In A Holder Or Container Patents (Class 422/401)
  • Patent number: 8691162
    Abstract: A biomedical diagnostic device includes a hydrophilic layer, hydrophobic layer, and at least one test pad. The hydrophilic layer includes an exposed introductory portion adapted to introduce a test fluid, and is stacked with the hydrophobic layer with multiple access holes. At least one test pad, each of which includes a distinguishing reaction medium, is disposed in the corresponding holes that extend to contact the hydrophilic layer. The relations within the device are as follows: hydrophilicity of any of the test pads>hydrophilicity of the hydrophilic layer>hydrophilicity of the hydrophobic layer.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: April 8, 2014
    Assignee: National Tsing Hua University
    Inventors: Shang-Chi Lin, Li-Ching Chen, Chen-Meng Kuan, Fan-Gang Tseng, Chao-Min Cheng
  • Patent number: 8691161
    Abstract: A test strip to assist in determining the concentration of an analyte in a fluid sample comprises a base, at least one tab and a break line. The base includes a capillary channel and a test element. The capillary channel is in fluid communication with the test element. The test element is adapted to receive the fluid sample. The at least one tab is removably attached to the base. The capillary channel extends from the base into a portion of the tab. The break line intersects the capillary channel in which an inlet to the capillary channel is exposed along the break line when the tab is separated from the base.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: April 8, 2014
    Assignee: Bayer HealthCare LLC
    Inventor: Roger Fleming
  • Patent number: 8691150
    Abstract: The invention relates to a system for testing a sample of bodily fluid, comprising a carrier band, which carries a plurality of consumable elements, wherein one end of the carrier band is attached to a wind-up device for winding the carrier band, together with used consumable elements, onto a reel for the band transport, and comprising a display for displaying information regarding the supply of yet unused consumable elements of the carrier band. According to the invention, it is provided that information regarding the supply of yet unused consumable elements of the carrier band is obtained from an angle of rotation and from a band transport length by which the carrier band is moved with a rotation of the reel about said angle of rotation.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: April 8, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Robert Lorenz, Kai-Oliver Schwenker
  • Patent number: 8685746
    Abstract: A system and method for preparing and analyzing samples. The system can include a sample preparation system and a sample detection system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition comprising a source and a diluent. The sample detection system can be positioned in fluid communication with the reservoir, and can be adapted to analyze a sample of the liquid composition for an analyte of interest. The system can further include a fluid path defined at least partially by the reservoir and the sample detection system. The method can include applying pressure to the deformable self-supporting receptacle to move a sample of the liquid composition in the fluid path to the sample detection system, and analyzing the sample for the analyte of interest with the sample detection system.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: April 1, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Kurt J. Halverson, Stephen C. P. Joseph, Raj Rajagopal, Matthew D. Reier, David J. Velasquez, Cynthia D. Zook, Sailaja Chandrapati
  • Patent number: 8685745
    Abstract: A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: April 1, 2014
    Assignee: Polestar Technologies, Inc.
    Inventor: James A. Kane
  • Patent number: 8685744
    Abstract: A mobile water analyzing system for determining an analyte in a water sample includes a basic unit and a test element configured to be inserted into the basic unit. The test element includes a sample line with an inlet opening configured to receive the water sample, a measuring section forming a measuring track and configured to allow the determination of an analyte, a pump opening, and a key reagent disposed inside the sample line. The basic unit includes a test element receptacle configured to hold the inserted test element, an analyzer with an analyzer measuring track formed by the measuring section, and a pump actuator cooperatively connected with the pump opening.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: April 1, 2014
    Assignee: Hach Lange GmbH
    Inventors: Ulrich Lundgreen, Aria Farjam, Rolf Uthemann, Andreas Mitreiter, Isabel Huenig, Markus Lenhard, Rainer Froemel, Hans-Joachim Kumpch
  • Patent number: 8679853
    Abstract: A test strip or biosensor comprising a base substrate on which an electrode system is formed. One or more laminate layers overlie the base substrate to form a sample-receiving chamber in which a reagent is deposited. An opening is provided from the sample-receiving chamber to the exterior of the biosensor. The layers and the base substrate are laser welded to secure the biosensor. One of the layer and base substrate is light transmissive to allow laser welding at the interface therebetween. The biosensor may be formed from a series of continuous webs that are subsequently sliced to form individual biosensors.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: March 25, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Raghbir S. Bhullar, Ali Razban
  • Patent number: 8679420
    Abstract: A device for testing a specimen comprising a first panel, a metering aperture structure having a plurality of metering apertures formed therein for receiving the specimen therethrough, a second panel opposite the first panel, a sheet disposed between the first and second panels, the sheet including a test area aligned with the plurality of metering apertures, a spacer element disposed between the first panel and the sheet, wherein the metering aperture structure is spaced away from the test area thereby improving readability of the testing. A method of manufacturing a specimen testing device is also disclosed.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: March 25, 2014
    Assignee: Immunostics, Inc.
