Enzyme Included In Apparatus Patents (Class 204/403.14)
-
Patent number: 8287703Abstract: An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.Type: GrantFiled: September 25, 2008Date of Patent: October 16, 2012Assignees: Roche Diagnostics Operations, Inc., Roche Operations Ltd.Inventors: Raghbir S. Bhullar, Eric R. Diebold, Brian S. Hill, Nigel Surridge, Paul Douglas Walling
-
Publication number: 20120247976Abstract: A non-invasive glucose sensor (10) for detecting an amount of glucose in bodily fluid, comprising: an organic electrochemical transistor (OECT) having a gate electrode (20); wherein a surface of the gate electrode (20) is modified with an enzyme and a nanomaterial to increase sensitivity and selectivity of the gate electrode (20).Type: ApplicationFiled: March 29, 2011Publication date: October 4, 2012Applicant: THE HONG KONG POLYTECHNIC UNIVERSITYInventors: Feng Yan, Helen L.W. Chan, Hao Tang
-
Publication number: 20120247964Abstract: Disclosed is a microfluidic control device which may electrochemically and simply measure the value of glycosylated hemoglobin in blood on a chip, a method for manufacturing the same, and a method for operating the same.Type: ApplicationFiled: March 30, 2012Publication date: October 4, 2012Applicant: Electronics and Telecommunications Research InstituteInventors: Dae Sik LEE, Moon Youn Jung, Seung Hwan Kim
-
Patent number: 8277635Abstract: Disclosed herein is an electrochemical biosensor measuring device which comprises at least two photodiodes for emitting light beams at regular time intervals in a sequential manner, with the insertion of an electrochemical biosensor thereto, and a detector for sensing the emitted light beams, thereby identifying the production lot information recorded on a production lot information identification portion on the electrochemical biosensor. Thus, the device enjoys economic advantages of not requiring a high-priced optical filter in detecting the light absorbed through or reflected from the production identification information recorded in biosensor and a complicated software algorithm to recover the production lot information.Type: GrantFiled: February 26, 2008Date of Patent: October 2, 2012Assignee: I-Sens, Inc.Inventors: Moon Hwan Kim, Keun Ki Kim, Gang Cui, Hakhyun Nam, Geun Sig Cha
-
Patent number: 8277636Abstract: The present invention relates to a glucose sensor (2) including an electrode (32) which includes a conductive component and glucose dehydrogenase immobilized to the conductive component. As the glucose dehydrogenase, use is made of a protein complex including a catalytic activity subunit which has glucose dehydrogenase activity, and an electron mediator subunit for supplying an electron donated from the catalytic activity subunit to the conductive component. Preferably, the glucose sensor (2) is designed to continuously measure the glucose level or successively measure the glucose level a plurality of times.Type: GrantFiled: February 17, 2009Date of Patent: October 2, 2012Inventor: Koji Sode
-
Patent number: 8273226Abstract: An electrochemical test sensor includes a base, a generally hard electrically-conductive layer, an electrochemically-active layer, and a lid. The electrically-conductive layer is located between the base and the electrochemically-active layer. The electrically-conductive layer and the electrochemically-active layer are made of a different material. The electrically-conductive layer and the electrochemically-active layer form an electrode pattern. The electrochemical test sensor includes a reagent adapted to assist in determining information related to an analyte of a fluid sample.Type: GrantFiled: December 9, 2008Date of Patent: September 25, 2012Assignee: Bayer HealthCare LLCInventor: Andrew J. Edelbrock
-
Patent number: 8273242Abstract: Embodiments of the invention provide devices and methods for extracting nucleic acid molecules from solution using electric fields. The structures and methods of embodiments of the invention are suited to incorporation into micro and nano fluidic devices, such as lab-on-a-chip devices and micro total analysis systems.Type: GrantFiled: October 14, 2011Date of Patent: September 25, 2012Assignee: Intel CorporationInventors: Steven A. Sundberg, Xing Su, Grace Credo
-
Patent number: 8273241Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.Type: GrantFiled: September 29, 2009Date of Patent: September 25, 2012Assignee: Abbott Diabetes Care Inc.Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
-
