Miscellaneous (e.g., Subcellular Parts Of Micro-organisms, Etc.) Patents (Class 435/317.1)
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Publication number: 20130115241Abstract: The present application relates to microvesicles derived from a protoplast which is a bacterial, arhaea, fungal or plant cell or the like from which a cell wall is removed. The microvesicles derived from a protoplast enables free loading of a material necessary for diagnosis, treatment, vaccine, target induction, cell membrane fusion with a target cell, reduction of in vivo and in vitro side effects, stability improvement, and the like, and allows the therapeutic material, the diagnostic material and/or the vaccine material to be delivered specifically to a specific tissue or cell.Type: ApplicationFiled: June 30, 2011Publication date: May 9, 2013Applicant: AEON MEDIX INC.Inventors: Yong Song Gho, Su Chul Jang, Yoon Keun Kim, Oh Youn Kim
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Publication number: 20130115238Abstract: fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.Type: ApplicationFiled: January 8, 2013Publication date: May 9, 2013Applicant: NOVARTIS AGInventor: Novartis AG
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Patent number: 8415159Abstract: The present invention pertains to the development of Extracellular Matrix (ECM) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction. In addition, the present invention features methods of isolating ECM scaffolds from mammalian organs, including but not limited to the ruminant forestomach. The invention further features laminated ECM scaffolds containing a polymer positioned between individual ECM sheets. The polymer may optionally contain bioactive molecules to enhance the functionality of the scaffold.Type: GrantFiled: July 30, 2009Date of Patent: April 9, 2013Assignee: Mesynthes Ltd.Inventors: Brian Roderick Ward, Keryn Dallas Johnson, Barnaby Charles Hough May
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Publication number: 20130074202Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.Type: ApplicationFiled: May 14, 2012Publication date: March 21, 2013Applicant: Monsanto Technology LLCInventors: Thomas Adams, Ameeta K. Agarwa, Jeffrey Ahrens, James A. Ball, Amarjit Basra, Erin Bell, Terry L. Bradshaw, Paul S. Chomet, James H. Crowley, Jill Deikman, Molian Deng, Meghan Donnarummo, Kimberly Faye Zobrist Duff, Stephen Duff, Michael D. Edgerton, Banu Gopalan, Xiaoping He, Mackenzie Heal, Brendan S. Hinchey, Shihshieh Huang, Richard G. Johnson, Vincent Jung, Keith Kretzmer, Lucille B. Laccetti, Chao Qiang Lai, Garrett J. Lee, Michael H. Luethy, Timothy J. Leland, Jingdong Liu, Bin Lu, Adrian A. Lund, Linda L. Madson, Kathleen P. Malloy, Marcus Paul McNabnay, Manchikanti Padmavati, Thomas Ruff, William Start, Daniel Tennessen, Carl P. Urwin, Gabriela Vaduva, K. R. Vidya, Steven Thomas Voss, Christine Voyles, Zhango Xin, Nanfei Xu, Qingzhang Xu, Qiang Zhang, Yajuan Zhao, Li Zhou
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Publication number: 20130052194Abstract: Disclosed herein are antibodies that detect a lipid-like antigen on prostate cancer cells and methods of detecting and treating prostate cancer using the same.Type: ApplicationFiled: December 16, 2010Publication date: February 28, 2013Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Mark I. Greene, Hongtao Zhang, Geng Zhang
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Publication number: 20130052727Abstract: Oogonial stem cell (OSC)-derived compositions, such as nuclear free cytoplasm or isolated mitochondria, and uses of OSC-derived compositions in autologous fertility-enhancing procedures are described.Type: ApplicationFiled: September 7, 2012Publication date: February 28, 2013Applicant: The General Hospital CorporationInventors: Jonathan L. Tilly, Dori C. Woods
