Containing A Carboxyl Group Patents (Class 435/136)
Sugar acid having five or more carbon atoms (i.e., aldonic, keto-aldonic, or saccharic acid) (Class 435/137)
Lactic acid (Class 435/139)
Acetic acid (Class 435/140)
Propionic or butyric acid (Class 435/141)
Polycarboxylic acid (Class 435/142)
Hydroxy carboxylic acid (Class 435/146)
  • Cellobiohydrolase variants and polynucleotides encoding same
    Publication number: 20140017737
    Abstract: The present invention relates to variants of a parent cellobiohydrolase II. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Application
    Filed: September 23, 2013
    Publication date: January 16, 2014
    Inventor: Mark Wogulis
  • CONVERSION OF BIOMASS
    Publication number: 20140011248
    Abstract: Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, especially, xylose, which can then be chemically converted to furfural and furfural-derived products.
    Type: Application
    Filed: July 3, 2013
    Publication date: January 9, 2014
    Inventors: Marshall Medoff, Thomas Craig Masterman, Christopher Cooper, Jihan Khan
  • MICROBES, METHODS, AND DEVICES FOR REDOX-IMBALANCED METABOLISM
    Publication number: 20140004578
    Abstract: The invention generally relates to methods, devices, and microbes involved in performing redox imbalanced fermentations. In one aspect, the invention provides a device that generally includes an electrode and at least one microbe in electron communication with the electrode. The microbe generally can exhibit increased activity of at least one enzyme involved in converting a substrate to a redox imbalanced product. In another aspect, the invention provides a method for performing redox imbalanced fermentation. Generally, the method includes providing a substrate to a microbe under conditions effective for the microbe to metabolize the substrate to a redox imbalanced product. At least one microbe may be in contact with an electrode. In some cases, metabolic conversion of the substrate to the redox imbalanced product can include transferring electrons between the electrode and the microbe.
    Type: Application
    Filed: September 13, 2011
    Publication date: January 2, 2014
    Inventors: Daniel R. Bond, Jeffrey A. Gralnick, Daniel E. Ross, Jeffrey M. Flynn
  • Identification and processing of secondary materials for the cosmetics-, pharmaceutical-, and fuel-producing industries and also further industrial fields of application
    Patent number: 8617855
    Abstract: A method for producing starting materials or additives for cosmetics, pharmaceuticals and/or hydrocarbon-based fuels, especially for heating systems or internal combustion engines, takes organic residues or waste materials and decontaminates or sterilizes them with a hydrogenation process. In particular, the materials classified as K1, K2 or K3 according to EU Directive 1774/2002 are used for generating or producing the cited starting materials or additives, whereby an adequate decontamination of the residues or waste materials that are classified as being hazardous to health is ensured.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: December 31, 2013
    Inventor: Dieter Tischendorf
  • Nitrilase biocatalysts
    Patent number: 8614081
    Abstract: The present disclosure relates to polypeptides having nitrilase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: December 24, 2013
    Assignee: Codexis, Inc.
    Inventors: Anke Krebber, Emily Mundorff, Marissa Mock, Spiros Kambourakis
  • FERMENTATION ROUTE FOR THE PRODUCTION OF LEVULINIC ACID, LEVULINATE ESTERS AND VALEROLACTONE AND DERIVATIVES THEREOF
    Publication number: 20130330779
    Abstract: The invention provides processes for the conversion of pyruvate obtained from sugars or other carbon sources, to valuable C5 materials such as levulinic acid, levulinate esters, valerolactone, and derivatives thereof.
    Type: Application
    Filed: August 30, 2011
    Publication date: December 12, 2013
    Inventor: Alexandre Luc Zanghellini
  • FERMENTATION PROCESSES AND BY-PRODUCTS
    Publication number: 20130330791
    Abstract: The present disclosure relates to an improved process of producing a fermentation product, in particular ethanol. The present disclosure relates also to the use of enzymes for improving the quality of by-products in the fermentative production process and to compositions comprising enzymes capable of degrading components in the fermented mash in the fermentation process.
    Type: Application
    Filed: December 21, 2011
    Publication date: December 12, 2013
    Applicant: DIREVO INDUSTRIAL BIOTECHNOLOGY GMBH
    Inventors: Klaudija Milos, Steffen Köhler, Christian Elend, Léonie Degener
  • 3-HYDROXYPROPIONIC ACID AND OTHER ORGANIC COMPOUNDS
    Publication number: 20130323807
    Abstract: Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.
