Miscellaneous (e.g., Subcellular Parts Of Micro-organisms, Etc.) Patents (Class 435/317.1)
  • MICROVESICLES ISOLATED FROM MESENCHYMAL STEM CELLS FOR USE AS IMMUNOSUPPRESSIVE AGENTS
    Publication number: 20140220053
    Abstract: The present invention concerns microvesicles isolated from mesenchymal stem cells as immunosuppressive agents for treatment of inflammatory and immune pathologies.
    Type: Application
    Filed: July 26, 2012
    Publication date: August 7, 2014
    Inventors: Maurizio Muraca, Alessandra Fierabracci
  • Agent for prevention of alcoholic hepatopathy
    Patent number: 8747836
    Abstract: The present invention provides an agent for inhibition of alcoholic hepatopathy comprising cells of a strain belonging to Lactobacillus brevis, or treated product thereof as an active ingredient. The agent for inhibition of alcoholic hepatopathy of the present invention is safe for living body and can be used as a component in foods and beverages.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: June 10, 2014
    Assignee: Sapporo Breweries Limited
    Inventors: Syuichi Segawa, Yoshihisa Wakita
  • PROCESS FOR DETERGENT-FREE PRODUCTION OF OUTER MEMBRANE VESICLES OF A GRAM-NEGATIVE BACTERIUM
    Publication number: 20140147469
    Abstract: The present invention relates to the fields of medical microbiology and vaccines. In particular the invention relates to a process for detergent-free preparation of outer membrane vesicles (OMV) of Gram negative bacteria for use in vaccines, to OMV obtainable by said process, and to a pharmaceutical composition comprising such OMV. The present invention further relates to the use of OMV of the present invention as a medicament in particular for use in a method for eliciting an immune response.
    Type: Application
    Filed: July 5, 2012
    Publication date: May 29, 2014
    Applicant: De Staat der Nederlanden, vert. door de minister van VWS Ministerie van Volksgezondheid, Welzjin en
    Inventors: Bas Van De Waterbeemd, Leonardus Aldolfus Van Der Pol
  • Lipid tripeptide-based hydrogelator and hydrogel
    Patent number: 8716248
    Abstract: A hydrogel that includes an aqueous solution or an alcohol aqueous solution, and a hydrogelator containing a lipid peptide represented by Formula (1), or a pharmaceutically usable salt thereof. In Formula (1), R1 represents an aliphatic group having 9 to 21 carbon atoms; R2, R3, and R4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms that optionally has a branched chain having 1 or 2 carbon atoms, a phenylmethyl group, or a —(CH2)n—X group, and at least one of R2, R3, and R4 represents a —(CH2)n—X group; n represents an integer from 1 to 4; and X represents an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: May 6, 2014
    Assignees: Nissan Chemical Industries, Ltd., Kyushu University
    Inventors: Nobuhide Miyachi, Takehisa Iwama, Masahiro Gotoh, Tatsuo Maruyama, Daisuke Koda
  • Photobioreactor With A Thermal System, And Methods of Using The Same
    Publication number: 20140099706
    Abstract: The invention relates to a photobioreactor system for a phototrophic microorganism, and culture medium therefor, comprising a reactor chamber and a thermal system.
    Type: Application
    Filed: September 13, 2013
    Publication date: April 10, 2014
    Applicant: Joule Unlimited Technologies, Inc.
    Inventors: Michael Y. Leshchiner, Stuart A. Jacobson
  • COMPOSITIONS, KITS, AND METHODS FOR ISOLATING VESICLES
    Publication number: 20140093880
    Abstract: A composition, a kit, and a method of isolating a vesicle from a sample using a compound comprising zwitterion moieties, which may be used to analyze vesicles, and proteins, glycoprotein, lipids, or nucleic acids thereof.
    Type: Application
    Filed: April 4, 2013
    Publication date: April 3, 2014
    Applicant: Samsung Electronics Co., Ltd.
    Inventors: Ga-hee KIM, Chang-eun YOO, Ye-ryoung YONG, Myo-yong LEE
  • IMMUNOMODULATORY MINICELLS AND METHODS OF USE
    Publication number: 20140093954
    Abstract: The present disclosure is related to immunomodulatory bacterial minicells and methods of using the minicells.
