Means Broken Or Pierced To Supply Treating Agent Patents (Class 128/203.21)
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Patent number: 8511304Abstract: There is provided a medicament dispenser for use with plural elongate form medicament carriers, each having multiple distinct medicament dose portions carried thereby, the dispenser having a dispensing mechanism for dispensing the distinct medicament dose portions carried by each of the plural medicament carriers. The mechanism comprises a receiving station for receiving each of the plural medicament carriers; a release for releasing a distinct medicament dose portion from each of the plural medicament carriers on receipt thereof by the receiving station; an outlet, positioned to be in communication with the distinct medicament dose portions releasable by said a release; and an indexer for individually indexing the distinct medicament dose portions of each of the plural medicament carriers.Type: GrantFiled: January 22, 2003Date of Patent: August 20, 2013Assignee: Glaxo Group LimitedInventors: Gregor John McLennan Anderson, Stanley George Bonney, Michael Birsha Davies, Daniel Thomas De Sansmarez Lintell, Alan Anthony Wilson
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Publication number: 20130206142Abstract: An inhaler, the inhaler including a body (104) and a cartridge (106), the cartridge comprising a dose storage portion (122) and an airway (124), 102 the dose storage portion being suitable for containing a plurality of doses of an inhalable medicament, the airway including a mouthpiece (128) at an end thereof, the inhaler device configured and arranged such that a dose of inhalable medicament from the dose storage portion can be accessed and arranged in a delivery configuration for delivery to a user through the airway upon inhalation through the mouthpiece by the user, the inhaler characterised in that the cartridge is replaceably removable from the body.Type: ApplicationFiled: September 28, 2011Publication date: August 15, 2013Applicant: NOVARTIS AGInventors: Steven Dudley, John Palmer-Felgate, Sean Reynolds, Iain Breakwell, Jon Jamin, Steve Augustyn, Grant Smetham, Laura Kaye, John McGarva
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Patent number: 8499758Abstract: The present invention relates to an inhalation-activatable device for administration of medicament in powder form to the respiratory system of a patient.Type: GrantFiled: April 30, 2008Date of Patent: August 6, 2013Assignee: Sun Pharma Advanced Research Company Ltd.Inventors: Subhas Balaram Bhowmick, Prashant Kane, Ganesh Sangaiah, Satish Madhukar Gokhale, Ajay Nandgaonkar, Abhijit Takale, Simon James Smith, Samantha Anne Musgrave, Richard Francis Day, Lee Wood, Becky Lynn Pilditch, David Stuart Harris, Jonathan Hugh Wilkins, Duncan Aleck Bishop, Matthew David Allen
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Patent number: 8499757Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.Type: GrantFiled: June 12, 2009Date of Patent: August 6, 2013Assignee: MannKind CorporationInventors: Chad C. Smutney, P. Spencer Kinsey, Carl R. Sahi, Benoit Adamo, John M. Polidoro, Scott McLean, Dennis Overfield, Anthony Bryant
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Patent number: 8496002Abstract: An improved inhalation device is provided for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device includes a staple assembly comprising a plunger and staple that are securely and robustly coupled to one another. Embodiments of the inhalation device have a cap that prevents or reduces the amount of dust and grime entering into the device. The cap is additionally configured to prevent or reduce inadvertent and unintentional operation of the device. The body portion and first casing portion of certain embodiments of the inhalation device are sealably coupled, restricting or reducing undesirable flow pathways that have an adverse effect on the operation of the device.Type: GrantFiled: June 10, 2008Date of Patent: July 30, 2013Assignee: Civitas Therapeutics, Inc.Inventors: Colleen Ellwanger, Brian Noble, Chuck Ganem, Jake Ganem, Kevin Stapleton
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Patent number: 8479730Abstract: An inhaler device (1) for powdered medicaments. The device (1) has a body (5) that has a recess (50) for holding a capsule containing a powdered medicament to be inhaled, at least one air passage (90) that is tangentially disposed to the recess (50) , and a mouthpiece (30) that includes a coaxially disposed inhalation passage (70) that communicates with the recess (50) of the body (5). The body (5) has a pair of opposed spring (105) biased push-buttons (40) that each include at least one piercing element (95) for piercing the capsule when loaded in the recess (50). The medicament is released from the pierced capsule when air is drawn through the air passage(s) (90) into the recess (50) and swirled about therein. The mouthpiece (30) is pivotally attached to the edge of the body (5) so that it is pivotable between an open loading position and a closed dispensing position about an axis that is perpendicular to the longitudinal axis of the inhaler (1).Type: GrantFiled: May 12, 2005Date of Patent: July 9, 2013Assignee: Novartis AGInventors: Dominik Ziegler, Grant Smetham, Mauro Citterio