    Type: Application
    Filed: June 25, 2013
    Publication date: December 5, 2013
    Applicant: Cargill, Incorporated
    Inventors: Ravi R. Gokarn, Olga V. Selifonova, Holly Jean Jessen, Steven John Gort, Thorsten Selmer, Wolfgang Buckel
  • PRODUCTION METHOD FOR CHEMICALS BY CONTINUOUS FERMENTATION
    Publication number: 20130323805
    Abstract: A method of producing chemicals through continuous fermentation includes washing a membrane with a washing liquid supplied from a permeate side of a membrane unit in a continuous fermentation; filtering a culture medium containing a fermentation feedstock, a chemical and a microbe or a cultured cell through a separation membrane; collecting the chemical from a filtrate; retaining or refluxing unfiltered remains in the culture medium; and adding a fermentation feedstock to the culture medium, wherein the washing liquid is high-temperature water having a temperature higher than a temperature of the culture medium and of 150° C. or less, and a concentration of the microbe in a fermenter is controlled by supplying the washing liquid.
    Type: Application
    Filed: September 5, 2011
    Publication date: December 5, 2013
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Atsushi Kobayashi, Jihoon Cheon, Norihiro Takeuchi, Makoto Nishida, Yuji Tanaka, Shin-ichi Minegishi
  • 3-HYDROXYPROPIONIC ACID AND OTHER ORGANIC COMPOUNDS
    Publication number: 20130323772
    Abstract: Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.
    Type: Application
    Filed: June 25, 2013
    Publication date: December 5, 2013
    Applicant: Cargill, Incorporated
    Inventors: Ravi R. Gokarn, Olga V. Selifonova, Holly Jean Jessen, Steven John Gort, Thorsten Selmer, Wolfgang Buckel
  • Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them
    Publication number: 20130316409
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: November 12, 2012
    Publication date: November 28, 2013
    Applicant: VERENIUM CORPORATION
    Inventor: VERENIUM CORPORATION
  • REVERSE BETA OXIDATION PATHWAY
    Publication number: 20130316413
    Abstract: The invention relates to recombinant microorganisms that have been engineered to produce various chemicals using genes that have been repurposed to create a reverse beta oxidation pathway. Generally speaking, the beta oxidation cycle is expressed and driven in reverse by modifying various regulation points for as many cycles as needed, and then the CoA thioester intermediates are converted to useful products by the action of termination enzymes.
    Type: Application
    Filed: February 7, 2012
    Publication date: November 28, 2013
    Applicant: William Marsh Rice University
    Inventors: Ramon Gonzalez, James Clomburg, Clementina Dellomonaco, Elliot N. Miller
  • LACCASES AND USES THEREOF
    Publication number: 20130309730
    Abstract: The present invention relates to novel enzymes and the uses thereof. The invention also relates to methods of producing such enzymes, coding nucleic acid molecules, recombinant cells and methods of modifying biomass from such materials. The invention is particularly suited to degrade biomass and/or to improve biomass degradation. The invention also relates to various applications of the enzymes of the invention for the production of bioenergy (such as bioethanol), as well as in the field of chemistry, paper industry, textile industry and beverage industry.
    Type: Application
    Filed: November 8, 2011
    Publication date: November 21, 2013
    Applicant: DEINOVE
    Inventors: Jean-Paul Leonetti, Jean-Michel Claverie, Nicolas Chabot
  • MUTANT CELLOBIOHYDROLASE
    Publication number: 20130309729
    Abstract: The invention relates to Mutant cellobiohydrolase, being a mutant of SEQ ID NO:1, having a substitution at position N247(I,F,H,W) of SEQ ID NO: 1, wherein the mutant cellobiohydrolase has at least 50% sequence identity with SEQ ID NO: 1, and wherein the mutant cellobiohydrolase has CBHI activity.
    Type: Application
    Filed: January 30, 2012
    Publication date: November 21, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventors: Jan Metske Van Der Laan, Margot Elisabeth Francoise Schooneveld-Bergmans, Denise Ilse Jacobs
  • Methods for Degrading or Converting Cellulosic Material
    Publication number: 20130309723
    Abstract: Provided are methods for degrading or converting a cellulosic material, comprising: treating the cellulosic material with an enzyme composition in the presence of a polypeptide having catalase activity; and enzyme composition used for degrading or converting a cellulosic material comprising one or more (e.g., several) enzymes having cellulolytic and/or hemicellulolytic activity and a polypeptide having catalase activity.
