Biological Material (e.g., Microbe, Enzyme, Antigen, Etc.) Analyzed, Tested, Or Included In Apparatus Patents (Class 204/403.01)
  • Patent number: 11953495
    Abstract: Disclosed are a molecule detection unit, a chip and a preparation method. The molecule detection unit includes a single-hole liquid storage cavity, a liquid resistance flow channel, a buffer flow channel, a sensing electrode, a substrate, a first structural layer, a second structural layer and a sample flow channel. The first structural layer is arranged on the top of the substrate; the single-hole liquid storage cavity and the buffer flow channel are arranged in the first structural layer and are independent of each other; the liquid resistance flow channel is arranged in the first structural layer, and two ends of the liquid resistance flow channel are respectively communicated with the single-hole liquid storage cavity and the buffer flow channel; the second structural layer is arranged on the top of the first structural layer and covers the top of the buffer flow channel.
    Type: Grant
    Filed: September 20, 2023
    Date of Patent: April 9, 2024
    Assignee: Beijing Qitan Tech Co., Ltd.
    Inventors: Yuan Wang, Xiaoxiang Xia, Lu Song
  • Patent number: 11955668
    Abstract: Leak detection sensors, appliances configured to detect leaks and methods of detecting leaks are provided. The leak detection sensor is a self-powered leak detection sensor. The leak detection sensor includes a water-permeable medium and at least one electrochemical cell. The electrochemical cell can include a first electrode and a second electrode, and an electrolyte disposed between the electrodes, wherein in a dormant state, the electrolyte is in a solid, dry state. The electrochemical cell can enter an active state when exposed to water. The electrochemical cell can be configured to generate electrical power in the active state. The leak detection sensor can further include a peripheral electronic component configured to receive electrical power produced by the electrochemical cell. The self-powered leak detection sensor is configured for, and related methods include, detecting exposure to water in response to electrical energy generation of the electrochemical cell.
    Type: Grant
    Filed: September 23, 2021
    Date of Patent: April 9, 2024
    Assignee: Haier US Appliance Solutions, Inc.
    Inventors: Gregory Sergeevich Chernov, Matthew R. Hunter
  • Patent number: 11944966
    Abstract: Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane, wherein the membrane has a first side and a second side, wherein the membrane has a first pore disposed therein, wherein the first pore extends through the membrane from the first side of the membrane to the second side of the membrane, wherein the membrane has a second pore disposed therein, and wherein the second pore extends through the membrane from the first side of the membrane to the second side of the membrane; a first channel disposed on the first side of the membrane, wherein the first channel is along a first longitudinal axis; a second channel disposed on the first side of the membrane, wherein the second channel is along a second longitudinal axis, and wherein the first channel and the second channel are disposed side by side adjacent to each other; a third channel disposed on the second side of the membrane, wherein the third channel is along a third longitudinal axis, wherein the third channel is in
    Type: Grant
    Filed: October 28, 2021
    Date of Patent: April 2, 2024
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventor: Aleksei Aksimentiev
  • Patent number: 11864894
    Abstract: Method and apparatus for providing calibration of analyte sensor including applying a control signal, detecting a measured response to the control signal, determining a variance in the detected measured response, and estimating a sensor sensitivity based on the variance in the detected measured response is provided.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: January 9, 2024
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Gary Alan Hayter, Kenneth J. Doniger, Erwin Satrya Budiman, Songbiao Zhang, John Charles Mazza
  • Patent number: 11867652
    Abstract: An analyte sensor comprising: a non-conductive material; a conductive material disposed on the non-conductive material; and at least two sensing structures defined by a removed portion of the conductive material, the at least two sensing structures comprising a reagent composition.
    Type: Grant
    Filed: February 28, 2022
    Date of Patent: January 9, 2024
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Udo Hoss, Tahir Sadik Khan, Phu X. Le
  • Patent number: 11808727
    Abstract: An electrochemical test for total cholesterol includes a test strip for an electrochemical testing testing of a blood analyte which includes a first receiving port, the first receiving port for receiving a blood sample, the first receiving port at a first end of the test strip. The test strip further includes a first electrode and a second electrode, the first and second electrodes proximate to the first receiving port. The test strip further includes a first contact and a second contact, the first and second contacts at a second end of the test strip, the first and second contacts interconnected with the first and second electrodes, respectively. The test strip further includes cholesterol oxidase, located proximate to the first and the second electrode. The test strip further includes a mediator, located proximate to the first and the second electrode, wherein the cholesterol oxidase and the mediator interact with the blood sample and the first and second electrode to generate a measurable electrical event.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: November 7, 2023
    Assignee: Polymer Technology Systems, Inc.
