Abstract: A fluid dispenser device comprising a body (10) provided with a dispenser orifice (15), said device further comprising: an elongate flexible strip (20) supporting a plurality of reservoirs (21) each containing a dose of fluid; reservoir-opening means (80) for opening a respective reservoir on each actuation; first displacement means (30) that can be actuated so as to cause said flexible strip (20) to advance before and/or during and/or after each actuation, so as to bring a full reservoir into register with said reservoir-opening means; and second displacement means (50) for displacing a full reservoir (21) against said opening means (80) each time the device is actuated, the leading end (25) of said flexible strip (20), in the advance direction of said strip, being fastened to a receiver element (500) that is rotatably mounted, said receiver element (500) being adapted to exert a traction force on said elongate strip (20), said device including an abutment element (5000) that is disposed between said first d

Abstract: A medicament dispenser for use with at least one medicament carrier carrying multiple distinct medicament portions, said medicament dispenser comprising (a) a dispensing mechanism actuable for dispensing the distinct medicament portions carried by the at least one medicament carrier; (b) a mouthpiece; and (c) a cover for the mouthpiece, the cover being movably mounted to the dispenser for sequential movement from a first position, in which the mouthpiece is covered, to a second position, in which the mouthpiece is at least part-uncovered, to a third position in which the mouthpiece is uncovered; wherein the cover is adapted to couple with the dispensing mechanism such that movement of the cover from the second position to the third position, but not the first position to the second position, results in actuation of the dispensing mechanism.

Abstract: An inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. A flexible guiding element receives the used blisters strip.

Abstract: A fluid dispenser device comprising: at least one predosed reservoir (10) that is hermetically sealed and that contains a single dose of powder; an expulsion channel (20) that is terminated by a mouthpiece; and a reservoir opening system (30), each reservoir (10) including a closure layer (12) that is suitable for being pierced and/or torn by said opening system (30) so as to enable the powder that is contained in said reservoir (10) to be expelled through said expulsion channel (20), said reservoir opening system (30) comprising at least two piercer elements (31) that are actuated so as to create at least two distinct openings (25, 26) in said closure layer (12), forming at least one inlet passage (25) for the flow of gas, in particular air, and at least one outlet passage (26) for the powder entrained by said flow of gas, and said device including an inhalation trigger system (50) that creates a flow of gas in said expulsion channel (20) only when a user inhales at or above a predetermined inhalation thresh

Abstract: An inhalation device comprising a base having a slot for insertion of a single blister containing a dose of medicament to be inhaled into the base is disclosed. The inhaler has a mouthpiece pivotably mounted to the base which carries a blister piercing element operable to pierce a blister received in said slot when the mouthpiece is pivoted relative to the base. When a user inhales on the mouthpiece, the dose is entrained in an airflow and flows out of the blister through the mouthpiece and into the user's airway.

Abstract: An atomizing device (1), an inhaler and a method for dispensing a liquid formulation (5) are proposed. An insert (2) comprises a cylinder (4) filled with the liquid, an atomizing nozzle (7) and a piston (6). The piston is moved in the cylinder to pressurize the liquid and force it out of cylinder through the atomizing nozzle in order to generate a spray (13). The insert is received in a holder (3) which is sealed. The insert is moved within the holder so that the sealing (9) is ruptured before the spray is generated.

Abstract: An inhaler (1) is proposed for delivering a preferably powdered formulation from a blister strip (3) having a plurality of blister pockets (4). The inhaler comprises a life span blocking device (31) which blocks opening of a cover (15) of the inhaler in a blocking state by means of locking element (39) interlocking the cover with a housing (19) of the inhaler.

Abstract: An inhaler is disclosed. It comprises a housing to receive a strip having a plurality of blisters, each blister having a breachable lid and containing a dose of medicament for inhalation by a user, an indexing wheel mounted in the housing rotatable to drive a strip to sequentially move blisters into alignment with a blister piercing member, a control element pivotally mounted to the housing and a drive mechanism configured to couple the control element to the indexing wheel during part of the rotation of the control element by a user so that the indexing wheel rotates together with the control element.

Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

Abstract: The present invention provides for elements of an improved drug or medicine dispersion and delivery system. The dispersion methods employ curved surfaces to impart rotational motions to one or more fluid flows from a pressurized container to create turbulence and improve mixing of medicament with fluid.

Abstract: Disclosed is an inhaler and a method for using the inhaler for the inhalation of a formulation from a carrier. The carrier contains the formulation in a receptacle and is set oscillating by an air current. An improved or defined delivery and nebulisation of the preferably powdered formulation is made possible by the fact that the carrier is set oscillating in defined manner, the formulation is dispensed through a cover element having three to five holes and/or the air current flows onto a fin associated with the carrier and flows past at least substantially only one flat side of the carrier.

