Abstract: Treatment of chronic neurodegenerative diseases such as multiple sclerosis (MS) remains a major challenge. Here we genetically engineer neural stem cells (NSCs) to produce a triply therapeutic cocktail comprising IL-10, NT-3, and LINGO-1-Fc, thus simultaneously targeting all mechanisms underlie chronicity of MS in the central nervous system (CNS): persistent inflammation, loss of trophic support for oligodendrocytes and neurons, and accumulation of neuroregeneration inhibitors. After transplantation, NSCs migrated into the CNS inflamed foci and delivered these therapeutic molecules in situ. NSCs transduced with one, two, or none of these molecules had no or limited effect when injected at the chronic stage of experimental autoimmune encephalomyelitis; cocktail -producing NSCs, in contrast, mediated the most effective recovery through inducing M2 macrophages/microglia, reducing astrogliosis, and promoting axonal integrity and endogenous oligodendrocyte/neuron differentiation.

Abstract: Embodiments of the present invention provide a network path computation method, apparatus and system, where the method includes: sending, by a first node, a path computation request to a first path computation element PCE, where the path computation request includes a resource sharing object, and a head node and a last node of a first label switched path LSP; and receiving, by the first node, a path computation result that is returned by the first PCE and that is obtained by means of computation according to the resource sharing object, and establishing a second path from the head node to the last node according to the path computation result. According to the network path computation method, apparatus, and system provided in the embodiments of the present invention, link resource utilization can be improved.

Abstract: A communication method and a communications apparatus are applied to discrete narrowband communication information. In a communication method, comprising: sending, by a network device, first indication information to a terminal, wherein the first indication information comprises a frequency channel number of a start sub-band in all discrete sub-bands of a serving cell in which the terminal is currently located, a bitmap representing whether each sub-band in a frequency band belongs to the serving cell, and a frequency spacing between sub-bands in the frequency band, wherein the frequency band is a frequency band to which all the discrete sub-bands of the serving cell belong; and sending, by the network device, second indication information to the terminal, wherein the second indication information is used to indicate a sub-band available to the terminal in all the discrete sub-bands of the serving cell.

Abstract: The present invention discloses a method for producing a 1,2-amino alcohol compound by utilizing whole-cell transformation, and belongs to the technical field of gene engineering and microorganism engineering. According to the present invention, engineered Escherichia coli co-expresses epoxide hydrolase, alcohol dehydrogenase, ?-transaminase and glutamate dehydrogenase, is capable of realizing whole-cell catalysis of an epoxide in one step to synthesize a 1,2-amino alcohol compound, and meanwhile, can realize regeneration of coenzyme NADP+ and an amino doner L-Glu; alcohol dehydrogenase expressed by the engineered Escherichia coli is RBS optimized alcohol dehydrogenase, and such RBS optimization can control the expression quantity of alcohol dehydrogenase, so that the catalysis rate of alcohol dehydrogenase and transaminase can achieve an optimum ratio, to eliminate influence caused by a rate-limiting step in a catalyzing course.

Abstract: Architecture that decomposes of one or more monolithic data concepts into atomic concepts and related atomic concept dependencies, and provides streaming data processing that processes individual or separate (atomic) data concepts and defined atomic dependencies. The architecture can comprise data-driven data processing that enables the plug-in of new data concepts with minimal effort. Efficient processing of the data concepts is enabled by streaming only required data concepts and corresponding dependencies and enablement of the seamless configuration of data processing between stream processing systems and batch processing systems as a result of data concept decomposition. Incremental and non-incremental metric processing enables realtime access and monitoring of operational parameters and queries.

Abstract: A DNA probe library for hybridization with microsatellite loci associated with microsatellite instability (MSI) detection. The said DNA probe library comprises one or more DNA probes that are capable of hybridizing with the MSI status-related microsatellite loci. Among the said DNA probes, probes for the MSI-related microsatellite loci are shown in the following sequences: SEQ ID NOS. 1-66. In addition, the present invention provides a method for enriching and detecting the MSI-related microsatellite loci using the probe library. The combination of this method and next-generation sequencing technology (NGS) can greatly improve the sensitivity, accuracy and comprehensiveness of the MSI detection.

Abstract: This application provides a node device implementing connection establishment for a Space Division Multiplexing (SDM) network. A first node receives a path (Path) message, which includes a plurality of label objects, each label object includes a field used to indicate a number of an optical core in a multi-core optical fiber, and idle spectrum information of each optical core. The first node then obtains an intersection set of the idle spectrum information of each optical core indicated in the path message and idle spectrum information of a corresponding optical core on a first link. The first node sends, over the first link, a path message that carries an intersection set result, where the first link is a link between the first node and an adjacent node in a direction from the first node to an end node.

