Patents by Inventor Stanislav Polonsky
Stanislav Polonsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11273426Abstract: Systems, computer program products, and methods for using a flow cell array are provided herein. A computer program product includes a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a device to cause the device to determine placement of multiple reaction site openings, wherein each reaction site opening is connected to a first sub-surface channel; connect the first sub-surface channel to two or more additional sub-surface channels by multiple vias; and provide a material for multiple reaction sites, wherein an overlap of the multiple reaction site openings and the material delineate the multiple reaction sites.Type: GrantFiled: December 6, 2017Date of Patent: March 15, 2022Assignee: International Business Machines CorporationInventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Patent number: 11266971Abstract: Systems, computer program products, and methods for using a flow cell array are provided herein. A system includes at least one processor coupled to a memory and configured for determining placement of multiple reaction site openings, wherein each reaction site opening is connected to a first sub-surface channel; connecting the first sub-surface channel to two or more additional sub-surface channels by multiple vias; and providing a material for multiple reaction sites, wherein an overlap of the multiple reaction site openings and the material delineate the multiple reaction sites.Type: GrantFiled: December 6, 2017Date of Patent: March 8, 2022Assignee: International Business Machines CorporationInventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Patent number: 11266972Abstract: Systems, computer program products, and methods for using a flow cell array are provided herein. A system includes at least one processor coupled to a memory and configured for delivering multiple items of chemical matter independently to multiple reaction sites of a flow cell array across multiple distinct instances of time; imaging multiple parallel chemical reactions at the multiple reaction sites of the flow cell array; and recording an emission from each of the multiple chemical reactions site.Type: GrantFiled: December 6, 2017Date of Patent: March 8, 2022Assignee: International Business Machines CorporationInventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Patent number: 11266970Abstract: Apparatus, computer program products, and methods for using a flow cell array are provided herein. A computer program product includes a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a device to cause the device to determine placement of one or more reaction sites on a first component; provide a material for the reaction sites in one or more surface channels of the first component; connect the first component to a second component to form an array, wherein the surface channels of the first component connect the reaction sites with one or more vias, and wherein the second component comprises the vias connected to multiple sub-surface channels; and align the surface channels of the first component with the vias of the second component to form a connection between the first component and the second component.Type: GrantFiled: December 4, 2017Date of Patent: March 8, 2022Assignee: International Business Machines CorporationInventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Patent number: 11207654Abstract: Systems and methods for using a flow cell array are provided herein. A system includes at least one processor coupled to a memory and configured for determining placement of one or more reaction sites on a first component; providing a material for the one or more reaction sites in one or more surface channels of the first component; connecting the first component to a second component to form an array, wherein the one or more surface channels of the first component connect the one or more reaction sites with one or more vias, and wherein the second component comprises the one or more vias connected to multiple sub-surface channels; and aligning the one or more surface channels of the first component with the one or more vias of the second component to form a connection between the first component and the second component.Type: GrantFiled: December 4, 2017Date of Patent: December 28, 2021Assignee: International Business Machines CorporationInventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Patent number: 11179697Abstract: Systems, computer program products, and methods for using a flow cell array are provided herein. A computer program product includes a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a device to cause the device to deliver multiple items of chemical matter independently to multiple reaction sites of a flow cell array across multiple distinct instances of time; image multiple parallel chemical reactions at the multiple reaction sites of the flow cell array; and record an emission from each of the multiple chemical reactions site.Type: GrantFiled: December 6, 2017Date of Patent: November 23, 2021Assignee: International Business Machines CorporationInventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Patent number: 10967372Abstract: An apparatus for an electro-fluidic flow probe includes a body portion including an electro-fluidic bias tee for receiving (i) a fluid electrolyte and (ii) an electrical connection for providing an electrical potential to the fluid electrolyte; a first inlet including a tube extending from the first inlet to an outlet through the electro-fluidic bias tee; and a second inlet including the electrical connection having a wire that extends from the second inlet to the outlet through the electro-fluidic bias tee to transfer the electrical potential to a device under test.Type: GrantFiled: December 17, 2014Date of Patent: April 6, 2021Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Yann Andre Nicolas Astier, Jingwei Bai, Young Hoon Kwark, Stanislav Polonsky, Joshua T. Smith