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Patent number: 8474453Abstract: An inhaler is disclosed. The inhaler has a housing to receive an elongate strip of blisters each containing a dose of medicament and being sequentially movable into alignment with means for breaching a blister to enable a user to inhale said dose contained therein. The device has a spiral wound element within the housing that receives and coils said strip of blisters that have been breached.Type: GrantFiled: July 27, 2007Date of Patent: July 2, 2013Assignee: Vectura Delivery Devices LimitedInventors: Stephen William Eason, Matthew Sarkar, Graham Gibbins, Nicholas John Campling, Howard William Biddle, Tristian Roger Thornhill, Duncan James Bradley
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Patent number: 8474454Abstract: A dispensing device has a storage device and an air pump for dispensing a medical formulation. The storage device has multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities can be individually opened for dispensing the respective dose from the respective insert by a connecting element that is moveable relative to the inserts for individually supplying air from a air pump to a respective one of the receptacles. A manually operated actuator is radially moveable to operate the air pump and to rotate the storage device to the next receptacle, and/or radially move the connecting element to individually open the respective receptacle, and to connect the pump to the respective receptacle and/or to push an insert out of the respective receptacle.Type: GrantFiled: May 15, 2008Date of Patent: July 2, 2013Assignee: Boehringer Ingelheim International GmbHInventors: Marc Rohrschneider, Stephen T. Dunne, Matthias Vehdelmann
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Patent number: 8464712Abstract: A medication inhaler comprising an inhaler body, having a medication container chamber for receiving a medication container and an air passage coupling the medication container chamber with exterior air, and a mouthpiece axially engageable with the inhaler body. The mouthpiece has a mouthpiece chamber and a medication delivery needle communicating with the mouthpiece chamber. The needle extends toward the medication container chamber and has an opening for supplying exterior air and medication from an interior cavity of the medication container, accommodated within the medication container chamber, through the needle and to mouthpiece chamber.Type: GrantFiled: September 7, 2007Date of Patent: June 18, 2013Assignee: Dose One, LLCInventors: Charles F. Ganem, Jake Ganem, Scott Ganem
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Patent number: 8464498Abstract: The present embodiments are directed to a medicinal extractor that may open and empty pharmaceutical capsules of variable sizes. The medicinal extractor may have a cover that swings open to expose an interior chamber for a powder-filled medication capsule to be dropped into, and the cover may then be closed. The medicinal extractor may have squeezable side depressors on each side for manually squeezing or holding the capsule in place horizontally. Once closed, the cover may be pushed down to compress two components of the medicinal extractor that are moveable with respect to each other. As the moveable components compress, the cover may press the capsule downward onto a hollow piercing element. The hollow piercing element may puncture the capsule to allow medication within the capsule to fall through the hollow piercing element and into a collection chamber or onto a surface below the medicinal extractor for collection.Type: GrantFiled: December 11, 2012Date of Patent: June 18, 2013Assignee: JCDS Holdings, LLCInventor: Jay Richard Ray, II
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Patent number: 8459257Abstract: A medicament delivery device for administering a medicament to a user includes a medicament reservoir and an entrance port and an exit port each disposed adjacent the reservoir. A gas chamber disposed adjacent the entrance port. The device includes a pressurizing mechanism operable to pressurize said gas chamber to at least a prescribed pressure. A first frangible membrane extends across the entrance port and separates the reservoir from the gas chamber. A second frangible membrane extends across the exit port. When the pressurizing mechanism is attached, at least one of the first and second membranes is responsive to the prescribed pressure in the gas chamber to burst to allow gas to flow through the entrance port and the reservoir and to carry the medicament through the exit port.Type: GrantFiled: May 22, 2009Date of Patent: June 11, 2013Assignee: Becton, Dickinson and CompanyInventors: Robert I. Connelly, Vincent J. Sullivan, Charles D. Shermer, Anjana Bhuta, Ronald J. Pettis
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Patent number: 8443798Abstract: An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway.Type: GrantFiled: January 6, 2011Date of Patent: May 21, 2013Assignee: Vectura Delivery Devices LimitedInventors: Stephen William Eason, Roger William Clarke, Quentin Harmer, Peter Alan Evans, David Gregory Ahern