    Inventors: Vincent P. LaStella, Kenneth Kupits
  • Patent number: 8673651
    Abstract: A package for holding and disguising a chromatographic test of food and drink is formed in the shape of a drinking straw or stirrer. The package encloses test patches which are sensitive to particular drugs and produce a color change upon contact with the drug. The package has a view port or slit to observe the condition of the test strip upon contact with food and drink.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: March 18, 2014
    Assignee: GelTech Solutions, Inc.
    Inventors: Peter Cordani, Anne Cordani
  • Patent number: 8667833
    Abstract: A protective cap 2 is engaged with a latch 10 of a diluent container 5 so as to fix the diluent container 5 at a liquid holding position of a diluent container containing section 11. The engagement is released when the protective cap 2 is set to an open position against the engagement so as to expose an inlet 13. When the protective cap 2 is shifted from the open position to a closed position, the protective cap 2 pushes the diluent container 5 into a liquid discharge position. Thus, it is possible to preserve a diluent for a long period of time and to easily open the diluent container 5 without having to complicate the structure of an analysis apparatus.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: March 11, 2014
    Assignee: Panasonic Corporation
    Inventors: Hiroshi Saiki, Yoshiyuki Fujii, Nobuyasu Higashi, Masaaki Kitoh, Kenji Okada, Hirofumi Sugimoto
  • Publication number: 20140065031
    Abstract: The invention relates to a container, tube or chemical apparatus, in particular for the construction of chemical apparatus for storing or for transporting aggressive storage media, comprising a solid inner layer with the inner side of which the storage medium can come into contact and which is made of a thermoplastic that is resistant to the storage medium, comprising an adhesion-promoting layer applied to the outer side of the inner layer, which is made of a textile sheet-like structure, and comprising a carrier layer applied to the outer side of the adhesion-promoting layer for providing mechanical support to the layer structure, wherein between the inner layer and the outer layer an indicator layer is provided, the material of the indicator layer being discolored by components of the storage medium which permeate through the inner layer.