Abstract: A dry powder inhaler comprises a disc-shaped assembly (14) having cavities (16) filled with medicament powder for inhalation. The assembly is rotatably mounted in a housing (6, 8) on which is mounted a rotatable external casing (11, 12). A mouthpiece (10) is movably mounted on the housing (6, 8) allowing it to be brought into and out of engagement with the edge of the disc (14) whereby the mouthpiece acts as a brake to prevent or permit rotational movement of the disc (14). The inhaler is opened by rotating the housing with respect to the casing (11, 12) to expose the mouthpiece (10). As the inhaler is opened and closed, cam followers (105) on the mouthpiece move along cam tracks (109) in the casing (11, 12), causing the mouthpiece to move against or away from the disc (14). A gap is defined between the disc and mouthpiece to allow a flow of bypass air to enter the mouthpiece.

Abstract: A dry powder inhaler for pulmonary or nasal use, employing capsules containing a dose of powder for inhalation, comprising two operating components and an optional cover. Air is drawn by the patient via a mouthpiece or nosepiece which is in communication with the capsule and travels via air paths through the device and through the capsule thereby dispersing and entraining the dose of powder. The capsule is cut by cutting means located on one of the components, in a manner which eliminates or minimizes capsule debris and minimizes powder leakage during use. The inhaler body and capsule cutting blades comprise a single operating component and they may be manufactured in a single unitary step. The invention affords a very economical and simple device for the delivery of pulmonary medicines.

Abstract: A fluid dispenser device comprising: a body (10); a plurality of individual reservoirs (21) each containing a dose of fluid, such as powder, said reservoirs being disposed one behind another on an elongate flexible strip (20); reservoir-opening means (80) comprising a perforator element that is stationary relative to the body; first strip displacement means (30) for causing the elongate flexible strip (20) to advance before and/or after each actuation of the device; and second reservoir-displacement means (50) for displacing a full reservoir (21) against said perforator element for opening said reservoir, said first displacement means including an indexer wheel (30) that is rotatably mounted on said second displacement means (50) and provided with at least one cavity (31) that is adapted to receive a respective reservoir, turning said indexer wheel (30) and thus causing said elongate flexible strip (20) to advance, said first displacement means include an actuator member (3000) that is disposed in coaxial man

Abstract: Dry powder inhalers include radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.

Abstract: An inhaler for delivery of a powder-form inhalation formulation from a blister strip has a plurality of blister pockets and uses a pivotable mouthpiece cover to move the blister strip onward via a conveyor, wherein the mouthpiece cover is drivingly coupled with the conveyor by engaging an axle in a recess to drive a conveying wheel.

Abstract: The present invention relates to capsules for housing pharmaceutical preparations for powder inhalers with increased medicinal product safety and capsules for pharmaceutical preparations for powder inhalers with improved adaption to use in powder inhalers. The capsules consist of non-water-soluble, hydrophobic plastics, which themselves do not substantially influence the pharmaceutical quality of the contents, but improve the usability of the filled capsules in respect of their operation, the period of use and/or the geographical location of their use and are advantageous in various steps from manufacture to use.

Abstract: Nebulizer ampoules are labelled by laser-marking or laser-engraving data on a film to produce a data film and affixing the film onto a nebulizer ampoule using a non-migratory adhesive.

Abstract: Dry powder inhalers with rotatable piercing mechanisms facilitate the use of dose container assemblies having dose containers arranged in concentric rows. A piercing mechanism is operably associated with the dose container assembly and is configured to pierce sealants that seal a dose container. The piercing mechanism is rotatable such that it can serially alternate between the two rows of dose containers. The piercing mechanism includes a rotatable drum, an elongate piercing member, and a biasing member operably associated with the piercing member. The rotatable drum has an open end, an opposite closed end, and a cylindrical wall that extends from the closed end and terminates at the open end. The closed end includes an aperture formed therein in a location adjacent to the wall. The elongate piercing member is extended and retracted through the aperture to pierce the sealants of a dose container.

Abstract: A delivery device that includes a cutter for opening a barrier layer to provide fluid access to a dose chamber, and a diverting structure for direct air flow toward the dose chamber.

Abstract: A fluid dispenser device comprising: a body (10); at least one individual reservoir (21); movable support means (50) that receive at least one reservoir (21), and that are displaceable between a non-dispensing position and a dispensing position; reservoir-opening means (80) for opening a reservoir when said opening means are actuated; loading means (800) for urging said movable support means towards said dispensing position; blocking means (100) for retaining said movable support means in the non-dispensing position; and inhalation trigger means (60); said blocking means (100) comprising a blocking element (110) that is movable between a blocking position and an unblocking position, said blocking element (110) co-operating with a projection (501) that is secured to movable support means (50).

