Abstract: The invention relates to a method for operating a circuit having a heat accumulator, having a coolant circuit, having a heat accumulator in a line of the circuit and having at least one valve and one pump, wherein, when the valve is open, the heat accumulator can be charged with coolant from the coolant circuit by means of the pump, or coolant can be discharged from the heat accumulator into the coolant circuit, wherein the charging or discharging of the heat accumulator takes place in an open-loop-controlled or closed-loop-controlled manner as a function of a temperature difference of a temperature of the coolant in the circuit and a temperature of the coolant in the heat accumulator.

Abstract: A method for producing starch soft capsules comprises the following steps: preparing a mixture comprising starch, plasticizer and water, wherein more than 50 weight percent of the starch is present in the form of particles of granular starch; shaping the mixture to form a film in a shaping process; solidifying the mixture by increasing the temperature of the mixture during and/or after the shaping process by more than 5° C.; and shaping the film to form a soft capsule. Soft capsules produced by this method have starch particles bonded to one another. A device for performing this method comprises a shaping device to enable shaping of the starch material to form a film, and a heating device to perform a heat treatment to destructure the starch during and/or after the shaping. It comprises a rotary die device.

Abstract: A method for producing starch films comprises the following steps: preparing a mixture comprising starch and water, wherein more than 50 weight percent of the starch is present in the form of particles of granular starch; shaping the mixture to form a film in a shaping process; solidifying the mixture by increasing the temperature of the mixture during and/or after the shaping process by more than 5° C. Films produced by this method have starch particles bonded to one another. A device for performing this method comprises a shaping device for enabling shaping of the starch material to form a film, and has a heating device for performing a heat treatment for destructuring of the starch during and/or after the shaping.

Abstract: Described herein are stabilized polymerase compositions comprising a polymerase and an polymerase stabilizing agent, such as a non-detergent zwitterionic stabilizer or a cationic ester disclosed, for use in nucleic acid amplification or nucleic acid sequencing. Compositions are provided for the stabilization of one or more polymerases in a single stabilized liquid formulation. Also disclosed are methods for making and using stabilized polymerase compositions and kits for nucleic acid amplification and sequencing comprising the stabilized polymerase compositions provided.

Abstract: The present invention provides novel chondramide derivatives of formula (I) which can be used for the treatment of cancer.

Abstract: The invention relates to a novel Mogul procedure for manufacturing sweets, in particular starch-based gummi candies, which have a comparable texture to gelatin-based gummi candies, with at least one portion of the starch not being completely dissolved until after the pouring into the form of the confection article. In comparison to previous Mogul technology, the casting mass is poured at a comparatively low temperature, and the gelling and/or settling occurs at a comparatively high temperature.

Abstract: Compositions and methods are disclosed for automated storing, tracking, retrieving and analyzing biological samples, including dry storage at ambient temperatures of nucleic acids, proteins (including enzymes), and cells using a dry storage matrix that permits recovery of biologically active materials. RFID-tagged biological sample storage devices featuring dissolvable or dissociable matrices are described for use as supports of biological samples, which matrices can be dried and subsequently rehydrated for sample recovery. Also disclosed are computer-implemented systems and methods for managing sample data.

Abstract: The present invention provides a tomaymycin biosynthetic gene cluster of Streptomyces species FH6421, and its use for producing 11-de-O-methyltomaymycin.

Abstract: The present invention concerns substances which act as selective ligands of nuclear receptors of the PPAR beta/delta subtype and which can be used for the treatment of PPAR beta/delta-mediated diseases. The substances of this invention act as inhibitors of PPAR beta/delta receptors.

Abstract: Compositions and methods are disclosed for automated storing, tracking, retrieving and analyzing biological samples, including dry storage at ambient temperatures of nucleic acids, proteins (including enzymes), and cells using a dry storage matrix that permits recovery of biologically active materials. RFID-tagged biological sample storage devices featuring dissolvable or dissociable matrices are described for use as supports of biological samples, which matrices can be dried and subsequently rehydrated for sample recovery. Also disclosed are computer-implemented systems and methods for managing sample data.

Abstract: The present invention refers to the gene cluster and genes comprised by the gene cluster which are involved in the biosynthesis of griselimycin and methylgriselimycin and to the use of the gene cluster, genes comprised thereby and proteins encoded thereby for the production of antibiotic agents.

Abstract: The invention relates to bioactive pre-tubulysin derivatives, their preparation and pharmacological use.

Abstract: A method for controlling a vertical control system of a vehicle with at least two vertical control devices that influence the driving stability of the vehicle, includes monitoring the functionality of the at least two vertical control devices, detecting a fault condition of a first vertical control device of the at least two vertical control devices, and adjusting the control parameters of at least a second vertical control device of the at least two vertical control devices for at least partially compensating of the fault condition of the first vertical control device.

Abstract: A sheet processing machine, in particular a sheet-fed printing press, includes a varnishing unit and at least one combination drier for applying radiation energy and heated air to a newly varnished sheet. The at least one combination drier includes a plurality of circular or polygonal air nozzles and narrow-band high-power infrared light sources disposed between the air nozzles. The infrared light sources apply radiation at a radiation density of at least 25 kW/m2 in total to the varnished sheet. The temperature of the heated air passing through the nozzles is below 100° C., preferably below 80° C. A method of drying sheets is also provided.

Abstract: Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.

Abstract: The present invention relates to an applicator (1) having an applicator element (8) for applying a product, conveyed to the application zone (5) from a separate reservoir, onto a strand of hair or of fibers comparable therewith, and having a strand gripper (12) movable back and forth between a closed position and a opened position. A strand gripper (12) of this kind serves to select and subsequently guide the hair or strands during actual product application. For improved guidance of the hair or strands during product application, the strand gripper (12) comprises a guidance surface (13) that, with the gripper (12) in the closed position, entirely overlaps the application zone (5) and holds the strand in contact with the application zone (5), by preference presses it onto the application zone (5).

Abstract: The invention relates to a method for operating a circuit having a heat accumulator, having a coolant circuit, having a heat accumulator in a line of the circuit and having at least one valve and one pump, wherein, when the valve is open, the heat accumulator can be charged with coolant from the coolant circuit by means of the pump, or coolant can be discharged from the heat accumulator into the coolant circuit, wherein the charging or discharging of the heat accumulator takes place in an open-loop-controlled or closed-loop-controlled manner as a function of a temperature difference of a temperature of the coolant in the circuit and a temperature of the coolant in the heat accumulator.

Abstract: Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.

Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.

Abstract: The present invention relates to a method of identifying a compound useful for the treating, reducing or preventing pathogenic infection caused by a microorganism and to the use of the PqsD protein or a functional fragment or variant thereof for the identification of a compound having said effect.