Publication number: 20120234700Abstract: A method for determining a concentration of an analyte is disclosed. The method includes applying a potential excitation to a fluid sample containing an analyte and determining if a current decay curve associated with the fluid sample has entered an analyte depletion stage. The method also includes measuring a plurality of current values associated with the fluid sample during the analyte depletion stage and calculating an analyte concentration based on at least one of the plurality of current values.Type: ApplicationFiled: December 20, 2011Publication date: September 20, 2012Inventor: David Deng
-
Patent number: 8268144Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.Type: GrantFiled: September 29, 2009Date of Patent: September 18, 2012Assignee: Abbott Diabetes Care Inc.Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
-
Patent number: 8268163Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.Type: GrantFiled: September 29, 2009Date of Patent: September 18, 2012Assignee: Abbott Diabetes Care Inc.Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
-
Patent number: 8262874Abstract: The disclosure provides for reagent compositions for biosensors comprising release polymers, methods of making such biosensors and films of reagent compositions comprising release polymers. The reagent compositions comprise a release polymer and an effective analyte detecting amount of an enzyme an enzyme cofactor and a redox compound capable of acting in a biosensor as (i) a redox mediator associated with a working electrode (ii) a redox couple associated with a reference electrode or (iii) the redox mediator associated with the working electrode and the redox couple for the reference electrode.Type: GrantFiled: April 14, 2008Date of Patent: September 11, 2012Assignee: Abbott Diabetes Care Inc.Inventors: Nigel John Forrow, Shridhara Alva Karinka
-
Patent number: 8252523Abstract: A reagent composition for a biosensor sensor strip is disclosed that provides for rapid rehydration after drying. The composition includes porous particles and is preferably formed as a colloidal suspension. The dried reagent composition including porous particles may provide analytically useful output from the sensor strip in a shorter time period than observed from dried reagent compositions using solid particles. The output signal from the porous particle compositions may be correlated to the analyte concentration of a sample within about two seconds. In this manner, an accurate concentration determination of an analyte concentration in a sample may be obtained in less time than from sensor strips including conventional compositions. The reagent composition including the porous particles also may allow for the redox reaction between the reagents and the analyte to reach a maximum kinetic performance in a shorter time period than observed from conventional sensor strips.Type: GrantFiled: December 10, 2008Date of Patent: August 28, 2012Assignee: Bayer HealthCare LLCInventor: Boru Zhu
-
Patent number: 8247189Abstract: Provided is an enzyme that is further advantageous in terms of practical aspects when compared to publicly known enzymes for blood sugar sensors, and that can be used in a blood sugar level measuring reagent A flavin adenine dinucleotide-dependent glucose dehydrogenase that has amino acid sequence including a specific amino acid in an amino acid sequence shown in SEQ ID NO:2 or an amino acid sequence that has 60% homology therewith, and that has an improved temperature dependency.Type: GrantFiled: March 15, 2012Date of Patent: August 21, 2012Assignee: Toyo Boseki Kabushiki KaishaInventors: Hiroshi Kawaminami, Masao Kitabayashi, Yoshiaki Nishiya
-
Publication number: 20120208226Abstract: In one form, a mutant fructosyl amino acid oxidase modified at an amino acid residue involved in a proton relay system is provided. The mutant fructosyl amino acid oxidase has reduced oxidase activity while substantially maintaining its dehydrogenase activity. Other forms include an assay device and assay method for measuring glycated protein. Still, other forms include unique methods, techniques, systems and devices involving a mutant fructosyl amino acid oxidase.Type: ApplicationFiled: February 3, 2012Publication date: August 16, 2012Inventors: Kazunori Ikebukuro, Sode Koji
-
Patent number: 8241486Abstract: A biosensor strip having a low profile for reducing the volume of liquid sample needed to perform an assay. In one embodiment, the biosensor strip includes an electrode support; an electrode arrangement on the electrode support; a cover; a sample chamber; and an incompressible element placed between the cover and the electrode support, the incompressible element providing an opening in at least one side or in the distal end of the sample chamber to provide at least one vent in the sample chamber. In another embodiment, the biosensor strip has an electrode support; an electrode arrangement on the electrode support; a cover; and a sample chamber, the cover having a plurality of openings formed therein, at least one of the openings in register with the sample chamber. The invention further includes methods for preparing such a biosensor strips in a continuous manner.Type: GrantFiled: March 7, 2011Date of Patent: August 14, 2012Assignee: Abbott LaboratoriesInventors: Adrian Petyt, Matthew Bates, Pamela Reid, Andrew J. Bull, Jeff Garner