    Type: Application
    Filed: October 2, 2013
    Publication date: April 3, 2014
    Inventor: Matthew J. Giacalone
  • Incorporation of flavan-3-ols and gallic acid derivatives into lignin to improve biomass utilization
    Patent number: 8685672
    Abstract: A method of manufacturing modified lignin and the resulting non-natural modified lignin product in which a lignin-producing polymerization reaction is performed using a polymerizable monomer having the structure: wherein at least one of the polymerizable monomers is incorporated into the resulting lignin.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: April 1, 2014
    Assignees: Wisconsin Alumni Research Foundation, The United States of America as Represented by the Secretary of Agriculture
    Inventors: John H. Grabber, John Ralph
  • LARGE ONCOSOMES IN HUMAN TUMORS AND IN CIRCULATION IN PATIENTS WITH CANCER
    Publication number: 20140056807
    Abstract: The invention provides methods for isolating large oncosomes and determining cancer metastasis based on the presence of large oncosomes in a subject in need thereof.
    Type: Application
    Filed: August 23, 2013
    Publication date: February 27, 2014
    Applicant: Cedars-Sinai Medical Center
    Inventors: Dolores Di Vizio, Michael R. Freeman, Matteo Morello
  • Methods, cells and systems for incorporating non-canonical amino acids into proteins
    Patent number: 8658394
    Abstract: The present disclosure pertains to methods of incorporating one or more non-canonical amino acids into a protein during a translation of the protein in bacterial cells. The present disclosure also pertains to methods of incorporating one or more non-canonical amino acids into a protein during an in vitro translation of the protein. In additional embodiments, the present disclosure pertains to isolated bacterial cells and in vitro translation systems (e.g., cell-free extract systems) for incorporating one or more non-canonical amino acids into a protein during a translation of the protein.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: February 25, 2014
    Assignee: Waterstone Pharmaceuticals
    Inventors: Ying Huang, Wenshe Liu
  • Defective ribosomal products in blebs (DRibbles) and methods of use to stimulate an immune response
    Patent number: 8652836
    Abstract: Methods are disclosed for producing defective ribosomal products (DRiPs) in blebs (DRibbles) by contacting cells with a proteasome inhibitor, and in some examples also an autophagy inducer, thereby producing treated cells. DRibbles can be used to load antigen presenting cells (APCs), thereby allowing the APCs to present the DRiPs and antigenic fragments thereof. Immunogenic compositions that include treated cells, isolated DRibbles, or DRibble-loaded APCs are also disclosed. Methods are also provided for using treated cells, isolated DRibbles, or DRibble-loaded APCs to stimulate an immune response, for example in a subject. For example, DRibbles obtained from a tumor cell can be used to stimulate an immune response against the same type of tumor cells in the subject. In another example, DRibbles obtained from a pathogen-infected cell or cell engineered to express one or more antigens of a pathogen can be used to stimulate an immune response against the pathogen in the subject.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: February 18, 2014
    Assignee: Providence Health System
    Inventor: Hong-Ming Hu
  • MULTI-COMPARTMENT DEVICE FOR CELL CLONING AND METHOD OF PERFORMING THE SAME
    Publication number: 20140045253
    Abstract: The problems associated with the traditional methods and devices in the field of cell cloning have been solved by the multi-compartment device and method in the present invention. The device combines the advantages of a traditional petri-dish and a traditional microplate. The multi-compartment device in the present invention comprises sidewalls, which are taller than openings of the multi-compartments. The cells in the suspension flow across the multi-compartments and seed inside the compartments during a plating process. The multi-compartment device in the present invention allows easier plating process, changing conditioned medium, and cell colony detachment and transfer. The multi-compartment device also minimizes the risk of cross-contamination during cloning process and during cell colony transfer. The invention also provides an exemplary method of using the multi-compartment device for cell cloning.
    Type: Application
    Filed: August 8, 2012
    Publication date: February 13, 2014
    Inventor: Qian Zou
  • Foam microreactor for multi-phase shear-sensitive reactions
    Patent number: 8647853
    Abstract: The present invention relates to a method for controlling multi-phase chemical reactions using the architecture of surfactant foams to control mass transport of chemical reactants, catalysts, and products and the kinetics with which they react. More specifically, the invention relates to transformations that require both gaseous and liquid components with dissolved or suspended catalysts that are unstable when sheared.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: February 11, 2014
    Assignee: Ensovi, LLC
    Inventors: Carlo Montemagno, David Wendell, Hyo-Jick Choi
  • TRANSGENIC PIG FOR MUTANT GUCY2D AS CONE DYSTROPHY MODEL
    Publication number: 20140033333
    Abstract: The present invention relates to a transgenic pig as a model for studying a cone affecting disease, in particular a cone dystrophy or cone-rod-dystrophy, wherein the pig model expresses a dominant negative guanylate-cyclase-2D (GUCY2D) protein, in particular a GUCY2D protein comprising at least one mutation responsible for the appearance of a CORD6 cone dystrophy in a human being. The invention further relates to methods by which the transgenic pig is produced, to uses of said transgenic pig or of one of its elements to identify new biomarkers of a cone affecting disease and/or new compounds for preventing or treating such a disease. Novel methods for preventing or treating a cone affecting disease or for evaluating conditions needed to alleviate such a disease are further herein described.
