Abstract: The present application provides an anti-OX40 human antibody. In particular, a human antibody specifically binding to OX40 is obtained with yeast display screening, and the affinity of the antibody is improved with affinity maturation. The present application also provides a use of the antibody for the prevention or treatment of tumors.

Abstract: The present disclosure provides proteinaceous complexes, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous complexes, methods for producing the proteinaceous complexes, and uses thereof.

Abstract: The present invention provides a liquid crystal display panel, which comprises a color film substrate, an array substrate and a liquid crystal layer sandwiched between the color film substrate and the array substrate, said array substrate has a pixel electrode where a surface is disposed with a number of recesses and a number of terraces, said number of recesses and said number of terraces are disposed in evenly intersectional arrangement, said respective recess is located at a position between two interconnected pixels, said respective recess is disposed with a first spacer, said respective terrace is disposed with a second spacer, a height of said first spacer protruded from said terrace is larger than a height of said second spacer protruded from said terrace, said first spacers and said second spacers are extended into the liquid crystal layer, for support of between said color film substrate and said array substrate.

Abstract: The present invention relates to the field of medical biology, and discloses a high-resolution crystal structure of a complex of PD-L1-blocking heavy-chain single-domain antibody KNO35 binding with PD-L1, and the use of the crystal structure. The invention also relates to novel PD-L1 binding polypeptides or compounds developed based on the crystal structure and uses thereof.

Abstract: The present disclosure provides proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: A gate driving circuit and an array substrate using the same are described. The gate driving circuit pulls up and pulls down the voltage level of the node in one display frame by a first voltage signal of a second driving module and a second voltage signal of a third driving module to control the high level and low level respectively of scan signal in the scan output terminal for sequentially writing data signal to all the first row sub-pixels, all the second row sub-pixels and all the third row sub-pixels of the one display frame in order to prevent the sub-pixels from RC delay and color deviation, thereby improving the display quality of the LCD.

Abstract: The present application provides a bispecific antibody or an antibody mixture with common light chains and a preparation method therefor. the present application also provides a nucleic acid molecule encoding the antibody or the mixture, a recombinant vector and a recombinant cell comprising the nucleic acid molecule, as well as a detection and quantitation method for the antibody or the mixture.

Abstract: A method for manufacturing a LTPS array substrate includes: forming a source electrode and a drain electrode on a substrate, forming a poly-silicon layer in a first region and a second region of the substrate including the source electrode and the drain electrode, such that the poly-silicon layer of the first region has a thickness greater than that of the second region and the poly-silicon layer of the first region partially covers the source electrode and the drain electrode; passivating a surface of the poly-silicon layer in order to turn a part of the poly-silicon layer of the second region and the first region that is adjacent to the surface into an insulating layer; and forming a gate electrode on the insulating layer between the source electrode and the drain electrode. The LTPS technical process is simple and can reduce the producing costs.

Abstract: The present application provides an anti-OX40 human antibody. In particular, a human antibody specifically binding to OX40 is obtained with yeast display screening, and the affinity of the antibody is improved with affinity maturation. The present application also provides a use of the antibody for the prevention or treatment of tumors.

Abstract: The present invention provides a liquid crystal display panel, which comprises a color film substrate, an array substrate and a liquid crystal layer sandwiched between the color film substrate and the array substrate, said array substrate has a pixel electrode where a surface is disposed with a number of recesses and a number of terraces, said number of recesses and said number of terraces are disposed in evenly intersectional arrangement, said respective recess is located at a position between two interconnected pixels, said respective recess is disposed with a first spacer, said respective terrace is disposed with a second spacer, a height of said first spacer protruded from said terrace is larger than a height of said second spacer protruded from said terrace, said first spacers and said second spacers are extended into the liquid crystal layer, for support of between said color film substrate and said array substrate.

Abstract: Disclosed are a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof. a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof.

Abstract: A liquid crystal display circuit and a method for driving a liquid crystal display circuit are disclosed. The method has steps of: in a first driving period, a GOA driving circuit successively inputs driving signals to pixel units having positive polarities in each row, so that positive-polarity signals are written into the pixel units having the positive polarities by data lines; and in a second driving period, the GOA driving circuit successively inputs the driving signals to the pixel units having negative polarities in each row, so that negative-polarity signals are written into the pixel units having the negative polarities by the data lines.

Abstract: The present invention proposes a GOA circuit and a display device adopting the same. The GOA circuit includes thirteen transistors and a first capacitor. The GOA circuit can be driven in 2D and 3D driving modes to prolong charging time of each pixel. Each two GOA circuit units share a set of Nth stage start pulse signals, Nth stage gate pulse signals and eight clock pulse signals. Because the charging time of each pixel is prolonged, the display device can show images with better display quality.

Abstract: A GOA (Gate driver On Array) for an LCD (Liquid Crystal Display) device is disclosed herein. The LCD device comprises a plurality of scanning lines. The GOA circuit comprises a plurality of GOA units, which are cascaded with each other as a plurality of level GOA units. The (n)th level GOA unit comprises a clock circuit, a pull-down circuit, a bootstrap capacitor circuit, a pull-up circuit, and a pull-down sustain circuit, to improve the color shift issue of a Tri-gate.

Abstract: A method for manufacturing a LTPS array substrate includes: forming a source electrode and a drain electrode on a substrate, forming a poly-silicon layer in a first region and a second region of the substrate including the source electrode and the drain electrode, such that the poly-silicon layer of the first region has a thickness greater than that of the second region and the poly-silicon layer of the first region partially covers the source electrode and the drain electrode; passivating a surface of the poly-silicon layer in order to turn a part of the poly-silicon layer of the second region and the first region that is adjacent to the surface into an insulating layer; and forming a gate electrode on the insulating layer between the source electrode and the drain electrode. The LTPS technical process is simple and can reduce the producing costs.

Abstract: The present invention provides a LTPS array substrate and a manufacturing method thereof. The method comprises: forming a source electrode and a drain electrode on a substrate, forming polysilicon layers of a first region and a second region on the substrate including the source electrode and the drain electrode, and the thickness of the polysilicon layer of the first region is greater than the one of the second region, the polysilicon layer of the first region partially covers the source electrode and the drain electrode; passivating the surface of the polysilicon layer in order to turn the part of the adjacent surface of the polysilicon layer of the second region and the first region into an insulating layer; forming a gate electrode on the insulating layer between the source electrode and the drain electrode. The present invention can simplify the LTPS technical process and reduce the producing costs.

Abstract: A gate driving circuit and an array substrate using the same are described. The gate driving circuit pulls up and pulls down the voltage level of the node in one display frame by a first voltage signal of a second driving module and a second voltage signal of a third driving module to control the high level and low level respectively of scan signal in the scan output terminal for sequentially writing data signal to all the first row sub-pixels, all the second row sub-pixels and all the third row sub-pixels of the one display frame in order to prevent the sub-pixels from RC delay and color deviation, thereby improving the display quality of the LCD.

Abstract: An array substrate and a manufacturing method thereof are provided. The method has steps of: forming a buffer layer, a light-shading layer, and a whole semiconductor layer on a substrate; simultaneously patterning the semiconductor layer and the light-shading layer; and forming a first insulation layer, a first metal layer, a second insulation layer, a second metal layer, a flat layer, and a first transparent conductive layer on the patterned semiconductor layer.

Abstract: The present disclosure provides proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.