Abstract: The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Focusing optics for mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A vibration stage may impart mechanical motion to a condenser lens to generate a homogeneous illumination field from a coherent light source.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Fiber-based mode mixing techniques may be used to homogenize different modes in an optical fiber used for surgical illumination. A vibrating fiber mechanism may impart mechanical motion to a portion of the optical fiber to generate a homogeneous illumination field from a coherent light source.

Abstract: Isoindolin-1-one compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoindolin-1-one compound or analogs thereof, in the treatment of disorders characterized by the activation of ASK1 (e.g., cardiovascular diseases, inflammatory disorders (acute or chronic), autoimmune diseases, destructive bone disorders, fibrotic diseases/disorders such as alcoholic steatohepatitis; non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH), neurodegenerative disorders, and metabolic diseases such as diabetes).

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The invention relates to the provision of apparatus for use in measuring the temperature of a body of matter and in particular the temperature of a foodstuff in a manner which allows the required apparatus in the form of a housing with data processing means and a temperature probe connected thereto, to be used effectively and without the apparatus itself becoming a safety hazard. This is achieved by using materials which are provided in a form to allow the apparatus, and portions thereof to be rendered detectable by metal detection and/or X-ray detection apparatus.

Abstract: An electronic device may include a printed circuit board having a physically unclonable function (PUF) source. The electronic device may also include an integrated circuit (IC) chip positioned on the printed circuit board, and the first PUF source may be embedded in or formed on the printed circuit board external to the IC chip. The IC chip has processing circuitry that is configured to determine PUF data based on the PUF source. The processing circuitry is further configured to determine a cryptographic key or authentication token based on the PUF data and to perform at least one secure operation using the cryptographic key or authentication token.

Abstract: The present disclosure provides a vitreous visualization system including a vitreous illuminator including a vitreous visualization light source and a vitreous visualization tool that transmits lights from the vitreous visualization light source into an eye having vitreous, a pupil, and a vitreous-pupil axis. The vitreous visualization system further includes a general illuminator, which may include a general light source and a general illumination tool that transmits light from the general light source into the eye. The present disclosure further provided a vitreous visualization system including only a vitreous illuminator that transmits light from the vitreous visualization light source into an eye having vitreous, a pupil, a vitreous-pupil axis, and a retina at an angle B with the vitreous-pupil axis of the eye such that the brightness of vitreous in the eye is higher than the brightness of the retina of the eye.

Abstract: Isoindolin-1-one compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoindolin-1-one compound or analogs thereof, in the treatment of disorders characterized by the activation of ASK1 (e.g., cardiovascular diseases, inflammatory disorders (acute or chronic), autoimmune diseases, destructive bone disorders, fibrotic diseases/disorders such as alcoholic steatohepatitis; non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH), neurodegenerative disorders, and metabolic diseases such as diabetes).

Abstract: Methods and systems are provided for controlling a vehicle engine to adjust exhaust warm-up strategy based on a vehicle network information. In one example, in response to an expected decrease in temperature of a catalyst of a vehicle below a threshold and an estimated duration thereof based on communications external from the vehicle, a method may include delaying catalyst heating actions, when the catalyst heating actions are determined to be unable to heat up the catalyst to threshold temperatures. However, the catalyst heating actions may be enabled when the catalyst heating actions are determined to be able to achieve the threshold temperature within the duration.

Abstract: A point of sale system has a display for receiving touch inputs, a controller to receive the touch inputs from the display, and a secure controller to receive touch input data from the controller. The system also has a card interface module and a contactless interface module to provide encrypted data to the secure controller. The secure controller can operate in either a secure mode or a non-secure mode. When a non-secure mode is engaged, the secure controller provides the touch input data to a processor. When a secure mode is engaged, the secure controller blocks at least a portion of the touch input data from the processor.

Abstract: A transaction device includes circuitry that provides a power supply to a processor of the transaction device. Attackers may attempt to glitch the processor power supply in a manner that causes processor to operate incorrectly such as by skipping instructions. A monitoring circuit may be coupled to the processor power supply circuitry to identify conditions that are indicative of a glitch attempt. Glitch attempts may be stored in a memory and reported to the processor to induce the execution of counter-measures.

Abstract: Methods and systems are provided for controlling a vehicle engine to adjust exhaust warm-up strategy based on a vehicle network information. In one example, in response to an expected decrease in temperature of a catalyst of a vehicle below a threshold and an estimated duration thereof based on communications external from the vehicle, a method may include delaying catalyst heating actions, when the catalyst heating actions are determined to be unable to heat up the catalyst to threshold temperatures. However, the catalyst heating actions may be enabled when the catalyst heating actions are determined to be able to achieve the threshold temperature within the duration.

Abstract: An electronic device may include a printed circuit board having a physically unclonable function (PUF) source. The electronic device may also include an integrated circuit (IC) chip positioned on the printed circuit board, and the first PUF source may be embedded in or formed on the printed circuit board external to the IC chip. The IC chip has processing circuitry that is configured to determine PUF data based on the PUF source. The processing circuitry is further configured to determine a cryptographic key or authentication token based on the PUF data and to perform at least one secure operation using the cryptographic key or authentication token.

Abstract: A ball launcher and method for actuating wellsite equipment at a wellsite is disclosed. The wellsite has wellhead equipment positioned at an inlet of a wellbore. The ball launcher includes a housing, a ball release, and a housing extension. The housing has a passage for receiving balls. The ball is release positionable about the housing. The ball release includes a feeder to selectively and sequentially release the balls from the housing. The housing extension includes a hopper tube and a feed tube. The hopper tube has an inlet to receive the balls from the housing, the feed tube extending at an angle from the hopper tube. The feed tube has an exit a distance above the wellhead equipment to release the balls therethrough whereby the balls are dropped into and activates the wellsite equipment in the wellbore.

Abstract: A hose coupler is described capable of quick connection and disconnection with only a small amount of rotation required to achieve a fluid-tight seal. A plurality of threaded segments are arranged about a central axis of the coupler into a segment set. Such segments comprise a flexible, elastic material that is capable bending towards or away from the central axis under an applied force but returns to their normal as-manufactured shape upon removal of the applied force. Ease of connection and disconnection without the requirement for substantial force to be applied is one of the salient advantages of the coupler described herein.