    Type: Application
    Filed: May 2, 2012
    Publication date: March 6, 2014
    Applicant: Simona AG
    Inventor: Achim K.E. Litzenburger
  • Patent number: 8663563
    Abstract: A reflective diffractometric hydrogel sensor includes an upper layer, including a microfluidic chamber formed from a substantially transparent material and configured to contain a solution, a reflective diffraction grating positioned within the microfluidic chamber, the diffraction grating including a plurality of hydrogel strips configured to change in dimension in response to a stimulus, each hydrogel strip having a top surface coated with a reflective material and a bottom surface in contact with the upper layer substrate, and a reflective surface below the reflective diffraction grating wherein when a coherent light is incident upon and reflected from the upper layer at an angle substantially normal to the upper layer an interference diffraction pattern results, including a first diffraction mode, a light intensity of which indicates the relative distance between the top surfaces of the plurality of hydrogel strips and the reflective surface.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: March 4, 2014
    Assignees: Purdue Research Foundation, Board of Regents, The University of Texas System
    Inventors: Cagri Savran, Chun-Li Chang, Zhenwen Ding, Babak Ziaie, Andrew Ellington, Venkata Naga Lakshmi Rekha Patchigolla
  • Patent number: 8663575
    Abstract: There is described a sample holder and associated fluid container assembly for optical analysis of a fluid sample within a translucent container of the fluid container assembly. The sample holder includes clamping members rotatably mounted to a frame for rotation, about parallel axes spaced apart from each other, between a container accepting position in which the clamping members are spaced apart from the translucent container, and an analysis position in the clamping members abut the translucent container. The clamping members each define an optical waveguide slot extending therethrough that is substantially aligned with the translucent container when the clamping members are disposed in the analysis position, to thereby provide optical access to the translucent container for optical analysis of the fluid sample therein.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: March 4, 2014
    Assignee: Canadian Blood Services
    Inventors: Elisabeth Maurer, Georg Maurer, Keddie Brown, Gyasi Bourne, Kenneth MacCallum, Paul Charlebois
  • Patent number: 8663561
    Abstract: An automated apparatus and method for analyzing liquid samples by forming discrete sample aliquots (boluses) in an elongated conduit which contains a hydrophobic carrier liquid. Aliquots may be analyzed by adding at least one reagent to the sample aliquot that reacts selectively with an analyte contained therein. The reaction product, which is selective for the analyte of interest and proportional to its concentration, is measured with an appropriate detector. Intrinsic sample properties of the sample may also be measured without the need for adding chemical reagents. The invention enables simple and accurate testing of samples using time honored wet-chemical analysis methods in microliter volume regimes while producing remarkably small volumes of waste.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: March 4, 2014
    Inventor: Charles J. Patton
  • Publication number: 20140051173
    Abstract: A multilayer Paper Analytical Device (PAD) is provided for detection of at least two chemical components indicative of a low quality pharmaceutical or dietary supplement product. A method for detection of at least two chemical components indicative of a low quality pharmaceutical or dietary supplement product is also provided that employs a multilayer PAD. A kit is provided for detection of at least two chemical components indicative of a low quality pharmaceutical or dietary supplement product that includes a multilayer PAD and instructions for using the kit.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 20, 2014
    Applicant: ST. MARY'S COLLEGE
    Inventors: Toni L. O. Barstis, Mary M. Bevilacqua
  • Patent number: 8652415
    Abstract: An apparatus for storing and dispensing a test strip includes a container configured to store a stack of test strips. The container maintains appropriate environmental conditions, such as humidity, for storing the test strips. An engaging member is disposed in the container and is adapted to contact one test strip of the stack of test strips. An actuator actuates the engaging member to dispense the one test strip from the container. Since one test strip is dispensed at a time, the remaining test strips are not handled by the user. Accordingly, the unused test strips remain free of contaminants such as naturally occurring oils on the user's hand.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: February 18, 2014
    Assignee: Becton, Dickinson and Company
    Inventor: John Lovell
  • Publication number: 20140044608
    Abstract: A process for producing an analytical aid for the detection of at least one analyte in a sample, such as a body fluid. The analytical aid includes at least one housing and at least one test element including at least one test chemistry. The process includes the following steps: providing the test element; and producing at least one housing part of the housing at least one shaping process, during which the test element is connected to the housing part.
    Type: Application
    Filed: October 11, 2013
    Publication date: February 13, 2014
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Hans List, Karl-Heinz Scherer
  • Patent number: 8647836
    Abstract: The invention relates to a method and device for the cross-referencing of identification (1) of tissue slice supports (2), for microtomised analytical samples still to be mounted thereon, with identification information (3) of a tissue sample holder (4) of a tissue sample (5) which is not yet microtomised. The conventional problem of cross-referencing is improved in a simple manner, whereby the identification information (3) for the tissue sample holder (4) is automatically detected when positioned in the microtome (6) and an identification (1) corresponding thereto is automatically transferred to at least one tissue slice support (2) and that tissue slice support (2), provided with the identification (1), is dispensed for application of the tissue sample slice at the moment when a tissue sample slice must be applied to a tissue slice support (2).