-
Patent number: 8242919Abstract: Provided is a moisture detection device including: a moisture detection label that has at least a pair of detection terminals and a pattern, the detection terminals being provided on a base material with an insulated front surface, the pattern being provided on the surface of the base material and formed between the detection terminals with water-dispersible and conductive paint; and detection circuit which detects an electrical connection state between the detection terminals.Type: GrantFiled: August 15, 2005Date of Patent: August 14, 2012Assignee: NEC CorporationInventor: Shinji Oguri
-
Patent number: 8241485Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.Type: GrantFiled: September 30, 2008Date of Patent: August 14, 2012Assignee: Abbott LaboratoriesInventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephan Walters
-
Publication number: 20120199497Abstract: An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes a substrate, at least one working electrode disposed on the substrate, a sample-soluble enzymatic reagent layer disposed above the working electrode, a diffusion-controlling layer (DCL) disposed between the at least one working electrode and the sample-soluble enzymatic reagent layer; and a sample-receiving chamber. In addition, the sample-soluble enzymatic reagent layer is configured and constituted for operable solubility in a bodily fluid sample applied to the electrochemical-based analytical test strip and received in the sample-receiving chamber and for electrochemical enzymatic reaction with an analyte in the bodily fluid sample.Type: ApplicationFiled: February 7, 2011Publication date: August 9, 2012Applicant: LifeScan Scotland LimitedInventors: Zuifang Liu, Marco F. Cardosi, Christopher Philip Leach, Scott Sloss
-
Publication number: 20120202235Abstract: In one form, a fructosyl peptidyl oxidase derived from a budding yeast Phaeosphaeria nodorum for assaying a glycated protein in a sample is provided. The fructosyl peptidyl oxidase has higher activity toward fructosyl valine as well as fructosyl valyl histidine, and may be useful in assaying HbA1c with higher sensitivity and specificity. Still, other forms include unique methods, techniques, systems and devices involving a fructosyl peptidyl oxidase.Type: ApplicationFiled: February 3, 2012Publication date: August 9, 2012Inventors: Kazunori Ikebukuro, Sode Koji
-
Publication number: 20120199498Abstract: An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes an electrically-insulating substrate, at least one working electrode disposed on the electrically-insulating substrate and a graded enzymatic reagent layer disposed on the at least one working electrode. The graded enzymatic reagent layer includes an upper reaction grade that contains an enzyme. The graded enzymatic layer also has a lower spacer grade devoid of the enzyme, the lower spacer grade disposed between the upper reaction grade and the working electrode such that the upper reaction grade is spaced equidistant from the working electrode by the lower spacer grade by a predetermined distance during use of the electrochemical-based analytical test strip.Type: ApplicationFiled: February 7, 2011Publication date: August 9, 2012Inventors: Manuel Alvarez-Icaza, Alan McNeilage, Zuifang Liu, Damian Baskeyfield
-
Patent number: 8236154Abstract: The present invention provides a surface-modified electrode strip for measuring an electrochemical signal that is synergistically amplified by means of a nano-scaled gold particle layer and a lipid-soluble electron mediator layer. A biosensor comprising the electrode strip is also provided.Type: GrantFiled: June 16, 2008Date of Patent: August 7, 2012Assignee: Apex Biotechnology Corp.Inventors: Sz-Hau Chen, Chih-Sheng Lin, Guan-Tin Chen, Yueh-Hui Lin, Thomas Y. S. Shen
-
Patent number: 8236153Abstract: An immobilization carrier containing an electron acceptor compound is used in addition to glutaraldehyde and poly-L-lysine to immobilize an enzyme and an electron acceptor compound simultaneously to an electrode. For example, here are used diaphorase as the enzyme and 2-amino-3-carboxy-1, 4-naphthoquinone (ACNQ) as the electron acceptor compound.Type: GrantFiled: February 27, 2009Date of Patent: August 7, 2012Assignee: Sony CorporationInventors: Atsushi Sato, Tokuji Ikeda, Kenji Kano
-