    Inventors: Brittney Werner, Aniruddha Patwardhan, Gary Hughes
  • Patent number: 11786153
    Abstract: A wearable sensor system includes a flexible patch, an electronic circuit disposed on the flexible patch, and a disposable sensor disposed on the flexible patch and connected to the electronic circuit via a socket. The disposable sensor detects a chemical compound. The electronic circuit generates a detection signal commensurate with the chemical compound detected by the disposable sensor. The disposable sensor is removably plugged into the socket, thereby permitting replacement of the disposable sensor upon satisfaction of a predetermined condition. A battery disposed is on the flexible patch and connected to the electronic circuit to power the electronic circuit. A transceiver is connected to the electronic circuit, wherein the transceiver transmits the detection signal.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: October 17, 2023
    Assignee: The Johns Hopkins University
    Inventors: Konstantinos Gerasopoulos, Julia B. Patrone, Leslie H. Hamilton, Luke J. Currano, Matthew A. Hagedon, Felix Connor Sage, Mekbib Astatke
  • Patent number: 11784319
    Abstract: This electrode catalyst of the present invention contains an electrically conductive material that supports a metal or a metal oxide, wherein electrical conductivity at 30° C. is 1×10?13 Scm?1 or greater.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: October 10, 2023
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Miho Yamauchi, Tatsuyoshi Morimoto
  • Patent number: 11774394
    Abstract: An inventive electrochemical sensor has a substrate with proximal and distal regions. The proximal region has at least one contact element configured to communicate with a measurement device. A working electrode is located in the distal region of the substrate and includes a conductive trace. A plurality of enzyme fields are provided, each enzyme field having an enzyme configured for providing a reaction with an analyte. The enzyme fields are spaced apart and each enzyme field is at least partially located on the conductive trace. The conductive trace may be provided in the form of a grid. The enzyme fields can be formed such that they extend beyond one or both edges of the trace or such that they cover only a portion of the full width of the trace. Manufacturing tolerances can be improved.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: October 3, 2023
    Inventors: Sebastian Pankalla, Jonathan Seidel, Tommi Kaehkoenen
  • Patent number: 11766203
    Abstract: The present invention is directed to devices including one or more hollow needles and a transducing wire disposed within at least one needle. In particular instances, arrays of such needles can be employed. Methods for fabricating and using such devices are also disclosed herein.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: September 26, 2023
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Philip Rocco Miller, Ronen Polsky, Nathaniel Bryant Pfeifer
  • Patent number: 11761110
    Abstract: The present invention relates to a Z-type heterojunction photoanode film used for the photocathode protection of a reinforcing bar, the preparation method thereof and a method for the corrosion inhibition of mental materials from concrete structures in marine engineering by using the Z-type heterojunction photoanode film used for the photocathode protection of a reinforcing bar. The preparation method includes steps of preparing Fe2O3 on the conducting surface of a clean conductive substrate through the hydrothermal process, preparing Fe2O3-PANI composite photoanode film by depositing polyaniline on the surface of Fe2O3 through the electrochemical synthesis and preparing Ru-Fe2O3-PANI composite photoanode film on the surface of the Fe2O3-PANI composite photoanode film through the in situ chemical reduction method.
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: September 19, 2023
    Assignee: Qingdao University of Technology
    Inventors: Zuquan Jin, Xiaoying Zhang, Jihong Jiang, Zhaoyi Chen, Pengcheng Ren, Xiaoqing Wang
  • Patent number: 11732301
    Abstract: The disclosure provides detection apparatus having one or more nanopores, methods for making apparatus having one or more nanopore and methods for using apparatus having one or more nanopores. Uses include, but are not limited to detection and sequencing of nucleic acids.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: August 22, 2023
    Assignee: Illumina, Inc.
    Inventors: Boyan Boyanov, Jeffrey G Mandell, Kevin L Gunderson, Jingwei Bai, Liangliang Qiang, Bradley Baas
  • Patent number: 11732296
    Abstract: An apparatus includes a biosensor integrated circuit (IC) chip having multiple well structures configured to receive a liquid comprising one or more biological analytes. The well structures include a passivation layer with an opening over one or more field effect transistors (gFETs) which include a layer of 2D channel material selected from molybdenum disulfide (MoS2) and graphene; a drain electrode connected to a first end of the channel; a source electrode connected to a second end of the channel, wherein the individual gFETs are configured such that liquid received by the well structure is confined to form a liquid gate above a top surface of the channel. A system and method perform various functions of the apparatus.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: August 22, 2023
    Assignee: Cardea Bio, Inc.