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: February 11, 2014
    Assignee: Microm International GmbH
    Inventors: Hans L. Heid, Jose Novoa
  • Patent number: 8647575
    Abstract: A blood glucose meter includes a front attachment part to which a test piece is attached, a measurement part for measuring a component of blood collected via a blood guide passage in the test piece, and a monitor for displaying the measurement results obtained by the measurement part. When the device is placed on a horizontal plane by referring to the display face of the monitor as the upper side and the opposite side as the lower side and placing the display face of the monitor upward, the central axis of the test piece extends obliquely downward toward the front side. The blood glucose meter comprises a main part provided with the monitor and a linking part between the main part and the front attachment part. The top face of the linking part is placed roughly parallel to the central axis line and is provided with an ejector lever.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: February 11, 2014
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Hirotaka Ohashi
  • Patent number: 8647588
    Abstract: An apparatus and method for packaging of an optical sensing fiber is disclosed. The apparatus includes a substrate with a plurality of openings, and each opening is configured for holding an optical sensing assembly. The assembly is positioned in the opening with a tip of the assembly extending through the opening to be suspended from the substrate. In addition, openings are arranged so the assembly positioned therein avoids contacting another assembly positioned therein. The apparatus can include a support member for supporting the substrate and positioning the substrate so the tip of the assembly suspended from the opening in the substrate contacts solution in one of a plurality of wells in a container adjacent to the substrate. The assembly can be configured for preparing of the optical assembly for assay. An agitation assembly for agitating the container to create flow of the solution in the container wells over an optical sensing assembly is also disclosed.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: February 11, 2014
    Assignee: Pall Corporation
    Inventors: Michael W. Recknor, Hong Tan, Robert Zuk, Krista Leah Witte, Sae Choo, Scott Lockard
  • Patent number: 8641986
    Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: February 4, 2014
    Assignee: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
  • Patent number: 8637326
    Abstract: Detection of detection target substances at a sensor portion is expedited and the efficiency thereof is improved in biological substance analysis, to enable accelerated analysis with high sensitivity. A biological substance analyzing cell equipped with a reaction chamber having a sample supply space, an acoustic matching layer which is provided at a predetermined region of an inner wall of the reaction chamber that faces another inner wall, and a sensor portion provided within the reaction chamber is employed. Ultrasonic waves are emitted such that a standing wave are generated between the acoustic matching layer and the inner wall of the reaction chamber that faces the acoustic matching layer. The detection target substance is concentrated by the capturing forces of the standing waves, and the concentrated detection target substance is detected at the sensor portion.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: January 28, 2014
    Assignee: Fujifilm Corporation
    Inventors: Kazuyoshi Horii, Ryuichi Nakayama, Yasutoshi Hirabayashi
  • Patent number: 8632733
    Abstract: The present invention provides for a device and a kit for collecting body fluids. The device includes a body fluid collection portion comprising a body fluid absorbing material. The body fluid connecting portion has a free edge and is hingedly connected at the edge opposite to the free edge to a first support panel and a second support panel. A base panel is hingedly connected to the first support panel or the second support panel. In a first folded condition the body fluid collection portion is sandwiched between the first support panel and the second support panel in a substantially face contacting relationship.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: January 21, 2014
    Assignee: Labor Diagnostika Nord GmbH & Co. KG
    Inventors: Bernhard Manz, Matthias Kuper
  • Patent number: 8632730
    Abstract: In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: January 21, 2014
    Assignee: Alverix, Inc.
    Inventors: John F. Petrilla, Daniel B. Roitman
  • Patent number: 8628732
    Abstract: Provided is an immobilization device for fitting a connecting member of a chip and a connecting member of a cover together, where a spatial clearance between the chip and cover is small. The immobilization device includes a substrate (102), a cover means (101) including a fitting means to fit with a chip (103) placed on the substrate (102), a rotating arm means (201) rotatably joined to a first joining means (301) of the substrate (102) and to a second joining means (302) of the cover means (101), and a parallel maintaining means (203) for fitting the fitting means and the chip (103) together with the fitting means and the chip (103) maintained in substantially parallel by the first joining means (301) or the second joining means (302) moving along a chip surface or a plane parallel to the chip surface. The fitting means rotates freely against the chip (103).
