Patents by Inventor Ryuji Ueno

Ryuji Ueno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Virus like particle composition
    Patent number: 9249191
    Abstract: The present invention provides a particle comprising a polypeptide and at least one antigen, and a composition comprising thereof.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: February 2, 2016
    Assignee: VLP Therapeutics, LLC
    Inventors: Ryuji Ueno, Wataru Akahata
  • Method for preparing a fatty acid derivative
    Patent number: 9242950
    Abstract: A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z1 is wherein R3 is a protecting group for a hydroxy group; which includes the step of reacting a compound of formula (II): wherein Z2 is the same as Z1 except for when Z1 is Z2 is with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: January 26, 2016
    Assignees: R-TECH UENO, LTD., SUCAMPO AG
    Inventors: Tatsuya Matsukawa, Noriyuki Yamamoto, Ryuji Ueno, Hiroyuki Kotajima, Shunsuke Fukuya, Michiharu Handa, Katsuya Sakata
  • METHOD FOR TREATING MUCOSITIS, METHOD FOR TREATING TUMOR, AND PHARMACEUTICAL COMBINATION
    Publication number: 20150272961
    Abstract: Disclosed is a method for treating tumor in a mammalian subject, which comprises administering a combination of (a) an anti-tumor agent and (b) a fatty acid derivative represented by the formula (I): to the subject in need thereof. The application also discloses a method for treating damages, especially gastrointestinal damages including mucositis such as stomatitis induced by an anti-tumor agent, wherein the method comprises administering a fatty acid derivative of formula (I) to the subject who is receiving the anti-tumor agent.
    Type: Application
    Filed: June 15, 2015
    Publication date: October 1, 2015
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
    Patent number: 9084815
    Abstract: Disclosed is a method for treating tumor in a mammalian subject, which comprises administering a combination of (a) an anti-tumor agent and (b) a fatty acid derivative represented by the formula (I): to the subject in need thereof. The application also discloses a method for treating damages, especially gastrointestinal damages including mucositis such as stomatitis induced by an anti-tumor agent, wherein the method comprises administering a fatty acid derivative of formula (I) to the subject who is receiving the anti-tumor agent.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: July 21, 2015
    Assignee: SUCAMPO AG
    Inventor: Ryuji Ueno
  • PHARMACEUTICAL COMPOSITION COMPRISING 11-DEOXY -PROSTAGLANDIN COMPOUND AND METHOD FOR STABILIZING THE COMPOUND
    Publication number: 20150126609
    Abstract: Provided is a pharmaceutical composition including an 11-deoxy-prostaglandin compound represented by formula (I): and a fatty acid ester. By mixing the compound of formula (I) and a fatty acid ester, the compound of formula (I) will be stabilized.
    Type: Application
    Filed: January 6, 2015
    Publication date: May 7, 2015
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Yasuhiro HARADA, Junichi KAWASAKI, Yoshie NISHIMURA, Ryuji UENO
  • SELECTIVE TUMOR TREATMENT
    Publication number: 20150099802
    Abstract: A method for treating a tumor with a decreased level of the 15-hydroxy-prostaglandin dehydrogenase (15-PGDH) in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a fatty acid derivative, a method for suppressing the growth of a tumor cell with a decreased level of the 15-hydroxy-prostaglandin dehydrogenase (15-PGDH), which comprises contacting said tumor cell with an effective amount of a fatty acid derivative, and a method for identifying a subject who would be responsive to a fatty acid derivative, comprising, (i) obtaining a biological sample from said subject; and (ii) measuring 15-hydroxyprostaglandin dehydrogenase (15-PGDH) level are provided.
    Type: Application
    Filed: October 1, 2014
    Publication date: April 9, 2015
    Applicant: SUCAMPO AG
    Inventors: Ryuji UENO, Sachiko KUNO
  • Pharmaceutical composition comprising 11-deoxy-prostaglandin compound and method for stabilizing the compound
    Patent number: 8969324
    Abstract: Provided is a pharmaceutical composition comprising a 11-deoxy-prostaglandin compound represented by formula (I): and a fatty acid ester. By mixing the compound of formula (I) and a fatty acid ester, the compound of formula (I) will be stabilized.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: March 3, 2015
    Assignees: R-Tech Ueno, Ltd., Sucampo AG
    Inventors: Yasuhiro Harada, Junichi Kawasaki, Yoshie Nishimura, Ryuji Ueno
  • METHOD FOR TREATING NEUROPATHIC PAIN
    Publication number: 20150057351
    Abstract: A method for treating neuropathic pain in a mammalian subject, which comprises administering an effective amount of a fatty acid derivative, is provided.
    Type: Application
    Filed: August 20, 2014
    Publication date: February 26, 2015
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • Method for the treatment of gastrointestinal disorders
    Patent number: 8962688
    Abstract: The present invention relates to combined use of (a) a specific prostaglandin (PG) compound and (b) a H+,K+-ATPase inhibitor for the treatment of gastrointestinal disorders.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: February 24, 2015
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • VIRUS LIKE PARTICLE COMPRISING PD-1 ANTIGEN OR PD-1 LIGAND ANTIGEN
    Publication number: 20150017194
    Abstract: The present invention provides a virus like particle comprising a virus structural protein and an antigen derived from PD-1 or a ligand of PD-1, and a composition or kit comprising thereof, its use in immune response etc.
