Abstract: The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. The amino acid composition of the amino terminal extension was found to be consistent with the amino acid composition of the amino terminal domain. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites.

Abstract: A dehumidifier includes an air flow path with first, second and third segments in series from upstream to downstream and passing ambient air respectively to an evaporator coil then to a condenser coil and then discharging same. The air flow path has a fourth segment passing ambient air to the condenser coil in parallel with the noted second air flow path segment.

Abstract: Methods and apparatus are provided for assessing the risk of an acute cardiovascular event that includes providing an endothelial or vascular function test to identify higher risk from lower risk individuals in a population of symptomatic individuals presenting with chest pain that have inconclusive results in ECG and cardiovascular marker tests, such as a tropinin test, and are administered for triage in hospital and additional tests such as ECG exercise and nuclear stress tests. The invention further provides methods and apparatus for assessing the vascular status and response of patients in clinical trials for cardiovascular therapies.

Abstract: A method of refinancing a mortgage loan is provided. The method of refinancing a mortgage loan comprises pre-approving a customer for refinancing of a mortgage loan. This customer is sent a pre-screened offer. The offer comprises materials setting forth the terms of the refinanced mortgage loan, materials providing all required pre-acceptance disclosures, and instructions describing how the customer may accept the offer. Upon receiving an indication of acceptance of the offer from the customer, a closing package is sent to the customer to be executed by the customer. The execution of the closing package by the customer creates a refinancing loan agreement. Also provided is a closing package for a mortgage loan comprising closing documents and a format and instructions providing specific guidance to the customer for completion and execution of the closing documents.

Abstract: The present invention is directed to methods and apparatus for modulation of the sympathetic-parasympathetic balance by application of heat, carotid and/or ocular message to reduce sympathetic tone or increase parasympathetic tone in a target muscle system to relieve a symptom of urinary hesitancy, shy bladder syndrome, DESD, urinary retention, or laryngeal spasm, as well as to monitor the efficacy of treatments for bladder conditions and to assist in the passage of medical devices through bodily sphincters as well as to treat congestive heart failure.

Abstract: A trim assembly is disclosed. The trim assembly includes a vehicular trim panel and a portion mounted to the vehicular trim panel that is movable between a stowed position and a deployed position relative the vehicular trim panel. The portion is defined to include a shape-changing polymer. The assembly also includes an energy transfer device that provides energy to the shape-changing polymer to cause movement of the portion between the stowed position and the deployed position. A method is also disclosed.

Abstract: A showerhead has at least a first set of nozzles and a second set of nozzles for discharging water. The showerhead discharges water according to one of multiple water delivery functions, where a first water delivery function corresponds to water being discharged through only the first set of nozzles, a second water delivery function corresponds to water being discharged through only the second set of nozzles and a third water delivery function corresponds to water being discharged through the first and second sets of nozzles simultaneously. The spacing between the first set of nozzles and the second set of nozzles is carefully selected so that the third water delivery function corresponds to the integrated nozzles of the first and second sets of nozzles. As a result, the third water delivery function provides a coherent and balanced water flow resulting in a more pleasant feel.

Abstract: The present invention provides methods and apparatus for assessing a patient's vascular health including endothelial function by monitoring changes in hemodynamic parameters responsive to the introduction of a vasostimulant. The invention provides a thermal energy measurement apparatus including a thermal energy sensor adapted to measure temperature of a body part while not substantially changing the temperature of the body part, and a display or recorder coupled to the thermal energy sensor, wherein the thermal energy sensor measures the temperature of the body part before and subsequent to the provision of a vasostimulant, and the display or recorder reports the temperature of the body part prior to the provision of the stimulant and the temperature of the body part after provision of the stimulant.

Abstract: Methods and apparatus are provided for identifying and minimizing neurovascular contributions to determinations of endothelial function, including by digital temperature monitoring such that an accurate status of vascular reactivity can be obtained. Methods are also provided for identifying individuals having increased sympathetic nervous system activity impacting peripheral vascular function as well as for determining a status of diabetic foot.