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: January 14, 2014
    Assignee: NEC Corporation
    Inventors: Minoru Asogawa, Hayataro Kochi
  • Patent number: 8628723
    Abstract: An apparatus for introducing a specimen into a flow cytometer comprises: a syringe having a hollow barrel containing the specimen, a plunger partially within the barrel and a needle that extends into a volume of a nozzle of the flow cytometer; a one-way port in the nozzle forming a seal against the needle; a mounting platform coupled to both the syringe and to the flow cytometer; and a syringe pump coupled to the plunger, the syringe pump comprising a motor, a drive mechanism coupled to the motor; and a clamping mechanism coupled to the drive mechanism, wherein the motor operates the drive mechanism so as to cause the clamping mechanism to depress the plunger into the barrel.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: January 14, 2014
    Assignee: Beckman Coulter, Inc.
    Inventor: Angela L. Vandergaw
  • Patent number: 8628728
    Abstract: A non-invasive, calorimetric infection detector is provided, comprised of a substrate, and one or more indicator compositions disposed upon or incorporated therein. These indicator compositions exhibit a persistent change color when exposed to gaseous oxides of nitrogen and acids formed therefrom, providing a means of detecting NO production in a wound, which has been found to occur at a high level at the onset of infection in a wound. In addition, a bandage is provided, comprised of the detector, as well as a porous portion, and preferably a hydrophobic barrier layer to protect the detector from contamination by water and other fluids draining from the wound. The non-invasive, calorimetric infection detector, and bandage containing same, can be utilized to provide a convenient, easily utilized colorimetric means of detecting the onset of wound infection, thereby enabling caregivers to effectively and timely treat infections.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: January 14, 2014
    Assignee: Polestar Technologies, Inc.
    Inventors: James A Kane, Melissa Ricci, Ranganathan Shashidhar
  • Publication number: 20140011288
    Abstract: The present invention provides a system for analyzing a sample liquid comprising a test tape having a plurality of test elements, a tape transport device which successively transports the test elements to a sample application site while advancing the tape, and a measuring device which scans the test elements loaded with sample liquid at a measuring site. The measuring site is located at a distance from the sample application site in the direction of tape movement. The tape transport is interrupted in order to exactly position a wetted area of the test elements carrying a sample liquid at the measuring site by means of a positioning device that responds to the presence of sample liquid on the test element.
    Type: Application
    Filed: September 11, 2013
    Publication date: January 9, 2014
    Inventors: Uwe Krämer, Hans List
  • Patent number: 8623291
    Abstract: The present invention relates to an assay device capable of testing for multiple analytes such as drugs using individual test strips for each analyte.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: January 7, 2014
    Inventor: Jin Po Lee
  • Patent number: 8623789
    Abstract: An integrated cartridge for sample processing and analysis is disclosed. The integrated cartridge contains a sample preparation chamber having a sample inlet and a sample outlet, and a sample purification chamber adapted to receive a replaceable sample purification unit containing a housing and an extraction filter inside the housing. The extraction filter specifically binds to a molecule of interest. The sample purification chamber has a sample inlet that is in fluid communication with the sample outlet of the sample preparation chamber. Also disclosed is a microarray-based sample analysis (MBSA) system.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: January 7, 2014
    Assignee: Akonni Biosystems, Inc.