    Inventors: Pieter van Rooyen, Mitchell Lerner, Paul Hoffman, Brett R. Goldsmith
  • Patent number: 11726056
    Abstract: Described herein is a field effect transistor sensor including: a substrate, a source electrode, a drain electrode, a gate electrode functionalized with a layer of biological recognition elements, a source-drain channel and a semiconductor layer. The layer of biological recognition elements of the gate electrode is patterned into a plurality of uncoupled domains.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: August 15, 2023
    Assignee: UNIVERSITA' DEGLI STUDI DI BARI ALDO MORO
    Inventors: Luisa Torsi, Gerardo Palazzo, Gaetano Scamarcio
  • Patent number: 11717220
    Abstract: A biosensor sheet includes a pressure-sensitive adhesive layer for attaching to a surface of a living body, and a probe disposed on the pressure-sensitive adhesive layer, wherein the probe has an exposure region in which the pressure-sensitive adhesive layer is exposed.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: August 8, 2023
    Assignee: NITTO DENKO CORPORATION
    Inventor: Ryoma Yoshioka
  • Patent number: 11714065
    Abstract: A method of measuring hematocrit is provided. The method for measuring hematocrit includes the following steps. A test strip is provided. The test strip includes a reaction region and a pair of electrodes disposed in the reaction region. A whole blood sample is entered to the reaction region. After the whole blood sample enters the reaction region, a plurality of sets of square wave voltages are intermittently applied to the pair of electrodes based on a square wave voltammetry method to obtain a plurality of feedbacks related to hematocrit. An interval between two adjacent sets of square wave voltages ranges from 0.1 seconds to 4 seconds. A feedback of an n-th set of square wave voltages is obtained to calculate a hematocrit value of the whole blood sample and n is a positive integer greater than 1. A hematocrit value is calculated according to the feedback.
    Type: Grant
    Filed: September 7, 2020
    Date of Patent: August 1, 2023
    Assignee: Industrial Technology Research Institute
    Inventors: Chu-Hsuan Chen, Yu-Fang Yen, Yi-Ting Tung, Fen-Fei Lin, Yi-Yun Yuan, Wen-Pin Hsieh
  • Patent number: 11701036
    Abstract: A test strip for sampling a bodily fluid may include multiple layers of a substrate material, an adhesive between at least some of the multiple layers, and a microfluidic channel formed between at least some of the multiple layers. The test strip may further include multiple electrodes on one of the multiple layers, positioned and partially exposed within the microfluidic channel, an additional material positioned at or near an entrance to the microfluidic channel, to selectively limit the flow of at least one of bubbles or debris into the microfluidic channel, and at least one exit port in at least one of the multiple layers to allow for release of pressure from the test strip. In some embodiments, the test strip is a saliva analysis test strip. In some embodiments, the test strip includes multiple exit ports to prevent blockage of sample flow.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: July 18, 2023
    Assignee: MX3 Diagnostics, Inc.
    Inventors: Thanh Cong Nguyen, Efstratios Skafidas, Duc Hau Huynh, Michael Erlichster, Duc Phuong Nguyen, Hsien Ming, Gursharan Chana, Ting Ting Lee, Chathurika Darshani Abeyrathne, You Liang, Trevor John Kilpatrick, Michael Luther, Alan Dayvault Luther
  • Patent number: 11668639
    Abstract: A method for processing a substrate by using fluid flowing through a particle detector is provided. The particle detector is utilized to detect nano-particles contained in fluid. The particle detector includes a substrate and a pair of sensing electrodes disposed on the substrate. The substrate includes nano-pores, wherein the pore size of the nano-pores is greater than the particle size of the nano-particles, allowing the nano-particles contained in the fluid passing through the nano-pores. The pair of sensing electrodes are positioned adjacent to at least one of the nano-pores.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: June 6, 2023
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: En-Tian Lin, Chwen Yu, Mei Lee, Shu-Yu Hsu
  • Patent number: 11609222
    Abstract: A water-soil interface physiochemical monitoring apparatus and a reservoir area hydro-fluctuation belt monitoring system based on the same. The water-soil interface physiochemical monitoring apparatus comprises a cylindrical shell, a conical head, a sensor data acquisition circuit, a sealing plug, and a plurality of sensor modules. One end of the cylindrical shell is in sealing connection with the conical head, and the other end is sealed by the sealing plug. The sensor modules are connected to the sensor data acquisition circuit, and are all located in the sealed space of the cylindrical shell. Each sensor module comprises a circuit board, a temperature sensor, a dissolved oxygen sensor and a conductivity sensor, which are combined together by casting using resin, and the temperature sensor, the dissolved oxygen sensor and the conductivity sensor are separately connected to the circuit board.