Patent number: 8231768Abstract: A biosensor includes a working electrode 101, a counter electrode 102 opposing the working electrode 101, a working electrode terminal 103 and a working electrode reference terminal 10 connected to the working electrode 101 by wires, and a counter electrode terminal 104 connected to the counter electrode 102 by a wire. By employing a structure with at least three electrodes, it is possible to assay a target substance without being influenced by the line resistance on the working electrode side.Type: GrantFiled: March 6, 2009Date of Patent: July 31, 2012Assignee: Panasonic CorporationInventors: Hiroya Ueno, Junji Nakatsuka
-
Publication number: 20120190950Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.Type: ApplicationFiled: January 20, 2011Publication date: July 26, 2012Applicant: MEDTRONIC MINIMED, INC.Inventors: Qingling Yang, Rajiv Shah, Xiaolong Li, Barry Phong Pham, Yiwen Li
-
Publication number: 20120186997Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.Type: ApplicationFiled: January 20, 2011Publication date: July 26, 2012Applicant: MEDTRONIC MINIMED, INC.Inventors: Xiaolong Li, Rajiv Shah, Qingling Yang, Yiwen Li, Barry Phong Pham
-
Publication number: 20120181189Abstract: An amperometric biosensor is provided for determination of creatinine in a sample fluid. The biosensor can be an enzyme-polymer composition having at least one redox polymer and a plurality of enzymes immobilized on an electrode surface. Methods of preparing the amperometric biosensor are included. In addition, methods and systems using the amperometric biosensor in measuring creatinine concentrations of a patient and treatments of a patient with monitoring of the progress of dialysis performed on the patient are also provided.Type: ApplicationFiled: August 18, 2010Publication date: July 19, 2012Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.Inventor: Stephen A. Merchant
-
Publication number: 20120181186Abstract: Described are methods for detecting a target analyte in a test sample by providing a solid support comprising an electrode comprising: (i) a self-assembled monolayer (SAM), (ii) a covalently attached electroactive active moiety (EAM) comprising a transition metal complex comprising a self-immolative moiety and a peroxide sensitive moiety (PSM), wherein said EAM has a first E0; then contacting the target analyte and said solid support under conditions wherein said target analyte reacts with a peroxide generating enzyme to generate peroxide and said self-immolative moiety is removed such that said EAM has a second E0 test sample; and then detecting said second E0 as an indication of the presence of said target analyte. Also provided are compositions for use in the preceding methods.Type: ApplicationFiled: January 19, 2012Publication date: July 19, 2012Applicant: OHMX CORPORATIONInventors: Paul A. Bertin, Michael J. Ahrens
-
Publication number: 20120181173Abstract: The invention relates to an electrochemical sensor for the detection of analytes in liquid media which comprises 4 layers, wherein the first layer (1) comprises a carbonaceous material deposited on a substrate, said layer forming the system of electrodes of the electrochemical sensor, formed at least by a pseudo-reference electrode, a working electrode and a counter electrode; and the fourth layer (4) comprises polythiophene deposited only on the lower end of the working electrode selected from (d1), which comprises a layer comprising a polythiophene deposited on the lower end of the working electrode and a layer comprising a non-conductive polymer gel deposited on said layer of polythiophene; (d2), which is a layer of conductive polymer gel comprising a non-conductive polymer gel and a polythiophene; and (d3), which comprises a layer comprising a polythiophene deposited on the lower end of the working electrode and a layer comprising functionalized magnetic nanoparticles deposited on said layer of polythiophType: ApplicationFiled: July 23, 2010Publication date: July 19, 2012Applicant: FUNDACION CIDETECInventors: Estibaliz Ochoteco Vaquero, Elena Jubete Diez, José Adolfo Pomposo Alonso, Hans-Jurgen Grande Telleria, Oscar A. Loaiza, German Cabañero, Georges Istamboulie, Thierry Noguer, Jean Louis Marty
-
Patent number: 8221994Abstract: An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.Type: GrantFiled: September 30, 2009Date of Patent: July 17, 2012Assignee: Cilag GmbH InternationalInventors: Ronald C. Chatelier, Dennis Rylatt
-