    Type: Application
    Filed: March 26, 2012
    Publication date: November 21, 2013
    Applicant: NOVZYMES A/S
    Inventors: Hongzhi Huang, Haiyu Ren
  • Nucleic acid molecule encoding xylose isomerase and xylose isomerase encoded by the nucleic acid molecule
    Patent number: 8586336
    Abstract: A novel xylose isomerase nucleotide sequence obtained from a bovine rumen fluid metagenomic library and also provides the amino acid sequence encoded by the nucleotide sequence, and a vector and a transformant containing the nucleotide sequence. When the xylose isomerase is expressed, a host cell is endowed with the capability of converting xylose into xylulose, and the xylulose is further metabolized by the host cell. Therefore, the host cell can take the xylose as a carbon source for growth. The xylose isomerase from a new source is expressed with high activity in Saccharomyces cerevisiae and is a mesophilic enzyme with optimal temperature of 60° C.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: November 19, 2013
    Assignee: Shandong University
    Inventors: Xiaoming Bao, Yu Shen, Ruilei Ge
  • Process for the production of ethanol and butanol
    Patent number: 8586335
    Abstract: The present invention relates to a process for the production of ethanol and butanol from biomass, and in particular to a process for the production of ethanol and butanol using two separate fermentation steps, said process comprising: a) passing a biomass feedstock to a first fermentation step, b) in said first fermentation step subjecting the biomass feedstock to anaerobic fermentation at a pH below 6.0 and at a temperature in the range 20 to 700° C.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: November 19, 2013
    Assignee: INEOS Bio SA
    Inventors: Peter Simpson Bell, Stephen John Benstead, Neil Turnbull
  • USE OF MONASCUS IN ORGANIC ACID PRODUCTION
    Publication number: 20130303802
    Abstract: The present invention provides tools and methods for producing organic acids using strains of Monascus which are tolerant to high organicacid concentrations at low pH.
    Type: Application
    Filed: October 28, 2011
    Publication date: November 14, 2013
    Applicant: TOTAL RAFFINAGE MARKETING
    Inventors: Alexander Ruud Weusthuis, Emil Johan Harald Wolbert, Jan Springer, John Van Der Oost, Gerrit Eggink
  • METHOD FOR TREATMENT OF CELLULOSIC BIOMASS AND METHOD FOR PRODUCTION OF SUGAR, ALCOHOL, OR ORGANIC ACID FROM CELLULOSIC BIOMASS
    Publication number: 20130302854
    Abstract: This invention is intended to improve saccharification efficiency by allowing cellulose and/or hemicellulose to relax sufficiently with an ionic liquid. Cellulose and/or hemicellulose is allowed to relax sufficiently with an ionic liquid through a step of soaking cellulosic biomass in a solution containing an ionic liquid and an alkali.
    Type: Application
    Filed: January 19, 2012
    Publication date: November 14, 2013
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Kazuhide Tabata, Nobuhiro Ishida, Satoshi Katahira, Risa Nakamura
  • PROCESSING BIOMASS
    Publication number: 20130295624
    Abstract: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.
    Type: Application
    Filed: July 3, 2013
    Publication date: November 7, 2013
    Inventors: Marshall Medoff, Thomas Craig Masterman
  • Nitrilases
    Publication number: 20130288315
    Abstract: The invention relates to a nitrilase having improved activity in the reaction of a nitrile to form the corresponding carboxylic acid, in particular with respect to reacting 2-methylglutaronitrile, 1-(cyanomethyl)cyclohexane-1-carbonitrile, and benzonitrile. The nitrilase according to the invention is related to nitrilase from acidovorax facilis.
    Type: Application
    Filed: October 12, 2011
    Publication date: October 31, 2013
    Applicant: c-LEcta GmbH
    Inventors: Andreas Vogel, Daniel Schwarze, Thomas Greiner-Stoeffele
  • USE OF MONASCUS IN ORGANIC ACID PRODUCTION
    Publication number: 20130288319
    Abstract: The present invention provides tools and methods for producing organic acids using strains of Monascus which are tolerant to high organic acid concentrations at low pH.