    Type: Grant
    Filed: October 25, 2020
    Date of Patent: March 21, 2023
    Assignee: Nanjing Hydraulic Research Institute
    Inventors: Qiuwen Chen, Dongsheng Liu, Haoyu Zhu, Jianyun Zhang, Yuchen Chen, Honghai Ma, Yingxin Hong
  • Patent number: 11608515
    Abstract: A method for quantifying a target substance, comprising: bringing a sample containing the target substance into contact with a biosensor which comprises an enzyme electrode containing an oxidoreductase and a counter electrode; measuring a change in the potential difference between the enzyme electrode and the counter electrode due to oxidation reaction of the target substance catalyzed by the oxidoreductase; and calculating the concentration of the target substance based on the change in the potential difference; wherein a potential is applied between the enzyme electrode and the counter electrode before the measurement of the change in the potential difference.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: March 21, 2023
    Assignee: ARKRAY, INC.
    Inventors: Koji Sode, Inyoung Lee, Wakako Tsugawa
  • Patent number: 11547330
    Abstract: Apparatus and methods are operative to probe the condition of a sensor either initially, at any point thereafter or continuously during a continuous sensor operation for measuring an analyte in a bodily fluid (such as performed by, e.g., a continuous glucose monitoring (CGM) sensor). Results of the probe may include calibration indices determined from electrical signals obtained during the probe. The calibration indices may indicate whether in-situ adjustment of the sensor's calibration should be performed either initially and/or at random check points. Probing potential modulation parameters also may be used during analyte calculations to reduce the effects of lot-to-lot sensitivity variations, sensitivity drift during monitoring, temperature, interferents, and/or the like. Other aspects are disclosed.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: January 10, 2023
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventor: Huan-Ping Wu
  • Patent number: 11510597
    Abstract: Analyte sensing and response systems include a sensor detecting one or more analytes in a medium. The sensor uses decoupled transmit and receive elements or antennas to transmit a signal into the medium, and receive a response to the transmitted signal. An action that is based on the detection of the analyte is generated which can directly or indirectly affect the detected analyte in the medium. The action is automatically performed. The action can be increasing or decreasing flow from a source of the analyte, or of a chemical compound interacting with the analyte. An example of the action is controlling an insulin pump, where the analyte is glucose.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: November 29, 2022
    Assignee: KNOW LABS, INC.
    Inventor: Phillip Bosua
  • Patent number: 11493472
    Abstract: To provide a sensor device and a measurement apparatus that are able to appropriately control a temperature of a sensing region where a potential is measured. Provided is a sensor device that includes an electrode array exposed to a sensing region, at least one or more wiring line layers provided in a layer same as the electrode array, a temperature determiner that determines a temperature of the sensing region on the basis of an electric resistance of the wiring line layer, and a temperature controller that controls the temperature of the sensing region on the basis of the temperature of the sensing region determined by the temperature determiner.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: November 8, 2022
    Assignee: SONY SEMICONDUCTOR SOLUTIONS CORPORATION
    Inventor: Motoko Jingu
  • Patent number: 11471092
    Abstract: Provided herein are microelectrodes and methods of localizing and targeting the same. The microelectrodes include electrochemical or biological sensors, an array of electrical contacts along a long axis of the microelectrode, or both. The methods of localizing and targeting use statistical manipulations to reduce the errors inherent in spike train analyses.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: October 18, 2022
    Inventors: Erwin B. Montgomery, Jr., He Huang
  • Patent number: 11471081
    Abstract: An apparatus includes a body and an actuator is coupled to the body. A needle is mounted to the actuator. The needle comprises a slot along a length to a tip. A sensor is coupled to a plurality of wires. A base is configured to be moveable by the actuator and includes a cutout, a circuit board having a microprocessor, and a plurality of contacts. Each contact is coupled to a wire of the plurality of wires. A power source is connected to the circuit board and to the base. A bracket is coupled to the bottom surface of the body and configured to receive the base. A patch is coupled to the bracket and has an adhesive. A needle is configured to be moveable by the actuator. The plurality of wires extend from the circuit board of the base, through the needle and out of the slot.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: October 18, 2022
    Assignee: Zense-Life Inc.
