Patents by Inventor Rolf Muller

Rolf Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROLOGOUS HOSTS
    Publication number: 20130089522
    Abstract: This invention is related to bacterial engineering and the heterologous expression of useful compounds. In particular, the invention relates to a heterologous host that has been engineered for expression of a gene which is capable of polyketide or non-ribosomal peptide synthesis. Methods of treating cancer are also disclosed.
    Type: Application
    Filed: December 17, 2010
    Publication date: April 11, 2013
    Applicant: GENE BRIDGES GMBH
    Inventors: Youming Zhang, Jun Fu, Xiaoying Bian, Francis Stewart, Rolf Muller
  • Recombinant preparation of selected bromelain fractions
    Patent number: 8409840
    Abstract: The present invention pertains in general to Bromelain and particularly to the different active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed cysteine proteases, which are found in Bromelain. It has been found that the method for expression of the recombinant proteins is superior to the purification from Bromelain itself.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: April 2, 2013
    Assignee: Ursapharm Arzneimittel GmbH
    Inventors: Rolf Müller, Nora Luniak, Klaus Eschmann
  • Synthetic pathway enzymes for the production of argyrins
    Patent number: 8404462
    Abstract: The invention provides the amino acid sequences comprised in or constituting the synthetic pathway enzymes participating in the production of Argyrins, as well as the nucleic acid sequences encoding the synthetic pathway enzymes participating in the production of Argyrins, as well as genetically manipulated micro-organisms containing nucleic acid sequences encoding the synthetic pathway enzymes for the production of Argyrins, e.g. for inserting one or more of these coding sequences, mutating in a targeted manner one or more of these nucleic acid sequences, in a wild type producer micro-organism or in a heterologous micro-organism, for the production of Argyrins.
    Type: Grant
    Filed: June 15, 2009
    Date of Patent: March 26, 2013
    Assignees: Helmholtz-Zentrum Fuer Infektionsforschung GmbH, Universitaet des Saarlandes
    Inventors: Rolf Müller, Silke Wenzel, Ronald Garcia
  • Polymer networks
    Patent number: 8202929
    Abstract: Polymer mixtures containing a first long-chain polymer and a second short-chain polymer. The structural parameters of the two polymers are coordinated in such a way that a polymeric material is obtained which is easier to process while being provided with improved mechanical properties and in part also improved thermal properties compared with the first polymer at suitable conditions for producing the polymer mixture as a result of networks being formed and heterocrystallization taking place.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: June 19, 2012
    Assignee: InnoGEL AG
    Inventors: Rolf Müller, Federico Innerebner
  • Polysaccharide based network and method for the production thereof
    Patent number: 8153783
    Abstract: The production of polysaccharide networks, especially starch networks, having a high network density, high solidity, a low swelling degree, and exhibiting reduced water absorption and to the uses thereof, especially, in the filed of biodegradable plastics.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: April 10, 2012
    Assignee: InnoGEL AG
    Inventors: Rolf Muller, Federico Innerebner, Paul Smith, Theo A. Tervoort
  • METHOD FOR CODING/INDIVIDUALIZING A CONTAINER USED TO RECEIVE NUTRIENT SOLUTIONS OR CULTURE MEDIA
    Publication number: 20120055993
    Abstract: A method for coding/individualizing a container used to receive nutrient solutions or culture media, in particular for cultivating microorganisms, cell cultures, bacteria and the like, the container being assigned a code, characterized in that the code is designed to be machine-readable, issued by the manufacturer and assigned to the container and that on the user side the code is assigned to a process as a data record.
    Type: Application
    Filed: November 19, 2009
    Publication date: March 8, 2012
    Applicant: HEIPHA GMBH
    Inventor: Rolf Müller
  • COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES
    Publication number: 20120052572
    Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA, RNA or protein components following the storage period.