    Type: Application
    Filed: October 28, 2011
    Publication date: October 31, 2013
    Applicant: TOTAL RAFFINAGE MARKETING
    Inventors: Alexander Ruud Weusthuis, Emil Johan Harald Wolbert, Jan Springer, Jan Van Der Oost, Gerrit Eggink
  • Polypeptides Having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same
    Publication number: 20130288300
    Abstract: Provided are isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: February 23, 2012
    Publication date: October 31, 2013
    Applicant: Novoozymes A/S
    Inventors: Yu Zhang, Junxin Duan, Lan Tang, Wenping Wu
  • Immobilized TAL biocatalyst for production of para-hydroxycinnamic acid
    Patent number: 8569036
    Abstract: TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: October 29, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Robert Dicosimo, Sharon L. Haynie, Lixuan Lisa Huang, Fateme Sima Sariaslani, Tina K. Van Dyk, Robert J. Trotman
  • Moving bed biofilm reactor (MBBR) process for conversion of syngas components to liquid products
    Patent number: 8563299
    Abstract: A process for converting a feed gas containing at least one of CO, CO2, and/or H2 to a liquid product using biomass that grow on the surface of carriers suspended in a fermentation broth within the vessel of a moving bed bioreactor (MMBR). An injector is used to at least partially dissolved the feed gas in the fermentation broth, at least partially entrain the gas in the broth as microbubbles and to introduce the mixture of the entrained gas and broth into the vessel in a substantially horizontal direction. The injection of the mixture creates eddy current in the surrounding liquid for thoroughly mixing the fermentation broth in the vessel and for keeping the biomass carrier moving to provide sufficient shear so as to maintain a biofilm thickness on the carrier in a desirable range.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: October 22, 2013
    Assignee: Coskata, Inc.
    Inventor: Robert Hickey
  • METHOD OF PRODUCING COMPOUND ORIGINATING FROM POLYSACCHARIDE-BASED BIO-MASS
    Publication number: 20130273608
    Abstract: A method of producing a compound originating from a polysaccharide-based biomass includes at least one of a saccharification step that produces a sugar solution containing a monosaccharide and/or an oligosaccharide from a product obtainable by hydrolyzing the polysaccharide-based biomass; a fermentation step that ferments the sugar solution containing the monosaccharide and/or oligosaccharide originating from the polysaccharide-based biomass; and a treatment that removes a fermentation inhibitor with the use of a separation membrane having a glucose removal rate and an isopropyl alcohol removal rate which simultaneously satisfy the following relationships (I) and (II) when a 500 ppm aqueous glucose solution at pH 6.5 at 25° C. and a 500 ppm aqueous isopropyl alcohol solution at pH 6.5 at 25° C. are respectively permeated through the membrane at an operation pressure of 0.
    Type: Application
    Filed: June 12, 2013
    Publication date: October 17, 2013
    Inventors: Masayuki Hanakawa, Shinichi Minegishi, Hiroyuki Kurihara
  • Hyperphotosynthetic Organisms
    Publication number: 20130273613
    Abstract: The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents.
    Type: Application
    Filed: March 12, 2013
    Publication date: October 17, 2013
    Inventors: Eric James Devroe, Sriram Kosuri, David Arthur Berry, Noubar Boghos Afeyan, Frank Anthony Skraly, Dan Eric Robertson, Brian Green, Christian Perry Ridley
  • Perhydrolase variant providing improved specific activity
    Patent number: 8557556
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: October 15, 2013
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert Dicosimo, Mark Scott Payne, John Edward Gavagan
  • Method for Producing Carboxylic Acid Using Methanol-Assimilating Bacterium
    Publication number: 20130266993
    Abstract: A method for producing a carboxylic acid by a fermentation process which comprises culturing a methanol-assimilating bacterium capable of producing the carboxylic acid in a liquid medium containing methanol and a counter ion to produce and accumulate the carboxylic acid in the medium, further comprising the feeding of a substance comprising methanol and a counter ion to the medium by fed-batch culturing to maintain the total ionic strength within the fermentation medium at or below a certain level.
