore in a membrane that is adjacent or in proximity to a sensing electrode.

Abstract: An optoelectronic device is disclosed. The optoelectronic device may be employed as a single or multi-channel opto-coupler that electrically isolates one circuit from another circuit. The opto-coupler may include one or more folded leads that establish an enhanced isolation gap. The enhanced isolation gap increases the creepage distance of the opto-coupler and increases operational voltages that can be accommodated by the opto-coupler.

Abstract: A device having an integrated noise shield is disclosed. The device includes a plurality of vertical shielding structures substantially surrounding a semiconductor device. The device further includes an opening above the semiconductor device substantially filled with a conductive fluid, wherein the plurality of vertical shielding structures and the conductive fluid shield the semiconductor device from ambient radiation. In some embodiments, the device further includes a conductive bottom shield below the semiconductor device shielding the semiconductor device from ambient radiation. In some embodiments, the opening is configured to allow a biological sample to be introduced into the semiconductor device. In some embodiments, the vertical shielding structures comprise a plurality of vias, wherein each of the plurality of vias connects more than one conductive layers together.

Abstract: This disclosure provides systems and methods for molecular identification and polymer (e.g., nucleic acid) sequencing using nanopores. The polymer may be passed through or in proximity to the nanopore and various subunits of the polymer may affect the current flowing through the nanopore. The various subunits may be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. In some cases, the polymerization of tagged nucleotides presents tag molecules to the nanopore that can be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. Also provided herein are systems and methods for sequencing both the sense and anti-sense strand of a double stranded nucleic acid molecule with a nanopore and methods for using ribonucleic acid (RNA) speed bump molecules to slow the passage of a nucleic acid molecule through or in proximity to a nanopore.

Abstract: A device having an integrated noise shield is disclosed. The device includes a plurality of vertical shielding structures substantially surrounding a semiconductor device. The device further includes an opening above the semiconductor device substantially filled with a conductive fluid, wherein the plurality of vertical shielding structures and the conductive fluid shield the semiconductor device from ambient radiation. In some embodiments, the device further includes a conductive bottom shield below the semiconductor device shielding the semiconductor device from ambient radiation. In some embodiments, the opening is configured to allow a biological sample to be introduced into the semiconductor device. In some embodiments, the vertical shielding structures comprise a plurality of vias, wherein each of the plurality of vias connects more than one conductive layers together.

Abstract: A lead anchor includes a body defining at least one first portion of a lead lumen, the body having a first opening and a second opening. An obstructing member is disposed within the body. The obstructing member defines a second portion of the lead lumen. A spring is disposed in the body and configured and arranged to operate on the obstructing member so that the second portion of the lead lumen is coterminous with the at least one first portion of the lead lumen and forms a continuous lead path when the spring is compressed and the second portion of the lead lumen is offset from the at least one first portion of the lead lumen when the spring is not compressed.

Abstract: Techniques for characterizing a molecule are described herein. In one example, a portion of the molecule is trapped in a nanopore, a variable voltage is applied across the nanopore until the trapped portion of molecule is moved within the nanopore, and the molecule is characterized based on the electrical stimulus required to affect movement of at least a portion of the trapped portion of the molecule within the nanopore.

Abstract: The present disclosure relates generally to connectors such as audio and data connectors and in particular to low profile audio connectors that can be used in place of standard audio and data connectors currently used. The plug connector has a reduced plug length and thickness, an intuitive insertion orientation and a smooth, consistent feel when inserted and extracted from its corresponding receptacle connector. The plug connector may be characterized by a flat tip portion at its distal end, a base portion near its proximal end, a shell coupled at the base portion and a plurality of external contacts.

Abstract: There is provided a method of controlling a transmission rate of a data stream by a server transmitting the data stream to a client device over a network, the method comprising receiving a feedback message from the client, the feedback message containing information indicating a positive or negative acknowledgement of receipt for each one of a plurality of data packets of the data stream; calculating values of a plurality of metrics, wherein each of the values is indicative of transmission quality of the network and is calculated based at least in part on the information contained in the feedback message, and wherein the values include a first value of a first metric representing packet loss; and adjusting the transmission rate if at least one of the values satisfies a corresponding condition; wherein the first metric is prioritized among the plurality of metrics such that an adjustment of the transmission rate responsive to a second value of a second metric satisfying the corresponding condition is condition

Abstract: Techniques for characterizing a molecule are described herein. In one example, a portion of the molecule is trapped in a nanopore, a variable voltage is applied across the nanopore until the trapped portion of molecule is moved within the nanopore, and the molecule is characterized based on the electrical stimulus required to affect movement of at least a portion of the trapped portion of the molecule within the nanopore.

Abstract: Techniques for characterizing a molecule are described herein. In one example, a portion of the molecule is trapped in a nanopore, a variable voltage is applied across the nanopore until the trapped portion of molecule is moved within the nanopore, and the molecule is characterized based on the electrical stimulus required to affect movement of at least a portion of the trapped portion of the molecule within the nanopore.

Abstract: A secondary battery includes a battery case configured subject to the configuration of a conventional 9V or 1.5V battery and a battery body and a battery charger mounted in the battery case. The battery charger controls the battery body for charging and voltage output, and provides a USB socket as charging interface and positive and negative electrodes as discharging interface. Thus, the secondary battery is connectable to a USB plug of a cell phone battery charger or computer for charging, and can be installed in an electric product like a conventional battery cell to provide DC power to the electric product. Under the provision of current detection function and voltage adjusting function, the 1.5V secondary battery can be connected in series or in parallel with one or a number of micro resistor-provided virtual batteries to output a voltage subject to its linking arrangement.

Abstract: A lead anchor includes a body defining at least one first portion of a lead lumen, the body having a first opening and a second opening. An obstructing member is disposed within the body. The obstructing member defines a second portion of the lead lumen. A spring is disposed in the body and configured and arranged to operate on the obstructing member so that the second portion of the lead lumen is coterminous with the at least one first portion of the lead lumen and forms a continuous lead path when the spring is compressed and the second portion of the lead lumen is offset from the at least one first portion of the lead lumen when the spring is not compressed.