    Type: Application
    Filed: July 26, 2011
    Publication date: March 1, 2012
    Inventors: Scott E. Whitney, Steven Wilkinson, Rolf Muller
  • STARCH FOILS AND/OR FILMS AND A METHOD AND USE OF A DEVICE FOR THE PRODUCTION THEREOF
    Publication number: 20120006226
    Abstract: A method for producing starch films comprises the following steps: preparing a mixture comprising starch and water, wherein more than 50 weight percent of the starch is present in the form of particles of granular starch; shaping the mixture to form a film in a shaping process; solidifying the mixture by increasing the temperature of the mixture during and/or after the shaping process by more than 5° C. Films produced by this method have starch particles bonded to one another. A device for performing this method comprises a shaping device for enabling shaping of the starch material to form a film, and has a heating device for performing a heat treatment for destructuring of the starch during and/or after the shaping.
    Type: Application
    Filed: March 3, 2010
    Publication date: January 12, 2012
    Applicant: INNOGEL AG
    Inventors: Rolf Muller, Federico Innerebner
  • SOFT CAPSULE BASED ON STARCH AND A METHOD AND DEVICE FOR THE PRODUCTION THEREOF
    Publication number: 20110319503
    Abstract: A method for producing starch soft capsules comprises the following steps: preparing a mixture comprising starch, plasticizer and water, wherein more than 50 weight percent of the starch is present in the form of particles of granular starch; shaping the mixture to form a film in a shaping process; solidifying the mixture by increasing the temperature of the mixture during and/or after the shaping process by more than 5° C.; and shaping the film to form a soft capsule. Soft capsules produced by this method have starch particles bonded to one another. A device for performing this method comprises a shaping device to enable shaping of the starch material to form a film, and a heating device to perform a heat treatment to destructure the starch during and/or after the shaping. It comprises a rotary die device.
    Type: Application
    Filed: March 3, 2010
    Publication date: December 29, 2011
    Inventors: Rolf Muller, Federico Innerebner
  • PRODUCTION OF OMEGA-3 FATTY ACIDS BY MYXOBACTERIA
    Publication number: 20110275846
    Abstract: The present invention provides a method for producing ?-3 polyunsaturated fatty acids by culturing specific myxobacterial stains and myxobacterial strains suitable for said method.
    Type: Application
    Filed: December 1, 2009
    Publication date: November 10, 2011
    Applicant: INTERMED DISCOVERY GMBH
    Inventors: Ernst Roemer, Rolf Müller, Ronald O. Garcia, Mark Stadler, Dominik Pistorius, Alexander Brachmann
  • BIOACTIVE PRE-TUBULYSINS AND USE THEREOF
    Publication number: 20110245295
    Abstract: The invention relates to bioactive pre-tubulysin derivatives, their preparation and pharmacological use.
    Type: Application
    Filed: September 22, 2009
    Publication date: October 6, 2011
    Applicant: UNIVERSITAT DES SAARLANDES
    Inventors: Yi Chai, Angelika Ullrich, Uli Kazmaier, Rolf Müller
  • RECOMBINANT PREPARATION OF BROMELAIN INHIBITORS AND BROMELAIN INHIBITOR PRECURSOR
    Publication number: 20110200541
    Abstract: The present invention pertains in general to Bromelain and particularly to the active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed Bromelain inhibitor precursor and Bromelain inhibitors, which are found in Bromelain. It has been found that the recombinant expressed inhibitors have superior effects in terms of treatment of disorders and conditions than Bromelain or its protein fractions from plant extracts.
    Type: Application
    Filed: July 27, 2009
    Publication date: August 18, 2011
    Applicant: Ursapharm Arzneimittel GmbH
    Inventors: Rolf Müller, Nora Luniak, Klaus Eschmann
  • SYNTHETIC PATHWAY ENZYMES FOR THE PRODUCTION OF ARGYRINS
    Publication number: 20110159537
    Abstract: The invention provides the amino acid sequences comprised in or constituting the synthetic pathway enzymes participating in the production of Argyrins, as well as the nucleic acid sequences encoding the synthetic pathway enzymes participating in the production of Argyrins, as well as genetically manipulated micro-organisms containing nucleic acid sequences encoding the synthetic pathway enzymes for the production of Argyrins, e.g. for inserting one or more of these coding sequences, mutating in a targeted manner one or more of these nucleic acid sequences, in a wild type producer micro-organism or in a heterologous micro-organism, for the production of Argyrins.
