Abstract: One embodiment is a method of extracting respiratory parameters from a short duration thoracic impedance (“TI”) signal, the method comprising preprocessing the TI measurement signal to obtain a respiratory signal therefrom; assessing the respiratory signal for at least one of signal quality and signal integrity; executing at least one of an autocorrelation algorithm and a time-domain zero-crossing algorithm on the respiratory signal to extract at least one respiratory parameter therefrom, the at least one respiratory parameter comprising at least one of respiration rate (“RR”) and tidal volume (“TV”).

Abstract: A method for reconstructing 12-lead standard electrocardiogram (ECG) system signals using an M lead system, the method comprising recording signals acquired by the 12-lead standard ECG system; recording signals acquired by the M-lead system; and using the recorded signals to train a machine learning model to produce the reconstructed 12-lead standard ECG system signals using the M-lead system.

Abstract: An impedance measurement system for detecting an analyte in a sample is disclosed. The system includes first, second, and third electrodes, wherein at least a portion of the third electrode is positioned between the first and second electrodes, means for generating an electromagnetic field between the first and second electrodes, means for electrically controlling the third electrode, wherein the third electrode modifies the electromagnetic field, and a processor for detecting a presence of the analyte in the sample, based at least in part on a property of the electromagnetic field.

Abstract: There is disclosed herein examples of systems and methods of processing captured heart sounds with frequency-dependent normalization. Based on an amount of attenuation of a first heart sound, a second heart sound can be normalized by modifying portions of the second heart sound by amounts determined based on frequencies of the portions. Accordingly, the systems and methods disclosed herein can result in different amounts of modification of different portions of the second heart sound based on the different frequencies of the portions.

Abstract: An example integrated circuit die includes: lower level conductor layers, lower level insulator layers between the lower level conductor layers, lower level vias extending vertically through the lower level insulator layers, upper level conductor layers overlying the lower level conductor layers, upper level insulator layers between and surrounding the upper level conductor layers, upper level vias; at least two scribe seals arranged to form a vertical barrier extending vertically from the semiconductor substrate to a passivation layer at an upper surface of the integrated circuit die; and at least one opening extending vertically through one of the at least two scribe seals and extending through: the upper level conductor layers, the upper level via layers, the lower level conductor layers, and the lower level via layers.

Abstract: Accurately measuring bio-impedance is important for sensing properties of the body. Unfortunately, contact impedances can significantly degrade the accuracy of bio-impedance measurements. To address this issue, a method is provided for estimating an impedance matrix of parasitic network disposed between a first network and a second network of a bio-impedance measurement system, the method comprising determining an impedance matrix for the first network (ZMUX) based on an impedance matrix for the second network (ZLOAD) for at least one known load condition; fitting ZMUX values for ZLOAD for the at least one known load condition to estimate parameters of the impedance matrix of the intervening network.

Abstract: The present disclosure describes a system for detecting abnormal blood pressure or blood volume in a user, the system comprising a processing system; a pulse transit time (PTT) detection system for providing a PTT signal indicative of a PTT of the user to the processing system, wherein PTT of the user is used as a surrogate for a blood pressure (BP) of the user; and an electrodermal activity (EDA) detection system for providing an EDA signal indicative of an EDA of the user to the processing system; wherein the processing system processes the PTT signal and the EDA signal to determine an index indicative of an abnormal blood pressure or blood volume of the user.

Abstract: There is disclosed herein examples of systems and methods for compressing a signal. Samples of the signal can be segmented and the samples within each of the segments can be averaged to produce a value that can represent the samples within the segment. The number of samples to average in each segment may be determined based on an error threshold, such that the number of samples being averaged can be maximized to produce less data to be transmitted while maintaining the representation of the samples within the error threshold. In some embodiments, a signal can be separated into a timing reference, a representative periodic function, and a highly compressible error signal. The error signal can be utilized for reproducing a representation of the signal.

Abstract: There is disclosed herein examples of systems and methods for compressing a signal. Samples of the signal can be segmented and the samples within each of the segments can be averaged to produce a value that can represent the samples within the segment. The number of samples to average in each segment may be determined based on an error threshold, such that the number of samples being averaged can be maximized to produce less data to be transmitted while maintaining the representation of the samples within the error threshold. In some embodiments, a signal can be separated into a timing reference, a representative periodic function, and a highly compressible error signal. The error signal can be utilized for reproducing a representation of the signal.

