Abstract: The present invention relates to implantable devices, which are coated or coatable with liposomes. The present invention further relates to liposomes encapsulating nucleic acids termed lipoplexes, to methods for the manufacture and coating of such implantable devices, and to the use of such implantable devices to improve treatment of patients with coronary artery disease or other vascular diseases and cancers.

Abstract: A method of manufacturing an assembly, including a structural member and an appearance feature formed therealong, is provided utilizing first and second molds. The method includes the steps of: injecting magnesium into the first mold to form the structural member; removing the structural member from the first mold; placing the structural member in the second mold; and injecting thermoplastic material into the second mold to overmold the appearance feature along a portion of the structural member.

Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is useful on food products to prevent microbial growth on the food from a broad spectrum of foodborne microbial contamination. Also disclosed is a method of contacting food products with the dilute QAC for an application time of at least 0.1 second. Foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be 10 treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

Abstract: The CA125 gene has been cloned. The CA125 molecule comprises three major domains: an extracellular amino terminal domain; a large multiple repeat domain; and a carboxy terminal domain which includes a transmembrane anchor with a short cytoplasmic domain. Additionally, an amino terminal extension is present. The molecular structure is dominated by a repeat domain comprising more than sixty 156-amino-acid repeat units The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The structure has potential for use as a new gold standard for detecting the CA125 antigen, and can provide a basis for the development of a vaccine useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.

Abstract: A data storage system includes an input/output server and a storage unit. The input/output server includes a processor, memory, and a host channel adapter. The storage unit includes a processor, memory, and a storage module. The storage module includes a storage controller, and an interface block for connecting the storage module to a corresponding memory-mapped interface. The storage unit further includes a host channel adaptor. The storage unit host channel adapter is connected to a corresponding memory-mapped interface. The storage unit host channel adapter is capable of remote direct memory access to the input/output server. Protocol translation logic is configured to intercept a memory access request from the storage controller, and initiate a corresponding remote direct memory access to the input/output server through the storage unit host channel adapter and the input/output server host channel adapter.

Abstract: A method of manufacturing an assembly, including a structural member and an appearance feature formed therealong, is provided utilizing first and second molds. The method includes the steps of: injecting magnesium into the first mold to form the structural member; removing the structural member from the first mold; placing the structural member in the second mold; and injecting thermoplastic material into the second mold to overmold the appearance feature along a portion of the structural member.

Abstract: The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. An amino terminal extension is presented, which comprises four genomic exons. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. More specifically, this invention is directed to a CA125 cDNA sequence which can be introduced into animal or human cells to achieve transcription or expression of the cDNA.

Abstract: The integration system comprises at least one vector capable of expressing at least one exogenous gene, the vector comprising a coding sequence for an attP gene region and a coding sequence for at least one therapeutic molecule and an integrase. The integration system has an application in bacterial metabolic engineering and in gene therapy.

Abstract: A data storage system includes an input/output server and a storage unit. The input/output server includes a processor, memory, and a host channel adapter. The storage unit includes a processor, memory, and a storage module. The storage module includes a storage controller, and an interface block for connecting the storage module to a corresponding memory-mapped interface. The storage unit further includes a host channel adaptor. The storage unit host channel adapter is connected to a corresponding memory-mapped interface. The storage unit host channel adapter is capable of remote direct memory access to the input/output server. Protocol translation logic is configured to intercept a memory access request from the storage controller, and initiate a corresponding remote direct memory access to the input/output server through the storage unit host channel adapter and the input/output server host channel adapter.

Abstract: A data storage system manager includes one or more servers, at least one data collector deployed on at least one of the servers, at least one policy engine deployed on at least one of the servers, and at least one configuration manager deployed on at least one the servers. The at least one data collector is configured to collect resource utilization information including data storage wear rate of data storage system data storage modules. The at least one policy engine is configured to evaluate the collected information and to initiate changes to a configuration of the data storage system based on data storage wear rate and work load distribution policies. The at least one configuration manager is configured to implement the changes initiated by the at least one policy engine to control the data storage wear rate and a skew of the work load distribution within the data storage system.