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Publication number: 20130052647Abstract: Described herein are methods, devices, and compositions for fractionation and processing of microparticles from biological samples, and to methods for obtaining and using the microparticles for biomarker discovery. Biological samples include cell-free fluids, for example blood plasma, blood serum, cerebrospinal fluid, urine, and saliva, as well as conditioned media. Conditioned media is the liquid growth media used to propagate cells in vitro. Purification of microparticles from cell-free fluids is challenging, typically accomplished by prolonged ultracentrifugation. Described herein is an alternative method for efficiently harvesting and processing microparticles from cell-free fluids and from conditioned media. Embodiments described herein relate to use of the microparticles and their contents recovered from conditioned media derived from propagation of human and animal cells, as a source of biomarkers for diagnosis and prognosis of diseases and pathological conditions.Type: ApplicationFiled: February 10, 2011Publication date: February 28, 2013Inventors: Marianna Goldrick, Lance Ford
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Publication number: 20130045291Abstract: It is to provide a composition derived from lactic acid bacteria having an anti-allergic effect (an effect of suppressing allergic symptoms such as hay fever) synergistically, and a food product, pet food, etc. containing the composition. It is to prepare a composition having an anti-allergic action, containing Lactobacillus crispatus KT-11 strain, KT-23 strain, or KT-25 strain bacterial cells and viable bacteria, dead bacteria, or a processed product of bacterial cells of other lactic acid bacteria belonging to the genus Lactobacillus, genus Bifidobacterium, genus Leuconostoc, genus Enterococcus, genus Pediococcus, etc. at a biomass-converted ratio of 99:1 to 50:50, preferably 99:1 to 75:25.Type: ApplicationFiled: March 4, 2011Publication date: February 21, 2013Applicant: KITII CO., LTD.Inventors: Keisuke Tobita, Hajime Otani
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Publication number: 20130034900Abstract: The present invention relates to a non-genetic, detergent-free, bacteria-free method for reprogramming a eukaryotic cell, in particular for obtaining induced pluripotent stem cells (iPS), by using engineered microvesicles carrying at least one reprogramming transcription factor, wherein said engineered microvesicles are virus-free.Type: ApplicationFiled: November 10, 2010Publication date: February 7, 2013Applicant: INSERM (Institut National de la Sante et de la Recherche Midicale)Inventors: Philippe Mangeot, Vincent Lotteau, Marc Peschanski, Mathilde Girard
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Publication number: 20130023478Abstract: This document provides aquaretic and natriuretic polypeptides. For example, this document provides polypeptides having aquaretic and/or natriuretic activities. In some cases, a polypeptide provided herein can have aquaretic and natriuretic activities, while lacking the ability to lower blood pressure. This document also provides methods and materials for inducing aquaretic and/or natriuretic activities within a mammal.Type: ApplicationFiled: August 23, 2012Publication date: January 24, 2013Inventors: Horng H. Chen, John C. Burnett, JR.
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Patent number: 8357529Abstract: Biological macromolecules are synthesized in vitro under conditions and in a reaction composition wherein oxidative phosphorylation is activated and protein folding is improved.Type: GrantFiled: January 8, 2008Date of Patent: January 22, 2013Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: James Robert Swartz, Michael Christopher Jewett
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Publication number: 20130011439Abstract: The invention relates to the use of lactic acid-producing bacteria to boost the immune system.Type: ApplicationFiled: September 13, 2012Publication date: January 10, 2013Applicant: Ganeden Biotech, Inc.Inventors: Sean Farmer, Michael A. Bush, David Keller
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Publication number: 20130007911Abstract: The present invention relates to methods of blocking or reducing genetically modified plant (GMO) pollen flow using a “non-lethal” approach. In this aspect, at least one transgenic polynucleotide of interest is linked to a pollen-ablation construct as described herein. The pollen-ablation construct contains a polynucleotide encoding a restriction enzyme that renders the transgenic pollen unable to fertilize a sexually compatible ovule.Type: ApplicationFiled: July 2, 2012Publication date: January 3, 2013Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventor: C. NEAL STEWART, JR.