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Patent number: 8443799Abstract: A dry powder inhalation system suitable for transpulmonary administration characterized by using a combination of: (1) A vessel housing a freeze-dried composition that contains a single dose of an active ingredient, and has: (i) a non-powder cake-like form, (ii) a disintegration index of 0.015 or more, and (iii) a property of becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and (2) A device capable of applying said air impact to the freeze-dried composition in said vessel and for discharging the powder-form freeze-dried composition that has been made into fine particles.Type: GrantFiled: August 30, 2008Date of Patent: May 21, 2013Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Chikamasa Yamashita, Shigeru Ibaragi, Yuichiro Fukunaga, Akitsuna Akagi
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Publication number: 20130112200Abstract: A sealed self-piercing capsule for storing and delivering a substance, such as a medicine, comprises one or more barrier layers forming a sealed chamber for containing the substance. An internal puncturing mechanism is disposed within the capsule chamber for puncturing a barrier layer to release the substance from the chamber. The internal puncturing mechanism may comprise a sharpened edge located on a movable tube, which moves relative to a barrier layer forming the sealed chamber to puncture the barrier layer.Type: ApplicationFiled: December 28, 2012Publication date: May 9, 2013Applicant: Manta Devices, LLCInventor: Manta Devices, LLC
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Patent number: 8434476Abstract: The invention relates to a dispenser (1) for pulverulent substances (30), in particular medicaments, from a blister pack (25), dome-shaped cavities (26) of which that are disposed on a base layer (28) can, by movement in a dispenser housing (4), be brought step by step into an emptying position, in which they can be opened by means of a needle (31) and can be emptied by a suction air stream (a) leading to a mouthpiece (6). To achieve optimum emptying of the cavities, it is proposed that the needle (31) passes crosswise through both lateral walls of the dome (29) of the cavities (preferably parallel to the base layer 28) in order to form a through path to the mouthpiece for suction air.Type: GrantFiled: July 18, 2007Date of Patent: May 7, 2013Inventor: Alfred Von Schuckmann
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Patent number: 8434477Abstract: An assembly of a tube-shaped body and a tube-shaped cap, which are open at one distal side, is provided to manufacture a capsule for enclosing a medicine. At least one recess is arranged in an outer surface of the body, wherein at least one fixating bulge is arranged in an inner surface of the cap, which is destined to be snugly received in the recess in the outer surface of the body in order to realize a fixed snap connection between the body and the cap. A smallest inner diameter of the fixating bulge of the cap is equal to or smaller than a smallest outer diameter of the recess in the body, which contributes to realizing a fixed snap connection which is firm to such an extent that the capsule is suitable for application in an inhalation apparatus comprising provisions for piercing the capsule at least one place.Type: GrantFiled: December 12, 2007Date of Patent: May 7, 2013Assignee: Pharmachemie B.V.Inventor: Dick De Vos
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Patent number: 8413652Abstract: An evaporation element for liquids, in particular aqueous solutions, has a first reservoir for storing the liquid that is to be evaporated, a second reservoir, which is separated from the first reservoir by a sheet and contains a reagent that in contact with the liquid that is to be evaporated carries out an exothermic chemical reaction, and an opening element which, on actuation, perforates the sheet and in this way brings the reagent into contact with the liquid that is to be evaporated.Type: GrantFiled: August 8, 2007Date of Patent: April 9, 2013Inventor: Alexander Stirzel
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Patent number: 8413650Abstract: A user inhales medicine ejected from the medicine ejecting section of an inhaler into the air flow duct of an air flow duct forming member through a hole. As the air flow duct forming member is taken off from the inhaler body, the medicine ejecting section is covered by a cap for protection. As the air flow duct forming member is fitted to the inhaler body, the cap is opened and a sensor recognizes the open state of the cap so that the air flow duct forming member is prohibited from being fitted to and taken off from the inhaler body by a claw that is secured to the air flow duct forming member. In this way, the medicine ejecting section is prevented from being damaged when the air flow duct is fitted to and taken away from the inhaler.Type: GrantFiled: July 2, 2009Date of Patent: April 9, 2013Assignee: Canon Kabushiki KaishaInventors: Sachiko Inoue, Hideki Kaneko, Masaru Sugita
