Abstract: A method for content caching in information centric network virtualization includes receiving, by a first node, a first data packet; in response to a cache distance identifier hop of the first data packet being less than a preset maximum cache distance, setting hop=hop+1 and sending the first data packet to a next node by the first node; in response to the hop being not less than the preset maximum cache distance and there being available cache space in the first node, setting hop=0, storing the first data packet, and sending the first data packet to the next node by the first node. The node determines whether to cache a data packet based on the cache distance identifier of the data packet, which comprehensively considers the cache energy consumption caused by caching the data packet in the node and the transmission energy consumption caused by transmission of the data packet in the link, thereby effectively reducing the total energy consumption of the network.

Abstract: Disclosed is a monoclonal antibody or an antigen binding fragment thereof which targets tissue factor pathway inhibitor (TFPI), and a medical use thereof.

Abstract: Disclosed are a method for treating a tumor using a CTLA4-binding protein and a use thereof, wherein the CTLA4-binding protein specifically binds to CTLA4 and does not compete with a ligand of CTLA4 for binding to CTLA4. The CTLA4-binding protein described in the present application can effectively inhibit tumor growth.

Abstract: The invention provides a test device and method for controlling a low-temperature environment. A double-layer stainless steel plate forms an interlayer cavity of a cooling box; four walls of the cooling box are provided with a heat insulation plate; a probe thermometer is disposed on a side wall of the cooling box; both the top of a press and the bottom of an indenter of a universal testing machine are provided with a fiberglass reinforced plastic pipe cover; the cooling box is disposed on the press; the indenter is disposed in the cooling box through a through hole; a cold bath device communicate with the cooling box; the cold bath device and the interlayer cavity are provided with a freezing liquid; a stress-strain data acquisition instrument is connected to a sample in the cooling box through a strain gage and a strain gage connection line.

Abstract: The present application provides a bispecific antibody or an antibody mixture with common light chains and a preparation method therefor. the present application also provides a nucleic acid molecule encoding the antibody or the mixture, a recombinant vector and a recombinant cell comprising the nucleic acid molecule, as well as a detection and quantitation method for the antibody or the mixture.

Abstract: The present invention relates to the field of medical biology, and discloses a high-resolution crystal structure of a complex of PD-L1-blocking heavy-chain single-domain antibody KN035 binding with PD-L1, and the use of the crystal structure. The invention also relates to novel PD-L1 binding polypeptides or compounds developed based on the crystal structure and uses thereof.

Abstract: Provided are a tripeptide compound, a preparation method therefor, and an application thereof. The structure of the related compound is represented by formula (I). The provided compound has angiotensin converting enzyme inhibiting bioactivity, and the compound and a pharmaceutical composition thereof play a role in preventing and treating hypertension and other cardiocerebral vascular system diseases.

Abstract: The present disclosure provides proteinaceous complexes, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous complexes, methods for producing the proteinaceous complexes, and uses thereof.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: The present disclosure discloses a display panel and a display apparatus. The display panel includes a base substrate; a plurality of light emitting devices and a plurality of light sensors, disposed on the base substrate; thin film transistor structures disposed between the base substrate and the light emitting devices; a pixel definition layer configured to define positions of the light emitting devices; a first planarization layer disposed on a side, facing the base substrate, of the pixel definition layer; a light shading layer; and reflection parts each corresponding to a respective one of the light sensors; wherein: the light emitting devices are electrically connected with the thin film transistor structures; the reflection parts are disposed on sides, facing the base substrate, of the light sensors, and a side, facing the respective one reflection part, of the each light sensor is a light inlet side of the each light sensor.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: The present disclosure provides a dimer formed by two polypeptide chains, with each of the two polypeptide chains comprising an antibody Fc subunit, wherein the dimer comprises two or more immunoglobulin single variable domains (ISVDs), at least one of the ISVDs is specific for PD-L1, and at least one of the ISVDs is specific for CTLA4.

Abstract: The present disclosure provides a dimer formed by two polypeptide chains, with each of the two polypeptide chains comprising an antibody Fc subunit, wherein the dimer comprises two or more immunoglobulin single variable domains (ISVDs), at least one of the ISVDs is specific for PD-L1, and at least one of the ISVDs is specific for CTLA4.

Abstract: A method for content caching in information centric network virtualization includes receiving, by a first node, a first data packet; in response to a cache distance identifier hop of the first data packet being less than a preset maximum cache distance, setting hop=hop+1 and sending the first data packet to a next node by the first node; in response to the hop being not less than the preset maximum cache distance and there being available cache space in the first node, setting hop=0, storing the first data packet, and sending the first data packet to the next node by the first node. The node determines whether to cache a data packet based on the cache distance identifier of the data packet, which comprehensively considers the cache energy consumption caused by caching the data packet in the node and the transmission energy consumption caused by transmission of the data packet in the link, thereby effectively reducing the total energy consumption of the network.

Abstract: The present application provides a bispecific antibody or an antibody mixture with common light chains and a preparation method therefor. the present application also provides a nucleic acid molecule encoding the antibody or the mixture, a recombinant vector and a recombinant cell comprising the nucleic acid molecule, as well as a detection and quantitation method for the antibody or the mixture.

Abstract: Disclosed are a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof. a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof.

Abstract: Provided are proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.

Abstract: The present application provides a bispecific antibody or an antibody mixture with common light chains and a preparation method therefor. the present application also provides a nucleic acid molecule encoding the antibody or the mixture, a recombinant vector and a recombinant cell comprising the nucleic acid molecule, as well as a detection and quantitation method for the antibody or the mixture.

Abstract: The invention provides a test device and method for controlling a low-temperature environment. A double-layer stainless steel plate forms an interlayer cavity of a cooling box; four walls of the cooling box are provided with a heat insulation plate; a probe thermometer is disposed on a side wall of the cooling box; both the top of a press and the bottom of an indenter of a universal testing machine are provided with a fiberglass reinforced plastic pipe cover; the cooling box is disposed on the press; the indenter is disposed in the cooling box through a through hole; a cold bath device communicate with the cooling box; the cold bath device and the interlayer cavity are provided with a freezing liquid; a stress-strain data acquisition instrument is connected to a sample in the cooling box through a strain gage and a strain gage connection line.

Abstract: A transient IR-drop waveform measurement system and method for a high speed integrated circuit are provided. The system includes all-digital elements and is based on a ring oscillator in GHz. Through oscillation with a Fast Ring Oscillator, sampling with an Edge Detector and counting with a Ripple Counter, a width and a peak of an IR-drop waveform are obtained. Moreover, a power supply network is adapted during a clock cycle through sending an adaptation signal to a connected dynamic voltage frequency scaling (DVFS) system. The measurement method includes 11 steps. The measurement system has following features: 1) IR-drop peak/width measurement ability; 2) low fabrication and test cost; 3) high accuracy and sensitivity; 4) early adaptation ability. Therefore, the measurement system can be used alone for chip monitoring or testing, in order to reduce a power supply noise disturbance to a chip.