Patents by Inventor Xiyun Zhang

Xiyun Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
    Publication number: 20170275598
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Application
    Filed: June 9, 2017
    Publication date: September 28, 2017
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Pentose fermentation by a recombinant microorganism
    Patent number: 9752171
    Abstract: The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: September 5, 2017
    Assignee: Codexis, Inc.
    Inventors: Ezhilkani Subbian, Xiyun Zhang, Benjamin N. Mijts, Catherine M. Cho
  • NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
    Publication number: 20170247667
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Application
    Filed: May 10, 2017
    Publication date: August 31, 2017
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • P450-BM3 variants with improved activity
    Patent number: 9708587
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: July 18, 2017
    Assignee: Codexis, Inc.
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
    Publication number: 20170191050
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Application
    Filed: February 13, 2017
    Publication date: July 6, 2017
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • ENONE REDUCTASES
    Publication number: 20170175087
    Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
    Type: Application
    Filed: February 27, 2017
    Publication date: June 22, 2017
    Inventors: Christopher K. Savile, Vesna Mitchell, Xiyun Zhang, Gjalt W. Huisman
  • P450-BM3 variants with improved activity
    Patent number: 9683220
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: June 20, 2017
    Assignee: Codexis, Inc.
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • ENGINEERED TYROSINE AMMONIA LYASE
    Publication number: 20170159038
    Abstract: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
    Type: Application
    Filed: February 14, 2017
    Publication date: June 8, 2017
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, David Elgart, Xiyun Zhang
  • GH61 GLYCOSIDE HYDROLASE PROTEIN VARIANTS AND COFACTORS THAT ENHANCE GH61 ACTIVITY
    Publication number: 20170159035
    Abstract: The present invention provides various GH61 protein variants comprising various amino acid substitutions. The GH61 protein variants have an improved ability to synergize with cellulase enzymes, thereby increasing the yield of fermentable sugars obtained by saccharification of biomass. In some embodiments, sugars obtained from saccharification are fermented to produce numerous end-products, including but not limited to alcohol.
    Type: Application
    Filed: February 16, 2017
    Publication date: June 8, 2017
    Inventors: Jie Yang, Xiyun Zhang, Jungjoo Yoon, Kripa K. Rao, John H. Grate, David M. Elgart, Dipnath Baidyaroy
  • 2G16 glucoamylase compositions and methods
    Patent number: 9670472
    Abstract: The invention is directed to novel glucoamylases.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: June 6, 2017
    Assignee: FORNIA BIOSOLUTIONS, INC
    Inventors: Jie Yang, Goutami Banerjee, Khin Oo, Xiyun Zhang
  • Synthesis of prazole compounds
    Patent number: 9631181
    Abstract: The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: April 25, 2017
    Assignee: Codexis, Inc.
    Inventors: Yong Koy Bong, Michael D. Clay, Steven J. Collier, Benjamin Mijts, Michael Vogel, Xiyun Zhang, Jun Zhu, Jovana Nazor, Derek J. Smith, Shiwei Song
  • Enone reductases
    Patent number: 9617568
    Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: April 11, 2017
    Assignee: Codexis, Inc.
    Inventors: Christopher K. Savile, Vesna Mitchell, Xiyun Zhang, Gjalt W. Huisman
  • Endoglucanase 1B (EG1B) variants
    Patent number: 9611462
    Abstract: The present invention provides endoglucanase 1b (EG1b) variants suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce EG1b variants, as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: April 4, 2017
    Assignee: Codexis, Inc.
    Inventors: Ee Lui Ang, Ellen D. Eberhard, Xiyun Zhang, Wei Zhang, Jing Tian, Derek J. Smith, Vesna Mitchell
  • Engineered phenylalanine ammonia lyase polypeptides
    Patent number: 9611468
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: April 4, 2017
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • Engineered tyrosine ammonia lyase
    Patent number: 9605252
    Abstract: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: March 28, 2017
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, David Elgart, Xiyun Zhang
  • Phytases and uses thereof
    Patent number: 9605245
    Abstract: The present invention relates to variant phytase enzymes and their use thereof.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: March 28, 2017
    Assignee: Fornia BioSoultions, Inc.
    Inventors: Goutami Banerjee, Khin Oo, Xiyun Zhang, Jie Yang, Yingxin Zhang
  • G16 glucoamylase compositions and methods
    Patent number: 9598680
    Abstract: The invention is directed to novel glucoamylases.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: March 21, 2017
    Assignee: Fornia Biosolutions, Inc.
    Inventors: Xiyun Zhang, Jie Yang, Goutami Banerjee, Khin Oo, Yingxin Zhang
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20170073651
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: November 2, 2016
    Publication date: March 16, 2017
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
    Publication number: 20170009213
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Application
    Filed: June 2, 2016
    Publication date: January 12, 2017
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Phytases and uses thereof
    Patent number: 9528096
    Abstract: The present invention relates to variant phytase enzymes and their use thereof.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: December 27, 2016
    Assignee: FORNIA BIOSOLUTIONS, INC.
    Inventors: Goutami Banerjee, Khin Oo, Xiyun Zhang, Jie Yang, Yingxin Zhang