    Type: Application
    Filed: July 10, 2014
    Publication date: January 15, 2015
    Applicant: VLP THERAPEUTICS, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • METHOD FOR MODULATING STEM CELL GROWTH
    Publication number: 20150005381
    Abstract: In one embodiment, provided is a composition including a prostaglandin compound for modulating stem cell proliferation and/or differentiation in a mammalian subject. In another embodiment, the instant application is directed to a composition which includes a prostaglandin compound for modulating proliferation and/or differentiation of stem cells of a mammalian subject, in which the stem cells are contacted directly or indirectly with the composition of the invention.
    Type: Application
    Filed: September 16, 2014
    Publication date: January 1, 2015
    Applicant: SUCAMPO AG
    Inventors: Ryuji UENO, Sachiko KUNO
  • METHOD FOR SUPPRESSING TUMORIGENICITY OF STEM CELLS
    Publication number: 20140371304
    Abstract: A method for suppressing tumorigenicity of stem cells in a mammalian subject, which comprises administering an effective amount of a fatty acid derivative and a method for suppressing tumorigenicity of stem cells of a mammalian subject, which comprises contacting said stem cell with an effective amount of a fatty acid derivative, are provided.
    Type: Application
    Filed: June 11, 2014
    Publication date: December 18, 2014
    Applicant: SUCAMPO AG
    Inventors: Ryuji UENO, Sachiko KUNO, John CUPPOLETTI
  • OPHTHALMIC SOLUTION
    Publication number: 20140371309
    Abstract: The present invention relates to an ophthalmic solution comprising a prostaglandin compound and viscosity-increasing compound. The ophthalmic solution of the invention is excellent in stability and can provide long lasting and increased effect when administrated topically to the eyes of a patient.
    Type: Application
    Filed: August 29, 2014
    Publication date: December 18, 2014
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • MALARIA VACCINE
    Publication number: 20140363458
    Abstract: The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
    Type: Application
    Filed: June 3, 2014
    Publication date: December 11, 2014
    Applicant: VLP THERAPEUTICS, LLC
    Inventors: Ryuji UENO, Wataru AKAHATA
  • Method for treating asthenopia
    Patent number: 8889735
    Abstract: The present invention relates to a method for treating asthenopia, accommodative dysfunction or ocular pain comprising an administration of a specific prostaglandin compound to a mammalian subject. The present invention also relates to a composition for treating asthenopia, accommodative dysfunction or ocular pain comprising a specific prostaglandin compound.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: November 18, 2014
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • Method for modulating stem cell growth
    Patent number: 8871752
    Abstract: In one embodiment, provided is a composition including a prostaglandin compound for modulating stem cell proliferation and/or differentiation in a mammalian subject. In another embodiment, the instant application is directed to a composition which includes a prostaglandin compound for modulating proliferation and/or differentiation of stem cells of a mammalian subject, in which the stem cells are contacted directly or indirectly with the composition of the invention.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: October 28, 2014
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, Sachiko Kuno
  • METHOD FOR TREATING GASTROINTESTINAL DISORDER
    Publication number: 20140315994
    Abstract: The present invention relates to a method for the long term treatment of gastrointestinal disorders in a human subject, which comprises administering an effective amount of a halogenated prostaglandin compound and/or its tautomer to the subject. The method induces substantially no electrolyte shifting during the term of the treatment. The compound used in the present invention can improve quality of life in the human subjects with gastrointestinal disorders, are similarly effective in treating male and female subjects, and also effective in a human subject aged even 65 years and older.
    Type: Application
    Filed: April 30, 2014
    Publication date: October 23, 2014
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • Ophthalmic solution
    Patent number: 8853268
    Abstract: The present invention relates to an ophthalmic solution comprising a prostaglandin compound and viscosity-increasing compound. The ophthalmic solution of the invention is excellent in stability and can provide long lasting and increased effect when administrated topically to the eyes of a patient.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: October 7, 2014
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • SOFT-GELATIN CAPSULE FORMULATION
    Publication number: 20140287036
    Abstract: The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
    Type: Application
    Filed: June 10, 2014
    Publication date: September 25, 2014
    Applicants: R-TECH UENO, LTD., SUCAMPO AG
    Inventors: Yukiko HASHITERA, Ryu HIRATA, Yasuhiro HARADA, Ryuji UENO
  • Fatty acid derivative-polymer conjugate
    Patent number: 8835571
    Abstract: A fatty acid derivative-polymer conjugate including a conjugate comprising a fatty acid derivative and an alkyl substituted polylactide compound is provided. A pharmaceutical composition comprising the conjugate is also provided.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: September 16, 2014
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, Peter Lichtlen, Robert Gurny, Michael Möller