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Patent number: 8408201Abstract: A fluid dispenser device including a body (10) with a dispenser orifice (1), a plurality of reservoirs (21) on a strip (20) that includes a leading end (25) and a trailing end (28), a reservoir-opening mechanism (30) adapted to open a respective reservoir upon actuation, and a drive mechanism (40) for the strip (20) and bring a reservoir into register with the opening mechanism. A movable wall (500; 600, 601) separates a storage housing (11) for the elongate strip (20) from a reception housing (15), the elongate strip (20) disposed mainly in the storage housing (11) before the device is used and displaced progressively in the reception housing (15) during use. The movable wall (500) causes the volume of the storage housing (11) to decrease progressively, and the volume of the reception housing (15) to increase progressively.Type: GrantFiled: December 10, 2007Date of Patent: April 2, 2013Assignee: Aptar France SASInventors: Andrew Pocock, Stuart Kay, Paul Greenhalgh, Wayne O'Hara
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Patent number: 8397718Abstract: An inhaler which comprises a base having at least one sealed cavity containing medicament and a foil portion comprising two sides, one side being attached to the base for sealing the medicament within the cavity. A separating element is attached to the other side of the foil portion for separating the foil portion from the cavity, the separating element having a first end and an opposite second end, wherein the separating element is movable to an intermediate tilted position in which said first end is moved-away from the cavity. The separating element is further movable from the intermediate tilted position to a removed position in which also said second end is moved-away from the cavity so that the foil portion is removed from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow.Type: GrantFiled: February 11, 2009Date of Patent: March 19, 2013Assignee: AstraZeneca ABInventor: Orest Lastow
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Patent number: 8393322Abstract: An inhaler which comprises a base having a plurality of consecutive sealed cavities containing medicament. Foil portions are on one side attached to the base for sealing the medicament within respective associated cavities. A plurality of separating elements are attached to the other side of the foil portions, each separating element being associated with a respective cavity for separating a foil portion from that cavity. Each separating element can be moved-away from its associated cavity so that the sealing foil portion is separated from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow, and then returned with the attached foil portion to cover its associated cavity. A method of operating an inhaler is also disclosed.Type: GrantFiled: February 11, 2009Date of Patent: March 12, 2013Assignee: AstraZeneca ABInventor: Orest Lastow
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Patent number: 8381722Abstract: Methods and apparatus for determining the occurrence of an apnea, patency and/or partial obstruction of the airway are disclosed. Respiratory air flow from a patient is measured to give an air flow signal. The determination of an apnea is performed by calculating the variance of the air flow signal over a moving time window and comparing the variance with a threshold value. One determination of partial obstruction of the airway is performed by detecting the inspiratory part of the air flow signal, scaling it to unity duration and area and calculating an index value of the amplitude of the scaled signal over a mid-portion. Alternatively, the index value is a measure of the flatness of the air flow signal over the mid-portion.Type: GrantFiled: September 29, 2010Date of Patent: February 26, 2013Assignee: ResMed LimitedInventor: Michael Berthon-Jones
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Patent number: 8381721Abstract: A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.Type: GrantFiled: September 25, 2009Date of Patent: February 26, 2013Assignee: Oriel Therapeutics, Inc.Inventors: Gerald A. Thoe, James G. Skakoon, David A. Schuelke, Thomas W. Ruckdeschel, David Harris, Scott Alexander Lewis, Andrew Murray Gow, Jonathan David Tuckwell
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Patent number: 8381720Abstract: An inhaler for delivery of a powder-form inhalation formulation from a blister strip has a plurality of blister pockets and uses a pivotable mouthpiece cover to move the blister strip onward. The mouthpiece cover is drivingly coupled with a conveyor wheel to drive the conveying wheel and to move the blister strip onward, and the axis of the actuator and of the conveying wheel is identical to the cover axis of the mouthpiece cover.Type: GrantFiled: January 23, 2009Date of Patent: February 26, 2013Assignee: Boehringer Ingelheim International GmbHInventors: Ralf Thoemmes, Jessica Frentzel-Beyme
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Patent number: 8375941Abstract: Dry powder inhalers include: (a) a first generally planar spiral travel path in an inhaler body, wherein the first spiral travel path has a plurality of adjacent curvilinear channels forming lanes with upstanding sidewalls, including an inner lane and an outer lane; and (b) a plurality of discrete sealed microcartridges with substantially rigid bodies disposed in the first travel path, each comprising a pre-metered (typically dose) amount of dry powder, the microcartridges being configured to slidably advance along the first travel path toward an inhalation chamber that merges into an inhalation output port. In operation, at least one microcartridge is held in the inhalation chamber to release the dry powder therein during inhalation.Type: GrantFiled: June 27, 2011Date of Patent: February 19, 2013Assignee: Oriel Therapeutics, Inc.Inventors: Michael King, Jeffrey Alan Warden, John Kim, Benjamin Finney, Nicholas Oxley