    Inventors: Phillip Belgrader, Christopher G. Cooney, Aleksandr N. Perov
  • Patent number: 8617486
    Abstract: An analytical device for performing an assay to determine the presence or approximate quantity of at least one analyte in a liquid sample is described. The device is manufactured to include an integrated desiccant within at least a test strip of the device. Addition of an integrated desiccant within the device improves signal to noise ratio, eases the manufacturing process, and saves in cost of production of the device.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: December 31, 2013
    Assignee: Quidel Corporation
    Inventors: Kevin J. Kirby, Sarah Dennison
  • Patent number: 8617469
    Abstract: The invention describes methods that use nanostructures and quantum confinement to detect and manipulate chemical and biochemical molecules. To increase selectivity and sensitivity nanostructures are built to have the density of states similar to that in analyte that will be detected and operated. Using device that incorporates such nanostructures, measuring electrical and optical properties of nanostructures and analyte or charge and energy transfer between the nanostructures and analyte a rapid and sensitive continuous detection in fluids can be achieved. Detection can be further enhanced by controlling external environmental parameters and applying external fields. In addition to be detected analyte can be positioned, moved, separated, extracted, and controlled.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: December 31, 2013
    Inventors: Branislav Vlahovic, Vanja Vlahovic Malloy
  • Patent number: 8617485
    Abstract: A sensor strip apparatus includes: a top plate having an entrance opening downward and a joint formed downward; a pad section including a support having a window opening downward, a reaction pad attached to the window of the support and reacting with a specimen, first and second hemolysis inhibition pads attached to the reaction pad to filter hemocytes from the specimen, a specimen pad attached to the first and second hemolysis inhibition pads to diffuse the specimen crosswise, and an adhesive film attached to the support around the first and second hemolysis inhibition pads to increase adhesion strength of the specimen pad; and a bottom plate having a second joint forcibly coupled with to the joint of the top plate, and a window configured to indentify the reaction pad through the window of the support.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: December 31, 2013
    Assignee: SD Biosensor, Inc.
    Inventors: Hyo Geun Lee, Hyo Lim Park, Eun Sun Song, Byung Hak Song
  • Patent number: 8613892
    Abstract: The present disclosure provides in vitro analyte meters that include a meter portion that is moveable relative to at least one other meter portion. Embodiments include moveable meters that are integrated with in vivo analyte systems. Also provided are methods, systems and kits.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: December 24, 2013
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Gary Ashley Stafford
  • Patent number: 8609043
    Abstract: The present invention relates to the use of a container, made of an inorganic additive containing plastic material, for reducing physical/chemical interaction between the container and an oil, fat and/or wax containing formulation contained therein.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: December 17, 2013
    Assignee: M & P Patent Aktiengesellschaft
    Inventor: Claudia Mattern
  • Patent number: 8609044
    Abstract: A micro vial assembly for performing microwave-assisted chemical reactions on small reaction mixture volumes is disclosed, wherein a reaction vessel (10) is sealed through a diaphragm (30) that is capped over an open end of the reaction vessel. The reaction vessel mouths in an end plane of a sleeve (20) surrounding the reaction vessel, the diaphragm being clamped for sealing the open end of the vessel by means of a cap (40) which is secured to the sleeve. The sleeve provides a radial extension of the reaction vessel in order to bridge the radial distance between a wall of the reaction vessel and other components in a system for performing microwave-assisted chemical reactions.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: December 17, 2013
    Assignee: Biotage AB
    Inventors: Johan Ulin, Per-Gunnar Eriksson, Fredrik Ekdahl
  • Patent number: 8609037
    Abstract: A disposable cartridge adapted to be used with a sensor-dispensing instrument comprises a housing, test sensors, a mechanical mechanism and moveable seals. The housing forms at least one opening therethrough. The test sensors are stacked in the housing. The test sensors are adapted to assist in testing at least one analyte. The mechanical mechanism is adapted to urge the test sensors in a first direction. One of the test sensors is positioned for ejection from the cartridge. The moveable seals is adapted to be in a closed position that seals the at least one opening so as to provide a substantially moisture-proof and a substantially air-tight cartridge, and one of the moveable seals is adapted to be in an open position that allows one of the test sensors to be moved therethrough.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: December 17, 2013
    Assignee: Bayer HealthCare LLC
    Inventors: Mohammad A. Kheiri, D. Glenn Purcell
  • Patent number: 8603835
    Abstract: Test cells have a first sorbent strip with a sample receiving location and defining a first migration path, a distinct second sorbent strip which receives buffer solution and at least partially defines a second migration path distinct from and elongated relative to the first migration path, conjugate supported by the second strip, a test site located at a junction of the first and second strips and having an immobilized ligand-binding mechanism, and a divider which directs a first amount of the buffer to the first strip to move the sample to the test site and a second amount to the second strip to move the conjugate to the test site. The first and second migration paths have first and second lengths chosen so that ligand in the sample reaches the test site and binds to the immobilized ligand-binding mechanism prior to the conjugate reaching the test site.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: December 10, 2013
    Assignee: Chembio Diagnostic Systems, Inc.