Abstract: Methods and apparatus are provided for determining individual vascular responses by employing iontophoresis to deliver vasoactive compounds to local area and determining resultant changes in blood flow by measuring changes in skin temperature as a correlate of local blood flow. The invention further provides methods and apparatus for assessing vascular reactivity in individuals under ambulatory conditions and relating stress responses to vascular reactivity.

Abstract: A new article of manufacture, for example a faucet or other article of hardware, has a specified decorative color, and is resistant to corrosion, abrasion and attack by chemicals. The article includes a substrate, one or more corrosion resistant layers applied to the substrate, a thin transition layer having a composition that varies systematically from a first composition to a second composition and in which the first composition has, at least in part, the function of corrosion protection, and in which the second composition determines the visible color or that portion of the substrate to which the transition layer is applied.

Abstract: The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. The amino acid composition of the amino terminal extension was found to be consistent with the amino acid composition of the amino terminal domain. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites.

Abstract: Provided is an imaging member comprising a substrate, an undercoat layer (UCL), a charge generation layer, a charge transport layer, and an optional overcoat layer. The undercoat layer is formed from a single-phase UCL coating formulation comprising an organic titanate, a polymer containing active hydrogen, and an aminosilane. The UCL formulation has improved properties such as stability, processing convenience, and longer pot life etc. The UCL formulation can be used to manufacture an imaging member such as photoreceptor with improved properties such as stable, thick UCL coating, resistance to electrical failure, and PIDC independency on UCL thickness etc.

Abstract: In a disk-based data storage system, a controller configured to control a reference count regeneration operation, the controller includes a control register, an address register, a status register, a boundary register, and an embedded memory. The control register may be configured to set up and initiate program instructions that are executed by at least one processor. The address register may be configured as a cache address pointer and correspond to at least one of a sort output list pointer, a virtual track table input list pointer, a reference list pointer, a track number table pointer, and a reference count mis-compare list pointer. The status register may be configured to indicate status of a routine. The routine includes at least one of a radix sort, a reference list count, a combine counts, and a merger of the reference list count into the TNT to generate an updated TNT.

Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.

Abstract: Percussive signal transmission tubes, of contrasting color, are joined along adjacent longitudinally extending portions by an adhesive bead of polymeric material. The tubes can be separated in the field and are provided on spools without any sheath. A small diameter (0.10 inch) tube can be used to reduce the size of the spool, or increase the length of tubing wound on the spool. An apparatus for assembling the product is also disclosed.

Abstract: In a data storage system in which there can be multiple references to a single instance of an object, a method for regenerating the number of references to each object instance. The method includes radix sorting the references to the objects to generate a reference list, counting the references to each unique object and merging the counts with the object descriptions, placing the count of the number of references to each object into the respective object description. The sorting, counting and merging techniques used by this method generate sequential memory access patterns that enable efficient use of low-cost memory and block-oriented memory access interconnect fabric protocols. Furthermore, multiple instances of the sorting, counting and merging processes can be used in parallel to reduce the time required to regenerate the reference counts for a large number of objects.

Abstract: An imaging member includes a substrate, a charge generating layer, and a charge transport layer, wherein an external of the imaging member includes a polyhedral oligomeric silsesquioxane modified silicone dispersed therein.

Abstract: The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.

Abstract: A method for configuring a computer network that includes a full duplex bi-directional first port and an initiator that can issue a request for the first port to assume a state. The first port, when in a first state, is able to bi-directionally communicate with a full duplex bi-directional second port, and when in a second state, is coupled to itself by having an output thereof coupled to an input thereof. The method comprises inhibiting the initiator from issuing the request, sending data to the initiator describing a desired state of the first port, and enabling the initiator to issue the request for the first port to assume the desired state.