Abstract: The present invention discloses a single-cell factory for efficiently synthesizing ?-aminobutyric acid and construction and application thereof, which belong to the technical field of microorganisms. The present invention expresses an L-threonine deaminase gene, an L-amino acid dehydrogenase gene and a dehydrogenase gene for providing cofactor NADH cycle in tandem to construct a recombinant Escherichia coli single-cell factory which is used for efficiently synthesizing ?-aminobutyric acid. The expression level of the L-threonine deaminase is optimized and controlled by an RBS sequence, so that the problem of transformation inhibition caused by the rapid accumulation of an intermediate product ketobutyric acid is solved, moreover, the expression level of the dehydrogenase for providing cofactor NADH cycle is optimized and controlled by a promoter and an RBS sequence, consequently, the NADH regeneration rate is increased, and ultimately, yield is increased.

Abstract: It involves the field of power trading technology and a method for microservice transformation of power trading function comprising the following steps: (1) divide the function in extranet trading cloud into many multiple individual micro services and divide the function in intranet trading cloud into multiple individual micro services; (2) register a node information for each individual micro service in service registry when service deployment starts; (3) extranet users and intranet users enter into extranet trading cloud and intranet trading cloud respectively through PC terminal or mobile terminal, obtain the actual network address that needs to be served from service registry, send a request to the requested service, and perform related business operation.

Abstract: The invention involves the field of power trading and especially involves a method for construction of power trading index system based on big data technology. Main steps are as follows: 1. data acquisition; 2. construction of index system: construction of index system is mainly based on cloud focus evaluation method to solve the problem of variables transformation and make data analysis through high concurrency distributed computing power of Spark memory access; 3. index calculation: adopt objective weighting approach to determine the weight of each index after index configuration and then adopt cloud focus evaluation method to calculate the weighted deviation of each index; store final evaluation result of each index into HDFS database after Spark calculation; 4. index display.

Abstract: The present invention discloses an alternating current (AC) permanent magnet motor, including a stator, a rotor, and a controller. Cable troughs and some same coil windings exist on a silicon steel sheet of a stator core. Grooves exist on the stator core, and stator permanent magnets are mounted in the grooves. The groove includes two types of grooves, namely, open grooves and enclosed grooves, and the two types of grooves are alternately laminated to form the stator core. A coil unit of the stator includes stator permanent magnets mounted in grooves of two stator cores and four same coils, and some same coil units form a three-phase stator coil. The rotor includes rotor cores, enclosed squirrel cages and rotor permanent magnets. The controller outputs a three-phase power source having a same positive and negative half sine-wave or step-wave pulse.

Abstract: The invention discloses a method for increasing the yield of L-arginine by knocking out flavin reductases, and belongs to the technical field of amino acid production by microbial fermentation. Genes frd1 and frd2 for encoding hypothetic NADPH-dependent FMN reductase in Corynebacterium crenatum SDNN403 are over-expressed in E. coli BL21 and are purified to form target proteins Frd181 and Frd188, and functions of the target proteins are identified to obtain a result showing that the proteins Frd181 and Frd188 both are NAD(P)H-dependent flavin reductases producing H2O2. By taking a genome of the Corynebacterium crenatum SDNN403 as a template, frd1 and frd2 gene deletion fragments are obtained by overlap extension PCR; connecting pK18mobsacB to obtain knockout plasmids pK18mobsacB-?frd1 and pK18mobsacB-?frd2; carrying out electric shock to transform the Corynebacterium crenatum SDNN403; and carrying out secondary screening to obtain recombinant strains 403?frd1 and 403?frd2.

Abstract: This application provides a node device implementing connection establishment for a Space Division Multiplexing (SDM) network. A first node receives a path (Path) message, which includes a plurality of label objects, each label object includes a field used to indicate a number of an optical core in a multi-core optical fiber, and idle spectrum information of each optical core. The first node then obtains an intersection set of the idle spectrum information of each optical core indicated in the path message and idle spectrum information of a corresponding optical core on a first link. The first node sends, over the first link, a path message that carries an intersection set result, where the first link is a link between the first node and an adjacent node in a direction from the first node to an end node.