    Type: Application
    Filed: June 17, 2013
    Publication date: October 10, 2013
    Inventors: Yuriko Murakoshi, Kohei Ishikawa, Kazuya Kondo
  • METHODS AND COMPOSITIONS FOR PROCESSING BIOMASS WITH ELEVATED LEVELS OF STARCH
    Publication number: 20130269061
    Abstract: Genetically engineered plants having altered levels of one or more starch regulation enzymes and a polysaccharide degrading enzyme are provided. Methods of genetically engineering plants to express products altering expression of one or more starch regulation enzymes and polysaccharide degrading enzymes, and genetic constructs are provided. Methods of agricultural processing and animal feed using the genetically engineered plants are described.
    Type: Application
    Filed: March 11, 2013
    Publication date: October 10, 2013
    Inventors: Philip A. Lessard, Michael Lanahan, Vladimir Samoylov, Oleg Bougri, Jonas Emery, R. Michael Raab, Dongcheng Zhang
  • INTEGRATED PROCESSES FOR REFINING SYNGAS AND BIOCONVERSION TO OXYGENATED ORGANIC COMPOUND
    Publication number: 20130266997
    Abstract: Integrated processes are provided for syngas refining and bioconversion of syngas to oxygenated organic compound. In the integrated processes ammonia contained in the syngas is recovered and used as a source of nitrogen and water for the fermentation. The integrated processes first remove tars from syngas by scrubbing using a first aqueous medium under conditions that ammonium bicarbonate is unstable. With tars removed, contact between the syngas and a second aqueous medium enables ammonia and carbon dioxide to be removed from the syngas without undue removal of components adverse to the fermentation, processing or oxygenated product such as benzene, toluene, xylene, ethylene, acetylene, and hydrogen cyanide. At least a portion of the second aqueous medium is supplied as a source of water and ammonia for the fermentation.
    Type: Application
    Filed: April 5, 2012
    Publication date: October 10, 2013
    Inventors: Robert Hickey, Jianxin Du
  • ENZYMES USEFUL FOR PERACID PRODUCTION
    Publication number: 20130261182
    Abstract: Acetyl xylan esterases and variants thereof having perhydrolytic activity are provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. Multi-component peracid generation systems comprising an enzyme catalyst having perhydrolytic activity are also provided, as are methods of using the present enzyme catalyst to produce peroxycarboxylic acids. The polypeptide having perhydrolytic activity may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, paper pulp processing, and personal care applications.
    Type: Application
    Filed: March 13, 2013
    Publication date: October 3, 2013
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Mark Scott PAYNE, Robert DiCosimo
  • Perhydrolase variant providing improved specific activity
    Patent number: 8546120
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: October 1, 2013
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert Dicosimo, Mark Scott Payne, John Edward Gavagan
  • Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
    Patent number: 8546112
    Abstract: The present invention relates to processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid ester and its salts. Also disclosed are processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid salt and a process for the preparation of 3-(aminomethyl)-5-methylhexanoic acid. (S)-5-Methyl-3-nitromethyl-hexanoic acid or (R)-5-methyl-3-nitromethyl-hexanoic acid in enantioenriched form or enantiopure form as well as salts thereof, (S)-5-methyl-3-nitromethyl-hexanoic acid ester or (R)-5-methyl-3-nitromethyl-hexanoic acid ester in enantioenriched form or enantiopure form and a compound, namely Formula (XIII), in racemic form, enantioenriched form or enantiopure form are also disclosed.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: October 1, 2013
    Assignee: Sandoz AG
    Inventors: Martin Albert, Ferdinand Zepeck, Andreas Berger, Waander Riethorst, Helmut Schwab, Daniel Luschnig, Peter Remler, Joerg Salchenegger, Doris Osl, Dominic De Souza
  • Perhydrolase variant providing improved specific activity
    Patent number: 8546119
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: October 1, 2013
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert DiCosimo, Mark Scott Payne, John Edward Gavagan
  • Esterases and their use
    Patent number: 8546115
    Abstract: The present invention relates to polyesterases having cutinase and/or suberinase activity obtainable from Coprinus and Trichoderma. The invention further relates to a method for producing the polyesterases, and to polynucleotides, vectors and host cells used therein. The enzymes are useful in hydrolysing cutin, suberin and other polyesters for example in treating agricultural or food raw materials, or wood raw materials, pulp and paper products and waste, and in modifying polyester fibers, or in laundry and dish applications.