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Patent number: 8360057Abstract: A medication inhaler for concurrently delivering multiple doses of medications including an inhaler body having a medication container chamber for receiving a plurality of medication containers and at least one air passage connecting the medication container chamber with external air, a mouthpiece axially engageable with the inhaler body and having a mouthpiece chamber for communication with a patient's respiratory system, and a hollow medication delivery needle communicating with the mouthpiece chamber. A medication delivery needle penetrates the medication containers when the inhaler is actuated and has at least one opening for passing exterior air and medication from interior spaces of the medication containers and through the needle to mouthpiece.Type: GrantFiled: March 18, 2011Date of Patent: January 29, 2013Assignee: Dose One, LLCInventors: Charles F. Ganem, Jake Ganem, Scott Ganem
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Patent number: 8360056Abstract: A body section 2 is formed with a capsule insertion hole 6. A movable section 3 includes a capsule puncture needle 9 arranged to be moved into or out of the capsule insertion hole 6. The body section 2 and the movable section 3 are connected to be relatively pivoted at least between a posture in which the capsule insertion hole 6 is exposed, and a posture in which the capsule insertion hole 6 is hid by the body section 2. The body section 2 (a side wall 6e of a protrusion 6a) is arranged to restrict the advancing movement of the capsule puncture needle 9 in the state in which the body section 2 and the movable section 3 are in the posture in which the capsule insertion hole 6 is exposed.Type: GrantFiled: August 31, 2007Date of Patent: January 29, 2013Assignees: Hitachi, Ltd., Dott Limited CompanyInventors: Kazunori Ishizeki, Hisatomo Ohki, Shigemi Nakamura, Akira Yanagawa
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Patent number: 8336542Abstract: A fault indicator for a strip advancement mechanism comprising a base that defines a fault sensing portion of a path for at least a component of a strip, an element for bearing against a strip, or a component of the strip, while it passes through the fault sensing portion of the path, wherein the element is adapted to move from that bearing or non-fault position, to a fault indicating position in the event of the strip or the component of the strip ceasing to pass through the fault sensing portion of the path.Type: GrantFiled: May 12, 2006Date of Patent: December 25, 2012Assignee: Glaxo Group LimitedInventors: Gregor John McLennan Anderson, Stephen James Harvey, Andrew Roderick Taylor, Daniel Thomas De Sausmarez Lintell, Mark Digby Teucher, James Anthony West
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Patent number: 8327610Abstract: The present embodiments are directed to a medicinal extractor that may open and empty pharmaceutical capsules of variable sizes. The medicinal extractor may have a cover that swings open to expose an interior chamber for a powder-filled medication capsule to be dropped into, and the cover may then be closed. The medicinal extractor may have squeezable side depressors on each side for manually squeezing or holding the capsule in place horizontally. Once closed, the cover may be pushed down to compress two components of the medicinal extractor that are moveable with respect to each other. As the moveable components compress, the cover may press the capsule downward onto a hollow piercing element. The hollow piercing element may puncture the capsule to allow medication within the capsule to fall through the hollow piercing element and into a collection chamber or onto a surface below the medicinal extractor for collection.Type: GrantFiled: August 1, 2012Date of Patent: December 11, 2012Assignee: JCDS Holdings, LLCInventor: Jay Richard Ray, II
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Patent number: 8322338Abstract: A dry powder inhaler consisting of first chamber having an orifice for holding a dry powder and a gas, and a second chamber for receiving a deaggregated form of the dry powder and for communicating the deaggregated dry powder to a user. A synthetic jet drives the dry powder from the first chamber to the second chamber.Type: GrantFiled: May 7, 2010Date of Patent: December 4, 2012Assignee: Microdose Therapeutx, Inc.Inventors: Anand V. Gumaste, John Bowers
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Patent number: 8322336Abstract: An inhaler comprising: at least one cover element (11, 12); individual reservoirs formed on a substrate; support means (50) that are movable between a non-dispensing position and a dispensing position; reservoir-opening means (80); displacement means (30) for displacing said reservoir substrate in a first direction, said reservoir substrate also being displaceable between said non-dispensing position and said dispensing position in which said opening means open a respective reservoir; loading means (51) for urging said movable support means towards said dispensing position; blocking means (100) for retaining said movable support means in the non-dispensing position; trigger means (60) that are actuated by inhalation; and connection means (1000) for displacing said reservoir substrate in said first direction when said at least one cover element is displaced, said connection means being activated while said movable support means are being displaced towards said dispensing position while the user is inhaling, anType: GrantFiled: July 17, 2007Date of Patent: December 4, 2012Assignee: Aptar France SASInventors: Andrew Gordon Pocock, Stuart Brian William Kay, Paul Greenhalgh, Wayne O'Hara, Xavier Donnette