Patent number: 8216446Abstract: The invention relates to a method of labelling and analysing nucleic acids. More specifically, the invention relates to a method of analysing nucleic acids, which comprises contacting the nucleic acids to be detected, which are in the form of single-stranded nucleic acid strands partially (i.e. over a part of the total length of the nucleic acid strands) hybridized with protective strands, with substances which specifically react with nucleobases of the single-stranded sections of the nucleic acid strands, and which are capable of subsequently participating in a reversible redox reaction in electroanalytical processes known to the skilled worker.Type: GrantFiled: August 17, 2006Date of Patent: July 10, 2012Assignee: Universität RostockInventors: Gerd-Uwe Flechsig, Thomas Reske
-
Patent number: 8211280Abstract: Devices and methods for determining the concentration of an analyte in a sample of liquid are provided.Type: GrantFiled: September 7, 2010Date of Patent: July 3, 2012Assignee: Abbott Diabetes Care Inc.Inventors: Adrian Petyt, Simon Andrew Hector
-
Publication number: 20120160708Abstract: The present invention provides compositions, devices and methods for detecting esterase activity. The present invention also provides devices and methods of detecting esterase inhibitors, for example, organophosphates. In particular, the present invention provides a biosensor comprising Neuropathy Target Esterase (NTE) polypeptides. Further, the present invention relates to medicine, industrial chemistry, agriculture, and homeland security.Type: ApplicationFiled: May 15, 2008Publication date: June 28, 2012Inventors: Neeraj Kohli, Devesh Srivastava, Rudy J. Richardson, Jun Sun, Ilsoon Lee, Robert M. Worden
-
Patent number: 8207336Abstract: Bis-(4,4?dimethyl-2,2?bipyridyl) picolinate osmium complexes are useful as mediators in the electrochemical test strips, such as those used in the detection of glucose.Type: GrantFiled: January 13, 2011Date of Patent: June 26, 2012Assignee: AgaMatrix, Inc.Inventor: Ian Harding
-
Publication number: 20120152763Abstract: A reagent layer (4) of a sensor (1) contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor 1.Type: ApplicationFiled: August 30, 2010Publication date: June 21, 2012Inventors: Yoshifumi Takahara, Takahiro Nakaminami, Shin Ikeda
-
Patent number: 8202409Abstract: A potentiometric sensor with suppressed leak current on the surface of an electrode and improved for a dynamic range and a response speed, in which a redox compound is immobilized through insulative molecules on the surface of a gold electrode, and a current between a source and drain of an insulated gate field-effect transistor along with reaction between an oxidized substance or a reduced substance produced by the reaction of a measured substance in a sample solution injector for supplying the sample solution containing the measured substance and an enzyme and a redox compound on the surface of the gold electrode, is monitored on real time to measure the change of the surface potential.Type: GrantFiled: November 20, 2007Date of Patent: June 19, 2012Assignee: Hitachi, Ltd.Inventors: Yu Ishige, Masao Kamahori
-
Publication number: 20120150005Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.Type: ApplicationFiled: December 8, 2011Publication date: June 14, 2012Inventors: Udo Hoss, Phu Le, Yi Wang, Frank David Fujimoto, Suyue Qian, Lam Tran
-
Publication number: 20120138484Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution and/or improved sensitivity and/or reduced sensitivity variation of the sensing layer by inclusion of a thickener and/or an enzyme stabilizer in the sensing layer. Embodiments of the present disclosure also relate to transition metal complexes having at least one pyridine boronic acid ligand are also described. Aspects of the disclosure include transition metal complexes chemically bonded to a polymer, such as a sensing layer polymer. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.Type: ApplicationFiled: November 16, 2011Publication date: June 7, 2012Inventors: Balasubrahmanya S. Bommakanti, Udo Hoss, Gary Sandhu
-
Publication number: 20120132525Abstract: Polymers for use as redox mediators in electrochemical biosensors are described. The transition metal complexes attached to polymeric backbones can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand.Type: ApplicationFiled: March 19, 2008Publication date: May 31, 2012Inventors: Zenghe Liu, Benjamin J. Feldman, Fei Mao, Adam Heller
-
Publication number: 20120125767Abstract: Analyte sensors for determining the concentration of an analyte in a sample. The sensors have a sample chamber having an inlet with a projection extending from an edge of the sensor for facilitating flow of sample into the sample chamber.Type: ApplicationFiled: September 12, 2011Publication date: May 24, 2012Inventor: Yi Wang
-
Publication number: 20120125789Abstract: The present invention relates to a composition for forming an electrode, an electrochemical sensor comprising the same, and a method for determining an analyte using the electrochemical sensor.Type: ApplicationFiled: November 15, 2011Publication date: May 24, 2012Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Gregor OCVIRK, Claudia GAESSLER-DIETSCHE
