Patents by Inventor Xiaoyun Wu

Xiaoyun Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bispecific antibodies which bind EGFR and VEGF
    Patent number: 9567403
    Abstract: Provided are bispecific antibodies having a full-size antibody portion with two light chains and two heavy chains, wherein the two heavy chains each is fused to a single-chain variable fragment (scFv) portion. In certain embodiments, the full-size antibody has specificity to EGFR and the scFv has specificity to VEGF.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: February 14, 2017
    Assignee: Bio-Thera Solutions, Ltd.
    Inventors: Xiaoyun Wu, Shengfeng Li, Chenchao Xu
  • Transgenic Plants With Enhanced Agronomic Traits
    Publication number: 20160272994
    Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: March 21, 2016
    Publication date: September 22, 2016
    Inventors: Mark Scott Abad, Thandoni Rao Ambika, Erin Bell, Kraig Brustad, R. Eric Cerny, Shobha Char, Jaishree M. Chittoor-Vijayanath, Paul S. Chomet, Julie Davis, Molian Deng, Todd DeZwaan, Michael D. Edgerton, Karen Gabbert, Barry S. Goldman, Brian Hauge, Steve He, Jacqueline E. Heard, Alberto Iandolino, Ping Li, Linda L. Lutfiyya, Savitha Madappa, Brad McDill, Robert J. Meister, Peter Morrell, Anil Neelam, Marie Petracek, John Pitkin, M. S. Rajani, Dhanalakshmi Ramachandra, Monica P. Ravanello, Maria F. Rodriguez, Thomas G. Ruff, Sangeetha Singh, Virginia Ursin, Tymagondlu V. Venkatesh, Kammaradi R. Vidya, K. Vijayalakshmi, Xiaoyun Wu, Jianmin Zhao
  • DRIVING SYSTEM FOR MULTI-ENERGY POWER SUPPLY MOTOR
    Publication number: 20160226424
    Abstract: A driving system for a multi-energy power supply motor comprises a distributed power supply, a frequency converter, a public power grid, and a motor load. The distributed power supply is connected to a direct-current bus of the frequency converter, and is used for acquiring and transmitting a direct current to the frequency converter. The frequency converter comprises a first bidirectional current transformer, an inverter, and a direct-current bus. The first bidirectional current transformer is connected to the inverter through the direct-current bus. The first bidirectional current transformer is connected to the public power grid. The inverter is connected to the motor load. The distributed power supply, the public power grid and the motor load are separately connected to the frequency converter.
    Type: Application
    Filed: December 16, 2013
    Publication date: August 4, 2016
    Applicant: CSR ZHUZHOU ELECTRIC LOCOMOTIVE RESEARCH INSTITUTE CO., LTD
    Inventors: Jianquan LI, Fang JIAN, Xiaoyun WU, Yun LI, Wenjie ZHAI, Rende GUAN, Jian CUI, Yuxu CHENG, Yifeng CHEN, Haiyan TANG
  • Distribution of parameter calculation for iterative optimization methods
    Patent number: 9355067
    Abstract: Systems and methods are disclosed for distributed first- or higher-order model fitting algorithms. Determination of the parameter set for the objective function is divided into a plurality of sub-processes, each performed by one of a plurality of worker computers. A master computer coordinates the operation of the plurality of worker computers, each operating on a portion of the parameter set such that no two worker computers contain exactly the same parameter subset nor the complete parameter set. Each worker computer performs its sub-processes on its parameter subset, together with training data. For maximum efficiency, the sub-processes are performed using a compact set of instruction primitives. The results are evaluated by the master computer, which may coordinate additional sub-process operations to perform higher-order optimization or terminate the optimization method and proceed to formulation of a model function.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: May 31, 2016
    Assignee: Google Inc.
    Inventors: Rajat Monga, Xiaoyun Wu, Andrew Yan-Tak Ng
  • Transgenic Plants With Enhanced Traits
    Publication number: 20150344899
    Abstract: This disclosure provides plants having enhanced traits such as increased yield, increased nitrogen use efficiency and increased water use efficiency; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing hybrid seed from such transgenic plants, growing such seed and selecting progeny plants with the composition or with enhanced traits.