    Type: Application
    Filed: January 27, 2012
    Publication date: January 30, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASILE DES AVEUGLES
    Inventors: Chamsy Sarkis, Christopher Bruce Alexander Whitelaw, Simon Lillico, Corinne Kostic, Yvan Arsenijevic
  • ZONA PELLUCIDA BINDING PEPTIDES, EXPRESSION VECTORS, COMPOSITIONS, AND METHODS FOR SPECIES-SPECIFIC IMMUNOCONTRACEPTION OF ANIMALS
    Publication number: 20140030283
    Abstract: Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals. The disclosed compositions may include immunogenic compositions or vaccines.
    Type: Application
    Filed: July 23, 2013
    Publication date: January 30, 2014
    Inventors: Tatiana I. Samoylova, Henry J. Baker, Nancy Cox, Stephen Ditchkoff, Kent Van Kampen
  • Conditioning chamber for storing samples in a time-controlled manner and method for storing samples in a time-controlled manner
    Publication number: 20140030802
    Abstract: The invention relates to an air-conditioning space (10) for storing samples in a time-controlled manner, comprising a device (22) for automatically feeding sample containers (18) into a climatically sealed space (12) having at least one wall (43), into which a sample container (18) can be inserted into the climatically sealed space (12) through an opening (40, 42), wherein the feed device (22) has at least one drive and control unit, and an incubator receptacle (30) for receiving the samples (18) is provided inside the climatically sealed space (12). The invention is distinguished by the fact that the feed device has an automatic feed arm (22, 24) which grips a sample container (18) from a receiving position outside the climatically sealed space (12) and deposits the sample container (18) there in a clear deposit position in an incubator receptacle (30).
    Type: Application
    Filed: November 17, 2011
    Publication date: January 30, 2014
    Applicant: ANDREAS HETTICH GMBH & CO. KG
    Inventors: Klaus-Guenter Eberle, Gavin Clarke
  • Methods of Making Nanotechnological and Macromolecular Biomimetic Structures
    Publication number: 20140017725
    Abstract: The present invention is in the fields of nanotechnology and biomimetics. In particular, the present invention relates to the use of modified ribosomes to produce biomimetic structures. These biomimetic structures, also known as directed element polymers, are not produced by traditional industrial means but instead are produced by living systems comprising modified ribosomes.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 16, 2014
    Inventor: Alexander SUNGUROFF
  • METHOD OF PURIFYING EXOSOMES
    Publication number: 20140004601
    Abstract: We describe a method of purifying a mesenchymal stem cell particle such as an exosome, the method comprising separating the mesenchymal stem cell particle on the basis of its negative charge. The method may comprise (a) providing a composition comprising mesenchymal stem cell particles such as a mesenchymal stem cell conditioned medium (MSC-CM); (b) applying the composition comprising mesenchymal stem cell particles to an ion exchange resin to enable mesenchymal stem cell particles to bind to the ion exchange resin; and (c) eluting bound mesenchymal stem cell particles. The ion exchange resin may comprise an anion exchange resin such as an anion exchange spin column.
    Type: Application
    Filed: December 19, 2011
    Publication date: January 2, 2014
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventor: Sai Kiang Lim
  • FUSION PROTEIN FOR SECRETORY PROTEIN EXPRESSION
    Publication number: 20130344099
    Abstract: There is provided a fusion protein suitable for secretion of more than one polypeptide(s) of interest (POI) comprising a signal peptide, a POI, a passenger domain comprising a beta stem domain from an autotransporter protein, and a translocator domain from an autotransporter protein, wherein the beta stem-forming sequence of the passenger domain is essentially intact and the POI(s) is/are fused to the beta stem domain.
    Type: Application
    Filed: September 28, 2011
    Publication date: December 26, 2013
    Applicant: ABERA BIOSCIENCE AB
    Inventors: Joen Luirink, Wouter S. P. Jong
  • ION CHANNEL MODULATORS AND METHODS OF USE
    Publication number: 20130345208
    Abstract: In general, the invention relates to novel 4-phenylpyrimidine compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels for the treatment of pain.