Abstract: A method and capsular medication delivery and inhalation device is used with a medication capsule. The capsule is free-standing in a capsule chamber and not secured in a fixed position. The capsule is moved with a moveable back wall and other cooperative structure into an opener which releases the medication inside the capsule. The device may include an aerosol stream for facilitating medication delivery. The device works with capsules of varying sizes and shapes.

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

Abstract: The invention relates to an inhaler (1) comprising a capsule housing (2) for containing a medicament capsule (4). The inhaler includes an airflow path (6) through which air flows during an airflow event from at least one air inlet (8) to an outlet (10), the airflow path passing through the capsule housing. There is a first sensor (16), a processor (18) and a power source (20) for powering the processor. The capsule housing is defined by at least one wall (22) and configured such that when a capsule is located in the capsule housing and sufficient air flows along the airflow path through the capsule housing, the capsule moves within the capsule housing. The first sensor is arranged on the inhaler so that it is able to detect the movement of the capsule within the capsule housing and generate a first signal indicative of said movement.

Abstract: The present invention relates to the use of a container, made of an inorganic additive containing plastic material, for reducing physical/chemical interaction between the container and an oil, fat and/or wax containing formulation contained therein.

Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

Abstract: The invention relates to a medicament magazine with a plurality of doses of medicament, wherein the magazine is formed from a single foil strip in which pouches (2) for holding a medicament are formed as depicted in exemplary FIG. 1. The foil strip comprises for transporting the strip openings (4) on at least one side for the engagement of transporting pins. The foil strip has a certain width in the region of the pouches, which is less than the width of the foil in other regions, and the openings are arranged in this broader part of the foil strip. The invention also relates to a method and a device for opening a medicament magazine of this kind, the device preferably being constructed as a segmented wheel.

Abstract: A method of treatment and a nasal treatment delivery device for mixed carbon dioxide and saline for treating head ailments includes: a) a main housing having a hollow central area containing a dosage that includes a saline fluid and a gas containing carbon dioxide; b) a dosage dispenser head located at the distal end of the main housing, and having at least one flow channel for movement of the dosage from the main housing through the dosage dispenser head and to external of the dosage dispenser head; c) a dosage release control component located between the main housing and the dosage dispenser head to permit flow of the dosage through the dosage dispenser head in response to increased pressure against the dosage; and d) a pressure-changing moveable component located on the main housing.

Abstract: An inhaler (1) for delivery of a powder-form inhalation formulation from a blister strip (2) with a plurality of blister pockets (3) is proposed. A tape is used for numbering.

Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container.

Abstract: A dispensing device and a storage device for dispensing a formulation as a spray. The storage device has multiple separate and pre-metered doses of the formulation in receptacles or cavities. In order to allow a very compact arrangement, the receptacles or cavities are arranged in a first group and a second group axially offset, and preferably, forming a double ring arrangement, and the storage device is rotatable and axially moveable for dispensing the doses one after the other.

Abstract: Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.

Abstract: A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.

Abstract: A medicament dispensing device, a medicament magazine thereof, and a method of removing a medicament from the medicament magazine. The inhaler has a mouthpiece (9) and an air channel (4) connected thereto, as well as a medicament magazine with at least one medicament chamber containing a powdered medicament. A drive current is produced in the air channel, while a vacuum flow (5?) can be produced by the drive current and a constriction formed in the air channel. This narrowest part of the air channel that produces the vacuum flow is connected to a removal opening (2) which communicates with a control opening (3), in order to form an emptying current through the control opening via the removal opening. In a preferred embodiment the at least one medicament chamber including the control opening, the removal opening and a fill opening are housing in the one-piece medicament magazine.

Abstract: An inhaler device having an opening device for opening an individual reservoir containing a single dose of fluid, such as powder, the reservoir including a closure wall, the opening device having hollow perforator mechanism that is adapted to perforate the closure wall of the reservoir, the hollow perforator mechanism being connected to an expulsion channel so as to transport the powder towards a dispenser orifice of the inhaler. The opening device includes at least one air channel connected to the expulsion channel, such that during inhalation, an air flow passing through the at least one air channel mixes, in the expulsion channel, with the air and powder flow leaving the reservoir through the hollow perforator mechanism. The air channel is formed by a through hole made in a wall of the perforator mechanism, the through hole being oriented substantially parallel to the expulsion channel.

Abstract: A delivery device that includes a cutter for opening a barrier layer to provide fluid access to a dose chamber, and a diverting structure for direct air flow toward the dose chamber.

Abstract: Dry powder inhalers include radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.

Abstract: The present invention provides a pharmaceutical composition comprising a low dose of zanamivir and a process for preparing the pharmaceutical composition comprising a low dose of zanamivir. The pharmaceutical composition comprising a low dose zanamivir may be used in the treatment and/or prophylaxis of influenza. The present invention also provides a method of treatment and/or prophylaxis of influenza which comprises administering a dry powder inhaler composition comprising a low dose zanamivir. The pharmaceutical composition of the present invention comprises zanamivir and one or more pharmaceutically acceptable excipients, wherein the total daily dose of the zanamivir is less than 10 mg, preferably for administration at least once a day, and preferably wherein the composition delivers from 3 mg to 8 mg of zanamivir per administered dose.