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Patent number: 8297278Abstract: An Inhaler for delivering an aerosolised dose of a powdered drug for inhalation by a user is disclosed. The inhaler comprises a drug entreinment device to a receive a package having a piercable lid containing a dose to be delivered, the device including a drug outlet tube terminating with a primary piercing element to pierce an opening in said lid when a package is located in the inhaler, a secondary piercing member to pierce a plurality of peripheral openings in said lid and, an airflow path to enable the supply of a charge of gas into the package via said peripheral openings to scour the interior of a pierced package such that all or substantially all of the dose is entrained in the gas and flows out of the package via the drug outlet tube. A medicament pack is also disclosed.Type: GrantFiled: September 28, 2010Date of Patent: October 30, 2012Assignee: Vectura Delivery Devices LimitedInventors: Quentin Harmer, Roger William Clarke, Stephen William Eason
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Patent number: 8297277Abstract: A dispensing device, a storage device and a method for dispensing a medical formulation are proposed. Multiple doses of the formulation are stored in a carrier having multiple inserts, each insert containing a single dose. Preferably, each insert has at least one duct or nozzle for dispensing the respective dose. Each insert is located in a separate and sealed cavity in the carrier. The cavities can be individually opened for dispensing the respective dose from the respective insert.Type: GrantFiled: November 30, 2006Date of Patent: October 30, 2012Assignee: Boehringer Ingelheim International GmbHInventors: Marc Rohrschneider, Matthias Vehdelmann, Stephen T. Dunne
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Patent number: 8291902Abstract: A conventional respiratory nebulizer has an emergency medication dose storage system delivering the stored medication dose directly to the nebulizing chamber with a single impulse of force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The delivery system includes a plunger assembly having a pair of converging blades coming to a point for piercing a medication capsule held within a docking chamber adjacent to a nebulizing mixing chamber and a hollow needle connected to an air power source directing air through said needle, to force liquid medication from said pierced medication capsule into said nebulizing mixing chamber of said nebulizer.Type: GrantFiled: June 30, 2011Date of Patent: October 23, 2012Inventor: Robert Abrams
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Patent number: 8291901Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.Type: GrantFiled: July 7, 2008Date of Patent: October 23, 2012Assignee: Manta Devices, LLCInventors: Andrew Jones, Richard L. Miller
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Patent number: 8286632Abstract: A dispensing device has a storage device and an air pump for dispensing a medical formulation in which the storage device has multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities can be individually opened for dispensing the respective dose from the respective insert.Type: GrantFiled: May 15, 2008Date of Patent: October 16, 2012Assignee: Boehringer Ingelheim International GmbHInventors: Marc Rohrschneider, Joern-Eric Schulz, Jens Besseler, Timo Von Brunn, Ralf Thoemmes, Thomas Sowden Reinhold
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Patent number: 8286631Abstract: The present invention relates to a dry powder inhalation device which is suitable for the simultaneous administration of a combination of pharmaceutical ingredients, wherein each pharmaceutical ingredient is packed in a separate blister of the same single dose blister strip. The medicaments that form the combination come into contact just before their exit from the mouthpiece of the device.Type: GrantFiled: May 9, 2007Date of Patent: October 16, 2012Inventor: Dimitrios Pentafragas
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Patent number: 8281784Abstract: A mouthpiece for an inhaler for administering a drug in the form of substances, substance formulations or substance mixtures that can be inhaled comprises an inhalation channel (4) for coupling to a chamber for receiving the drug. At least one component (10) having an aerodynamic cross-section is arranged in the inhalation channel (4).Type: GrantFiled: April 4, 2007Date of Patent: October 9, 2012Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventor: Herbert Wachtel