    Inventors: Robert James Boock, Jocelyn Lo, Paul Smith
  • Patent number: 11448571
    Abstract: Provided is a specimen collection tip having a novel structure, with which it is possible to collect a trace amount of a specimen with good quantitative precision. Also provided is a specimen preparation container having a novel structure, with which it is possible to dilute and prepare the specimen collected with the specimen collection tip with good quantitative precision. A specimen collection tip 10, wherein a specimen holding region 12 having a predetermined volume is provided inside the specimen collection tip 10, and in a distal end portion extending from a support part 15, there is formed a specimen collection hole 22 and an air vent hole 24 placing the specimen holding region 12 in communication with a surface 23. Also, a specimen preparation container 26 with a cap 30, wherein the specimen collection tip 10 is attached to the cap 30 at the support part 15.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: September 20, 2022
    Assignee: NIPRO CORPORATION
    Inventors: Toshiaki Baba, Koutarou Tanimura, Dosaku Tokudome, Yukihiro Yabe, Kanako Miura
  • Patent number: 11378547
    Abstract: We provide an electrochemical sensor in which working microelectrodes are arranged in an array and interconnected in parallel. The working electrodes are arranged so that in use, they are electrochemically coupled to a counter electrode structure through an electrolyte. The sensor also includes a microporous body arranged so that in use, it is situated at a boundary between a gaseous environment and the electrolyte. In another aspect, we provide a method of sensing in which a sample of gas is admitted to a liquid electrolyte maintained by pores of a porous substrate. A voltage is applied to the liquid electrolyte, and an electrical response to the applied voltage is observed, thereby to detect electrochemical evidence of an analyte within the liquid electrolyte.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: July 5, 2022
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Kyle Chris Klavetter, William G. Yelton, Tina M. Nenoff, Michael P. Siegal, Carlos R. Perez
  • Patent number: 11371958
    Abstract: An electrochemical device for identifying electroactive analytes. The device includes a substrate; a sample region; a counter electrode; a reference electrode; a working electrode disposed in communication with the substrate, and the working electrode may be an electron conducting fiber. Further, the counter electrode, reference electrode, and working electrode are partially disposed in the sample region configured to be exposed to the electroactive analyte. Further yet, a counter electrode channel, reference electrode channel, and working electrode channel are disposed in the substrate configured to: accommodate each of the counter electrode, reference electrode, and working electrode, respectively, for placement in the respective channels.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: June 28, 2022
    Assignee: University of Virginia Patent Foundation
    Inventors: Cheng Yang, B. Jill Venton
  • Patent number: 11340189
    Abstract: The enzyme telomerase is present at about 85% of human cancers that makes it not only an excellent target for cancer treatment but also an excellent marker for cancer detection. Using a single stranded DNA probe specific for telomerase binding and reverse transcription tethered to an interdigital gold electrode array surface, the chromosome protection provided by the telomerase was replicated and followed by Electrochemical Impedance Spectroscopy as an unlabeled biosensor. Using a custom system, which is simple and affordable, the impedance measurements were taken while incubating at 37° C. and promoting the probe elongation. This resulted in up to 14-fold increase in the charge transfer resistance when testing a telomerase-positive nuclear extract from Jurkat cells compared to the heat-inactivated telomerase-negative nuclear extract.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: May 24, 2022
    Assignee: University of Puerto Rico
    Inventors: Carlos Raul Cabrera, Lisandro Federico Cunei, Carlos I. Gonzalez, Marina Martinez-Vargas
  • Patent number: 11329113
    Abstract: The disclosure relates to an array substrate, a display panel, a display device, and a method for manufacturing the array substrate. The array substrate includes a first substrate, a light emitting device on the first substrate, the light emitting device including a first electrode, a light emitting layer, and a second electrode sequentially disposed in a direction away from the first substrate, wherein the first electrode is transparent, and wherein the second electrode is reflective, an opaque portion between the first substrate and the light emitting device, wherein a projection of the light emitting device on the first substrate partially overlap with a projection of the opaque portion on the first substrate, and a reflective member between the opaque portion and the light emitting layer.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: May 10, 2022
    Assignees: BEIJING BOE DISPLAY TECHNOLOGY CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Mingxiao Jiang, Dan Wang, Yun Qiu, Xiao Sun, Weipin Hu, Qianqian Bu
  • Patent number: 11300537
    Abstract: An analyte sensor comprising: a non-conductive material; a conductive material disposed on the non-conductive material; and at least two sensing structures defined by a removed portion of the conductive material, the at least two sensing structures comprising a reagent composition.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: April 12, 2022
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Udo Hoss, Tahir Sadik Khan, Phu X. Le
  • Patent number: 11262345
    Abstract: A method for measuring a glycated protein in a sample, the method comprising (1) a step of allowing a sample in which a degradation product has been generated from a glycated protein by a protease to react with an oxidoreductase in the presence of an electron mediator to generate a reduced electron mediator; and (2) a step of detecting the reaction state in the step (1) by an electrochemical technique using an interdigitated electrode.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: March 1, 2022
    Assignee: Ultizyme International Ltd.