    Type: Application
    Filed: June 15, 2009
    Publication date: June 30, 2011
    Applicants: Universitat des Saarlandes, Helmholtz-Zentrum fur Infektionsforchung GmbH
    Inventors: Rolf Müller, Silke Wenzel, Ronald Garcia
  • Method for determining operating parameters of a printing press
    Patent number: 7954431
    Abstract: A printing press, in particular a sheet-fed offset printing press, includes at least one control device, a plurality of printing units, one or more varnishing units, and one or more dryers. Variables determining a dryness of the printing material are determined and used to optimize the drying process. For that purpose, the important material streams influencing the drying process are determined at least for the region of the printing press that contains the drying device(s).
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: June 7, 2011
    Assignee: Heidelberger Druchmaschinen AG
    Inventors: Jochen Jung, Rolf Müller, Michael Rohleder, Matthias Niedernhuber
  • POLYSACCHARIDE BASED NETWORK AND METHOD FOR THE PRODUCTION THEREOF
    Publication number: 20110124777
    Abstract: The production of polysaccharide networks, especially starch networks, having a high network density, high solidity, a low swelling degree, and exhibiting reduced water absorption and to the uses thereof, especially, in the filed of biodegradable plastics.
    Type: Application
    Filed: October 18, 2010
    Publication date: May 26, 2011
    Applicant: INNOGEL AG
    Inventors: Rolf Müller, Federico Innerebner, Paul Smith, Theo A. Tervoort
  • SLOWLY DIGESTIBLE STARCH PRODUCT
    Publication number: 20110117265
    Abstract: The invention relates to a starch product in the form of a foodstuff ingredient and to a foodstuff per se whose hydrolysis speed during digestion can be set to low and especially almost constant in that the starch is obtained as a partially crystalline network with a low degree of swelling by means of targeted conditioning, starting from an at least partly amorphous state.
    Type: Application
    Filed: November 11, 2010
    Publication date: May 19, 2011
    Applicant: INNOGEL AG
    Inventors: Rolf Müller, Federico Innerebner
  • Polysaccharide based network and method for the production thereof
    Patent number: 7943765
    Abstract: The production of polysaccharide networks, especially starch networks, having a high network density, high solidity, a low swelling degree, and exhibiting reduced water absorption and to the uses thereof, especially, in the field of biodegradable plastics.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: May 17, 2011
    Assignee: Innogel AG
    Inventors: Rolf Müller, Federico Innerebner, Paul Smith, Theo A. Tervoort
  • COMPOSITIONS AND METHODS FOR BIOLOGICAL SAMPLE STORAGE
    Publication number: 20110081363
    Abstract: Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.
    Type: Application
    Filed: May 11, 2010
    Publication date: April 7, 2011
    Applicant: BIOMATRICA, INC.
    Inventors: Scott E. Whitney, Sohela De Rozieres, Rolf Muller
  • Hair Coloring Agent Applicator
    Publication number: 20110005546
    Abstract: The present invention relates to an applicator (1) having an applicator element (8) for applying a product, conveyed to the application zone (5) from a separate reservoir, onto a strand of hair or of fibers comparable therewith, and having a strand gripper (12) movable back and forth between a closed position and a opened position. A strand gripper (12) of this kind serves to select and subsequently guide the hair or strands during actual product application. For improved guidance of the hair or strands during product application, the strand gripper (12) comprises a guidance surface (13) that, with the gripper (12) in the closed position, entirely overlaps the application zone (5) and holds the strand in contact with the application zone (5), by preference presses it onto the application zone (5).
    Type: Application
    Filed: July 7, 2010
    Publication date: January 13, 2011
    Inventors: Rolf Müller-Grünow, Manuela Geuther
  • RECOMBINANT PREPARATION OF SELECTED BROMELAIN FRACTIONS
    Publication number: 20100272659
    Abstract: The present invention pertains in general to Bromelain and particularly to the different active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed cysteine proteases, which are found in Bromelain. It has been found that the method for expression of the recombinant proteins is superior to the purification from Bromelain itself.
    Type: Application
    Filed: August 8, 2008
    Publication date: October 28, 2010
    Applicant: URSAPHARM ARZNEIMITTEL GMBH
    Inventors: Rolf Müller, Nora Luniak, Klaus Eschmann