Abstract: The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a ?2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.

Abstract: The present invention provides an anti-placenta chondroitin sulfate (pl-CS) chimeric antigen receptor and application thereof. The chimeric antigen receptor mainly comprises anti-pl-CS antigen recognition region, a hinge region, a transmembrane region and intracellular region, wherein the anti-pl-CS antigen recognition region is any one of a plasmodium protein VAR2CSA, a part of peptide segment of plasmodium protein VAR2CSA or a pl-CS antibody; and the part of peptide segment of the plasmodium protein VAR2CSA is a peptide segment with the number of amino acid greater than 500 in the plasmodium protein VAR2CSA.

Abstract: A high-strength integrated water channel pack with a plurality of channels is composed of a water channel pack body and a cover plate, with both being injection molded of a mixture of polypropylene and glass fibers. The water channel pack body is provided with at least one filter element connecting port. All filter element connecting ports and the water channel pack body are integrally molded. The filter element connecting port is internally provided with at least one water inlet hole and at least one water outlet hole. The bottom surface of the water channel pack body and/or the top surface of the cover plate are each provided with a plurality of slots. The water channel pack body and cover plate are connected to each other and enclose the slots to form the channels. At least one water inlet hole and at least one water outlet hole are connected with the channels.

Abstract: The present invention relates to a hot melt extrusion composition, a process for preparing a hot melt extruded product using the hot melt extrusion composition, a solid dispersion of decoquinate, and pharmaceutical uses of the composition and the solid dispersion of decoquinate. The hot melt extrusion composition comprises 5 to 30% of decoquinate, 60 to 90% of a polymeric carrier and 0 to 10% of a surfactant. The hot melt extrusion composition can be melted into a liquid at a temperature below the melting point of decoquinate to achieve complete mixing, effectively avoiding the possible thermal decomposition of decoquinate and other components of the composition during the hot-melt process, thus retaining their original structures and pharmacodynamic activity.

Abstract: A control circuit for generating a switching control signal to control switching operations of a power switch in a power stage circuit, can include: a first control loop configured to receive a first voltage feedback signal, and to generate a first compensation signal; a voltage regulating circuit configured to receive an output voltage signal of the power stage circuit, and to generate a second compensation signal according to a difference between an output voltage signal of the power stage circuit during different time periods; and control and driving circuit configured to receive the first and second compensation signals and a sense voltage signal that represents a current through an inductor of the power stage circuit, and to generate an OFF signal, and a switching control signal according to the OFF signal and an ON signal.

Abstract: An electric valve and a control method therefor are disclosed. The electric valve comprises a mechanical valve body, a motor (1), a valve switch state detection apparatus, a control line (9) and a control circuit (80). The motor and the mechanical valve body are in transmission connection; the control line is electrically connected to the control circuit; the control circuit comprises a drive module (2) and a power supply module (5); and the motor, the valve switch state detection apparatus and the power supply module are respectively connected to the drive module. The control circuit further comprises a backup power supply (90) electrically connected thereto.

Abstract: The present application relates to a method for preparing Ibutinib as shown by the following synthetic route and the intermediate compounds involved therein.

Abstract: A control circuit for generating a switching control signal to control switching operations of a power switch in a power stage circuit, can include: a first control loop configured to receive a first voltage feedback signal, and to generate a first compensation signal; a voltage regulating circuit configured to receive an output voltage signal of the power stage circuit, and to generate a second compensation signal according to a difference between an output voltage signal of the power stage circuit during different time periods; and control and driving circuit configured to receive the first and second compensation signals and a sense voltage signal that represents a current through an inductor of the power stage circuit, and to generate an OFF signal, and a switching control signal according to the OFF signal and an ON signal.

Abstract: A water purifier, a method, and a device for controlling the water purifier are provided. The water purifier may include: a filter device including an input end for water to be purified connected with a source of water to be purified, and an output end for purified water connected with a faucet; a water flow detection device for detecting water flow condition in the filter device; a control device electrically connected to the water flow detection device and a power assembly of the filter device. When there exists a requirement on water purification from a user, the control device the control device sends a corresponding state control instruction to the power assembly based on whether the water flow condition satisfies a pre-defined water supply condition. The state control instruction controls whether to switch a working state of the filter device.

Abstract: The present invention relates to the field of treatment of tumor, and especially to a composition comprising a plasmodium, a treatment method and an application thereof. The composition of the present invention has therapeutic effects on colorectal carcinoma, lung carcinoma, breast carcinoma, gastric carcinoma and hepatic carcinoma etc., can inhibit the growth of tumor and prolong the life of the tumor patients, whereas has no therapeutic effect on melanoma and lymphoma; meanwhile, the present invention describes that the long-term plasmodium infection has better therapeutic effect on tumors, and the plasmodium immunotherapy of the present invention does not take the fever time as a course standard when treating tumors, but should be used to extend the duration of plasmodium infection as much as possible until the progression of tumors can be controlled under the premise of protecting the organ functions and life safety of the patients.

Abstract: A composite filter cartridge, comprising a filter cartridge body provided with two filter devices. Each filter device is respectively provided with a support component which fixes the filter device, and the filter devices are arranged in a linear manner and fixed with respect to one another. Each filter device is respectively provided with an independent housing, a filter module and a filter water channel, the filter module and the filter water channel being arranged within the housing, the filter water channel sequentially comprising a water inlet cavity and a water outlet cavity, the water inlet cavity and the water outlet cavity being connected via the corresponding filter module.