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: October 1, 2013
    Assignee: Valtion Teknillinen Tutkimuskeskus
    Inventors: Johanna Buchert, Tiina Nakari-Setälä, Pasi Halonen, Hanna Kontkanen, Ann Westerholm-Parvinen, Marjaana Rättö
  • Method of conversion of syngas using microorganism on hydrophilic membrane
    Patent number: 8541214
    Abstract: A stable system for producing liquid products such as ethanol, butanol and other chemicals from syngas components contacts CO or a mixture of CO2 and H2 with a hydrophilic membrane under anaerobic conditions and transfers these components into contact with microorganisms contained as a biofilm on the membrane. Maintaining the microorganisms as a biolayer on the surface of the membrane facilitates cleaning of the membrane surface that retains the biofilm. In addition the shell gas space that surrounds the membranes may be flooded to reduce or remove the biofilm. Agitation of the liquid, by for example the bubbling of gas in the surrounding shell space, can fully or partially remove the biofilm from the membrane.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: September 24, 2013
    Assignee: Coskata, Inc.
    Inventors: Robert Hickey, Rahul Basu, Rathin Datta, Shih-Perng Tsai
  • Biofuel Production
    Publication number: 20130244295
    Abstract: The invention relates to the combination of the TLG1 glucoamylase from Thermomyces lanuginoses with: (i) the SFA1 alpha-amylase from Saccharomycopsis fibuligera; and/or (ii) the LKA alpha-amylase. The enzyme combinations may be expressed in a host cell (e.g. in Saccharomyces cerevisiae) or provided as an enzyme composition. Methods for making the enzyme combinations of the invention are provided. The invention also relates to a yeast strain which exhibits amylolytic activity and promising fermentative abilities. Processes for producing a fermentation product (in particular alcohol) from starch-containing material are described.
    Type: Application
    Filed: April 12, 2010
    Publication date: September 19, 2013
    Applicants: Universita Degli Studi Di Padova, Stellenbosch University
    Inventors: Willem Heber Van Zyl, Tania Jooste, Johann Ferdinand Gorgens, Maryna Saayman, Lorenzo Favaro, Marina Basaglia, Sergio Casella
  • Methods for Producing a Fermentation Product from Lignocellulose-Containing Material
    Publication number: 20130236933
    Abstract: The present invention provides a method for producing a fermentation product from lignocellulose-containing material, a method for converting lignocellulose-containing material into a hydrolyzate comprising mono- and oligo-saccharides, and a method for treating lignocellulose-containing material, all of which comprise the step of mixing an acid pre-treated lignocellulose-containing material and an alkaline pre-treated lignocellulose-containing material. The present invention further provides a fermentation product made according to the method for producing a fermentation product.
    Type: Application
    Filed: December 9, 2011
    Publication date: September 12, 2013
    Applicants: Novozymes A/S, Sinopec, Cofco
    Inventors: Hongzhi Huang, Yun Wang, Haiyu Ren, Ye Chen, Feng Xu
  • Method for producing probiotically derived compounds
    Patent number: 8530209
    Abstract: A method for producing naturally derived beneficial compounds including dispersing a microbiological culture media including at least one live probiotic organism, and at least one nutraceutical and/or at least one nutritive agent in distilled water to form a broth, incubating the broth at a predetermined temperature for a select period of time to induce probiotic activity; halting the probiotic activity, and separating the desired compound from the broth.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: September 10, 2013
    Assignee: Premier Research Labs, LP
    Inventor: Robert J. Marshall
  • "Variants of polypeptides having cellulolytic enhancing activity and polynucleotides encoding same"
    Publication number: 20130227748
    Abstract: The present invention relates to polypeptide having cellulolytic enhancing activity variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Application
    Filed: September 29, 2011
    Publication date: August 29, 2013
    Applicant: Novozymes, Inc.
    Inventors: Matt Sweeney, Mark Wogulis
  • Methods of Hydrolyzing Oligomers in Hemicellulosic Liquor
    Publication number: 20130224802
    Abstract: The present invention relates to methods of degrading or converting biomass material enriched with hemicellulosic material into fermentable sugars.
    Type: Application
    Filed: December 6, 2011
    Publication date: August 29, 2013
    Applicant: Novozymes North America, Inc.