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Patent number: 8267082Abstract: The invention is a medicament magazine having at least one medicament chamber for use in a powder inhaler, wherein the magazine is formed from two foil strips applied to one another and the at least one medicament chamber is formed between the foil strips as depicted in exemplary FIGS. 1a and 1b. The medicament chambers have an internal structure (3) which comprises in its interior a space for receiving a powdered medicament and stabilizes this inner space against external mechanical influences. In another embodiment in which the internal structure preferably also has a stabilizing function, the structure has means for opening one foil strip. In addition, the medicament chamber contains a retaining device which holds the internal structure on the medicament magazine after the medicament chamber has been opened.Type: GrantFiled: April 13, 2007Date of Patent: September 18, 2012Assignee: Boehringer Ingelheim International GmbHInventors: Herbert Wachtel, Johannes Geser, Burkhard Metzger, Michael Spallek, Michael Krueger, Hubert Kunze, Achim Moser, Elmar Mock, Antonino Lanci, Andre Klopfenstein
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Patent number: 8261739Abstract: A dry powder inhaler has a main airflow path including a cyclone chamber (16) having an air inlet and being so shaped that at least a part of the chamber decreases in cross-sectional area in a direction away from the air inlet, so as thereby in use to set up a reverse flow cyclone in the chamber. A bypass airflow path (8) bypasses the cyclone chamber and the main and bypass airflow paths communicate with a mouthpiece (6). The cyclone chamber may be provided by a part (22) which is removable from the rest of the inhaler for regular replacement thereof.Type: GrantFiled: December 9, 2005Date of Patent: September 11, 2012Assignee: Cambridge Consultants LimitedInventors: David Stuart Harris, Simon James Smith
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Patent number: 8261740Abstract: An inhaler comprising: a body; at least one cover element that is movable between a closed position and an open position; individual reservoirs formed on a reservoir substrate; movable support means that receive said reservoir substrate and that are displaceable between a non-dispensing position and a dispensing position; and an indicator device for indicating doses that have been dispensed or that remain to be dispensed, said indicator device comprising: a rotary indicator element that supports indicator means, such as numbers, colors, and/or symbols; and an actuator that co-operates with said movable support means so as to cause said rotary indicator element to turn when said movable support means return from the dispensing position to the non-dispensing position.Type: GrantFiled: July 17, 2007Date of Patent: September 11, 2012Assignee: Valois SASInventors: Andrew Gordon Pocock, Stuart Brian William Kay, Paul Greenhalgh, Wayne O'Hara, Xavier Donnette
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Patent number: 8256416Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.Type: GrantFiled: June 7, 2010Date of Patent: September 4, 2012Assignee: Pfizer LimitedInventors: Peter John Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant
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Patent number: 8240305Abstract: A dispensing device with a storage device and an air pump for dispensing a medical formulation in which the storage device has multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities can be individually opened for dispensing the respective dose from the respective insert. Furthermore, a mechanism is provided for aligning the connecting element relative to a respective receptacle and/or insert which has guiding portions formed at or by the respective receptacle and/or insert.Type: GrantFiled: May 15, 2008Date of Patent: August 14, 2012Assignee: Boehringer Ingelheim International GmbHInventors: Marc Rohrschneider, Stephen T. Dunne, Jens Besseler, Timo Von Brunn, Ralf Thoemmes
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Patent number: 8235040Abstract: A dispensing device having a storage device and an air pump for dispensing a medical formulation. The storage device has multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities can be individually opened for dispensing the respective dose from the respective insert by movement of the respective insert through the seal, so as to break the seal only at one side of the outlet opening so that the seal is pivoted mainly to an opposite side of the outlet opening by the movement of the insert for minimizing potential interference by the opened seal with flowing of the formulation from the receptacle toward the mouthpiece.Type: GrantFiled: May 15, 2008Date of Patent: August 7, 2012Assignee: Boehringer Ingelheim International GmbHInventors: Marc Rohrschneider, Stephen T. Dunne
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Patent number: 8225784Abstract: A fluid dispenser device comprising a body (10), said device further comprising: an elongate flexible strip (20) supporting a plurality of reservoirs (21) each containing a dose of fluid or powder; reservoir-opening means (30) for opening a respective reservoir on each actuation; first displacement means (40) for causing said flexible strip (20) to advance before and/or during and/or after each actuation, so as to bring a full reservoir into register with said reservoir-opening means; and second displacement means (45) for displacing a full reservoir (21) against said opening means (30) each time the device is actuated, the leading end (25) of said flexible strip (20), in the advance direction of said strip, being fastened to a receiver element (50) that is rotatably mounted, said receiver element (50) being fastened to a loaded spring (500) that is adapted to exert a force on said receiver element (50) so as to urge it to turn, such that said receiver (50) exerts a traction force on said elongate strip (20),Type: GrantFiled: December 10, 2007Date of Patent: July 24, 2012Assignee: Valois SASInventors: Zakaria Sallak, Maxime Kirniak
