Abstract: The .alpha.,.alpha.-dibromo-substituted or unsubstituted-4-pivaloyl toluenes, e.g., .alpha.,.alpha.-dibromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 125.degree. C.

Abstract: Alkanoyl substituted benzoic acids and esters, e.g., p-pivaloyl ethyl benzoate, are prepared by oxidizing alkanoyl substituted toluene and reacting with lower alkanols and are useful as hypolipidemic, anti-obesity, and anti-diabetic agents.

Abstract: Substituted -4'-aminoacetyl alkanoylphenones, e.g., 4'-(4-methyl-1-piperazinylacetyl)pivalophenone, are prepared by treating corresponding 4'-(haloacetyl)alkanoylphenones with substituted amines, and are useful as hypolipidemic agents.

Abstract: Disclosed are compounds of the class of 1-alkyl-4-phenyl and 4-(2-thienyl)-6,7-methylenedioxy-2(1H)-quinazolinones and quinazolinthiones, including the 3,4-dihydro derivatives thereof, useful as pharmaceutical agents, e.g. as anti-inflammatory agents. Such compounds, e.g. 1-isopropyl-4-phenyl-6,7-methylenedioxy-2(1H)-quinazolinones and 1-isopropyl-4-phenyl-6,7-methylenedioxy-2(1H)-quinazolinthiones, may be prepared by reacting the corresponding N-alkyl-N-(3,4-methylenedioxyphenyl)urea or thiourea with an aromatic aldehyde, e.g. benzaldehyde, in the presence of an acid at elevated temperatures to obtain the 3,4-dihydro-2(1H)-quinazolinones or 3,4-dihydro-2(1H)-quinazolinthiones which may then be oxidized to the corresponding 3,4-unsaturated compounds.

Abstract: Acyl substituted phenyl alkanoic acids, e.g. p-pivaloyl phenyl acetic acid, are prepared by hydrolyzing p-pivaloyl phenyl acetonitriles and are useful as hypolipidemic agents.

Abstract: 10-(2-substituted-aminoethyl)-10,11-dihydro-5-methylene-2 or 3 7 or 8-substituted or unsubstituted-5H-dibenzo[a,d]cycloheptenes e.g., 10-(2-dimethylaminoethyl)-10,11-dihydro-5-methylene-5H-dibenzo[a,d]cyclohe ptane, prepared by various methods including acid dehydration of the corresponding dibenzo[a,d]cycloheptene-5-ols. The compounds are useful as anti-depressants.

Abstract: Substituted 1,2-dihydrobenz[f]isoquinolines, e.g., 4-(p-chlorophenyl)-1,2-dihydrobenz[f]isoquinoline, are prepared by cyclizing N-substituted-.alpha.-naphthylethylamines and are useful as non-estrogenic antifertility agents.

Abstract: 10-(2-substituted-aminoethyl)-10,11-dihydro-5-methyl-2 or 3, 7 or 8-substituted or unsubstituted-5H-dibenzo[a,d]cycloheptenes, e.g., 10-(2-dimethylaminoethyl)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepte ne, are prepared by hydrogenating a corresponding 10-(2-dimethyl-aminoethyl)-10,11-dihydro-5-methylene-2 or 3, 7 or 8-substituted or unsubstituted-5H-dibenzo[a,d]cycloheptenes and are useful as anti-depressants.

Abstract: 3-Substituted-4-aryl isoquinolines, e.g. 3-tertiary butyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, prepared from corresponding isoquinoline intermediates, are useful as anti-diabetic agents.

Abstract: Highly branched .alpha.-substituted indoles, e.g., 2-(1-methylcyclohexyl)-indole, are prepared by treating N-(.alpha.-branched carbonyl) toluidines with alkyl lithium.

Abstract: 2,6-halo and trifluoromethyl-substituted-benzoic acids, e.g., 2,3,4,6-tetrafluorobenzoic acid or 2-chloro-6-trifluoromethylbenzoic acid, are prepared from substituted 2,4-halo and trifluoromethyl-substituted benzene compounds and are useful as plant growth regulators.

Abstract: 1,4 disubstituted-methylenedioxy-quinazoline-2(1H)-thiones are provided which are useful as pharmaceutical agents, e.g. anti-inflammatory agents. The title compounds are intermediates in their preparation.

Abstract: Substituted benzylidene hydrazines e.g. N-(4-phenylbenzylidene)-N'-amidino hydrazine and their use as hypoglycemic-antihyperglycemic agents, anti-obesity agents and anti-inflammatory agents.

Abstract: Amino and substituted amino-hydrazinopyridazines, e.g., 4-methyl-amino-3-hydrazinopyridazine and 4-ethylamino-6-chloro-3-hydrazinopyridazine, are prepared from 3,4,6-trihalopyridazines and are active as hypotensive/antihypertensive agents.

Abstract: 2-Amino-4,5-methylenedioxyphenyl nitriles are useful as intermediates for 2-amino-4,5-methylenedioxybenzophenonimines when reacted with a phenyl lithium or phenyl magnesium halide.

Abstract: Acyl substituted or unsubstituted benzyl ethers, e.g., p-(phenoxymethyl)pivalophenone, are prepared by reacting a corresponding .alpha.-bromo-p-pivaloyl toluene with a corresponding phenol and are useful as hypolipidemic agents.

Abstract: Substituted 7,12-methano-dibenzazocines and 8,13-methanodibenzazonines, e.g., 7,12-dihydro-6,13-dimethyl-7,12-methano-6H-dibenz [c,f] azocine, are prepared by cyclizing 3-benzylamino or 3-phenethylamino -2-alkyl-indan-1-ols and are useful as anti-inflammatory agents.

Abstract: Certain substituted or unsubstituted p-alkanoyl toluenes, e.g., p-alkanoyl toluene, are useful as anti-obesity and anti-diabetic agents.

Abstract: Anti-inflammatories and analgesics of the formula ##SPC1##WhereinX y is --OCH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 O--,R is lower alkyl, allyl or cycloalkylalkyl andR' is phenyl or phenyl monosubstituted by halo, alkyl, alkoxy or trifluoromethyl,Are prepared by oxidation of the corresponding dihydro intermediates.

Abstract: The .alpha.-bromo-substituted or unsubstituted-4-pivaloyl toluenes, e.g., .alpha.-bromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 100.degree.C.