Abstract: A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPK? and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

Abstract: A biguanide derivative compound with N4-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPK and inhibition of cancer cell proliferation in a low dose, compared with conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

Abstract: Provided is a terminal allowing a user to easily search for and execute an application, and a method of controlling the terminal. The method includes displaying a first output screen including a screen of an application; receiving a first gesture; displaying a second output screen including a keyboard interface, according to the received first gesture; receiving a search word via the keyboard interface; displaying a third output screen including a list of applications searched by using the received search word; receiving a second gesture; and executing at least one application from among the applications, according to the received second gesture.

Abstract: A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPK? and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

Abstract: An apparatus and method for inputting a character on a touch keyboard in a terminal are provided. A touch screen displays a basic key set and an extended key set. The basic key set includes consonant keys and the extended key set includes character keys corresponding to characters combinable with a consonant corresponding to a consonant key input from the basic key set. The touch screen displays the extended key set, upon input of the consonant key from the basic key set and receiving at least one character from the basic key set and the extended key set.

Abstract: A N1-cyclic amine-N5-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.

Abstract: A method and an apparatus are provided for providing a character input interface in a terminal having a touchscreen. A single keyboard is displayed in a keyboard area of the touchscreen. A first keyboard and a second keyboard are simultaneously displayed in place of the single keyboard in the keyboard area, upon detecting selection of a key on the single keyboard. At least one of the first keyboard and the second keyboard includes a plurality of character-type selection keys, and at least one of the plurality of character-type selection keys includes a language selection key. A controlling unit of the terminal changes a type of characters displayed on one of the first keyboard and the second keyboard, upon detecting selection of one of the plurality of character-type selection keys on the one of the first keyboard and the second keyboard.

Abstract: An apparatus and method for scaling a layout of an application in an image display device are provided. The method for scaling includes generating a scaling variable considering a distance between the image display device and a user, and scaling a layout of an application using the scaling variable.

Abstract: An apparatus and method for inputting a character on a touch keyboard in a terminal are provided. A touch screen displays a basic key set and an extended key set. The basic key set includes consonant keys and the extended key set includes character keys corresponding to characters combinable with a consonant corresponding to a consonant key input from the basic key set. The touch screen displays the extended key set, upon input of the consonant key from the basic key set and receiving at least one character from the basic key set and the extended key set.

Abstract: A biguanide derivative compound with N4-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPK and inhibition of cancer cell proliferation in a low dose, compared with conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

Abstract: An apparatus and method for inputting a character on a touch keyboard in a terminal, in which a touch screen displays a basic key set and an extended key set, the basic key set including with consonant keys and the extended key set including character keys corresponding to characters combinable with a consonant corresponding to a consonant key input from the basic key set, and a controller for controlling the touch screen to display the extended key set, upon input of the consonant key from the basic key set, and receiving at least one character from the basic key set and the extended key set are provided.

Abstract: A biguanide derivative compound with N4-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPK and inhibition of cancer cell proliferation in a low dose, compared with conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

Abstract: A method and apparatus for easily selecting a character in a terminal including a touch screen, wherein a touch keypad is divided into a central layout including keys, and a sub layout including extended keys. According to an inclined angle and an inclined direction of a terminal, the sub layout opposite to the inclined direction based on the central layout is combined with the central layout, displaying a combined keypad including the central layout and the sub layout, on the display.

Abstract: A text input method in a portable device and a portable device supporting the same are provided. The portable device includes, a touch screen including a display unit for displaying a text input area and a text display area including at least one consonant and vowel, and a touch panel provided at an upper side of the display unit for generating a touch event, and a control unit for controlling text displayed according to a touch event generated from the touch screen, in which the control unit detects multi-touch events for at least two key icons output on the text input area, and controls the display of a specific text composed of a combination of the multi-touched key icons based on the detected multi-touch events.

Abstract: A character input apparatus and method in a terminal are provided, in which a touch screen displays a first key set and a second key set. The first key set includes first letter keys with all consonants and a second letter key with symbols indicating Tone Marks (Tms) and positions of predetermined vowels, for inputting all vowels and Tms. The second key set includes the predetermined vowels or Tms. Upon selection of a symbol by the second letter key, the controller controls the touch screen to display the second key set and receives at least one letter by the first key set and the second key set.

Abstract: A N1-cyclic amine-N5-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.

Abstract: An N1-cyclic amine-N5-substituted phenyl biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.

Abstract: A radiation detecting device is provided, according to which it is possible use only one radiation detecting device to measure radiation and measure gamma ray and neutron at once and discriminately in a restricted space. The radiation detecting device includes a radiation detecting unit to measure gamma ray and neutron discriminately at once, and a signal processing circuit which applies voltage to the neutron detecting unit and indicates measured gamma ray and neutron discriminately.

Abstract: A character input apparatus and method in a terminal are provided, in which a touch screen displays a first key set and a second key set. The first key set includes first letter keys with all consonants and a second letter key with symbols indicating Tone Marks (Tms) and positions of predetermined vowels, for inputting all vowels and Tms. The second key set includes the predetermined vowels or Tms. Upon selection of a symbol by the second letter key, the controller controls the touch screen to display the second key set and receives at least one letter by the first key set and the second key set.