    Inventors: Prashant Iyer, Harry Showmaker, Hui Xu, Kishore Rane
  • Production of peracids using an enzyme having perhydrolysis activity
    Patent number: 8518675
    Abstract: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: August 27, 2013
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert DiCosimo, John E. Gavagan, Mark S. Payne, Frederick B. Cooling, III
  • Process for producing alcohol and other bioproducts from biomass extracts in a kraft pulp mill
    Patent number: 8518213
    Abstract: A method for the production of alcohol and other bioproducts from power boiler woody biomass extract containing hemicelluloses, with or without combining extract from wood prior to Kraft cooking. The process is integrated with the host Kraft pulp mill plant process to minimize the heat loss from extracting hemicelluloses and the energy used in the process.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: August 27, 2013
    Assignee: API Intellectual Property Holdings, LLC
    Inventors: Theodora Retsina, Vesa Pylkkanen
  • Polypeptides Having Cellobiohydrolase Activity and Polynucleotides Encoding Same
    Publication number: 20130210087
    Abstract: The present invention provides isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 4, 2011
    Publication date: August 15, 2013
    Applicant: NOVOZYMES INC.
    Inventors: Ye Liu, Lan Tang
  • Enzymatic Hydrolysis of Lignocellulosic Material in the Presence of Sulfite, Dithionite and/or Dithiothreitol
    Publication number: 20130210088
    Abstract: A method is provided for improving enzymatic hydrolysis in saccharification of a lignocellulosic material. The method is comprising pretreating the lignocellulosic material to obtain a slurry of pretreated lignocellulosic material; adding at least one reducing agent to the slurry of pretreated lignocellulosic material or the liquid fraction thereof to decrease the enzymatic hydrolysis inhibitory properties of slurry of the pretreated lignocellulosic material or the liquid fraction thereof; and subjecting the slurry of pretreated lignocellulosic material or the liquid fraction thereof to enzymatic hydrolysis in the presence of the at least one reducing agent.
    Type: Application
    Filed: October 6, 2010
    Publication date: August 15, 2013
    Inventors: Bjorn Alriksson, Lelf Jonsson, Venkata Prabhakar Soudham
  • PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-CARBOXYLIC ACID OR ESTERS THEREOF, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF
    Publication number: 20130210091
    Abstract: Process for the enzymatic synthesis of the compound of formula (I): wherein R1 represents a hydrogen atom or an alkyl group. Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Application
    Filed: February 5, 2013
    Publication date: August 15, 2013
    Applicant: LES LABORATOIRES SERVIER
    Inventor: LES LABORATOIRES SERVIER
  • Carbon capture in fermentation
    Patent number: 8507228
    Abstract: The invention relates to methods of capturing carbon by microbial fermentation of a gaseous substrate comprising CO. The methods of the invention include converting CO to one or more products including alcohols and/or acids and optionally capturing CO2 to improve overall carbon capture. In certain aspects, the invention relates to processes for producing alcohols, particularly ethanol, from industrial waste streams, particularly steel mill off-gas.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: August 13, 2013
    Assignee: LanzaTech New Zealand Limited
    Inventors: Sean Dennis Simpson, Christophe Collet, Richard Llewellyn Sydney Forster, Michael Charles Milner Cockrem, Simon David Oakley, Michael Kopke
  • BIOLOGICAL PRODUCTION OF ORGANIC COMPOUNDS
    Publication number: 20130203136
    Abstract: Strains of cyanobacteria that produce high levels of alpha ketoglutarate (AKG) and pyruvate are disclosed herein. Methods of culturing these cyanobacteria to produce AKG or pyruvate and recover AKG or pyruvate from the culture are also described herein. Nucleic acid sequences encoding polypeptides that function as ethylene-forming enzymes and their use in the production of ethylene are further disclosed herein. These nucleic acids may be expressed in hosts such as cyanobacteria, which in turn may be cultured to produce ethylene.
    Type: Application
    Filed: July 27, 2012
    Publication date: August 8, 2013
    Applicant: ALLIANCE FOR SUSTAINABLE ENERGY, LLC
    Inventors: Jianping YU, Troy PADDOCK, Damian CARRIERI, Pin-Ching MANESS, Michael SEIBERT
  • Perhydrolase variant providing improved specific activity
    Patent number: 8501447
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: August 6, 2013
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert DiCosimo, Mark Scott Payne, John Edward Gavagan