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Patent number: 8220455Abstract: A dispensing device having a storage device and an air pump for dispensing a medical formulation. The storage device has multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities can be individually opened for dispensing the respective dose from the respective insert. At least one lifespan blocking device is provided for preventing operating of the dispensing device after a predetermined number of uses corresponding to the number of receptacles.Type: GrantFiled: May 15, 2008Date of Patent: July 17, 2012Assignee: Boehringer Ingelheim International GmbHInventors: Marc Rohrschneider, Jens Besseler, Timo Von Brunn, Ralf Thoemmes, Thomas Sowden Reinhold
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Patent number: 8210167Abstract: The sprayer device utilizes a friction held piston that fires automatically upon full depression of the firing cap. A user may procure a monodose of medicine by (i) unlocking a child resistant mechanism; (ii) applying compressive force against the firing cap to first compress the spring and then to push the piston out of a friction area such that the spring causes the distal end of the piston to break the medicine container to drive medicine through the spray nozzle. The device includes a tear-away child resistant outer locking mechanism. Different length stops meter the amount of medicine dispensed. A two cap plug cap on the proximal and distal ends of the medicine package act as pistons. A piercer attached to a proximal end of the monodose medicine package moves upwardly when the piston is fired to pierce the medicine package and to drive medicine through the spray nozzle.Type: GrantFiled: January 24, 2008Date of Patent: July 3, 2012Assignee: Corbco, Inc.Inventor: Hipolito P. Corbacho
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Patent number: 8205614Abstract: A delivery device, e.g. an inhaler, includes a rotatable metering member adapted to dispense a measured amount of material, a material delivery passage and a material delivery orifice and at least one actuator member adapted to move the metering member from a material retaining position to a material dispensing position. In a magazine including a plurality of metering members, the actuator and metering members may operate in a radial direction. A plurality of rotatable magazines may be utilized in the delivery device. The delivery device may be used to deliver a single or a combination therapy.Type: GrantFiled: August 10, 2009Date of Patent: June 26, 2012Assignee: Innovata Biomed LimitedInventor: Philip Braithwaite
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Patent number: 8201555Abstract: A dry powder inhaler (101) comprises an inhaler body (110), including an air passageway, and a medicament container (120). The medicament container (120) holds a dose of medicament and is provided with at least one dispensing aperture (123) through which the medicament may be drawn from the medicament container (120). The medicament container (120) is displaceable from a first position, in which the dispensing aperture (123) is occluded, to a second position, in which the dispensing aperture (123) is open and air is able to flow along the air passageway. When the medicament container (120) is in the first position, the air passageway is occluded by the medicament container (120).Type: GrantFiled: June 26, 2007Date of Patent: June 19, 2012Assignee: Brintech International LimitedInventor: Brinda Paul Singh Chawla
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Patent number: 8201556Abstract: There is provided a sheet driver for use in a medicament dispenser including a medicament carrier having a plurality of pockets for containing medicament wherein said pockets are spaced along the length of and defined between first and second sheets secured to each other and separable by drivable pulling action, the sheet driver comprising a base; ascending from the base, a shaft defining a rotational axis; on the base, a drive surface for receipt of drive to rotate the base about the rotational axis; about the shaft, a torsion spring defining first and second spring legs; mounting about the shaft and the torsion spring for rotation about the rotational axis, a hub defining a hub surface for receipt of a sheet of the medicament carrier. A first leg receiver of the base receives the first spring leg of the torsion spring and a second leg receiver of the hub receives the second spring leg of the torsion spring such that relative rotation of the base and the hub results in tensioning of the torsion spring.Type: GrantFiled: August 12, 2005Date of Patent: June 19, 2012Assignee: Glaxo Group LimitedInventors: Christopher John Jones, James John May, Daniel Thomas De Sausmarez Lintell, Mark Gregory Palmer, Robert William Tansley