    Type: Application
    Filed: August 23, 2013
    Publication date: December 26, 2013
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: ESTHER MARTINBOROUGH, Nicole Zimmerman, Robert B. Perni, Michael Arnost, Upul K. Bandarage, Francois Maltais, Guy Bemis
  • Single-molecule real-time analysis of protein synthesis
    Patent number: 8609421
    Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of analytical reactions in which protein synthesis is occurring. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance, inhibit, or otherwise affect such reactions including, but not limited to, affecting the reaction rate, processivity, fidelity, duration, and the like.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: December 17, 2013
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Benjamin Flusberg, Stephen Turner, Jonas Korlach, Eric Schadt
  • Genes and uses for plant enhancement
    Publication number: 20130333068
    Abstract: Transgenic seed for crops with enhanced agronomic traits are provided by trait-improving recombinant DNA in the nucleus of cells of the seed where plants grown from such transgenic seed exhibit one or more enhanced traits as compared to a control plant. Of particular interest are transgenic plants that have increased yield. The present invention also provides recombinant DNA molecules for expression of a protein, and recombinant DNA molecules for suppression of a protein.
    Type: Application
    Filed: April 24, 2009
    Publication date: December 12, 2013
    Inventor: Marie Coffin
  • Influenza inhibiting compositions and methods
    Patent number: 8604165
    Abstract: The present invention provides peptides, peptide analogs, peptide derivatives and pharmaceutical compositions useful for treating or preventing influenza infections or preventing the person-to-person transmission of an influenza infection. A peptide of the invention comprises an influenza virus-cell fusion inhibiting portion of the fusion initiation region (FIR) of a wild-type influenza hemagglutinin 2 protein or a variant thereof. In a preferred embodiment, a peptide of the invention consists of 8 to 40 consecutive amino acid residues a portion of a wild-type influenza hemagglutinin 2 protein or a variant thereof, the portion of the protein comprising the FIR of the protein and up to five amino acid residues on the amino-terminal and carboxy-terminal sides of the FIR.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: December 10, 2013
    Assignees: The Administrators of the Tulane Educational Fund, Autoimmune Technologies, LLC
    Inventors: Robert F. Garry, Russell B. Wilson
  • Genetic encryption
    Patent number: 8592199
    Abstract: The present invention relates to a method to engineer either the genome of a genetically modified organism, other bioengineered reagent, or in vitro translation system for protein synthesis from specific protein-coding genes so that the protein-coding genes so engineered can only produce proteins with an intended structure when translated within the context of that specifically engineered GMO or in vitro translation system. It also relates to nucleic acids for use in such GMOs or translation systems.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: November 26, 2013
    Inventor: David H. Ardell
  • METHODS FOR ALTERING THE REACTIVITY OF PLANT CELL WALLS
    Publication number: 20130312141
    Abstract: Methods and means are provided for the modification of the reactivity of plant cell walls, particularly as they can be found in natural fibers of fiber producing plants by inclusion of positively charged oligosaccharides or polysaccharides into the cell wall. This can be conveniently achieved by expressing a chimeric gene encoding an N-acetylglucosamine transferase, particularly an N-acetylglucosamine transferase, capable of being targeted to the membranes of the Golgi apparatus in cells of a plant.
    Type: Application
    Filed: July 15, 2013
    Publication date: November 21, 2013
    Applicant: BAYER BIOSCIENCE N.V.
    Inventors: Marc De Block, Frank Meulewaeter, Rainhard Koch, Bernd Essigmann
  • Genes and uses for plant enhacement
    Publication number: 20130305398
    Abstract: Transgenic seed for crops with enhanced agronomic traits are provided by trait-improving recombinant DNA in the nucleus of cells of the seed where plants grown from such transgenic seed exhibit one or more enhanced traits as compared to a control plant. Of particular interest are transgenic plants that have increased yield. The present invention also provides recombinant DNA molecules for expression of a protein, and recombinant DNA molecules for suppression of a protein.
    Type: Application
    Filed: February 16, 2012
    Publication date: November 14, 2013
    Inventor: Marie Coffin
  • Apparatus and Method for Growing Cells
    Publication number: 20130295662
    Abstract: A system and method for culturing cells is provided that includes an extra-capillary space between at least one permeable hollow fiber and an enclosed chamber. Cells are placed in the extra-capillary space to grow. One or more reservoirs containing cell-culture media and/or an oxygen-containing gas are provided in communication with the at least one fiber. The system is configured to generate alternating flows of both the cell-culture media and the gas through a lumen of the hollow fiber(s), thereby passing both nutrients and gas through the walls of the fiber(s) to the cells in the extra-capillary space to provide a suitable environment for growth and/or proliferation of the cells. Flows of liquid and gas through the hollow fiber(s) can be produced by gravity and/or various pumping configurations.