Abstract: A link control node and method, and a system are provided. An MPTCP sublink is identified; and from the MPTCP sublink, a first MPTCP sublink on which link control needs to be performed is determined, and an adjustment manner applicable to the first MPTCP sublink is determined. By adding centralized management and control measures on MPTCP connections, a data transmission process on each MPTCP sublink can be performed on an expected communication link, which adapts to running requirements of a system. Therefore, radio resources can be appropriately allocated, and system performance can be improved.

Abstract: The present disclosure discloses a composite balance ring and a washing machine. The balance ring is internally hollow to form a chamber. The chamber is horizontally provided with a partition plate which divides the chamber into upper and lower chambers. The upper and lower chambers communicate through an overflow structure and a backflow structure, and the chamber is filled with balancing liquid with a level close to the partition plate. During the dehydration process of the washing machine, the balancing liquid in the lower chamber overflows into the upper chamber by a low overflow speed through a narrow gap that forms the overflow structure, and the balancing liquid remaining in the lower chamber provided with a counterweight force in the inner tub, so that the increase of eccentric displacement of the inner tub due to eccentric flowing of the balancing liquid is avoided.

Abstract: Embodiments of the present invention provide a link control node and method, and a system. An MPTCP sublink is identified; and from the MPTCP sublink, a first MPTCP sublink on which link control needs to be performed is determined, and an adjustment manner applicable to the first MPTCP sublink is determined. By adding centralized management and control measures on MPTCP connections, a data transmission process on each MPTCP sublink can be performed on an expected communication link, which adapts to running requirements of a system. Therefore, radio resources can be appropriately allocated, and system performance can be improved.

Abstract: The present invention relates to application of a novel signal peptide in L-arginine and its derivatives production from konjac powder, which belongs to the field of gene engineering, enzyme engineering and metabolism engineering. The present invention fused the signal peptide set forth in SEQ ID NO.1 with the ?-mannanase of Bacillus subtilis CCTCC M 209200, and expressed the fused gene in the strain with high L-arginine yield. The recombinant strain Corynebacterium crenatum CGMCC 0890/p MSPman had advantages on utilizing cheaper konjac powder as substrate, and after fermenting for 96 hours in a 5 L bioreactor, the L-arginine yield reached 45 g/L. Another two recombinant strains were constructed based on Corynebacterium crenatum CGMCC 0890/pMSPman, and after fermenting for 96 hours in a 5 L bioreactor, the L-ornithine yield and L-citrulline reached 23.5 g/L and 26.3 g/L respectively.

Abstract: The present invention discloses an alternating current (AC) permanent magnet motor, including a stator, a rotor, and a controller. Cable troughs and some same coil windings exist on a silicon steel sheet of a stator core. Grooves exist on the stator core, and stator permanent magnets are mounted in the grooves. The groove includes two types of grooves, namely, open grooves and enclosed grooves, and the two types of grooves are alternately laminated to form the stator core. A coil unit of the stator includes stator permanent magnets mounted in grooves of two stator cores and four same coils, and some same coil units form a three-phase stator coil. The rotor includes rotor cores, enclosed squirrel cages and rotor permanent magnets. The controller outputs a three-phase power source having a same positive and negative half sine-wave or step-wave pulse.

Abstract: A heat exchanger includes a shell; multiple exchange tubes disposed in multiple layers from the center to the wall of the shell inside the shell; a first board and a second board arranged in parallel inside the shell; and a first spiral gas tube winding in a same direction, the first spiral gas tube having a first wall provided with a plurality of first gas pores, and the first spiral gas tube has a first inlet and a first outlet that respectively communicates with out-source gas. The heat exchanger can carry out online disturbance to the fluid in the shell internally, even in the case that the fluid media are dirty and viscous, the mixing of the fluid media tends to be uniform continuously, thus effectively improving the heat exchange effect, and convenient for cleaning, purging and maintaining the interior of the device.

Abstract: Implementations provide an improved system for presenting search results based on entity associations of the search items. An example method includes, for each of a plurality of crowdsource workers, initiating display of a first randomly selected cluster set from a plurality of cluster sets to the crowdsource worker. Each cluster set represents a different clustering algorithm applied to a set of search items responsive to a query. The method also includes receiving cluster ratings for the first cluster set from the crowdsource worker and calculating a cluster set score for the first cluster set based on the cluster ratings. This is repeated for remaining cluster sets in the plurality of cluster sets. The method also includes storing a cluster set definition for a highest scoring cluster set, associating the cluster set definition with the query, and using the definition to display search items responsive to the query.