Patents by Inventor Xiyun Zhang

Xiyun Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • P450-BM3 variants with improved activity
    Patent number: 10100289
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: October 16, 2018
    Assignee: Codexis, Inc.
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Lactonase enzymes and methods of using same
    Patent number: 10081800
    Abstract: Novel lactonases are provided.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: September 25, 2018
    Assignee: Fornia BioSolutions, Inc.
    Inventors: Goutami Banerjee, Jie Yang, Khin Oo, Xiyun Zhang, Eric Lin Hu, Tatsuya Fukushima
  • G16 glucoamylase compositions and methods
    Patent number: 10053678
    Abstract: The invention is directed to novel glucoamylases.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: August 21, 2018
    Assignee: Fornia BioSolutions, Inc.
    Inventors: Xiyun Zhang, Jie Yang, Goutami Banerjee, Khin Oo, Yingxin Zhang
  • Imidazoyl anilide derivatives and methods of use
    Patent number: 10045987
    Abstract: The present invention provides kinase inhibitor analogs with improved properties, such as improved efficacy, pharmacokinetics, safety, and specificity. In some embodiments, the present invention provides nilotinib analogs that provide therapeutic benefits.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: August 14, 2018
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Jed Lee Hubbs, Xiyun Zhang, Robert Osborne
  • G24 glucoamylase compositions and methods
    Patent number: 10035997
    Abstract: The invention is directed to variant glucoamylases as compared to SEQ ID NO:1, including amino acid substitutions at positions including 24, 32, 47, 71, 75, 88, 102, 104, 114, 118, 190, 201, 204, 260, 228, 230, 269, 271, 272, 281, 283, 284, 285, 293, 350, 313, 321, 338, 343, 367, 371, 386, 372, 401, 408, 420, 448, 463, 483, 484, 507, 530, 563 599 and 605 that retain glucoamylase activity.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: July 31, 2018
    Assignee: Fornia BioSolutions, Inc.
    Inventors: Jie Yang, Goutami Banerjee, Xiyun Zhang, Khin Oo, Yingxin Zhang
  • Enone reductases
    Patent number: 10035988
    Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: July 31, 2018
    Assignee: Codexis, Inc.
    Inventors: Christopher K. Savile, Vesna Mitchell, Xiyun Zhang, Gjalt W. Huisman
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20180201911
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: March 6, 2018
    Publication date: July 19, 2018
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • PENICILLIN-G ACYLASES
    Publication number: 20180201919
    Abstract: The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
    Type: Application
    Filed: March 7, 2018
    Publication date: July 19, 2018
    Inventors: Goutami Banerjee, Jie Yang, Xiyun Zhang, Erika M. Milczek, Melissa Ann Mayo, Stephan Jenne
  • Penicillin-G acylases
    Patent number: 9944916
    Abstract: The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: April 17, 2018
    Assignee: Codexis, Inc.
    Inventors: Goutami Banerjee, Jie Yang, Xiyun Zhang, Erika M. Milczek, Melissa Ann Mayo, Stephan Jenne
  • Polynucleotides encoding transaminase polypeptides
    Patent number: 9944909
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: April 17, 2018
    Assignee: Codexis, Inc.
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • 2G16 GLUCOAMYLASE COMPOSITIONS AND METHODS
    Publication number: 20180037879
    Abstract: The invention is directed to novel glucoamylases.
    Type: Application
    Filed: December 15, 2016
    Publication date: February 8, 2018
    Inventors: Xiyun Zhang, Jie Yang, Goutami Banerjee, Khin Oo, Yingxin Zhang
  • G16 GLUCOAMYLASE COMPOSITIONS AND METHODS
    Publication number: 20180037878
    Abstract: The invention is directed to novel glucoamylases.
    Type: Application
    Filed: August 5, 2016
    Publication date: February 8, 2018
    Inventors: Xiyun Zhang, Jie Yang, Goutami Banerjee, Khin Oo, Yingxin Zhang
  • ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
    Publication number: 20180037880
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Application
    Filed: September 29, 2017
    Publication date: February 8, 2018
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • G24 GLUCOAMYLASE COMPOSITIONS AND METHODS
    Publication number: 20180023066
    Abstract: The invention is directed to variant glucoamylases as compared to SEQ ID NO:1, including amino acid substitutions at positions including 24, 32, 47, 71, 75, 88, 102, 104, 114, 118, 190, 201, 204, 260, 228, 230, 269, 271, 272, 281, 283, 284, 285, 293, 350, 313, 321, 338, 343, 367, 371, 386, 372, 401, 408, 420, 448, 463, 483, 484, 507, 530, 563 599 and 605 that retain glucoamylase activity.
    Type: Application
    Filed: July 21, 2016
    Publication date: January 25, 2018
    Inventors: Jie Yang, Goutami Banerjee, Xiyun Zhang, Khin Oo, Yingxin Zhang
  • ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
    Publication number: 20180016568
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Application
    Filed: September 29, 2017
    Publication date: January 18, 2018
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • NOVEL PHYTASES AND USES THEREOF
    Publication number: 20180002680
    Abstract: The present invention relates to variant phytase enzymes and their use thereof.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 4, 2018
    Inventors: Goutami Banerjee, Khin Oo, Xiyun Zhang, Jie Yang, Yingxin Zhang
  • HUMAN ALPHA-GALACTOSIDASE VARIANTS
    Publication number: 20170360900
    Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH <4.5) and basic (pH >7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
    Type: Application
    Filed: December 2, 2015
    Publication date: December 21, 2017
    Inventors: Nicholas J. Agard, Mathew G. Miller, Xiyun Zhang, Gjalt W. Huisman
  • BIOCATALYSTS AND METHODS FOR HYDROXYLATION OF CHEMICAL COMPOUNDS
    Publication number: 20170355968
    Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
    Type: Application
    Filed: April 19, 2017
    Publication date: December 14, 2017
    Inventors: Jovana Nazor, Robert Osborne, Jack Liang, Jonathan Vroom, Xiyun Zhang, David Entwistle, Rama Voladri, Ravi David Garcia, Jeffrey C. Moore, Shane Grosser, Birgit Kosjek, Matthew Truppo
  • N-SUBSTITUTED 4-AMINOQUINAZOLINE DERIVATIVES AND METHODS OF USE
    Publication number: 20170334886
    Abstract: The present invention provides kinase inhibitor analogs with improved properties, such as improved efficacy, pharmacokinetics, safety, and specificity. In some embodiments, the present invention provides lapatinib analogs that provide therapeutic benefits.
    Type: Application
    Filed: August 27, 2015
    Publication date: November 23, 2017
    Applicant: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Jed Lee Hubbs, Xiyun Zhang, Robert Osborne
  • IMIDAZOYL ANILIDE DERIVATIVES AND METHODS OF USE
    Publication number: 20170273978
    Abstract: The present invention provides kinase inhibitor analogs with improved properties, such as improved efficacy, pharmacokinetics, safety, and specificity. In some embodiments, the present invention provides nilotinib analogs that provide therapeutic benefits.
    Type: Application
    Filed: August 27, 2015
    Publication date: September 28, 2017
    Inventors: Gjalt W. Huisman, Jed Lee Hubbs, Xiyun Zhang, Robert Osborne