Abstract: A clock dividing frequency circuit can include: a controlled current source configured to generate a driving current that varies with a dividing frequency control signal; a ramp signal generating circuit configured to generate a ramp signal having a slope that varies according to the driving current, where the ramp signal is reset according to pulses of a dividing frequency clock signal; and a dividing frequency pulse generating circuit configured to generate the dividing frequency clock signal by a dividing frequency operation according to the ramp signal and a system clock signal.

Abstract: A position lock and position shift controlling mechanism for a multi-position shifting switch includes a position lock and position shift assembly and a controlling assembly to control the locking of the position lock and position shift assembly. The position lock assembly includes a locked body, a moving body and a housing body. The locked body includes a roundel pedestal which rotates synchronously with a switching shaft, a lock tooth component rotatably attached with the roundel pedestal, and an inner core component. The lock tooth component includes evenly distributed location teeth and plural radial slots. The moving body locks the lock tooth component and pushes the inner core component away from the lock tooth component. The switching shaft actuates the roundel pedestal to rotate a preset angle about the lock tooth component to shift the multi-position shifting switch to a stop control mode position from an automation control mode position.

Abstract: The present application relates to a method for preparing Ibutinib as shown by the following synthetic route and the intermediate compounds involved therein.

Abstract: The present invention relates to a hot melt extrusion composition, a process for preparing a hot melt extruded product using the hot melt extrusion composition, a solid dispersion of decoquinate, and pharmaceutical uses of the composition and the solid dispersion of decoquinate. The hot melt extrusion composition comprises 5 to 30% of decoquinate, 60 to 90% of a polymeric carrier and 0 to 10% of a surfactant. The hot melt extrusion composition can be melted into a liquid at a temperature below the melting point of decoquinate to achieve complete mixing, effectively avoiding the possible thermal decomposition of decoquinate and other components of the composition during the hot-melt process, thus retaining their original structures and pharmacodynamic activity.

Abstract: A control circuit for generating a switching control signal to control switching operations of a power switch in a power stage circuit, can include: a first control loop configured to receive a first voltage feedback signal, and to generate a first compensation signal; a voltage regulating circuit configured to receive an output voltage signal of the power stage circuit, and to generate a second compensation signal according to a difference between an output voltage signal of the power stage circuit during different time periods; and control and driving circuit configured to receive the first and second compensation signals and a sense voltage signal that represents a current through an inductor of the power stage circuit, and to generate an OFF signal, and a switching control signal according to the OFF signal and an ON signal.

Abstract: A skeleton unit to mount mosaic plates, includes a main body section and an extension section. The main body section is integrally formed by strip pieces perpendicularly crossing each other to provide a grille shape. The extension section extends out from four edges of the main body section and is integrally formed with the main body section. The extension section includes prolongation pieces which respectively extend out from both ends of each strip piece, and parallel strips which connect with the outside ends of each prolongation piece on the same side and are in parallel with the edges of the main body section respectively. The parallel strip has lap joint hole portions, which penetrates the parallel strips and are used to overlap another skeleton unit. The sum of double the length of the prolongation piece and the width of the parallel strip is equal to the length of the grid.

Abstract: The present invention relates to a water purifying machine component and a control method thereof, wherein the water purifying machine component comprises a flow divider body and a water purifier body which are connected by a calandria tube, wherein the flow divider body is provided with a first electric control device, an external water inlet, a purified water inlet, a tap water outlet, a tap water discharging port, a purified water discharging port and a first electric component, the external water inlet is connected with the tap water outlet, and the inner end of the purified water inlet is connected with the purified water discharging port; the water purifier body is provided with a second electric control device, a purified water outlet, a tap water inlet and a second electric component; and the first electric control device and the second electric control device are electrically connected.

Abstract: A method for establishing an animal model of hepatocellular carcinoma (HCC) bone metastasis, the method including: 1) establishing 97H and LM3 cell clones with stable expression of firefly luciferase (LUC); 2) allowing HCC cells to form bone metastasis in nude mice via intratibial injection; 3) reproducing HCC bone metastasis in nude mice via intracardiac injection of tumor cells; and 4) isolating a sub-population of tumor cells that targets metastasis to bone. The 97H and the LM3 are highly metastatic HCC cell lines transfected with luciferase gene. BALB/cA-nu mice are 4-5 weeks old and maintained in laminar flow cabinets under SPF conditions and received human care throughout an entire study. A cell number for intratibial injection is 0.5×106, and a cell number for intracardiac injection is 1×106.

Abstract: A method for establishing an animal model of hepatocellular carcinoma (HCC) bone metastasis, the method including: 1) establishing 97H and LM3 cell clones with stable expression of firefly luciferase (LUC); 2) allowing HCC cells to form bone metastasis in nude mice via intratibial injection; 3) reproducing HCC bone metastasis in nude mice via intracardiac injection of tumor cells; and 4) isolating a sub-population of tumor cells that targets metastasis to bone. The 97H and the LM3 are highly metastatic HCC cell lines transfected with luciferase gene. BALB/cA-nu mice are 4-5 weeks old and maintained in laminar flow cabinets under SPF conditions and received human care throughout an entire study. A cell number for intratibial injection is 0.5×106, and a cell number for intracardiac injection is 1×106.