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Patent number: 10967373Abstract: An apparatus for an electro-fluidic flow probe includes a body portion including an electro-fluidic bias tee for receiving (i) a fluid electrolyte and (ii) an electrical connection for providing an electrical potential to the fluid electrolyte; a first inlet including a tube extending from the first inlet to an outlet through the electro-fluidic bias tee; and a second inlet including the electrical connection having a wire that extends from the second inlet to the outlet through the electro-fluidic bias tee to transfer the electrical potential to a device under test.Type: GrantFiled: June 19, 2015Date of Patent: April 6, 2021Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Yann Andre Nicolas Astier, Jingwei Bai, Young Hoon Kwark, Stanislav Polonsky, Joshua T. Smith
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Patent number: 10753903Abstract: A technique for electrical detection of a molecule is provided. A fluidic bridge is formed between a nanopipette and a fluid cell, where the molecule is in the nanopipette. A voltage difference is applied between the nanopipette and the fluid cell, where the fluid cell contains an electrolyte solution. Entry of the molecule into the fluidic bridge is determined by detecting a fore pulse. The fluidic bridge between the nanopipette and the fluid cell is broken to form a nanogap. In response to waiting a time interval, the fluidic bridge is reformed between the nanopipette and the fluid cell to close the nanogap. The molecule is determined to exit the nanopipette by detecting an after pulse.Type: GrantFiled: November 28, 2017Date of Patent: August 25, 2020Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Venkat K. Balagurusamy, Stanislav Polonsky
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Patent number: 10596540Abstract: Apparatus and methods for using a flow cell array are provided herein. A method includes delivering multiple items of chemical matter independently to multiple reaction sites of a flow cell array across multiple distinct instances of time; imaging multiple parallel chemical reactions at the multiple reaction sites of the flow cell array; and recording an emission from each of the multiple chemical reactions site.Type: GrantFiled: December 17, 2015Date of Patent: March 24, 2020Assignee: International Business Machines CorporationInventors: Evan G. Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Patent number: 10583414Abstract: Apparatus and methods for using a flow cell array are provided herein. A method includes determining placement of multiple reaction site openings, wherein each reaction site opening is connected to a first sub-surface channel; connecting the first sub-surface channel to two or more additional sub-surface channels by multiple vias; and providing a material for multiple reaction sites, wherein an overlap of the multiple reaction site openings and the material delineate the multiple reaction sites.Type: GrantFiled: December 17, 2015Date of Patent: March 10, 2020Assignee: International Business Machines CorporationInventors: Evan G. Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Patent number: 10258954Abstract: Apparatus and methods for using a flow cell array are provided herein. An apparatus includes an array comprising one or more pixels, wherein each of the one or more pixels comprises multiple reaction sites openings; a first set of one or more sub-surface channels, wherein each of the multiple reaction site openings is connected to a sub-surface channel from the first set of one or more sub-surface channels; a second set of two or more sub-surface channels; and multiple vias connecting each channel from the first set of one or more sub-surface channels to (i) a first sub-surface channel from the second set of two or more sub-surface channels and (ii) a second sub-surface channel from the second set of two or more sub-surface channels.Type: GrantFiled: December 17, 2015Date of Patent: April 16, 2019Assignee: International Business Machines CorporationInventors: Evan G. Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Patent number: 10232337Abstract: Apparatus and methods for using a flow cell array are provided herein. A method includes determining placement of one or more reaction sites on a first component; providing a material for the one or more reaction sites in one or more surface channels of the first component; connecting the first component to a second component to form an array, wherein the one or more surface channels of the first component connect the one or more reaction sites with one or more vias, and wherein the second component comprises the one or more vias connected to multiple sub-surface channels; and aligning the one or more surface channels of the first component with the one or more vias of the second component to form a connection between the first component and the second component.Type: GrantFiled: December 17, 2015Date of Patent: March 19, 2019Assignee: International Business Machines CorporationInventors: Evan G. Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Patent number: 10041114Abstract: A mechanism is provided for sequencing a biopolymer. The biopolymer is traversed from a first medium to a second medium. The biopolymer includes bases. As the biopolymer traverses from the first medium to the second medium, different forces are measured corresponding to each of the bases. The bases are distinguished from one another according to the different measured forces which are measured for each of the bases.Type: GrantFiled: June 10, 2016Date of Patent: August 7, 2018Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Venkat K. Balagurusamy, Stanislav Polonsky
