Patents by Inventor William J. Houlihan

William J. Houlihan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bis-substituted benzyl acetic acids
    Patent number: 3962320
    Abstract: Bis-substituted benzyl acetic acids, e.g., bis-(p-pivaloylbenzyl)acetic acid, are prepared by hydrolyzing and decarboxylating a corresponding bis-(p-pivaloylbenzyl)malonic acid diethyl ester and are useful as hypolipidemic agents.
    Type: Grant
    Filed: January 31, 1975
    Date of Patent: June 8, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Substituted naphtho pyrazoles
    Patent number: 3959308
    Abstract: Substituted naphtho [1,2-c] pyrazoles, e.g., 3-(4-pyridyl)-2H-naphtho[1,2-c]-pyrazole, are useful as non-estrogenic anti-fertility agents.
    Type: Grant
    Filed: June 27, 1974
    Date of Patent: May 25, 1976
    Assignee: Sandoz, Inc.
    Inventors: Robert V. Coombs, William J. Houlihan
  • 2-Substituted-3-disubstituted-4,5,6,7-substituted or unsubstituted phthalimidines
    Patent number: 3959269
    Abstract: 2-Substituted-3-disubstituted-4,5,6,7-substituted or unsubstituted phthalimidines, e.g., 3-t-butyl-5-chloro-3-hydroxy-2-methylphthalimidine prepared by treating a substituted or unsubstituted N-substituted-2-lithiobenzamidelithium salts with a substituted acetylhalide. The compounds are useful as minor tranquilizers/sedative hypnotics.
    Type: Grant
    Filed: July 12, 1974
    Date of Patent: May 25, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Substituted naphtho pyrazoles
    Patent number: 3957816
    Abstract: Substituted naphtho [1,2-c] pyrazoles e.g., 4,5-dihydro-5-methyl-3-(4-pyridyl)-2H-naphtho[1,2-c]-pyrazole, are useful as non-estrogenic anti-fertility agents.
    Type: Grant
    Filed: June 27, 1974
    Date of Patent: May 18, 1976
    Assignee: Sandoz, Inc.
    Inventors: Dietmar A. Habeck, William J. Houlihan
  • Amino substituted tetrahydropleiadenes
    Patent number: 3956391
    Abstract: 1,2,3,12a-tetrahydro-1-(substituted-aminomethyl)-7-methylene-7(12H) pleiadenes, e.g., 1,2,3,12a-tetrahydro-1-(dimethylaminomethyl)-7-methylene-7(12H)-pleiadene, prepared by various methods including acid dehydration of the corresponding 1,2,3,12a-tetrahydro-1-(dimethylaminomethyl)-7-methyl-7(12H) -pleiaden-7-ols, are useful as anti-depressants.
    Type: Grant
    Filed: January 27, 1975
    Date of Patent: May 11, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Citronellyl benzimidazoles
    Patent number: 3953600
    Abstract: Citronellyl benzimidazoles, e.g., (.+-.) 1-(3,7-dimethyl-6-octen-1-yl)-2-phenylbenzimidazole, are prepared by reacting an alkali metal salt of a 2-phenylbenzimidazole with citronellyl halide and are useful as hypolipidemic agents.
    Type: Grant
    Filed: August 21, 1975
    Date of Patent: April 27, 1976
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • 5-Hydroxy-5-substituted phenyl-pyrrolidones and piperidinones
    Patent number: 3947460
    Abstract: 5-hydroxy-5-substituted phenyl-pyrrolidones and piperidinones, 3.g., 5-hydroxy-1-methyl-5-(m-trifluoromethylphenyl)pyrrolidone, are useful as sedative-hypnotic agents and minor tranquilizers.
    Type: Grant
    Filed: August 8, 1974
    Date of Patent: March 30, 1976
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • 3,3-Disubstituted phthalides
    Patent number: 3944570
    Abstract: Phthalanols disubstituted in the 3-position, e.g. 3-(4-chlorophenyl)-3-(2-dimethylaminomethyl phenyl)-1-methyl-1-phthalanol, prepared by alkylating corresponding phthalides, are useful as anti-inflammatory agents.
    Type: Grant
    Filed: June 27, 1974
    Date of Patent: March 16, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Process for imidazo isoindoles
    Patent number: 3943147
    Abstract: Imidazo isoindoles, e.g. 5-(p-chlorophenyl)-5-hydroxy-2,3-dihydro-5H-imidazo[2,1a]isoindol, may be prepared by treating a corresponding 2-benzoyl benzoic acid with a substituted ethylene diamine, and treating a resulting intermediate first with concentrated acid and then with base. The products are active as anorexic agents.
    Type: Grant
    Filed: October 26, 1973
    Date of Patent: March 9, 1976
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Substituted or unsubstituted p-alkanoyl toluenes as hypolipidemics
    Patent number: 3941888
    Abstract: Certain substituted or unsubstituted p-alkanoyl toluenes, e.g., p-alkanoyl toluene, are useful as hypolipidemic agents.
    Type: Grant
    Filed: February 3, 1975
    Date of Patent: March 2, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Preparation of 1-aryl-4,5-dihalo-pyridazone-6
    Patent number: 3935210
    Abstract: Disclosed is single phase multi-stage process for preparation of 1-aryl-4,5-dihalo-pyridazones-6 involving the diazotization of an amino aryl compound, e.g. aniline, followed by reduction with sulfurous acid to obtain the corresponding aryl hydrazine which is then reacted at elevated temperatures with a mucohalic acid to obtain the 1-aryl-4,5-dihalo-pyridazone-6.
    Type: Grant
    Filed: May 20, 1974
    Date of Patent: January 27, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jerome Linder
  • Substituted indeno, naphtho and cyclohepta pyrazoles
    Patent number: 3932430
    Abstract: Substituted indeno [1,2-c] pyrazoles, naphtho [1,2-c] pyrazoles and benzo [6,7] cyclohepta [1,2-c] pyrazoles e.g., 3-(2,3-dimethoxyphenyl)-4H-indeno[1,2-c] pyrazole and 4,5-dihydro-3-(4-pyridyl)-2H-naphtho[1,2-c] pyrazole, are useful as non-estrogenic anti-fertility agents and antihypertensive agents.
    Type: Grant
    Filed: April 11, 1973
    Date of Patent: January 13, 1976
    Assignee: Sandoz, Inc.
    Inventors: Dietmar A. Habeck, William J. Houlihan
  • Intermediates in the preparation of imidazo(2,1-alpha)isoindoles
    Patent number: 3932450
    Abstract: Imidazo[2,1-a]isoindoles useful as anorexics and psychic-energizers are prepared from the N,o-dilithium derivative of substituted 2-phenyl-2-imidazoline by various routes.
    Type: Grant
    Filed: August 19, 1974
    Date of Patent: January 13, 1976
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Hydroxyalkyl substituted-4,5-dihydropyridazin(2H)-3-ones
    Patent number: 3931176
    Abstract: Hydroxyalkyl and aryl or heterocyclic substituted-4,5-dihydropyridazin(2H)-3-ones and diazabicyclo-ene-ones e.g., 6-(p-chloro-phenyl)-2-(2-hydroxybutyl)-4,5-dihydropyridazin(2H)-3-on e are prepared by condensing 1-hydrazino-2-alkanols with aryl or heterocyclic-.gamma.-keto acids and are useful as central nervous system depressants.
    Type: Grant
    Filed: October 25, 1973
    Date of Patent: January 6, 1976
    Assignee: Sandoz Inc.
    Inventor: William J. Houlihan