-
Publication number: 20120129195Abstract: A method of quick laboratory diagnosis of diseases, based on the discovery of specific protein targets characteristic to the disease in the reaction of their specific interaction with other protein reagents, distinct in that specific protein targets for the given disease are hydrolyzed with proteolytic enzymes and then the chemical structure of the oligopeptide formula created is modified in such a way that its charge is changed to the opposite. This method of quick laboratory diagnosis of illnesses based on the discovery of specific proteins, and the equipment for its implementation, may be applied for the discovery of viral and microbial antigens in various human biological fluids. The method may also be used for the detection of new and little-studied infectious diseases in connection with the ease of diagnostic preparation.Type: ApplicationFiled: February 1, 2011Publication date: May 24, 2012Inventors: Artur Martynov, Boris S. Farber, Sonya Sophya Farber
-
Patent number: 8182663Abstract: A BUN (blood urea nitrogen) sensor containing immobilized carbonic anhydrase and immobilized urease for the in vitro detection of urea nitrogen in blood and biological samples with improved performance and precision characteristics.Type: GrantFiled: February 25, 2009Date of Patent: May 22, 2012Assignee: Abbott Point of Care Inc.Inventors: G. Bruce Collier, Eric Brouwer, Anjulia Wong
-
Publication number: 20120111739Abstract: This invention is a method for determining a hematocrit value. The steps include applying a first pulse of potential excitation at a first frequency to a test strip containing a fluid sample. The method also includes applying a second pulse at a second frequency that is higher than the first frequency. Based on first and second impedance measurements associated with each pulse, a hematocrit value may be determined. Also, a concentration of an analyte contained within the fluid sample may be determined based on the hematocrit value.Type: ApplicationFiled: October 8, 2008Publication date: May 10, 2012Inventors: John J. Pasqua, Christine Shields, Angela Carlson
-
Patent number: 8172996Abstract: An enzyme electrode and its producing method are disclosed. The method includes providing a substrate having a carbon surface; forming a gold surface on the carbon surface and forming an electrode; modifying the gold surface by L-cysteine; modifying the gold surface by N,N?-dicyclohexylcarbodiimide; and chemically bonding the modified gold surface with a glucose oxidase.Type: GrantFiled: April 9, 2009Date of Patent: May 8, 2012Assignee: Chung Yuan Christian UniversityInventors: Chean-Yeh Cheng, Kuo-Chung Chang
-
Patent number: 8168052Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.Type: GrantFiled: July 26, 2010Date of Patent: May 1, 2012Assignee: Abbott Diabetes Care Inc.Inventors: Fei Mao, Adam Heller
-
Publication number: 20120097554Abstract: Embodiments of the invention disclosed herein comprise amperometric glucose sensor systems that include multiple working electrodes having different material properties as well as algorithms and other elements designed for use with such systems. While embodiments of the innovation can be used in a number of contexts, typical embodiments of the invention include glucose sensors used to facilitate the management of diabetes.Type: ApplicationFiled: October 18, 2011Publication date: April 26, 2012Applicant: MEDTRONIC MINIMED, INC.Inventors: Rajiv Shah, Eric Allan Larson, Katherine T. Wolfe, Daniel E. Pesantez
-
Patent number: 8163160Abstract: The present invention provides reagent compositions, and analyte measuring devices and methods that utilize the reagent compositions.Type: GrantFiled: June 14, 2010Date of Patent: April 24, 2012Assignee: Abbott Diabetes Care Inc.Inventors: Nigel J. Forrow, Shridhara Alva Karinka
-
Patent number: 8160670Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.Type: GrantFiled: July 3, 2008Date of Patent: April 17, 2012Assignee: Abbott Diabetes Care Inc.Inventors: Tianmei Ouyang, Zenghe Liu, Hyun Cho, Benjamin J. Feldman
-
Publication number: 20120073987Abstract: An electrochemical method of identifying the presence of a target protein in a sample is provided. The method comprises providing a redox probe modified to include a detector that is suitable to bind to the target protein, and exposing the sample to the detector-modified redox probe. A change in the electrochemical signal produced by the redox probe as compared to a control signal is indicative of the presence of the target protein.Type: ApplicationFiled: June 8, 2010Publication date: March 29, 2012Inventors: Heinz-Bernhard Kraatz, Kagan Kerman