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Publication number: 20180093245Abstract: Systems, computer program products, and methods for using a flow cell array are provided herein. A computer program product includes a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a device to cause the device to deliver multiple items of chemical matter independently to multiple reaction sites of a flow cell array across multiple distinct instances of time; image multiple parallel chemical reactions at the multiple reaction sites of the flow cell array; and record an emission from each of the multiple chemical reactions site.Type: ApplicationFiled: December 6, 2017Publication date: April 5, 2018Inventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Publication number: 20180093244Abstract: Systems, computer program products, and methods for using a flow cell array are provided herein. A system includes at least one processor coupled to a memory and configured for determining placement of multiple reaction site openings, wherein each reaction site opening is connected to a first sub-surface channel; connecting the first sub-surface channel to two or more additional sub-surface channels by multiple vias; and providing a material for multiple reaction sites, wherein an overlap of the multiple reaction site openings and the material delineate the multiple reaction sites.Type: ApplicationFiled: December 6, 2017Publication date: April 5, 2018Inventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Publication number: 20180093243Abstract: Systems, computer program products, and methods for using a flow cell array are provided herein. A computer program product includes a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a device to cause the device to determine placement of multiple reaction site openings, wherein each reaction site opening is connected to a first sub-surface channel; connect the first sub-surface channel to two or more additional sub-surface channels by multiple vias; and provide a material for multiple reaction sites, wherein an overlap of the multiple reaction site openings and the material delineate the multiple reaction sites.Type: ApplicationFiled: December 6, 2017Publication date: April 5, 2018Inventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Publication number: 20180093246Abstract: Systems, computer program products, and methods for using a flow cell array are provided herein. A system includes at least one processor coupled to a memory and configured for delivering multiple items of chemical matter independently to multiple reaction sites of a flow cell array across multiple distinct instances of time; imaging multiple parallel chemical reactions at the multiple reaction sites of the flow cell array; and recording an emission from each of the multiple chemical reactions site.Type: ApplicationFiled: December 6, 2017Publication date: April 5, 2018Inventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Publication number: 20180085727Abstract: Apparatus, computer program products, and methods for using a flow cell array are provided herein. A computer program product includes a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a device to cause the device to determine placement of one or more reaction sites on a first component; provide a material for the reaction sites in one or more surface channels of the first component; connect the first component to a second component to form an array, wherein the surface channels of the first component connect the reaction sites with one or more vias, and wherein the second component comprises the vias connected to multiple sub-surface channels; and align the surface channels of the first component with the vias of the second component to form a connection between the first component and the second component.Type: ApplicationFiled: December 4, 2017Publication date: March 29, 2018Inventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky
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Publication number: 20180085728Abstract: Systems and methods for using a flow cell array are provided herein. A system includes at least one processor coupled to a memory and configured for determining placement of one or more reaction sites on a first component; providing a material for the one or more reaction sites in one or more surface channels of the first component; connecting the first component to a second component to form an array, wherein the one or more surface channels of the first component connect the one or more reaction sites with one or more vias, and wherein the second component comprises the one or more vias connected to multiple sub-surface channels; and aligning the one or more surface channels of the first component with the one or more vias of the second component to form a connection between the first component and the second component.Type: ApplicationFiled: December 4, 2017Publication date: March 29, 2018Inventors: Evan Colgan, Alexey Y. Lvov, Stanislav Polonsky