    Type: Application
    Filed: March 6, 2013
    Publication date: December 3, 2015
    Inventors: Mark S. Abad, Paul S. Chomet, Dhanalakshmi Ramachandra, Tyamagondlu V. Venkatesh, Xiaoyun Wu
  • PLANTS CONTAINING A HETEROLOGOUS FLAVOHEMOGLOBIN GENE AND METHODS OF USE THEREOF
    Publication number: 20150275224
    Abstract: Plant nitrogen use efficiency in corn has been improved by transformation with a flavohemoglobin gene. Plants comprising a flavohemoglobin gene have decreased nitric oxide (NO) levels, increased biomass accumulation under a sufficient nitrogen growth condition, and increased chlorophyll content under a limiting nitrogen growth condition. Additionally, these transformed plants evidence higher levels of yield.
    Type: Application
    Filed: April 13, 2015
    Publication date: October 1, 2015
    Inventors: Amarjit Basra, Mike Edgerton, Garrett J. Lee, Maolong Lu, Linda L. Lutfiyya, Wei Wu, Xiaoyun Wu
  • TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS
    Publication number: 20150197764
    Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced trait.
    Type: Application
    Filed: February 26, 2015
    Publication date: July 16, 2015
    Applicant: MONSANTO TECHNOLOGY LLC
    Inventors: Eric D. Aasen, Mark Scott Abad, Edwards Allen, Thandoni Rao Ambika, Veena S. Anil, Alice Clara Augustine, Stephanie L. Back, Pranesh Badami, Amarjit Basra, Kraig L. Brustad, Molian Deng, Todd Dezwaan, Charles Dietrich, Stephen M. Duff, Karen K. Gabbert, Steve He, Bill L. Hendrix, Hongwu Jia, Vidya Kammaradi Ramanath Bhat, Balasulojini Karunanandaa, Kevin R. Kosola, Kempagangaiah Krishnamurthy, Ganesh Kumar, Saritha V. Kuriakose, Shantala Lakkanna, Mark E. Leibman, Linda Lutfiyya, Savitha Madappa, Sivalinganna Manjunath, Robert J. Meister, Bellur Narasimha Prasad, Sasha Preuss, Qungang Qi, Dhanalakshmi Ramachandra, Aniruddha Raychaudhuri, S. Sangeetha, Scott Saracco, Chitresh Sharma, Vijay K. Sharma, Rajani Monnanda Somaiah, Padmini Sudarshana, Rebecca L. Thompson-Mize, Srikanth Venkatachalayya, Tyamagondlu V. Venkatesh, Huai Wang, Jingrui Wu, Xiaoyun Wu, Xiaofeng Sean Yang, Qin Zeng, Jianmin Zhao
  • Distribution of parameter calculation for iterative optimization methods
    Patent number: 9015083
    Abstract: Systems and methods are disclosed for distributed first- or higher-order model fitting algorithms. Determination of the parameter set for the objective function is divided into a plurality of sub-processes, each performed by one of a plurality of worker computers. A master computer coordinates the operation of the plurality of worker computers, each operating on a portion of the parameter set such that no two worker computers contain exactly the same parameter subset nor the complete parameter set. Each worker computer performs its sub-processes on its parameter subset, together with training data. For maximum efficiency, the sub-processes are performed using a compact set of instruction primitives. The results are evaluated by the master computer, which may coordinate additional sub-process operations to perform higher-order optimization or terminate the optimization method and proceed to formulation of a model function.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: April 21, 2015
    Assignee: Google Inc.
    Inventors: Rajat Monga, Xiaoyun Wu, Andrew Yan-Tak Ng
  • Transgenic Plants With Enhanced Traits
    Publication number: 20150096069
    Abstract: This disclosure provides transgenic plants having enhanced traits such as increased yield, enhanced nitrogen use efficiency and enhanced drought tolerance; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing hybrid seed from such transgenic plants, growing such seed and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.
    Type: Application
    Filed: March 6, 2013
    Publication date: April 2, 2015
    Inventors: Paolo Castiglioni, Jaishree M. Chittoor-Vijayanath, Barry S. Goldman, Robert J. Meister, Monnanda S. Rajani, G. Ramamohan, Naveen Silvester, Tyamagondlu V. Venkatesh, Jingrui Wu, Xiaoyun Wu
  • Transgenic Plants With Enhanced Traits
    Publication number: 20150089683
    Abstract: This disclosure provides transgenic plants having enhanced traits such as increased yield, increased nitrogen use efficiency and enhanced drought tolerance; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing hybrid seed from such transgenic plants, growing such seed and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.