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Publication number: 20130004475Abstract: The present invention provides a means and a method for effectively increasing Bifidobacteria in the large intestine. Specifically, the present invention relates to an agent for increasing Bifidobacteria and/or reducing the decrease of Bifidobacteria in the large intestine, which comprises spores of Bacillus subtilis and a means of delivering the spores to the large intestine of a subject while maintaining the spore form of Bacillus subtilis.Type: ApplicationFiled: March 10, 2011Publication date: January 3, 2013Inventors: Misaki Hatanaka, Yasunori Nakamura
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Publication number: 20120328622Abstract: The invention provides BASB082, BASB083, BASB091, BASB092 and BASB101 polypeptides and polynucleotides encoding BASB082, BASB083, BASB091, BASB092 and BASB101 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.Type: ApplicationFiled: June 15, 2012Publication date: December 27, 2012Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Catherine Defrenne, Christine Delmelle, Jean-Louis Ruelle
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Publication number: 20120329065Abstract: Nucleic acids encoding erythropoietin isoforms are described herein, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer.Type: ApplicationFiled: August 27, 2012Publication date: December 27, 2012Inventors: Murat O. Arcasoy, Zishan A. Haroon
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Publication number: 20120322147Abstract: The present invention relates to direct protein delivery with engineered micro vesicles.Type: ApplicationFiled: November 10, 2010Publication date: December 20, 2012Applicant: INSERM(institut National de la Sante et de la Recherche Medicale)Inventors: Philippe Mangeot, Vincent Lotteau
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Publication number: 20120315651Abstract: Oogonial stem cell (OSC)-derived compositions, such as nuclear free cytoplasm or isolated mitochondria, and uses of OSC-derived compositions in autologous fertility-enhancing procedures are described.Type: ApplicationFiled: April 13, 2012Publication date: December 13, 2012Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: JONATHAN L. TILLY, DORI C. WOODS
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Publication number: 20120315695Abstract: The present invention provides for a composition comprising a solution comprising (a) an ionic liquid (IL) or ionic liquid-aqueous (ILA) phase and (b) an organic phase, wherein the solution comprises a sugar and a boronic acid. The present invention also provides for a method of removing a sugar from a solution, comprising: (a) providing a solution comprising (i) an IL or ILA phase and (ii) an organic phase, wherein the solution comprises an IL, a sugar and a boronic acid; (b) contacting the sugar with the boronic acid to form a sugar-boronic acid complex, (c) separating the organic phase and the aqueous phase, wherein the organic phase contains the sugar-boronic acid complex, and optionally (d) separating the sugar from the organic phase.Type: ApplicationFiled: March 29, 2012Publication date: December 13, 2012Applicants: SANDIA CORPORATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Timothy Charles R. Brennan, Bradley M. Holmes, Blake A. Simmons, Harvey W. Blanch
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Publication number: 20120315698Abstract: Provided are methods for sterilizing a material comprising a biologically-active agent comprising irradiating said material with ionizing radiation at a dose of about 5 kGy to about 25 kGy while maintaining said material in an atmosphere comprising at least 95% by volume inert gas and at a temperature of about 4° C. or lower. Also provided are sterilized materials comprising a biologically-active agent, wherein said materials exhibit substantially the same amount of biological activity as a non-sterilized control.Type: ApplicationFiled: June 8, 2012Publication date: December 13, 2012Applicant: Advanced Technologies and Regenerative Medicine LLCInventors: ALEXANDER M. HARMON, LAURA J. BROWN, CHARLES J. BUCKLE, FREDERICK HALPERIN, STANKO BODNAR
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Publication number: 20120301904Abstract: The present invention provides compositions and methods of use in investigations of the formation of mulitprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.Type: ApplicationFiled: April 26, 2012Publication date: November 29, 2012Applicant: Prosetta Antiviral, IncInventors: Vishwanath R. Lingappa, Clarence R. Hurt, Debendranath Dey
