Abstract: Methods for designing heterobifunctional small molecules which selectively degrade/disrupt CDK4/6 and compositions and methods of using such degraders/disruptors to treat CDK4/6-mediated cancer are provided.

Abstract: An audio data recovery method, an audio data recovery device and a Bluetooth device are provided in the present invention. The audio data recovery method comprises: receiving a plurality of audio data packets each comprising M segments of frame data and M CRC codes each corresponding to one of the M segments of frame data; and recovering one audio data packet according to the segments of frame data and the CRC codes in N audio data packets received incorrectly N times for the same audio data.

Abstract: An audio data recovery method, an audio data recovery device and a Bluetooth device are described in the present invention. The audio data recovery method comprises: receiving audio data in time domain, the audio data including a first type of data and a second type of data; transforming the audio data from the time domain into frequency domain to produce transformed first type of data and transformed second type of data; performing packet loss concealment estimation on the transformed second type of data to generate estimated second type of data in the frequency domain; transforming inversely the transformed first type of data together with the estimated second type of data from the frequency domain to the time domain; and obtaining recovered audio data in the time domain according to the first type of data in the audio data in the time domain and the estimated second type of data in the time domain.

Abstract: An audio data recovery method, an audio data recovery device and a Bluetooth device are described. The audio data recovery method comprises: dividing audio data into a first frequency domain component and a second frequency domain component in a frequency domain; using a second data recovery algorithm to recover the audio data in the second frequency domain component; and using a first data recovery algorithm with lower complexity than the second data recovery algorithm to recover the audio data in the first frequency domain component.

Abstract: A lighting device (10) is disclosed comprising a glass housing (20) delimiting an optical chamber (21), wherein at least one solid state lighting (SSL) element (30) is mounted within the optical chamber. The optical chamber (21) further comprises a light exit window (50) mounted in an aperture (23) of the optical chamber opposite the at least one solid state lighting element, the light exit window comprising a sealing plate sealed to the glass housing by a glass seal (51); and a light-transmissive thermal barrier (40) extending across the optical chamber in between the sealing plate and the at least one solid state lighting element, which protects the at least one SSL element (30) from thermal damage during the formation of the glass seal (51). Also disclosed are a luminaire including such a lighting device and a method of manufacturing such a lighting device.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing a joint simulation for satisfying multiple different coexisting commitments to allocate digital resources. In one aspect, a method includes accessing logged data for prior allocations of digital resources, where the logged data includes at least one property associated with respective allocations of the digital resources. Different allocations of the digital resources included in the logged data are assigned to different ones of the multiple different commitments. For each commitment to allocate digital resources, an expected required resource amount that results in the commitment being allocated at least a specified minimum resource based on the allocations of digital resources of the logged data that were assigned to the multiple different commitments is determined.

Abstract: The present subject matter relates to a voxel and methods of organizing an object into a three-dimensional (3D) array using the voxel. The voxel can include a plurality of frames including at least one single stranded (ss) DNA motif with at least one free base, wherein the at least one ssDNA motif hybridizes with a complementary strand fragment of other frames.

Abstract: A lighting device (10) is disclosed comprising a glass housing (20) delimiting an optical chamber (21), wherein at least one solid state lighting (SSL) element (30) is mounted within the optical chamber. The optical chamber (21) further comprises a light exit window (50) mounted in an aperture (23) of the optical chamber opposite the at least one solid state lighting element, the light exit window comprising a sealing plate sealed to the glass housing by a glass seal (51); and a light-transmissive thermal barrier (40) extending across the optical chamber in between the sealing plate and the at least one solid state lighting element, which protects the at least one SSL element (30) from thermal damage during the formation of the glass seal (51). Also disclosed are a luminaire including such a lighting device and a method of manufacturing such a lighting device.

Abstract: A dialog generation method, apparatus, and device, and a storage medium are provided. The method includes converting each term in a Kth round of a query sentence into a first word vector, and calculating a positive latent vector and a negative latent vector of each term according to the first word vector, where K denotes a positive integer greater than or equal to 2. A content topic of the Kth round of the query sentence is obtained, and converted into a second word vector. An initial latent vector output for the Kth round of the query sentence is determined according to the second word vector, the positive latent vector of a last term in the Kth round of the query sentence, a latent vector of a last term in a (K-1)th round of a reply sentence output for a (K-1)th round of the query sentence, and an initial latent vector of the (K-1)th round of the reply sentence output for the (K-1)th round of the query sentence.

Abstract: A lighting device or a lamp bulb (100, 200) with a smooth appearance comprises at least one light source (101); a heat sink component (104, 204), having a bottom (1043) and a side wall (1044) extending from the bottom (1044), wherein the bottom (1043) comprises a protrusion (1041) and wherein the at least one light source (101) thermally contacts the protrusion (1041) of the heat sink component (104, 204); and a cover provided on the sidewall (1044) opposite to the bottom (1043), thereby defining an air chamber (1051, 2051) between the cover, the side wall (1044), the bottom (1043) and the protrusion (1041).