    Type: Application
    Filed: May 1, 2013
    Publication date: November 7, 2013
    Applicant: FiberCell Production Solutions LLC
    Inventors: John J. S. Cadwell, Kevin Barnes
  • Methods for sterilizing materials containing biologically active agents
    Patent number: 8574897
    Abstract: Provided are methods for sterilizing a material comprising a biologically-active agent comprising irradiating said material with ionizing radiation at a dose of about 5 kGy to about 25 kGy while maintaining said material in an atmosphere comprising at least 95% by volume inert gas and at a temperature of about 4° C. or lower. Also provided are sterilized materials comprising a biologically-active agent, wherein said materials exhibit substantially the same amount of biological activity as a non-sterilized control.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: November 5, 2013
    Assignee: DePuy Synthes Products, LLC
    Inventors: Alexander M. Harmon, Laura J. Brown, Charles J. Buckle, Frederick Halperin, Stanko Bodnar
  • Stackable electrochemical analyte sensors, systems and methods including same
    Patent number: 8574510
    Abstract: In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base with first and second ends, a concave recess in the first end, a second end receiving surface, and a sidewall extending between the ends. An electrode may be provided on the receiving surface with an electrochemically-active region coupled to the electrode. A conductor in electrical contact with the electrode may extend along the sidewall and may be adapted to be in electrical contact with a first contact of an analyte meter. Manufacturing methods and systems utilizing and dispensing the analyte sensors are provided, as are numerous other aspects.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: November 5, 2013
    Assignee: Bayer Healthcare LLC
    Inventors: Igor Gofman, Robert S. Sams
  • Transgenic plants with enhanced agronomic traits
    Publication number: 20130283461
    Abstract: This invention provides recombinant DNA constructs, transgenic plant nuclei and cells with such recombinant DNA construct for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: February 27, 2013
    Publication date: October 24, 2013
    Inventors: Mark Scott Abad, Jeffery E. Ahrens, Alice Clara Augustine, Erin Bell, Robert J. Bensen, Srikanth Venkatachalayya, Paolo Castiglioni, Richard E. Cerny, Jaishree M. Chittoor-Vijayanath, Maureen Daley, Jill Deikman, Molian Deng, Todd DeZwaan, Stephen Duff, Michael D. Edgerton, Bradon J. Fabbri, Jason Fenner, Karen Gabbert, Meghan Galligan, Garrett J. Lee, Barry S. Goldman, Deborah J. Hawkins, Steve He, Xianfeng Chen, Balasulojini Karunanandaa, Paul Loida, Savitha Madappa, Robert J. Meister, Ming Peng, Donald E. Nelson, Anand Pandravada, Obed Patty, Marie Petracek, Rajani Monnanda Somaiah, Monica P. Ravanello, Richard Johnson, Thomas G. Ruff, Rick A. Sanders, Beth Savidge, Steven H. Schwartz, Shobha Char, Padmini Sudarshana, Jindong Sun, Rebecca L. Thompson-Mize, Virginia Ursin, Dale L. Val, Tyamagondlu V. Venkatesh, Kammaradi R. Vidya, K. Vijayalakshmi, Todd C. Weber, Jingrui Wu, Wei Zheng, Zhidong Xie, Dhanalakshmi Ramachandra
  • Gene Constructs Comprising Nucleic Acids That Modulate Chlorophyll Biosynthesis And Uses Thereof
    Publication number: 20130276162
    Abstract: The present invention provides isolated nucleic acids encoding Ch1 d synthase, gene constructs comprising the isolated nucleic acids and cells, chloroplasts, plant tissue and whole plants ectopically expressing cyanobacterial Ch1 d synthase. The invention also provides isolated antibodies prepared using recombinant Ch1 d synthase. The antibodies and gene constructs of the invention are used to produce Ch1 d in organisms that do not normally produce Ch1 d, and to modify Ch1 d level in cyanobacterial cells, such as for modifying environmental host range and photosynthetic capacity of organisms in low light and/or red or far-red or near far-red light environments.