    Inventors: Yuki Ueda, Koji Sode, Wakako Tsugawa, Masaaki Kurita, Takashi Nishimori
  • Patent number: 11262324
    Abstract: A gas sensor includes: a substrate; a first conductor and a second conductor that are disposed on the substrate; an insulating layer; and an adsorbent layer. The insulating layer covers the first conductor and the second conductor, and has a first opening that allows a part of a surface of the first conductor to be exposed therethrough and a second opening that allows a part of a surface of the second conductor to be exposed therethrough. The adsorbent layer contains a conductive material and an organic adsorbent that can adsorb a gas. The adsorbent layer is in contact with the first conductor and the second conductor respectively through the first opening and the second opening.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: March 1, 2022
    Assignee: PANASONIC CORPORATION
    Inventors: Atsuo Nakao, Masaya Nakatani, Kiyoshi Toko, Rui Yatabe, Bartosz Wyszynski
  • Patent number: 11255814
    Abstract: Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions, suitable for holding an electrolyte solution which may contain an analyte such as a protein biomolecule to be detected as it is passed through the tip opening. Biomolecules are detected by specific reaction with peptide ligands chemically immobilized in the vicinity of the tip. Analytes which bind to the ligands cause a detectible change in ionic current. A sensitive detection circuit, using a feedback amplifier circuit, and alternating voltages is further disclosed. Detection of IL-10 at a concentration of 4 ng/ml is also disclosed, as is detection of VEGF.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: February 22, 2022
    Assignee: The Regents of the University of California
    Inventors: Miloslav Karhanek, Chris David Webb, Senkei Umehara, Nader Pourmand
  • Patent number: 11243184
    Abstract: Various bioFET sensor readout circuits and their methods of operation are described. A readout circuit includes a plurality of logic gates coupled in cascade, a delay extractor, and a counting module. Each logic gate of the plurality of logic gates includes at least one bioFET sensor. The delay extractor is designed to generate a pulse-width signal based on a time difference between an output signal from the plurality of logic gates and a reference signal. The counting module is designed to receive the pulse-width signal and output a digital count corresponding to a width of the pulse-width signal.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: February 8, 2022
    Inventors: Yu-Jie Huang, Jui-Cheng Huang
  • Patent number: 11242274
    Abstract: The present invention discloses a beverage dispenser, including: an inlet connected to a water source; an outlet for dispensing the water to a user vessel; at least one filter element having an input and an output for filtered water; a pump for pumping water to the input of the filter element; a flow sensor connected between the inlet and the outlet, wherein the flow sensor determines the actual flow rate of the water; at least one water preparation element connected between the output for outputting filtered water and the outlet and adapted to prepare the water for drinking by a human, wherein the water preparation element comprises a water preparation rate input by which the water preparation rate of the water preparation element can be controlled; and a controller connected to the water preparation rate input of the water preparation element and the flow sensor, wherein the controller controls the water preparation rate of the water preparation element by a signal to the water preparation rate input such t
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: February 8, 2022
    Assignee: RIPRUP Company S.A.
    Inventors: Monique Bissen, Josef Schucker
  • Patent number: 11243188
    Abstract: Disclosed are methods and devices for detection of ion migration and binding, utilizing a nanopipette adapted for use in an electrochemical sensing circuit. The nanopipette may be functionalized on its interior bore with metal chelators for binding and sensing metal ions or other specific binding molecules such as boronic acid for binding and sensing glucose. Such a functionalized nanopipette is comprised in an electrical sensor that detects when the nanopipette selectively and reversibly binds ions or small molecules. Also disclosed is a nanoreactor, comprising a nanopipette, for controlling precipitation in aqueous solutions by voltage-directed ion migration, wherein ions may be directed out of the interior bore by a repulsing charge in the bore.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: February 8, 2022
    Assignee: The Regents of the University of California
    Inventors: Nader Pourmand, Boaz Vilozny, Paolo Actis, R. Adam Seger
  • Patent number: 11226306
    Abstract: A microbial sensor, microbial sensing system, and method that can be used to determine the chemical environment of unsaturated soils, rhizosphere, and/or plants are disclosed. The microbial sensing system can be used for monitoring the health of plants including nutrients, salinity, contaminants, chemicals (pesticides, herbicides) and diseases. A microbial sensing system can include one or more indicator electrodes and a reference electrode. The microbial sensing system can include a signal acquisition and/or communication module to allow the real-time collection of data from field deployments and laboratory investigations.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: January 18, 2022
    Assignee: Burge Environmental. Inc.