    Type: Application
    Filed: March 6, 2013
    Publication date: March 26, 2015
    Inventors: Mark Scott Abad, Pranesh Badami, Amarjit Basra, Erin Bell, Christopher P. Bonin, Paolo Castiglioni, Eric R. Cerny, Jaishree M. Chittoor-Vijayanath, Paul Chomet, Todd Dezwaan, Stephen Duff, Michael D. Edgerton, Barry S. Goldman, Balasulojini Karunanandaa, Kempagangaiah Krishnamurthy, Ping Li, Adrian A. Lund, Llinda Lutfiyya, Thomas M. Malvar, Donald E. Nelson, Monnanda S. Rajani, Dhanalakshmi Ramachandra, Thomas G. Ruff, Sara Salvador, S. Sangeetha, Char Shobha, Jeffrey M. Staub, Virginia Ursin, Tyamagondlu V. Venkatesh, Kammaradi R. Vidya, Xiaoyun Wu, Sean Yang, Jianmin Zhao
  • BISPECIFIC ANTIBODIES
    Publication number: 20150044216
    Abstract: Provided are bispecific antibodies having a full-size antibody portion with two light chains and two heavy chains, wherein the two heavy chains each is fused to a single-chain variable fragment (scFv) portion. In certain embodiments, the full-size antibody has specificity to EGFR and the scFv has specificity to VEGF.
    Type: Application
    Filed: August 5, 2014
    Publication date: February 12, 2015
    Inventors: Xiaoyun Wu, Shengfeng Li, Chenchao Xu
  • Aminopyrrolidines as chemokine receptor antagonists
    Patent number: 8754107
    Abstract: The present invention is directed to novel aminopyrrolidines of formula I pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: June 17, 2014
    Assignee: AbbVie Inc.
    Inventors: Dawn M. George, Richard W. Dixon, Michael Friedman, Adrian D. Hobson, Biqin Li, Lu Wang, Xiaoyun Wu, Neil Wishart
  • TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS
    Publication number: 20130276161
    Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: August 3, 2012
    Publication date: October 17, 2013
    Applicant: Monsanto Technology LLC
    Inventors: Mark Abad, Erin Bell, R. Eric Cerny, Jaishree M. Chittoor-Vijayanath, Molian Deng, Michael D. Edgerton, Karen K. Gabbert, Barry S. Goldman, Brian Hauge, Steve He, Jacqueline E. Heard, Ping Li, Linda Lutfiyya, Bradley McDill, Robert J. Meister, Peter Morrell, Anil Neelam, Marie Petracek, John Pitkin, M. S. Rajani, Maria F. Rodriguez, Thomas Ruff, T. V. Venkatesh, Xiaoyun Wu, Jianmin Zhao, Albert Iandolino, Monica Ravanello, Kraig Brustad, Paul Chomet, Julie Davis, Virginia Ursin, T. Ambika, Shobha Char, Savitha Madappa, Dhanalakshmi Ramachandra, S. Sangeetha, K. R. Vidya, K. Vijayalakshmi, Todd Dezwaan
  • VECTORS AND METHODS FOR RECOMBINANT PROTEIN EXPRESSION
    Publication number: 20130273650
    Abstract: The present invention discloses a series of eukaryotic expression vectors utilizing the reduction of transcription read-through events to create stable and high-yield cell lines for recombinant protein expression. The vectors comprise more than one polyadenylation signal or one or more polyadenylation signals plus other DNA fragment which is known to enhance transcription termination to control the expression level of selection marker, with the configuration to transcribe the minimal level of full-length bicistronic mRNA to express the selection marker, which can be used to create stable cell lines at high expression levels, without the need for drug selection or drug mediated gene amplification.
    Type: Application
    Filed: July 26, 2011
    Publication date: October 17, 2013
    Applicant: ADV BIOLOGICS ,INC.