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Patent number: 8318436Abstract: The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga cells, particularly in the chloroplast. Single enzymes or multiple enzymes may be produced by the methods disclosed. The methods disclosed herein allow for the production of biofuel, including ethanol.Type: GrantFiled: October 7, 2011Date of Patent: November 27, 2012Assignees: Sapphire Energy, Inc., The Scripps Research InstituteInventors: Stephen Mayfield, Bryan O'Neill, Michael Mendez, Yan Poon
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Publication number: 20120288930Abstract: The invention provides methods of modifying the lipids produced by microbial organisms through genetic engineering. The invention also provides genetically engineered microbes and methods of fermenting microbes for oil production. Also provided are oils, fuels, oleochemicals, chemical precursors, and other compounds manufactured by such modified microorganisms. Exemplary oil-bearing organisms include organisms containing one or more exogenous genes encoding a fatty acyl-ACP thioesterase, fatty acyl-CoA/aldehyde reductase, fatty acyl-CoA reductase, fatty aldehyde reductase, fatty aldehyde decarbonylase, and/or an acyl carrier protein.Type: ApplicationFiled: July 25, 2012Publication date: November 15, 2012Applicant: Solazyme, Inc.Inventors: Donald E. Trimbur, Chung-Soon Im, Harrison F. Dillon, Anthony G. Day, Scott Franklin, Anna Coragliotti
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Publication number: 20120283317Abstract: Disclosed herein recombinant and/or isolated nucleic acid molecules which comprise, consist essentially of, or consist of a first nucleic acid sequence, which is a wild-type sequence or an altered sequence, directly or indirectly linked to a second nucleic acid sequence selected from the group consisting of: (1) a mitochondria localization sequence, (2) an RNA import sequence, or (3) a combination thereof, and methods of using thereof.Type: ApplicationFiled: March 7, 2012Publication date: November 8, 2012Inventors: Michael A. Teitell, Carla M. Koehler, Geng Wang
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Publication number: 20120264957Abstract: A method for isolating chlorophylls from intact algal cells is provided. The method includes dewatering intact algal cells from an algal cell culture to make an algal biomass, extracting lipids along with carotenoids and chlorophylls from the algal biomass, and separation of the chlorophylls using adsorption or membrane diafiltration or other methods. The method can include selective extraction of other algal components including polar lipids, neutral lipids, proteins, and carbohydrates. The method may include esterifying the lipids with a catalyst in the presence of an alcohol, and separating a water soluble fraction comprising glycerin from a water insoluble fraction comprising fuel esters and distilling the fuel esters under vacuum to obtain a C16 or shorter fuel esters fraction, a C16 or longer fuel ester fraction, and a residue comprising omega-3 fatty acids esters and remaining carotenoids.Type: ApplicationFiled: June 22, 2012Publication date: October 18, 2012Applicant: HELIAE DEVELOPMENT, LLCInventor: Aniket KALE
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Publication number: 20120255044Abstract: A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and inflammation-related disease. The method can include a step for detecting variations in genes that encode ABCG2 protein. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F208S, G268R, E334X, S441N, L447V, S486N, F506SfsX4, R575X, and/or C608X, it can be concluded that the subject has a factor that is capable of inducing urate transport failure, or a state or disease attributable to that failure. When a subject has an SNP of V12M, it can be concluded that, unlike the other SNPs, there is a possibility that the subject does not possess such a factor because, although this variation itself does not lead to a change in urate transport capability, said variation is related to linkage disequilibrium with other SNPs.Type: ApplicationFiled: June 22, 2010Publication date: October 4, 2012Applicant: The University of TokyoInventors: Hirotaka Matsuo, Nariyoshi Shinomiya, Takahiro Nakamura, Tappei Takada, Hiroshi Suzuki, Yuki Ikebuchi, Kousei Ito, Kimiyoshi Ichida