    Type: Application
    Filed: May 20, 2011
    Publication date: October 17, 2013
    Inventors: Robert Blankenship, Min Chen, Robert Willows
  • Complete liquefication of lignocellulosic agrowaste to form liquid biofuels
    Patent number: 8557000
    Abstract: A process for converting lignocellulosic materials which are field residues such as cotton stalks and corn stover, process residues such as sugarcane bagasse and sweet sorghum bagasse, woody parts of energy crops such as switchgrass and miscanthus, forest residues or byproducts of the wood processing industries such as sawdust from sawmills to a liquid biofuel by a series of processing steps wherein the feed materials are hydrolysed in three stages and withdrawn as three product streams each consisting of solubilized fragments of one of the three major components of the feed materials and a set of concurrently operating processing steps wherein each of the three product streams is transformed through chemical or biochemical processes into products, such as pure lignin and ethanol, that have a high calorific value and process wherein these products with high calorific value are combined to form a liquid biofuel.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: October 15, 2013
    Assignee: Lignoil Technologies Private Limited
    Inventor: Pradyot A. Agaskar
  • Condensate Prevention Hood
    Publication number: 20130266946
    Abstract: The invention relates to a device for controlling the temperature of laboratory vessels, comprising at least one vessel receptacle for receiving the laboratory vessels, at least one removably designed peripheral unit, and a base unit which has a temperature control device and a mounting for placing the at least one removable peripheral unit in a defined position, characterised in that the base unit and the at least one peripheral unit each have at least one coupling element, with said elements, when the peripheral unit is placed onto the base unit in the defined position, forming at least one releasable coupled pair by which the electrical power and/or at least one signal can be transmitted.
    Type: Application
    Filed: May 3, 2011
    Publication date: October 10, 2013
    Applicant: Eppendorf AG
    Inventors: Matthias Baumgartner, Gerrit Walter, Florian Dürr, Janine Röhrs, Arne Schafrinski
  • GENES AND USES FOR PLANT IMPROVEMENT
    Publication number: 20130269056
    Abstract: Transgenic seed for crops with improved traits are provided by trait-improving recombinant DNA in the nucleus of cells of the seed where plants grown from such transgenic seed exhibit one or more improved traits as compared to a control plant. Of particular interest are transgenic plants that have increased yield. The present invention also provides recombinant DNA molecules for expression of a protein, and recombinant DNA molecules for suppression of a protein.
    Type: Application
    Filed: June 11, 2013
    Publication date: October 10, 2013
    Inventors: Barry S. Goldman, Mark Scott Abad, Jaishree S. Chittoor-Vijayanath, Ronald C. Rish, Faten Shaikh, Joseph C. Mitchell, Diana Wray
  • Method for isolating nuclei
    Patent number: 8546134
    Abstract: This invention relates to methods of isolating cell nuclei from the other cell components in cell samples, e.g., cell samples from cell cultures or tissue samples. The method does not comprise ultracentrifugation or super-centrifugation rather the method comprises centrifuging cell samples in a table-top conventional centrifuge or microfuge. The method also comprises the use of buffers that are substantially devoid of protease inhibitor or enzyme treatments. The methods facilitate separation of nuclei from nuclear outer membranes leaving the cellular structures and inner membranes of nuclei intact. The method also provides for rapid and consistent results.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: October 1, 2013
    Assignees: The George Washington University, The United States of America as Represented by the Department of Veteran Affairs
    Inventor: Takako Nagata
  • METHOD FOR IDENTIFYING IMMUNOREACTIVE PEPTIDES
    Publication number: 20130251751
    Abstract: The invention relates to a method for identifying immunoreactive peptides. According to said method, a sample of tumorous and corresponding healthy tissue is first provided, the tumor-specific expression profile is subsequently determined and antigenic peptides are isolated from the tumorous tissue and analyzed. The respective data that has been obtained is then matched and peptides are identified on the basis of said data.
    Type: Application
    Filed: February 22, 2013
    Publication date: September 26, 2013
    Applicant: IMMATICS BIOTECHNOLOGIES GMBH
    Inventors: Toni WEINSCHENK, Hans Georg RAMMENSEE
  • DEVELOPMENTS IN MENINGOCOCCAL OUTER MEMBRANE VESICLES
    Publication number: 20130236489
    Abstract: A first aspect of the invention provides meningococcal outer membrane vesicles in which NHBA is over-expressed. A second aspect of the invention provides meningococcal outer membrane vesicles in which NadA is over-expressed. A third aspect of the invention provides a panel of bacterial strains, each member of which is isogenic except for a single gene which in each strain encodes a different variant of an antigen of interest.