    Inventor: Javanbakhsh Esfandiari
  • Patent number: 8597589
    Abstract: The invention relates to an analysis system for analyzing a sample on a test element. The system has an analysis unit for generating a signal as a function of an analyte contained in a sample, and a detection unit for detecting the signal. The analysis system further includes a test element holder into which the test element can be reversibly introduced and in which it can be positioned relative to the analysis unit and the detection unit. The test element contains at least one guide element, which is suitable for laterally guiding the test element, so that the test element in the test element holder is held and guided only on an outer region of the test element, and an inner region of the test element introduced into the test element holder remains free. The test element contains a sample application site in the inner region.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: December 3, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Paul Jansen, Jochen Schulat, Yvonne Hillenbrand
  • Patent number: 8591827
    Abstract: A stack of test strips comprises individual test strips which are stacked over each other and carry a test field for examining a bodily fluid sample. Test strips lying one on top of the other are detachably adhesively bonded to each other so that the test strips can be individually removed from the stack, wherein the test fields are packed in chambers and adjacent test strips form the bottom and the lid of such a chamber. A method for producing such a stack of test strips is also disclosed.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: November 26, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Herbert Harttig
  • Patent number: 8585989
    Abstract: A retaining clip for retaining reagent test slides in a stacked arrangement is formed as a unitary member and has first, second and third plates, each having an inner surface and an outer surface. The inner surface of the first plate pivots towards the inner surface of the second plate, and the inner surface of the third plate also pivots such that the inner surfaces of the first and third plates at least partially face each other upon pivoting. The inner surfaces of the first and third plates are separated by a distance to accommodate the reagent test slides in a stacked arrangement. Alternatively, the third and second plates can be fixed rigidly to each other with only the first plate pivoting to at least partially face the third plate upon pivoting.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: November 19, 2013
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Carl Russell Rich, Justin Jay Griffin, James M. Sellers, Haydn B. Taylor
  • Patent number: 8585983
    Abstract: The disclosed invention is a composition for a humidity indicating device comprising (a) an organic pH indicator dye compound, (b) a Bronsted acid or base, and (c) a polyol having the general formula HOCH2—(CHOH)n—CH2OH, wherein n can be 0, 1, 2, 3 or 4, wherein said components (a), (b), and (c) do not contain halogen and/or heavy metals. Furthermore, the invention relates to a humidity indicator device comprising a sheet substrate and the composition for a humidity indicating device containing no heavy metals or halogen compounds, and to a process for preparing said humidity indicator device.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: November 19, 2013
    Assignee: Sud-Chemie IP GmbH & Co. KG
    Inventors: Johanna Knyrim, Stefan Dick
  • Patent number: 8586375
    Abstract: A rapid diagnostic device, assay and multifunctional buffer reagent are provided for the detection of a target analyte in a fluid test sample. The 2-step assay utilizes a dual component flow-through device comprising a test unit and a dried indicator reagent delivery unit for receiving the fluid sample and multifunctional buffer, respectively. The test unit comprises a reaction zone containing immobilized capture reagent that can bind to the target analyte, an absorbent zone supporting the reaction zone, and optionally, a blood separation zone in lateral fluid communication with the reaction zone. The delivery unit comprises a label zone permeated with a dried indicator reagent which can be placed in transient fluid communication with the reaction zone of the test unit during the assay procedure. The rapid diagnostic assay system reduces the number of assay reagents, method steps and time required for performance compared to other conventional assays.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: November 19, 2013
    Assignee: MedMira Inc.