    Inventors: Scott R. Burge, David A. Hoffman
  • Patent number: 11197627
    Abstract: A continuous glucose monitoring system and method has an inserter assembly for inserting a sensor through the skin and into subcutaneous tissue where an inserter housing with the sensor remains on the skin after insertion, a sensor housing cover attachable to the sensor housing after insertion where the sensor housing cover has an electronic module and a battery, and an electronic device equipped with wireless communication for communicating with the electronic module of the sensor housing cover assembly, the electronic device configured for receiving input signals from the sensor, converting the input signals to analyte date, displaying the analyte data on a user interface of the electronic device, storing the data for recall, and creating and/or sending reports of the data.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: December 14, 2021
    Assignee: SANVITA MEDICAL CORPORATION
    Inventors: Thomas H. Peterson, Handani Winarta, Anthony Florindi
  • Patent number: 11174183
    Abstract: The present invention discloses a beverage dispenser, including: an inlet connected to a water source; an outlet for dispensing the water to a user vessel; at least one filter element having an input and an output for filtered water; a pump for pumping water to the input of the filter element; a flow sensor connected between the inlet and the outlet, wherein the flow sensor determines the actual flow rate of the water; at least one water preparation element connected between the output for outputting filtered water and the outlet and adapted to prepare the water for drinking by a human, wherein the water preparation element comprises a water preparation rate input by which the water preparation rate of the water preparation element can be controlled; and a controller connected to the water preparation rate input of the water preparation element and the flow sensor, wherein the controller controls the water preparation rate of the water preparation element by a signal to the water preparation rate input such t
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: November 16, 2021
    Assignee: RIPRUP Company S.A.
    Inventors: Monique Bissen, Josef Schucker
  • Patent number: 11168361
    Abstract: A chip, a detection system and a gene sequencing method are provided. When the chip is used for gene sequencing, sample genes and reversible terminating nucleotides are added into micropores and matched therein to release hydrogen ions such that a Nernst potential is induced on an ion-sensitive film surface, and a voltage is applied to the transparent electrode layer to generate an electric field, thereby controlling the switching layer to change its state, and then a base type of the genes is determined based on a type of reversible terminating nucleotide corresponding to information of light emitted from the switching layer upon changes in the state of the switching layer, thereby gene sequencing is achieved.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: November 9, 2021
    Assignees: BOE TECHNOLOGY GROUP CO., LTD., BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD.
    Inventors: Fengchun Pang, Peizhi Cai, Yue Geng
  • Patent number: 11156581
    Abstract: A biosensor that can perform analysis based on a sample noninvasively collected from a human body is provided. The biosensor comprises an identification substance (38) that binds to a substance to be detected (40), and an electrode (16) charged with a charge of the identification substance (38), comprises an inhibitor (39) that inhibits a substance not to be detected (42) from attaching to at least one of the identification substance (38) and the electrode (16), and detects a change in a charge density of the electrode (16) caused by binding of the substance to be detected (40) to the identification substance (38).
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: October 26, 2021
    Assignee: The University of Tokyo
    Inventors: Toshiya Sakata, Taira Kajisa, Yuya Miyazawa, Yuta Uematsu
  • Patent number: 11134874
    Abstract: Briefly, a sensor for a continuous biological monitor is provided that has a working electrode with an enhanced carbon-enzyme layer that in one embodiment is made by mixing an aqueous polyurethane emulsion with an acrylic polyol emulsion to make a base emulsion. An enzyme and carbon materials are added to the base emulsion, which is applied to the working electrode and cured. The carbon materials may include carbon and graphite to provide strength, as well as graphene or pyrolytic graphite to provide a desirable electrical resistance for the carbon-enzyme layer. Optionally, other additives can be added to the base emulsion prior to application, such as hydophiles, cross linkers, adding imodeoesters, hydroxysuccimide, carboldilite, melamines, epoxies, benzoyl peroxide or dicumyl peroxide.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: October 5, 2021
    Assignee: Zense-Life Inc.