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Publication number: 20120237971Abstract: The present disclosure pertains to methods of incorporating one or more non-canonical amino acids into a protein during a translation of the protein in bacterial cells. The present disclosure also pertains to methods of incorporating one or more non-canonical amino acids into a protein during an in vitro translation of the protein. In additional embodiments, the present disclosure pertains to isolated bacterial cells and in vitro translation systems (e.g., cell-free extract systems) for incorporating one or more non-canonical amino acids into a protein during a translation of the protein.Type: ApplicationFiled: January 18, 2012Publication date: September 20, 2012Applicant: Waterstone PharmaceuticalsInventors: Ying Huang, Wenshe Liu, Ying Huang
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Publication number: 20120231496Abstract: According to the present invention, a composition possessing cell-free protein synthesis activity with reduced contaminating lipopolysaccharide, and a method for producing a protein using the same are provided. When ribosome display is performed using the composition and method for protein production of the present invention, the background that is caused by non-specific binding is reduced, so that a nucleic acid that encodes the desired polypeptide can be selected with high accuracy and high efficiency.Type: ApplicationFiled: May 3, 2011Publication date: September 13, 2012Applicants: THE UNIVERSITY OF TOKYO, GENEFRONTIER CORPORATIONInventors: Takashi KANAMORI, Yuki HAYAMI, Kanehisa KOJOH, Takuya UEDA, Kumiko TSUIHIJI, Tomoe FUSE, Mikiko NAKAMURA, Shizue KATO
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Publication number: 20120231459Abstract: A novel method is disclosed for simultaneous detection and quantification of two or more nucleic acid targets, without need for amplification. The method depends on spectral-temporal resolution of chemiluminescence emitted from independent hybridization-induced chemiluminescent signal (HICS) probes. The utility of this method has been demonstrated by use of resolvable N-linked acridinium and 2,7-dimethoxyacridinium ester labeled probes in a homogeneous assay for sensitive and simultaneous independent quantification of several bacterial and fungal target sequences. Compositions and kits for practicing the method of the present invention are also disclosed.Type: ApplicationFiled: April 12, 2012Publication date: September 13, 2012Applicant: GEN-PROBE INCORPORATEDInventors: Kenneth A. BROWNE, Ian WEEKS
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Publication number: 20120227134Abstract: A method for producing a plant with increased yield as compared to a corresponding wild type plant whereby the method comprises at least the following step: increasing or generating in a plant or a part thereof one or more activities of a polypeptide selected from the group consisting of 2-oxoglutarate-dependent dioxygenase, 3-ketoacyl-CoA thiolase, 3?-phosphoadenosine 5?-phosphate phosphatase, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, 5OS chloroplast ribosomal protein L21, 57972199. R01.1-protein, 60952769. R01.1-protein, 60S ribosomal protein, ABC transporter family protein, AP2 domain-containing transcription factor, argonaute protein, AT1 G29250.Type: ApplicationFiled: November 5, 2010Publication date: September 6, 2012Applicant: BASF PLANT SCIENCE COMPANY GMBHInventors: Hardy Schön, Oliver Thimm, Gerhard Ritte, Oliver Bläsing, Stefan Henkes, Koen Bruynseels, Yves Hatzfeld, Valerie Frankard, Ana Isabel Sanz Molinero, Christophe Reuzeau, Steven Vandenabeele, Bryan McKersie, Krishna Kolliparra, Christian Dammann
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Publication number: 20120227131Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.Type: ApplicationFiled: September 8, 2011Publication date: September 6, 2012Inventors: Mark S. Abad, Thomas R. Adams, Ameeta K. Argarwal, James A. Ball, Paolo Castiglioni, Banu Gopalan, Erin Bell, Shobha Char, Robert J. Bensen, Raghava S. Boddupalli, Alessandra Frizzi, Jill Deikman, Robert D'Ordine, Michael D. Edgerton, Xianfeng Chen, Mary Fernandes, Paul S. Chomet, Stephen Duff, Deborah G. Rucker, Changlin Fu, Jeffrey E. Ahrens, Stanton B. Dotson, Richard E. Finger, Jinzhuo Dong, Molian Deng
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Publication number: 20120196883Abstract: The present invention relates to compositions and methods for the treatment and/or prevention of neurodegenerative disorders, e.g., Parkinson's disease (PD). In particular, the present invention provides compositions comprising selective antagonists of calcium ion channels (e.g., cav1.3-type ion channels), and methods of use thereof to treat or prevent neurodegenerative disorders.Type: ApplicationFiled: January 19, 2012Publication date: August 2, 2012Inventors: Dalton J. Surmeier, JR., Richard B. Silverman, Soosung Kang, Garry Cooper