Abstract: Methods for designing heterobifunctional small molecules which selectively degrade/disrupt CDK4/6 and compositions and methods of using such degraders/disruptors to treat CDK4/6-mediated cancer are provided.

Abstract: A lighting device or a lamp bulb (100, 200) with a smooth appearance comprises at least one light source (101); a heat sink component (104, 204), having a bottom (1043) and a side wall (1044) extending from the bottom (1044), wherein the bottom (1043) comprises a protrusion (1041) and wherein the at least one light source (101) thermally contacts the protrusion (1041) of the heat sink component (104, 204); and a cover provided on the sidewall (1044) opposite to the bottom(1043), thereby defining an air chamber (1051, 2051) between the cover, the side wall (1044), the bottom (1043) and the protrusion (1041).

Abstract: A non-methane total hydrocarbons analysis apparatus and method are introduced. The analysis apparatus includes a six-pass valve, quantification ring, first stored gas pipe, second stored gas pipe, multi-pass valve, molecular sieve filling pipe, first air source, and detector. The six-pass valve and the multi-pass valve are configured to have a load status bit. A gas under test passes through the molecular sieve to remove non-methane total hydrocarbons such that the treated gas functions as a background gas for filling the first stored gas pipe and the second stored gas pipe. The six-pass valve and the multi-pass valve are configured to have an entered sample status bit such that zero-grade compressed air drives the gas inside the second stored gas pipe, quantification ring, and first stored gas pipe to enter the detector. The background gas inside the second stored gas pipe and the second stored gas pipe provides a baseline.

Abstract: A lighting device or a lamp bulb (100, 200) with a smooth appearance comprises at least one light source (101); a heat sink component (104, 204), having a bottom (1043) and a side wall (1044) extending from the bottom (1044), wherein the bottom (1043) comprises a protrusion (1041) and wherein the at least one light source (101) thermally contacts the protrusion (1041) of the heat sink component (104, 204); and a cover provided on the sidewall (1044) opposite to the bottom(1043), thereby defining an air chamber (1051, 2051) between the cover, the side wall (1044), the bottom (1043) and the protrusion (1041).

Abstract: Devices and methods are provided for processing network nodes. For example, a sorting request is detected; one or more first network nodes to be sorted are acquired corresponding to the sorting request; a first characteristic matrix is constructed based on at least information associated with the first network nodes; association information between the first network nodes is acquired; a sparse matrix is constructed based on at least information associated with the association information between the first network nodes; iterative multiplication is performed on the sparse matrix and the first characteristic matrix to obtain a second characteristic matrix upon convergence; and the first network nodes are sorted based on at least information associated with the second characteristic matrix.

Abstract: A lamp (10) for replacement of a HPS or HID lamp, is disclosed that comprises a support element (13) including a mounting shaft (15) extending therefrom, said mounting shaft being substantially parallel and having lateral displacement relative to a central axis of the lamp and a plurality of modules (20) each comprising a heat spreading element (23) wherein at least one module is mounted on the mounting shaft and is rotatable about the mounting shaft such that said at least one module can be pivoted between a first orientation in which the modules cooperate to define a closed structure; and a second orientation in which the at least one module is pivoted away from at least one neighboring module to define an opened structure.

Abstract: Various embodiments of the present application provide a lamp device, an LED lamp, and a luminaire. The lamp device according to the embodiments of the present utility mode comprises: a lamp cap having a central pin (21, 211) for providing an electrical connection to the lamp device; and a printed circuit board at least partially located within the lamp cap, wherein a lamp driver (12) is mounted on the printed circuit board; characterized in that a bottom edge of said printed circuit board includes a notch (16, 161) comprising a first contact electrically contacting said central pin. The lamp device according to the present application improves the assembly of the lamp device and enhances the production efficiency.

Abstract: A dialog generation method, apparatus, and device, and a storage medium are provided. The method includes converting each term in a Kth round of a query sentence into a first word vector, and calculating a positive latent vector and a negative latent vector of each term according to the first word vector, where K denotes a positive integer greater than or equal to 2. A content topic of the Kth round of the query sentence is obtained, and converted into a second word vector. An initial latent vector output for the Kth round of the query sentence is determined according to the second word vector, the positive latent vector of a last term in the Kth round of the query sentence, a latent vector of a last term in a (K?1)th round of a reply sentence output for a (K?1)th round of the query sentence, and an initial latent vector of the (K?1)th round of the reply sentence output for the (K?1)th round of the query sentence.

Abstract: A hot beverage maker is provided that has a water tank, a boiler, a dispensing device, a water outlet pipe and a control device. The control device of the hot beverage maker has a mechanical configuration that includes a rotatable cam provided inside the case of the hot beverage maker. The cam has bumps arranged in, for example, three circles about a periphery of the cam. Spring leaves are arranged to interact with the cam bumps. The spring leaves are electrically connected to control aspects of the hot beverage maker while the rotational position of the cam also controls other aspects of the hot beverage maker.