Abstract: Devices, systems, and methods for non-invasively detecting and monitoring medical conditions using multiple modalities of sensing include at least two electrodes configured to be positioned on a subject, an acoustic sensor configured to be positioned on a subject, a thoracic impedance measurement module connected to the electrodes, for measuring a first impedance between the electrodes, and a heart acoustic measurement module connected to the acoustic sensor, for detecting and measuring a heart sound from the acoustic sensor.

Abstract: Determining bio-impedance of a body, or portion thereof, of a subject has been utilized for determining health characteristics (such as heart conditions) of the subject. The systems and procedures described herein may provide for correction and/or compensation for electrode contact impedance and for accurately determining bio-impedance. The system may take into account impedance sensitivity and/or frequency sensitivity when performing the bio-impedance determination to improve the bio-impedance determination.

Abstract: There is disclosed herein examples of systems and methods of processing captured heart sounds with frequency-dependent normalization. Based on an amount of attenuation of a first heart sound, a second heart sound can be normalized by modifying portions of the second heart sound by amounts determined based on frequencies of the portions. Accordingly, the systems and methods disclosed herein can result in different amounts of modification of different portions of the second heart sound based on the different frequencies of the portions.

Abstract: An impedance measurement system for detecting an analyte in a sample is disclosed. The system includes first, second, and third electrodes, wherein at least a portion of the third electrode is positioned between the first and second electrodes, means for generating an electromagnetic field between the first and second electrodes, means for electrically controlling the third electrode, wherein the third electrode modifies the electromagnetic field, and a processor for detecting a presence of the analyte in the sample, based at least in part on a property of the electromagnetic field.

Abstract: In described examples, a first die includes a primary LC tank oscillator having a natural frequency of oscillation to induce a forced oscillation in a secondary LC tank oscillator of a separate second die via a magnetic coupling between the primary LC tank oscillator and the secondary LC tank oscillator.

Abstract: There is disclosed herein examples of systems and methods for compressing a signal. Samples of the signal can be segmented and the samples within each of the segments can be averaged to produce a value that can represent the samples within the segment. The number of samples to average in each segment may be determined based on an error threshold, such that the number of samples being averaged can be maximized to produce less data to be transmitted while maintaining the representation of the samples within the error threshold. In some embodiments, a signal can be separated into a timing reference, a representative periodic function, and a highly compressible error signal. The error signal can be utilized for reproducing a representation of the signal.

Abstract: In described examples, a first die includes a primary LC tank oscillator having a natural frequency of oscillation to induce a forced oscillation in a secondary LC tank oscillator of a separate second die via a magnetic coupling between the primary LC tank oscillator and the secondary LC tank oscillator.

Abstract: An example integrated circuit die includes: lower level conductor layers, lower level insulator layers between the lower level conductor layers, lower level vias extending vertically through the lower level insulator layers, upper level conductor layers overlying the lower level conductor layers, upper level insulator layers between and surrounding the upper level conductor layers, upper level vias; at least two scribe seals arranged to form a vertical barrier extending vertically from the semiconductor substrate to a passivation layer at an upper surface of the integrated circuit die; and at least one opening extending vertically through one of the at least two scribe seals and extending through: the upper level conductor layers, the upper level via layers, the lower level conductor layers, and the lower level via layers.

Abstract: Devices, systems, and methods for non-invasively detecting and monitoring medical conditions using multiple modalities of sensing include at least two electrodes configured to be positioned on a subject, an acoustic sensor configured to be positioned on a subject, a thoracic impedance measurement module connected to the electrodes, for measuring a first impedance between the electrodes, and a heart acoustic measurement module connected to the acoustic sensor, for detecting and measuring a heart sound from the acoustic sensor.

Abstract: An example integrated circuit die includes: a plurality of lower level conductor layers, a plurality of lower level insulator layers between the plurality of lower level conductor layers, a plurality of lower level vias extending vertically through the lower level insulator layers, a plurality of upper level conductor layers overlying the lower level conductor layers, a plurality of upper level insulator layers between and surrounding the upper level conductor layers, a plurality of upper level vias; at least two scribe seals arranged to form a vertical barrier extending vertically from the semiconductor substrate to a passivation layer at an upper surface of the integrated circuit die; and at least one opening extending vertically through one of the at least two scribe seals and extending through: the upper level conductor layers, the upper level via layers, the lower level conductor layers, and the lower level via layers.