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Publication number: 20120192295Abstract: The present application relates to a composition comprising extracellular membrane vesicles derived from indoor air. In addition, the present application provides a method for diagnosing, preventing and/or treating an inflammatory respiratory disease, lung cancer and the like using the extracellular membrane vesicles. In detail, the present application involves injecting extracellular membrane vesicles present in indoor air into an animal in order to prepare an animal respiratory disease model, and enables the search and/or discovery of drug candidates for preventing or treating respiratory diseases using the animal model.Type: ApplicationFiled: August 5, 2010Publication date: July 26, 2012Applicant: AEON MEDIX INC.Inventors: Yoon Keun Kim, Yong Song Gho, Yu Sun Kim, Eun Jeong Choi, Sung Wook Hong, Eun Young Lee, Bok Sil Hong, Jun Pyo Choi, Young Koo Ji
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Publication number: 20120190098Abstract: Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.Type: ApplicationFiled: March 1, 2012Publication date: July 26, 2012Applicants: LELAND STANFORD JUNIOR UNIVERSITY, KENT STATE UNIVERSITYInventors: ROBERT J. TWIEG, WILLIAM E. MOERNER, SAMUEL J. LORD, NA LIU, REICHEL SAMUEL
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Publication number: 20120184004Abstract: Provided herein are methods and compositions for the production of renewable fatty acids from photosynthetic prokaryotic microorganisms, such as a blue green algae, any specie of the phylum Cyanophyta, a chloroplast of a green algae and/or a Cyanobacterium. Engineered or natural strains of these organisms or organelles can be used to produce both saturated and unsaturated fatty acids with variable chain length specificity from 8-18 carbons. The fatty acids can then be secreted into the culture medium, allowing for rapid, continuous and efficient separation of fatty acid product without harvesting of cell mass.Type: ApplicationFiled: July 22, 2010Publication date: July 19, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Steve A. Kay, Ewa Lis, Susan Golden, Michael Melnick, Dawn M. Adin, James W. Golden
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Publication number: 20120167245Abstract: Transgenic seed for crops with improved traits are provided by trait-improving recombinant DNA in the nucleus of cells of the seed where plants grown from such transgenic seed exhibit one or more improved traits as compared to a control plant. Of particular interest are transgenic plants that have increased yield. The present invention also provides recombinant DNA molecules for expression of a protein, and recombinant DNA molecules for suppression of a protein.Type: ApplicationFiled: February 14, 2012Publication date: June 28, 2012Inventors: Mark S. Abad, Jaishree M. Chittoor-Vijayanath, Marie Coffin, Barry S. Goldman, Joseph C. Mitchell, Ronald C. Rich, Faten Shaikh, Diana Wray
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Publication number: 20120159658Abstract: The present application relates to extracellular vesicles (EVs) derived from gram-positive bacteria. In detail, the present application provides animal models of disease using extracellular vesicles derived from gram-positive bacteria, provides a method for screening an active candidate substance which is capable of preventing or treating diseases through the animal models of disease, provides vaccines for preventing or treating diseases caused by extracellular vesicles derived from gram-positive bacteria, and provides a method for diagnosing the causative factors of diseases caused by gram-positive bacteria using extracellular vesicles.Type: ApplicationFiled: August 26, 2010Publication date: June 21, 2012Applicant: AEON MEDIX INC.Inventors: Yong Song Gho, Yoon Keun Kim, Eun Young Lee, Sung Wook Hong, Ji Hyun Kim, Seng Jin Choi
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Publication number: 20120149014Abstract: The present invention relates to a method of enriching fetal nuclei from a sample. Enriched fetal nuclei can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.Type: ApplicationFiled: April 20, 2010Publication date: June 14, 2012Applicant: GENETIC TECHNOLOGIES LIMITEDInventors: Richard Allman, Debbie Mantzaris, Eduardo Vom, Craig Matthew Lewis