    Inventor: Xiaoyun Wu
  • PLANTS CONTAINING A HETEROLOGOUS FLAVOHEMOGLOBIN GENE AND METHODS OF USE THEREOF
    Publication number: 20120090051
    Abstract: Plant nitrogen use efficiency in corn has been improved by transformation with a flavohemoglobin gene. Plants comprising a flavohemoglobin gene have decreased nitric oxide (NO) levels, increased biomass accumulation under a sufficient nitrogen growth condition, and increased chlorophyll content under a limiting nitrogen growth condition. Additionally, these transformed plants evidence higher levels of yield.
    Type: Application
    Filed: October 4, 2010
    Publication date: April 12, 2012
    Inventors: Amarjit Basra, Mike Edgerton, Garrett J. Lee, Maolong Lu, Linda L. Lutfiyya, Wei Wu, Xiaoyun Wu
  • Indazole Compounds
    Publication number: 20120053345
    Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
    Type: Application
    Filed: August 4, 2011
    Publication date: March 1, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Anna M. Ericson, Andrew Burchat, Kristine E. Frank, David J. Calderwood, Lily K. Abbott, Maria A. Argiriadi, David W. Borhani, Kevin P. Cusack, Richard W. Dixon, Thomas D. Gordon, Kelly D. Mullen, Robert V. Talanian, Xiaoyun Wu, Xiaolei Zhang, Lu Wang, Biqin Li, Claude E. Barberis, Neil Wishart
  • Thienopyrroles and pyrrolothiazoles as new therapeutic agents
    Patent number: 8101645
    Abstract: The present invention is directed to novel compounds of Formula (I) wherein the variables are defined as herein. The compounds of Formula (I) are useful as CRTH2 antagonists and as such would be useful in treating certain conditions and diseases, especially asthma, allergic asthma, allergic inflammation, rhinitis, allergic rhinitis or atopic dermatitis.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: January 24, 2012
    Assignee: Abbott Laboratories
    Inventors: Dominique F. Bonafoux, Xiaoyun Wu
  • TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS
    Publication number: 20120005773
    Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced trait.
    Type: Application
    Filed: September 30, 2009
    Publication date: January 5, 2012
    Inventors: Eric D. Aasen, Mark Scott Abad, Edwards Allen, Thandoni Rao Ambika, Veena S. Anil, Alice Clara Augustine, Stephanie L. Back, Pranesh Badami, Amarjit Basra, Kraig L. Brustad, Molian Deng, Todd Dezwaan, Charles Dietrich, Stephen M. Duff, Karen K. Gabbert, Steve He, Bill L. Hendrix, Hongwu Jia, Vidya Kammaradi Ramanath Bhat, Hongwu Jia, Vidya Kammaradi Ramanath Bhat, Balasulojini Karunanandaa, Kevin R. Kosola, Kempagangaiah Krishnamurthy, Ganesh Kumar, Saritha V. Kuriakose, Shantala Lakkanna, Mark E. Leibman, Linda Lutfiyya, Savitha Madappa, Sivalinganna Manjunath, Robert J. Meister, Bellur Narasimba Prasad, Sasha Preuss, Qungang Qi, Dhanalakshmi Ramachandra, S. Sangeetha, Scott Saracco, Chitresh Sharma, Vijay K. Sharma, Rajani Monnanda Somaiah, Padmini Sudarshana, Rebecca L. Thompson-Mize, Srikanth Venkatachalayya, Tyamagondlu V. Venkatesh, Huai Wang, Jingrui Wu, Xiaoyun Wu, Xiaofeng Sean Yang, Qin Zeng, Jianmin Zhao
  • Fusion Protein Delivery System and Uses Thereof
    Publication number: 20110229964
    Abstract: The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition.
    Type: Application
    Filed: February 25, 2011
    Publication date: September 22, 2011
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: John C. Kappes, Xiaoyun Wu
  • Indazole compounds
    Patent number: 8008481
    Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: August 30, 2011
    Inventors: Anna M. Ericsson, Andrew Burchat, Kristine E. Frank, David J. Calderwood, Lily K. Abbott, Maria A. Argiriadi, David W. Borhani, Kevin P. Cusack, Richard W. Dixon, Thomas D. Gordon, Kelly D. Mullen, Robert V. Talanian, Xiaoyun Wu, Xiaolei Zhang, Lu Wang, Biqin Li, Claude E. Barberis, Neil Wishart