Abstract: An inhaler for inhaling powdered medicaments from capsules, having: a lower part which is cup-shaped, a plate latched to the lower part to close off the lower part, a capsule holder arranged on the underside of the plate, a mouthpiece that can be latched to the top of plate, and an actuating member for interacting with at least one pin for piercing a capsule in the capsule holder, where the actuating member includes a larger outer actuating member and a smaller inner actuating member, the outer actuating member forms a user-operated push-button, the inner actuating member contacts and holds the pin below a suspension element of the outer actuating member from the plate, and the point of application of force by the user onto push-button is lower than the inner actuating member.

Abstract: The invention relates to a dry powder inhaler, having a base housing, having a capsule receptacle for a capsule containing dry powder, having at least one needle- or blade-like opening means, movably arranged in relation to the base housing, for opening the capsule, and having a mouthpiece, through which the dry powder from an opened capsule can be inhaled. The invention is distinguished in that the opening means are fastened on the mouthpiece, and that the mouthpiece can be moved in respect to the base housing out of a normal position into an opening position which opens the capsule.

Abstract: A medicated module containing a medicament is configured for removable attachment to the mouthpiece of an inhaler. The inhaler may contain a first medicament such that a single firing of the inhaler will deliver both medicaments to the user.

Abstract: A medicated module containing a second medicament is configured for removable attachment to the mouthpiece of an inhaler containing a first medicament such that a single inhalation by a user will deliver both medicaments to the user.

Abstract: An inhalation device comprising a base having a slot for insertion of a single blister containing a dose of medicament to be inhaled into the base is disclosed. The inhaler has a mouthpiece pivotally mounted to the base which carries a blister piercing element operable to pierce a blister received in said slot when the mouthpiece is pivoted relative to the base. When a user inhales on the mouthpiece, the dose is entrained in an airflow and flows out of the blister through the mouthpiece and into the user's airway.

Abstract: An inhaler (1) device for inhalation of a medicament from a pierceable capsule (10) comprises a housing (2) for receiving a medicament, capsule, closure means (3) for closing the housing, said closure means being moveable relative to the housing; piercing means (7) suitable for piercing a medicament capsule; wherein movement of the closure means relative to the housing causes movement of the piercing means, and wherein the device comprises an air inlet (71) and an air outlet (72) defining an inhalation passage therebetween, the passage comprising one or more vents (70).

Abstract: An inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets. The used part of the blister strip with empty blister pockets is wound onto a drum which is driven via a gear mechanism which is coupled to the drum via a spring. The spring allows for the different peripheral speeds of the wound-up part to be compensated.

Abstract: An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway.

Abstract: An inhaler which comprises a base having a plurality of consecutive sealed cavities containing medicament. Foil portions are on one side attached to the base for sealing the medicament within respective associated cavities. A plurality of separating elements are attached to the other side of the foil portions, each separating element being associated with a respective cavity for separating a foil portion from that cavity. Each separating element can be moved-away from its associated cavity so that the sealing foil portion is separated from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow, and then returned with the attached foil portion to cover its associated cavity. A method of operating an inhaler is also disclosed.

Abstract: A nebulizer 1 particularly for home use includes a housing 2 having an aerosol generator 3 mounted therein. The housing is closed by a hinged cap 4 and has an outlet 5 through which aerosol generated by the generator 3 is delivered. A suitable connector such as a mouthpiece 6 may be connected to the outlet 5. The housing 2 has a receiver for receiving a nebule 8. The receiver includes a slot 7 which is sized and/or shaped to accommodate only a nebule 8 of predetermined shape and/or size. The nebulizer cap 4 has a nebule opening device which may be in the form of a puncture pin 10 projecting therefrom to pierce the nebule 8 when the cap is moved to the closed position. The pin 10 is hollow or splined to regulate flow from the nebule. The nebulizer 1 also has a switch device for enabling operation of the aerosol generator 3 when the nebule 8 is opened. The switch device comprises a microswitch 12 on the housing which is engageable by a trigger 13 on the cap 4 when the cap is moved to the closed position.

Abstract: The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein individual blister packs are positioned within the housing to be simultaneously engaged with the flow channel and the vibration element. The flow channel includes a blister pack clamping surface that engages the blister pack near the top of the crown and allows the blister three rotational degrees of freedom. The advantages of this arrangement include improved consistency and higher airspeed of the synthetic jet, as well as other advantages.

Abstract: A passive inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. The inhaler has a flow resistance of at least 75000 Pa1/2s/m3.