    Type: Application
    Filed: September 9, 2011
    Publication date: September 12, 2013
    Applicant: NOVARTIS AG
    Inventors: Davide Serruto, Mariagrazia Pizza, Isabel Delany
  • CHIMERIC PROMOTER MOLECULES FOR GENE EXPRESSION IN PROKARYOTES
    Publication number: 20130217008
    Abstract: The present invention provides regulatory polynucleotide molecules isolated from a 16S rDNA for enhanced expression of heterologous genes. The invention further discloses compositions, polynucleotide constructs, transformed host cells containing the regulatory polynucleotide sequences, and methods for preparing and using the same.
    Type: Application
    Filed: March 20, 2013
    Publication date: August 22, 2013
    Applicant: Monsanto Technology LLC
    Inventor: Monsanto Technology LLC
  • RAPID MEMBRANE ISOLATION METHOD FOR ANIMAL AND PLANT SAMPLES
    Publication number: 20130217114
    Abstract: Disclosed herein are methods for quickly obtaining crude membranes from cells, including animal and plant cells. The methods include incubating cells in a buffer and forcing the cells through a filter that causes rupture of the cells, and then separating the resulting crude membranes from most cytosolic proteins.
    Type: Application
    Filed: February 14, 2013
    Publication date: August 22, 2013
    Inventors: Lin Yan, Quanzhi Li
  • INDUCTION OF A PHYSIOLOGICAL DISPERSION RESPONSE IN BACTERIAL CELLS IN A BIOFILM
    Publication number: 20130216637
    Abstract: The present invention is directed to a compound which induces a physiological dispersion response in bacterial cells in a biofilm. The present invention is also directed to compositions containing this compound, methods of isolating the compound, and uses thereof.
    Type: Application
    Filed: April 1, 2013
    Publication date: August 22, 2013
    Applicant: Research Foundation of State University of New York
    Inventor: Research Foundation of State University of New York
  • MICROVESICLES CARRYING SMALL INTERFERING RNAS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20130209544
    Abstract: Microvesicles containing interfering RNAs, preparation methods and uses thereof are provided. Pharmaceutical compositions and kits comprising the microvesicles containing interfering RNAs are also provided. Microvesicles containing interfering RNAs, pharmaceutical compositions and kits comprising such microvesicles can be used to study the effects of interfering RNAs on receptor cells. As microvesicles containing interfering RNAs can stably, high efficiently and specifically deliver interfering RNAs, microvesicles containing interfering RNAs can be used to treat related diseases.
    Type: Application
    Filed: May 26, 2010
    Publication date: August 15, 2013
    Applicants: JIANGSU MICROMEDMARK BIOTECH CO., LTD.
    Inventors: Chenyu Zhang, Ke Zeng, Danqing Liu, Yujing Zhang, Hongwei Gu
  • NOVEL LIPID TRIPEPTIDE-BASED HYDROGELATOR AND HYDROGEL
    Publication number: 20130203687
    Abstract: A hydrogel that includes an aqueous solution or an alcohol aqueous solution, and a hydrogelator containing a lipid peptide represented by Formula (1), or a pharmaceutically usable salt thereof. In Formula (1), R1 represents an aliphatic group having 9 to 21 carbon atoms; R2, R3, and R4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms that optionally has a branched chain having 1 or 2 carbon atoms, a phenylmethyl group, or a —(CH2)n—X group, and at least one of R2, R3, and R4 represents a —(CH2)n—X group; n represents an integer from 1 to 4; and X represents an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms.
    Type: Application
    Filed: March 4, 2013
    Publication date: August 8, 2013
    Applicants: KYUSHU UNIVERSITY, NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: NISSAN CHEMICAL INDUSTRIES, LTD., KYUSHU UNIVERSITY
  • Transgenomic Mitochondria, Transmitochondrial Cells and Organisms, and Methods of Making and Using
    Publication number: 20130203160
    Abstract: This invention provides transgenomic mitochondria, transmitochondrial cells and organisms, and the materials and methods for making such mitochondria, cells and organisms.
    Type: Application
    Filed: April 8, 2013
    Publication date: August 8, 2013
    Inventors: Michael D. Koob, Young G. Yoon
  • OMV VACCINES
    Publication number: 20130195907
    Abstract: The invention is in the field of outer membrane vesicles (OMV) and their uses. More particularly the present invention provides OMV obtained from a bacterium being an ompA mutant and/or a mutant in one or more components of the TolPal complex and presenting a heterologous antigen on its surface. The heterologous antigen is selected from the group consisting of Chlamydia trachomatis CT823, CT681, CT372, CT443, CT043, CT733, CT279, CT601 and CT153 for the treatment, prevention or diagnosis of Chlamydia infection.
