Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R1, R2, R100, R200, A, A1, B, B1, BG, n, Q and Q1 are substituents described. Also disclosed is the use of compounds of Formula 1 to treat proliferative disorders.

Abstract: Methods of killing prostate-specific membrane antigen (PSMA)-expressing, taxane-resistant cancer cells are provided. In particular, PSMA-expressing, taxane-resistant cancer cells are contacted with an antibody-drug conjugate (ADC) that comprises an antibody or antigen-binding fragment thereof that specifically binds to PSMA conjugated to monomethylauristatin norephedrine or monomethylauristatin phenylalanine.

Abstract: A method for processing data for a system model including the steps of providing a model specification having a plurality of types of items including at least one first item type wherein associated data is obtained from data input into the system and at least one second item type wherein associated data is obtained from an operation performed on the data associated with at least one item stored in a first database, inputting data into the system, searching the input data for first item types, storing data associated with first item types in the first database, reading the or one of the second item types in a determining step including determining whether the first database includes the or each prerequisite item necessary to determine the one second item type by obtaining associated data from an operation performed on data associated with at least one item stored in the first data base, storing the one second item type in the first database if the or each prerequisite item is present, successively reading each

Abstract: A compound of Formula 1.1A: 1.1A or salt thereof, as well as methods of making compounds of Formula 1.1A, methods of using compounds of Formula 1.1A to treat proliferative disorders such as cancer, and related compounds, composition, and methods.

Abstract: A self-piercing blind fastener comprising a mandrel having an elongate cylindrical shell mounted on a stem of such mandrel and which extends co-axially about a central elongate axis of the blind fastener, the shell having a radially extending flange at one end and a tail-end portion at the opposite end for insertion through a workpiece, the mandrel further having a mandrel head in operative engagement with the tail-end of the fastener for transmitting a setting force thereto during setting of such fastener, the blind fastener further comprising a longitudinally extending indenting member extending co-axial with and away from the tail-end of the blind fastener, which indenting member having a cross sectional area less than the cross sectional area of the shell.

Abstract: There is provided a blind rivet including an axially extending hollow tubular body having a tail end face at one end and a pre-formed radially enlarged flange at the other end, together with a mandrel having a stem which extends co-axially though the body and having enlarged head adjacent the tail end of the body, the stem having a weakened region immediately adjacent the head. There is also provided a method of fastening at least two workpieces using such a blind rivet, including providing the blind side of the workpieces with a countersunk region to accommodate the conically deformed tail end of the body after setting, substantially flush therewith.

Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R1, R2, R100, R200, A, A1, B, B1, BG, n, Q and Q1 are substituents described. Also disclosed is the use of compounds of Formula 1 to treat proliferative disorders.

Abstract: A method and means for determining the thickness, or curvature, of a thin film or stack of thin films disposed on the surface of a substrate having a curvature comprising generating a beam of radiation, focusing the beam through the one or more films onto a surface of the substrate, measuring the intensity across the reflected beam as a function of the angle of incidence of a plurality of rays derived from the focussed beam, determining the path of each of the plurality of rays and determining the thickness, or curvature of the film, or films, from the angular dependent intensity measurement.

Abstract: A transport vehicle includes a self-balancing vehicle base. A platform is supported on the base and is displaceable relative thereto between a first position and a second position. A support device engages the platform and supports at least a portion thereof during displacement between the first position and the second position. A method is also included.

Abstract: There is provided a blind rivet including an axially extending hollow tubular body having a tail end face at one end and a pre-formed radially enlarged flange at the other end, together with a mandrel having a stem which extends co-axially though the body and having enlarged head adjacent the tail end of the body, the stem having a weakened region immediately adjacent the head. There is also provided a method of fastening at least two workpieces using such a blind rivet, including providing the blind side of the workpieces with a countersunk region to accommodate the conically deformed tail end of the body after setting, substantially flush therewith.

Abstract: A package of sheet media and method of loading the package are presented in which a stack of sheet media is wrapped in a multi-layer strap, the multi-layer strap is operative to allow a user to load the package of sheet media into a media supply tray of an associated print engine, the multi-layer strap includes a third layer disposed between a first layer and a second layer, and the third layer is operative to allow the user to remove the multi-layer strap from the stack of sheet media while the stack of sheet media is positioned within the media supply tray.

Abstract: A stage for aligning a workpiece relative to analysing apparatus. The stage has a platform and means for maintaining a workpiece on the platform. The platform is operable to tilt relative to the analysing apparatus and thereby rotate the workpiece relative to the analysing apparatus.

Abstract: A method for imaging a subsurface material, the method including: receiving a first image of the subsurface material and a second image of the subsurface material, the first image displaying a first property of the subsurface material and the second image displaying a second property of the subsurface material wherein the first property is different from the second property; and combining the first image and the second image to create a combined image. A system and computer program product are also disclosed.

Abstract: An apparatus and method for providing images of a downhole tool during drilling of a wellbore are provided. A sensor on a rotating tool occupies a number of azimuthal sectors of the wellbore which are determined by a processor. The processor determines a time during which the sensor is in each of the azimuthal sectors during each revolution of the tool and provides a depth-correlated image of the sector residence times for the tool.

Abstract: A collapsible bone screw for healing bone fragments across a bone fracture includes an externally threaded inner screw member and an externally threaded outer screw member. The inner screw member is initially screwed into an inner bone portion. An unthreaded portion of the outer screw member is movably joined to the inner screw member. The outer screw member is screwed until it gains purchase in an outer bone portion. As impaction occurs over time, the collapsible bone screw apparatus may shorten in length as the two screw members slide, telescope or otherwise axially move toward each other to shorten the overall length, thereby preventing any portion of the screw apparatus from protruding out of the bone. A bone screw kit of multiple inner and outer screw members are provided as well as a method of surgically fastening bone fragments.

Abstract: There is provided a blind rivet including an axially extending hollow tubular body having a tail end face at one end and a pre-formed radially enlarged flange at the other end, together with a mandrel having a stem which extends co-axially though the body and having enlarged head adjacent the tail end of the body, the stem having a weakened region immediately adjacent the head. There is also provided a method of fastening at least two workpieces using such a blind rivet, including providing the blind side of the workpieces with a countersunk region to accommodate the conically deformed tail end of the body after setting, substantially flush therewith.

Abstract: A method, system and apparatus are provided for dynamically pre-positioning content from servers located in a network, which may be a content distribution network. The content is pre-positioned on a proxy server, and the pre-positioning is triggered by at least one of the scheduling of an event and the presence of a user. Users commuting between different locations of a company can quickly and easily access the pre-positioned content. This content may be prioritized and pre-positioned, based on a user requiring a specific content at a particular time.

Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R1, R2, R100, R200, A, A1, B, B1, BG, n, Q and Q1 are substituents described. Also disclosed is the use of compounds of Formula 1 to treat proliferative disorders.

Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R1, R2, R100, R200, A, A1, B, B1, BG, n, Q and Q1 are substituents described. Also disclosed is the use of compounds of Formula 1 to treat proliferative disorders.

Abstract: A tissue positioning device comprising a biocompatible member having a size and shape suitable for placement within a space adjacent to a tissue to be positioned and which acts to maintain the tissue in a desired position. The member may be a rigid or flexible spacer having a defined shape, or a bladder capable of receiving and being at least partially expanded by a filler material. The device can made from a variety of materials or a composite of materials as needed, and may include one or more attachment means by which it can be secured to nearby tissues such that it is maintained in a desired spatial location. The filler material can be any of a number of substances, including liquids, gases, a curable liquid such as bone cement or urethane foam, or a spring.