Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.

Abstract: A starch-based coating compound for packaging materials, in particular for paper, pasteboard or cardboard, wherein the starch has a molecular weight in the range of 800,000 to 50,000,000 g/mol, preferably in the range of 800,000 to 20,000,000 g/mol. The coating compound is used for surface-sealing packaging materials, to prevent the passage of mineral oil contaminants from the packaging material into packaged goods. The subject disclosure furthermore relates to a multi-layer packaging material, which is produced using the coating compound, and to a method for producing said packaging material.

Abstract: A core ring for an impeller or turbine of a torque converter is provided. The core ring includes an annular base portion including a convex blade side surface portion and a concave stator side surface portion and a wrapped outer diameter portion including an outwardly extending lip protruding radially outward from the annular base portion. A method of forming a torque core ring for an impeller or turbine of a torque converter is also provided. The method includes forming a wrapped outer diameter portion including an outwardly extending protrusion protruding radially outward from an annular base portion including a convex blade side surface portion and a concave stator side surface portion. A torque converter including the core ring is also provided.

Abstract: The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.

Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.

Abstract: Described herein are stabilized polymerase compositions comprising a polymerase and an polymerase stabilizing agent, such as a non-detergent zwitterionic stabilizer or a cationic ester disclosed, for use in nucleic acid amplification or nucleic acid sequencing. Compositions are provided for the stabilization of one or more polymerases in a single stabilized liquid formulation. Also disclosed are methods for making and using stabilized polymerase compositions and kits for nucleic acid amplification and sequencing comprising the stabilized polymerase compositions provided.

Abstract: The present invention relates to the stabilization of one or more metabolically-active cell in a blood sample at ambient temperatures. In particular, formulations, compositions, articles of manufacture, kits and methods for substantially stable storage of one or more metabolically-active cell in a blood sample at ambient temperatures are provided.

Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.

Abstract: Provided herein are formulations for the stabilization of one or more polypeptide or nucleic acid molecule in a native, non-denatured state at ambient temperatures. Also provided are compositions, articles of manufacture, kits and methods for substantially stable storage of one or more polypeptide or nucleic acid molecule in a native, non-denatured, and/or functionally active conformation substantially free on intracellular polypeptides and nucleic acids at ambient temperatures are provided. Also provided are formulations for the stabilization of one or more exosome at ambient temperatures, and compositions, articles of manufacture, kits and methods of use.

Abstract: A method for autofocusing a microscope at a correct autofocus position in a sample includes the steps: generating a reference pattern by an autofocus light device, projecting the reference pattern towards a sample, whereby the reference pattern is backscattered by at least two interfaces being located at or close to the sample, projecting the backscattered reference pattern towards a detector which provides spatial resolution, obtaining a superposition of a number of detection patterns, each detection pattern related to one of the interfaces, on the detector, analyzing the superposition of detection patterns to identify at least one autofocus detection pattern related to at least one of the interfaces, and analyzing the at least one autofocus detection pattern to determine the direction and/or magnitude of deviation of the microscope's current focus position from the correct focus position.

Abstract: The invention relates to a monitoring system for monitoring a watercraft or several watercrafts, having an identification device and a first hydrophone, which is configured such that acoustic signals that are emitted by watercrafts are determined as underwater sound information therein, whereby the identification device has a first memory for storing the underwater sound information and a second memory for storing watercraft information, whereby the first and second memories are interconnected, characterized in that the first hydrophone is arranged in a stationary and fixed manner.

Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.

Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA, RNA or protein components following the storage period.

Abstract: A method for producing starch films comprises the following steps: preparing a mixture comprising starch and water, wherein more than 50 weight percent of the starch is present in the form of particles of granular starch; shaping the mixture to form a film in a shaping process; solidifying the mixture by increasing the temperature of the mixture during and/or after the shaping process by more than 5° C. Films produced by this method have starch particles bonded to one another. A device for performing this method comprises a shaping device for enabling shaping of the starch material to form a film, and has a heating device for performing a heat treatment for destructuring of the starch during and/or after the shaping.

Abstract: The present invention relates to a polymer mixture with a low viscosity, allowing processes for the processing of plastics materials to be accelerated while the final properties of the end products remain the same or are improved. The polymer mixture is mixed with the plastics materials in the manner of an additive. The invention further relates to the production of suitable polymer mixtures of this type and to the use thereof.

Abstract: The present invention refers to the gene cluster and genes comprised by the gene cluster which are involved in the biosynthesis of griselimycin and methylgriselimycin and to the use of the gene cluster, genes comprised thereby and proteins encoded thereby for the production of antibiotic agents.

Abstract: A starch-based coating compound for packaging materials, in particular for paper, pasteboard or cardboard, wherein the starch has a molecular weight in the range of 800,000 to 50,000,000 g/mol, preferably in the range of 800,000 to 20,000,000 g/mol. The coating compound is used for surface-sealing packaging materials, to prevent the passage of mineral oil contaminants from the packaging material into packaged goods. The subject disclosure furthermore relates to a multi-layer packaging material, which is produced using the coating compound, and to a method for producing said packaging material.

Abstract: A packaging material includes a starch-based barrier coating. After deducting an optional filler component, the barrier coating has 30 to 90% by weight of starch, wherein at least >20% of the starch has an average molecular weight of at least 500,000 g/mol, and >20% by weight of the starch are present in the barrier coating in the form of gelatinized starch particles. A content of 0-70% by weight of plasticizer in the barrier coating and a surface weight in the range of 3 to 80 g/m2, make it possible to produce a mechanically stable barrier coating, which effectively prevents the diffusion of nonpolar hydrocarbons and hydrocarbon derivatives, for example on the inside of cardboard packaging, and thus protects the packaged food against contaminations. The packaging material can be produced easily and cost-effectively at high process speeds and can be recycled without restrictions and meets possible food regulations.

Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration in a form that permits recovery of intact DNA or RNA components following the storage period.

Abstract: The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections: