Patents by Inventor Zhong Zheng

Zhong Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200270311
    Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: May 8, 2020
    Publication date: August 27, 2020
    Inventors: Richard E. Lee, Ying Zhao, Elizabeth Griffith, Zhong Zheng, Aman P. Singh
  • Patent number: 10729747
    Abstract: The present invention discloses methods and compositions for treating or ameliorating a condition associated with increased or decreased myofibroblast activities and use thereof.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: B. Chia Soo, Kang Ting, Zhong Zheng
  • Publication number: 20200243698
    Abstract: A photoelectric detector, which includes a substrate, a MoS2 semiconductor layer, an electrical signal detector, a first electrode and a second electrode. Said MoS2 semiconductor layer is located on the substrate, with the first electrode and the second electrode spaced from each other and electrically connected to the MoS2 semiconductor layer respectively. The electrical signal detector is configured to detect changes in electrical properties of the MoS2 semiconductor layer, and the material of the MoS2 semiconductor layer is amorphous MoS2 sheet.
    Type: Application
    Filed: December 13, 2019
    Publication date: July 30, 2020
    Inventors: ZHONG-ZHENG HUANG, TIAN-FU ZHANG, XIAO-YANG XIAO, JIE ZHAO, QUN-QING LI, SHOU-SHAN FAN
  • Patent number: 10716878
    Abstract: Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. Silver nanoparticle/poly(DL-lactic-co-glycolic acid) (PLGA)-coated stainless steel alloy (SNPSA) was evaluated as a potential antimicrobial implant material. It was found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. The results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: July 21, 2020
    Assignee: The Regents of the University of California
    Inventors: B. Chia Soo, Kang Ting, Zhong Zheng
  • Publication number: 20200206846
    Abstract: A method for making an infrared light absorber is provided, and the method includes following steps: providing a first carbon nanotube array on a substrate; truncating the carbon nanotube array by irradiating a top surface of the carbon nanotube array by a laser beam in two directions, the top surface being away from the substrate, wherein the two directions being at an angle, the angle is in a range of 30 degrees to 90 degrees.
    Type: Application
    Filed: December 9, 2019
    Publication date: July 2, 2020
    Inventors: YING-CHENG WANG, ZHONG-ZHENG HUANG, YUAN-HAO JIN, QUN-QING LI, SHOU-SHAN FAN
  • Publication number: 20200209067
    Abstract: An infrared detector is provided, and the infrared detector includes: a thermoelectric element; an infrared light absorber, located on and in contact with the thermoelectric element, and configured to absorb infrared light and convert infrared light into heat; an electrical signal detector, electrically connected to the thermoelectric element and configured to detect a change in electrical performance of the thermoelectric element; wherein the infrared light absorber includes a carbon nanotube array, the carbon nanotube array includes a plurality of carbon nanotubes, a height of the plurality of carbon nanotubes are substantially the same, and the plurality of carbon nanotubes are perpendicular to the thermoelectric element.
    Type: Application
    Filed: December 9, 2019
    Publication date: July 2, 2020
    Inventors: YING-CHENG WANG, ZHONG-ZHENG HUANG, YUAN-HAO JIN, QUN-QING LI, SHOU-SHAN FAN
  • Publication number: 20200212249
    Abstract: A method for making an infrared light absorber is provided, and the method includes following steps: providing a carbon nanotube array on a substrate; truncating the carbon nanotube array by dry etching a top surface of the carbon nanotube array, the top surface being away from the substrate, the carbon nanotube array comprises a plurality of carbon nanotubes substantially parallel with each other, the plurality of carbon nanotubes in the carbon nanotube array are truncated to a height in a range of 100 micrometers to 300 micrometers.
    Type: Application
    Filed: December 9, 2019
    Publication date: July 2, 2020
    Inventors: YING-CHENG WANG, ZHONG-ZHENG HUANG, YUAN-HAO JIN, QUN-QING LI, SHOU-SHAN FAN
  • Publication number: 20200180269
    Abstract: A method for making a graphene adhesive film includes the following steps: growing a graphene on a growth substrate, wherein the material of the growth substrate is copper; depositing an adhesive layer on a surface of the graphene away from the growth substrate, to form an adhesive/graphene/growth substrate composite structure; and removing the growth substrate from the adhesive/graphene/growth substrate composite structure with an etching solution, wherein the etching solution is a mixture of hydrogen peroxide, hydrochloric acid, and deionized water.
    Type: Application
    Filed: March 12, 2019
    Publication date: June 11, 2020
    Inventors: TIAN-FU ZHANG, ZHONG-ZHENG HUANG, XIAO-YANG XIAO, YING-CHENG WANG, QUN-QING LI, SHOU-SHAN FAN
  • Patent number: 10676510
    Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the C1pP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: June 9, 2020
    Assignee: St. Jude Children's Research Hospital
    Inventors: Richard E. Lee, Ying Zhao, Elizabeth Griffith, Zhong Zheng, Aman P. Singh
  • Publication number: 20190321445
    Abstract: The present invention discloses methods and compositions for treating or ameliorating a condition associated with increased or decreased myofibroblast activities and use thereof.
    Type: Application
    Filed: May 7, 2019
    Publication date: October 24, 2019
    Inventors: B. Chia Soo, Kang Ting, Zhong Zheng
  • Publication number: 20190205124
    Abstract: A comment quality system for improving comments for source code includes a processor and memory. An operating system is executed by the processor and memory. A comment quality application, executed by the processor and memory, is configured to receive data relating to a number of source code comments that are associated with source code developed in a code developer application, generate a desired number of comments based on an estimated quality of comments for a code developer and a number of reviewers of the source code, and send feedback to the code developer application based on the desired number of comments for the source code and the number of source code comments.
    Type: Application
    Filed: September 8, 2016
    Publication date: July 4, 2019
    Inventors: Liya FAN, Haibo LIN, Zhong ZHENG
  • Patent number: 10279010
    Abstract: The present invention discloses methods and compositions for treating or ameliorating a condition associated with increased or decreased myofibroblast activities and use thereof.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: May 7, 2019
    Assignee: The Regents of the University of California
    Inventors: B. Chia Soo, Kang Ting, Zhong Zheng
  • Patent number: 10266544
    Abstract: The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: April 23, 2019
    Assignee: St. Jude Children's Research Hospital, Inc.
    Inventors: Richard E. Lee, Samanthi L. Waidyarachchi, David F. Bruhn, Jiuyu Liu, Zhong Zheng, Jason W. Rosch
  • Patent number: 10262054
    Abstract: The upgrading of a relational database on multiple of machines (e.g., a service) that perform data operations via stored procedures. The upgrade occurs without changing the functionality of the set of one or more stored procedures. Accordingly, even if the machine itself is not upgraded, the machines can still interface with the database via the set of one or more stored procedures. The upgrade of the relational database occurs by adding occur by adding new table(s) to the relational database, and thereafter adding new stored procedures to the stored procedure store, the new stored procedures referencing parameters of the new tables. Since the machines that interface with the relational database can still operate on the upgraded database using the old stored procedures, each machine may then be upgraded in an orderly manner to interface with the new stored procedures.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: April 16, 2019
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Zhong Zheng, Haibo Lin, Silan Wang
  • Patent number: 10190097
    Abstract: The present invention provides a method of forming a fibromodulin (FMOD) reprogrammed (FReP) cell. The method comprises steps of treating a human cell with a cell culture medium comprising fibromodulin (FMOD) for a period ranging from a day to a month, and changing the cell culture medium regularly until a FMOD reprogrammed (FreP) cell forms; wherein the FreP cell expresses NANOG and does not form teratoma, and wherein the human cell is a fibroblastic cell.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: January 29, 2019
    Assignee: The Regents of the University of California
    Inventors: B. Chia Soo, Kang Ting, Zhong Zheng
  • Publication number: 20180323656
    Abstract: A passive tag transponder circuit comprising a receive antenna, reflect antenna, and rectifier network. The receive antenna can be configured to receive an ambient RF signal having a frequency of fc, or, a backscattered RF signal having a frequency of 2fc. The reflect antenna can be configured to receive a rectified output signal from the rectifier network, the rectified output signal having a frequency of 2fc. The reflect antenna can be configured to send a backscattered signal at the frequency of 2fc. The rectifier network can be connected to receive an input corresponding to the ambient RF from the receive antenna and send the rectified output to the reflect antenna.
    Type: Application
    Filed: April 23, 2018
    Publication date: November 8, 2018
    Inventors: Zygmunt Haas, Zhong Zheng
  • Publication number: 20180127469
    Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: January 5, 2018
    Publication date: May 10, 2018
    Inventors: Richard E. Lee, Ying Zhao, Elizabeth Griffith, Zhong Zheng, Aman P. Singh
  • Patent number: 9885014
    Abstract: The present invention provides pluripotent stem cell like (PSCL) cells or clones, a culture medium therefore, and a supernatant thereof, and methods of making and using the same.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: February 6, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kang Ting, B. Chia Soo, Zhong Zheng
  • Patent number: 9879050
    Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: August 30, 2014
    Date of Patent: January 30, 2018
    Assignee: St. Jude Children's Research Hospital
    Inventors: Richard E. Lee, Ying Zhao, Elizabeth Griffith, Zhong Zheng, Aman P. Singh
  • Publication number: 20170333528
    Abstract: The present invention discloses methods and compositions for treating or ameliorating a condition associated with increased or decreased myofibroblast activities and use thereof
    Type: Application
    Filed: August 10, 2017
    Publication date: November 23, 2017
    Inventors: B. Chia SOO, Kang TING, Zhong ZHENG