Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds of Formula (I) to pharmaceutical compositions comprising compounds of Formula (I) and to methods of use thereof, such as methods of treating cancer using the compounds of Formula (I) and pharmaceutical compositions comprising those compounds.

Abstract: The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds of Formula (I) to pharmaceutical compositions comprising compounds of Formula (I) and to methods of use thereof, such as methods of treating cancer using the compounds of Formula (I) and pharmaceutical compositions comprising those compounds.

Abstract: Compounds that inhibit KRas G12D; in particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: An electronic device may include circuitry and an anti-tamper device having a physical characteristic that changes in response to a tamper attempt. The circuitry is configured to determine physically unclonable function (PUF) data based on the physical characteristic and to perform at least one secure operation based on the PUF data. The circuitry is further configured to detect the tamper attempt based a change to the physical characteristic and to perform at least one action in response to detection of the tamper attempt for protecting the electronic device from the tamper attempt.

Abstract: A glove of a type worn to provide masking effect between a wear's hand and another surface, such as surface of food stuff. The glove, or fragments thereof, is rendered detectable by X-ray and/or metal detection apparatus. Apparatus and/or indication means can be provided to allow a detected glove or glove portion to be allocated to a particular location and/or personnel to allow, if necessary, remedial action to be taken.

Abstract: The present invention relates to compounds that inhibit at least one of KRas wild type, KRas G12A, KRas G12C, KRas G12D, KRas G12R, KRas G12S, KRas G12V, KRas G13D and KRas Q61H, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The invention relates to a writing implement such as a pen which includes a housing and an internal component in which there is provided a reservoir of ink. The internal component typically includes a portion such as a ballpoint which allows ink to be transferred from the reservoir to a surface to which the said portion is applied. The writing implement and/or internal component is rendered detectable by metal detection and/or X-ray detection apparatus when the internal component is within range of the same so that the internal component is detectable when separated, deliberately or inadvertently, from the remainder of the writing implement.

Abstract: This invention is a portable beverage cooler that dispenses two kinds of beverages within the same cooler. This is possible by dividing the cooler in the middle with a single partition to separate the two beverages. Both sides have a separate and detachable lid for adding the desired beverage. It is designed as a tall rectangle shape with handles to make it easy to carry to a location and transport from a vehicle. Durable plastic for the product material is used to keep the container weight light enough to carry. The beverage cooler is propped up at waist high onto a table for easy access. Each side of the cooler has a valve to dispense the beverage. A cup is placed below the valve to release the desired beverage into the cup. Lids can be removed separately to confine the beverage to the section, when more beverage is added to the cooler and for easy access.

Abstract: The invention relates to the provision of apparatus for use in measuring the temperature of a body of matter and in particular the temperature of a foodstuff in a manner which allows the required apparatus in the form of a housing with data processing means and a temperature probe connected thereto, to be used effectively and without the apparatus itself becoming a safety hazard. This is achieved by using materials which are provided in a form to allow the apparatus, and portions thereof to be rendered detectable by metal detection and/or X-ray detection apparatus.

Abstract: Described herein are apparatus, methods, and systems for detecting the presence of a targeted substance. The apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the apparatus can include a top layer coupled to a top surface of the detection layer and a bottom layer coupled to a bottom surface of the detection layer.

Abstract: Methods and systems are provided for controlling a vehicle engine to adjust exhaust warm-up strategy based on a vehicle network information. In one example, in response to an expected decrease in temperature of a catalyst of a vehicle below a threshold and an estimated duration thereof based on communications external from the vehicle, a method may include delaying catalyst heating actions, when the catalyst heating actions are determined to be unable to heat up the catalyst to threshold temperatures. However, the catalyst heating actions may be enabled when the catalyst heating actions are determined to be able to achieve the threshold temperature within the duration.

Abstract: A patient monitor is disclosed for detecting patient movement or abnormal breathing. Images of a patient are obtained by a stereoscopic camera. These images are then processed by a 3D position determination module which determines measurements indicative of positions of at least part of a patient. The obtained measurements are then passed to a model generation module which generates a breathing model of the variation in position of the at least part of a patient during a breathing cycle. Subsequently abnormal breathing or patient movement can be detected by processing further images obtained by the stereoscopic camera to determine more measurements indicative of positions of at least part of a patient. These measurements are then compared with a stored breathing model by a comparison module.

Abstract: The invention to which this application relates to improvements to a retaining band which can be used to securely locate, form and retain a load of items or goods, in one embodiment on a pallet, and thereby retain the said items or goods as a single integral package. The invention allows for the adaptation of the retaining bands to be detectable when with a predetermined range of detection apparatus such as X-ray and/or metal detection apparatus so that should the retaining band or fragments thereof be discarded or dislodged, the presence of the same is detectable and therefore prevented from becoming a potential contaminant or safety hazard.

Abstract: Mechanical optics for mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A mechanical optical element, such as a rotating prism or a mirror membrane, may impart motion to an incident beam entering the optical fiber to generate a homogeneous illumination field from a coherent light source.

Abstract: The present invention relates to compounds that inhibit Son of sevenless homolog 1 (SOS1) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Abstract: Pixelated array optics for mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A pixelated phase array, such as a digital micromirror device or an LCD phase plate, may impart motion to an incident beam entering the optical fiber to generate a homogeneous illumination field from a coherent light source.

Abstract: A glove of a form typically, although not necessarily exclusively, provided for single or limited use purposes and discarded thereafter. The glove is to prevent contact between a product and a person's hand and to avoid contamination. The glove material includes components capable of detection by at least one form of noncontact detection apparatus which renders the glove or portion detectable if discarded and inadvertently becomes part of a manufacturing process or product. The components render the glove detectable by using metal detection apparatus and/or X-ray detection apparatus which may allow removal of the glove. The glove may also include an antimicrobial agent as part to prevent or reduced contamination on the surface of the glove. The glove can also be rendered biodegradable.

Abstract: The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Abstract: The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.