    Inventors: Robert James Boock, Huashi Zhang
  • Patent number: 11099149
    Abstract: A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: August 24, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Klaus Andreas Bauer-Espindola, Michael Marquant, Christine Nortmeyer, Reiner Stein
  • Patent number: 11067527
    Abstract: A system includes a sample analyzer having a sensor assembly. The sensor assembly includes a first microsensor having a first outer sheath, a first membrane core within the first outer sheath, and a first conductive element at least partially encased by and in contact with the first membrane core. The first conductive element detects a first electrical response signal when the first membrane core is in contact with the fluid. The sensor assembly may include a second microsensor that is adjacent to the first microsensor. The second microsensor has a second outer sheath, a second membrane core within the outer sheath, and a second conductive element at least partially encased by and in direct contact with the second membrane core. The second conductive element detects the second electrical response signal when the second membrane core is in contact with the fluid.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: July 20, 2021
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Jennifer Samproni
  • Patent number: 11060955
    Abstract: A microtome for producing thin sections from a sample includes a sample holder configured to receive the sample and a cutting edge configured to cut the sample, the cutting edge having a specified cutting direction, the cutting direction and the cutting edge spanning a cutting plane. The microtome further includes a movement device configured to produce a relative movement between the sample holder and the cutting unit for cutting the sample in the cutting direction, a feed device configured to produce a relative movement between the sample holder and the cutting edge for cutting the sample in a feed direction at an angle not equal to 0° to the cutting plane, and a liquid volume with a liquid abutting the cutting edge on a side of the cutting edge facing away from the sample holder.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: July 13, 2021
    Assignee: KARLSRUHER INSTITUT FUER TECHNOLOGIE
    Inventors: Waldemar Spomer, Ulrich Gengenbach, Julian Hoffmann, Andreas Hofmann, Leonard J. Ness, Warren J. P. Brey, Rasmus Schroeder, Irene Wacker-Schroeder
  • Patent number: 11060053
    Abstract: The invention relates to a device for hydrating with a liquid sample, the device comprising a container (4) for receiving at least one liquid sample, and a lid (5) possessing a bottom face (51) having at least one hydrating support (3) fastened thereto to present an absorption face (31) for absorbing a liquid sample. According to the invention, the container (4) presents, by means of at least one well (6), a calibrated volume for receiving a liquid sample, the at least said well presenting a hydrating calibrated open section for hydrating a hydrating support (3) defined by the top edge (8) of at least said well (6), the hydrating calibrated open section possessing an area that is less than the area of the absorption face of the hydrating support (3) in order to control the absorption by capillarity of the liquid sample by the hydrating support.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: July 13, 2021
    Assignee: BIOMERIEUX
    Inventors: Bruno Colin, Laurence Dévigne, Sandrine Ghirardi, Marie-Pierre Montet, Christine Rozand, Philippe Wandels
  • Patent number: 11035816
    Abstract: A miniaturized electrochemical cell (2) comprising a main body (20) comprising a tip (21) wherein inlet (41) and outlet (51) hollow conduits of millimeter-size diameter are hollowed out separated by a partition wall (200) integral with the main body (20) in which an electrolytic liquid solution (10) flows, in a space between the tip (21) and a surface (90) of a conductor material to be analyzed (9) is identified a millimeter-size chamber for redox reactions (6), the tip (21) of the main body (20) comprises a millimeter-size opening (210) of millimetric dimension in communication with said millimeter-size chamber for redox reactions (6).
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: June 15, 2021
    Assignee: NANOMATERIALS. IT S.R.L.
    Inventor: Massimiliano Bestetti
  • Patent number: 11009383
    Abstract: In one example in accordance with the present disclosure a fluid property sensing device is described. The fluid property sensing device includes a substrate having a trench formed therein. The trench includes a bottom surface and opposite side surfaces. A first electrode is disposed on a first side surface of the trench and a second electrode is disposed on a second side surface of the trench. The first electrode and second electrode form a capacitor to measure a complex impedance of a fluid that fills a space between the first electrode and the second electrode. This complex impedance indicates a property of the fluid. A fluid level sensing die, having a number of fluid level sensing components disposed thereon, may be attached to the substrate, preferably in such a way that the fluid level sensing die is surrounded by the trench. In this way the surface area of the electrodes provided in the trench can be increased. The number of level sensing components may be thermal sensing components.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: May 18, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Michael W. Cumbie, Chien-Hua Chen, Greg Scott Long
  • Patent number: 11002718
    Abstract: Gas sensors for the detection of rare events consume very little or no power. The sensors include materials that interact with a target gas. Accumulation of the target gas on the sensor materials leads to a change in electrical properties of the sensor. The sensors may have high gain, meaning that a large electrical change is induced upon gas accumulation. The sensor might change from an extremely high resistance (open circuit) to a measurably low resistance, or it might change from a relatively low capacitance to a high capacitance. The gas sensors are connected to electronics that can transmit an alarm signal after gas has been detected. The electronics may be in a low power sleep mode until awakened by a signal from the sensor.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: May 11, 2021
    Assignee: PALO ALTO RESEARCH CENTER INCORPORATED
    Inventors: David Eric Schwartz, Jianer Bao