    Inventor: Hermes K. W. Chan
  • Patent number: 8580201
    Abstract: Embodiments of the present invention include processing steps and subsystems, within automated-biopolymer-synthesis systems and within other automated systems for organic-chemistry-based processing, for removing reagent solutions and solvents from reaction chambers following various synthetic reaction steps and washing steps undertaken during biopolymer synthesis. Embodiments of the present invention employ any of various different types of liquid-absorbing materials to wick, or remove by capillary action, liquids from reaction chambers. Wicking-based methods and subcomponents of the present invention remove significantly greater fractions of solutions from reaction chambers than conventional methods and subsystems and, in addition, are mechanically simpler and produce fewer deleterious side effects than currently used methods and subsystems.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: November 12, 2013
    Assignee: OligoCo, Inc.
    Inventors: Hsing-Yeh Parker, John C. Tabone, John Mulligan
  • Patent number: 8574511
    Abstract: It is an object to provide a test instrument and an optical measurement apparatus which enable easy matching of test results when tests by optical measurement are performed with respect to a large number of patients. To the above end, a test instrument B is provided, which includes reagent retaining portions 8A, 8B, 8C retaining a reagent which reacts with a sample to produce a color reaction. The test instrument B includes a patient information entry section 64 as an example of patient identifying information region in which patient identifying information is to be written.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: November 5, 2013
    Assignee: ARKRAY, Inc.
    Inventors: Takashi Nakagawa, Shinya Nakajima, Tokuo Kasai
  • Patent number: 8574510
    Abstract: In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base with first and second ends, a concave recess in the first end, a second end receiving surface, and a sidewall extending between the ends. An electrode may be provided on the receiving surface with an electrochemically-active region coupled to the electrode. A conductor in electrical contact with the electrode may extend along the sidewall and may be adapted to be in electrical contact with a first contact of an analyte meter. Manufacturing methods and systems utilizing and dispensing the analyte sensors are provided, as are numerous other aspects.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: November 5, 2013
    Assignee: Bayer Healthcare LLC
    Inventors: Igor Gofman, Robert S. Sams
  • Patent number: 8569072
    Abstract: A system and method for preparing and delivering samples for analyte testing. The system can include a sample preparation system and a sample delivery system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition comprising a source and a diluent. The sample delivery system can include a valve positioned in fluid communication with the reservoir and adapted to control the removal of a sample from the sample preparation system. The method can include applying pressure to the deformable self-supporting receptacle to remove a sample from the sample preparation system via the sample delivery system.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: October 29, 2013
    Assignee: 3M Innovative Properties Company
    Inventors: Kurt J. Halverson, Stephen C. P. Joseph, Raj Rajagopal, Matthew D. Reier, David J. Velasquez, Cynthia D. Zook, Sailaja Chandrapati
  • Publication number: 20130280698
    Abstract: Disclosed herein are devices, systems and methods for simultaneously conducting multiple assays on a liquid sample for the presence of, and/or quantification of, analytes in the liquid sample. The device, which is referred to herein as a multi-assay cartridge or multi-strip assay cartridge (MSC), may be used in a system comprised of the cartridge and a reading device or reader for reading the assays in the cartridge.
    Type: Application
    Filed: April 24, 2013
    Publication date: October 24, 2013
    Inventors: Catherine R. Propper, John T. Tester, Timothy L. Vail, Niranjan Venkatraman
  • Patent number: 8562911
    Abstract: Disclosed herein is a centrifugal rotor for delivering and analyzing biological sample. Chambers within the centrifugal rotor is used to split a biological sample, which comprises biological cellular components and biological fluids, into separate parts under centrifugal force after the biological sample being diluted, metered and distributed by the centrifugal rotor.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: October 22, 2013
    Assignee: MEDI Medical Engineering Corp.
    Inventor: Ying-Lan Tsai
  • Patent number: 8557180
    Abstract: The present invention provides a system for analyzing a sample liquid comprising a test tape having a plurality of test elements, a tape transport device which successively transports the test elements to a sample application site while advancing the tape, and a measuring device which scans the test elements loaded with sample liquid at a measuring site. The measuring site is located at a distance from the sample application site in the direction of tape movement. The tape transport is interrupted in order to exactly position a wetted area of the test elements carrying a sample liquid at the measuring site by means of a positioning device that responds to the presence of sample liquid on the test element.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: October 15, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Uwe Krämer, Hans List