    Type: Application
    Filed: June 10, 2011
    Publication date: August 1, 2013
    Applicant: Norvartis AG
    Inventors: Renata Maria Grifantini, Erika Bartolini, Oretta Finco, Guido Grandi
  • MESOPOROUS SILICA NANOPARTICLE-MEDIATED DELIVERY OF DNA INTO ARABIDOPSIS ROOT
    Publication number: 20130185823
    Abstract: Transient gene expression is a powerful tool for plant genomics studies. Recently, the use of nanomaterials has drawn great interest. Delivery with mesoporous silica nanoparticles (MSNs) has many advantages. We used surface-functionalized MSNs to deliver and express foreign DNA in Arabidopsis thaliana root cells without the aid of particle bombardment. Gene expression was detected in the epidermis layer and in the more inner cortex and endodermis root tissues. This method is superior to the conventional gene-gun method to deliver DNA, which delivers the gene to the epidermis layer only. Less DNA is needed for the MSN method. Our system is the first use of nanoparticles to deliver DNA to plants with good efficiency and without external aids. MSNs, with multifunctionality and the capability of cargo delivery to plant cells as we demonstrated, provide a versatile system for biomolecule delivery, organelle targeting, and even agriculture, such as improved nutrient uptake.
    Type: Application
    Filed: January 15, 2013
    Publication date: July 18, 2013
    Applicant: Academia Sinica
    Inventor: Academia Sinica
  • METHODS OF PREPARING CHORION TISSUE AND PRODUCTS DERIVED THEREFROM
    Publication number: 20130156863
    Abstract: Disclosed herein, in certain instances, are tissue grafts derived from chorion or amnio-chorion. Further disclosed herein, in certain instances, are use for tissue grafts derived from chorion or amnio-chorion.
    Type: Application
    Filed: June 30, 2011
    Publication date: June 20, 2013
    Applicant: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Ek Kia Tan, Lorraine Siok May Chua
  • METHODS AND COMPOSITIONS FOR SENSORS
    Publication number: 20130152667
    Abstract: Provided herein are methods and devices for sensing air quality. In some embodiments, materials from mitochondrial membranes, and/or material that is present in mitochondrial membranes can be used as a detection system to optically detect the presence and/or absence of various materials.
    Type: Application
    Filed: December 19, 2011
    Publication date: June 20, 2013
    Applicant: Empire Technology Development LLC
    Inventor: Michael Keoni Manion
  • METHODS OF QUANTIFYING EXOSOME IN CELL CULTURE AND METHOD OF INCREASING RECOVERY RATE OF EXOSOME USING THE SAME
    Publication number: 20130157300
    Abstract: A method of detecting and recovering of exosomes in a sample, as well as a method of determining the recovery rate of exosomal recovery, and a method of screening for a material that induces secretion of the exosomes in a sample, which methods employ the use of a protease.
    Type: Application
    Filed: November 15, 2012
    Publication date: June 20, 2013
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventor: SAMSUNG ELECTRONICS CO., LTD.
  • Genes and uses for plant improvement
    Publication number: 20130152224
    Abstract: Transgenic seed for crops with improved traits are provided by trait-improving recombinant DNA in the nucleus of cells of the seed where plants grown from such transgenic seed exhibit one or more improved traits as compared to a control plant. Of particular interest are transgenic plants that have increased yield. The present invention also provides recombinant DNA molecules for expression of a protein, and recombinant DNA molecules for suppression of a protein.
    Type: Application
    Filed: November 28, 2012
    Publication date: June 13, 2013
    Applicant: Monsanto Technology LLC
    Inventors: Mark Scott Abad, Marie Coffin, Barry S. Goldman
  • Nanoengineered Biophotonic Hybrid Device
    Publication number: 20130119499
    Abstract: Apparatus, compositions, methods, and articles of manufacture are disclosed relating to the design and production of biological components and/or their incorporation in devices and systems, including biohybrid photosensitive devices and systems. In some embodiments, biological components include light antenna structures that collect light and emit Stokes-shifted light to a photoactive non-biological component. In some embodiments, the characteristics of biological components are engineered via force-adaptation of an organism or adaptive system. In some embodiments, biological components are modified by removing reaction centers or other structure not contributing to desired performance.
    Type: Application
    Filed: May 8, 2012
    Publication date: May 16, 2013
    Inventors: Jeffrey T. LaBelle, Vincent B. Pizziconi