Abstract: A data storage system includes a plurality of servers, a plurality of external interface providers each deployed on one of the servers, and a plurality of data storage controllers each deployed on one of the servers. Each of the providers is configured to receive a data access request, to identify one of the controllers that can satisfy the request, and to forward the request to the identified controller. The system further includes a plurality of data storage modules independent of the servers. The providers, controllers and modules are in communication with each other. Each of the controllers exclusively manages a portion of data content in at least one of the modules, and satisfies data access requests received from the providers by accessing the portion of data content in the at least one module.

Abstract: An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics or parameters of the fluid, such as temperature, pressure, or flow rate. In response to the measured characteristic or parameter, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response to this, the control logic may initiate a specific response designed to alleviate the blockage. This response may be a temperature change, a vibration, a change in fluid flow path, or some other action. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced.

Abstract: Osteopontin for the prediction and treatment of cardiovascular diseases The present invention relates to the use of endothelial progenitor cells (EPCs) and osteopontin for the treatment of cardiovascular diseases or complications. The invention also relates to the use of EPC osteopontin levels as a marker of the risk of the development of these cardiovascular complications. In particular, the invention provides compositions and methods based on osteopontin and the genes encoding osteopontin.

Abstract: Apparatus and methods for approving financing for the sale of real estate. The apparatus and methods may involve receiving from a seller, or a seller's agent, information regarding the property so that a financial institution can determine a loan amount before the seller is engaged by a buyer. The financial institution may order from vendors documentation and certification desired or required for closing. The financial institution may issue a seal certifying that the financial institution has pre-approved a loan in a stated amount. The amount may be subject to change based on the qualifications of a buyer.

Abstract: Methods and apparatus for improving measurements of cardiovascular health status in a given individual are provided. The comprehensive assessment of cardiovascular health includes at least two components: risk factor assessment based on epidemiologic studies and functional status of the individual. Structural studies of the individual can also be included in the comprehensive assessment of cardiovascular health. The invention aims to improve detection, treatment, devices, and administration of cardiovascular risk assessment.

Abstract: Abstract Markers, antibodies and recombinant scFvs for Mesenchymal Stem Cell sub-populations and osteoclasts. The present invention relates to specific epitopes of surface membrane bound glycoproteins expressed by mesenchymal stem cells and pre-osteoclasts and relates to antibodies such as monoclonal antibodies and recombinant scFv or fragments thereof, raised to the particular epitope and their use in identifying, isolating, and characterization of mesenchymal stem cell sub-populations such as that termed “Stromal Progenitor Cells” (SPCs) in bone marrow and identifying, isolating, and characterization of pre-osteoclasts in peripheral blood. By binding to a specific epitope on the cell surface, limbin/EVC-2 detection and separation by conventional cell sorting methodologies are facilitated.

Abstract: The Eph (erythropoietin-producing hepatocellular carcinoma) receptors and their cell surface anchored ligands, the Ephrins, comprise the largest of the receptor tyrosine kinases families with 14 receptors and 8 ligands. The receptors are subdivided into Eph-A and Eph-B categories and have known actions in the development of the vascular and nervous system. The present invention relates to an isolated mesenchymal stem cell selected from the group consisting of an isolated mesenchymal stem cell that expresses Ephrin-B2, an isolated mesenchymal stem cell that over-expresses Ephrin-B2, and an isolated mesenchymal stem cell that is genetically modified to increase Ephrin-B2 expression. The invention further relates to the various applications of the isolated mesenchymal stem cells of the present invention.

Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

Abstract: A method of manufacturing an assembly, including a structural member and an appearance feature formed therealong, is provided utilizing first and second molds. The method includes the steps of: injecting magnesium into the first mold to form the structural member; removing the structural member from the first mold; placing the structural member in the second mold; and injecting thermoplastic material into the second mold to overmold the appearance feature along a portion of the structural member.