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Patent number: 8187861Abstract: For extracting phosphorous from algae-in a body of water, the algae are deposited into a sealable tank (200) that is then evacuated, thereby rupturing the algal cell walls. The ruptured algae are then moved to a second tank (260), mixed with water and bacterial cultures, and allowed to settle until the lipids rise to the top and the oil-less debris settles to the bottom. The second tank also contains sacrificial (295) and rusted electrodes (320). The phosphorous from the algae combines with the rust. The lipids and debris are then removed. Next, an electrical source (315) causes the rust to be removed from the rusted electrodes and settle. In addition, a phosphorous-rich scum floats to the top. These components are placed in storage containers for later use and the water is returned, thereby reducing its phosphorous content.Type: GrantFiled: February 26, 2010Date of Patent: May 29, 2012Inventor: Allen John Schuh
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Publication number: 20120107333Abstract: The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 35, which bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL). The peptides may include one of the above mentioned amino acid sequences with substitution, deletion, or addition of one, two, or several amino acids sequences. The present invention also provides pharmaceutical compositions including these peptides. The peptides of this invention can be used for treating cancer.Type: ApplicationFiled: March 1, 2010Publication date: May 3, 2012Applicant: Oncotherapy Science, Inc.Inventors: Takuya Tsunoda, Ryuji Ohsawa, Sachiko Yoshimura, Tomohisa Watanabe
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Publication number: 20120107413Abstract: We describe an pre-natal mesenchymal stem cell obtainable from a pre-natal tissue such as a foetal tissue, a descendent of such a mesenchymal stem cell, a cell culture or a cell line comprising either. The pre-natal mesenchymal stem cell, cell culture or cell line may comprise a cell line F1Ib, F2lb, F3lb, F1ki or F3li. We further describe a conditioned medium conditioned by such a pre-natal mesenchymal stem cell, cell culture or cell line. These may comprise cardioprotective activity, and may in particular be used to treat or prevent a range of cardiac disorders of diseases.Type: ApplicationFiled: July 21, 2010Publication date: May 3, 2012Applicants: SINGAPORE HEALTH SERVICES PTE LTD, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Sai Kiang Lim, Kok Hian Tan
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Publication number: 20120110693Abstract: The present invention relates to a shuttle system with which nucleic acids of interest may be imported into a mitochondrion. This system is based on the use of a fusion protein between a mitochondrial targeting sequence and a protein binding a nucleic acid of interest. This shuttle system is for example useful in agronomics, in the field of gene therapy, and within the scope of research products aiming at characterizing the function of mitochondrial genes.Type: ApplicationFiled: April 27, 2010Publication date: May 3, 2012Inventors: Laurence Drouard, Antonio Placido, Francois Sieber
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Publication number: 20120100130Abstract: A hetero-dimeric or hetero-oligomeric receptor, comprising at least one chemokine receptor subunit associated with at least one angiotensin receptor subunit.Type: ApplicationFiled: March 26, 2010Publication date: April 26, 2012Applicant: DIMERIX BIOSCIENCE PTY LTD.Inventors: Kevin Donald George Pfleger, Matthew Blake Dalrymple, James Williams, Elizabeth McCall
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Incorporation of Flavan-3-ols and Gallic Acid Derivatives into Lignin to Improve Biomass Utilization
Publication number: 20120094330Abstract: A method of manufacturing modified lignin and the resulting non-natural modified lignin product in which a lignin-producing polymerization reaction is performed using a polymerizable monomer having the structure: wherein at least one of the polymerizable monomers is incorporated into the resulting lignin.Type: ApplicationFiled: April 19, 2011Publication date: April 19, 2012Inventors: John H. Grabber, John Ralph -
Patent number: 8153364Abstract: An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality of compartments containing a functional in vitro eukaryotic expression system.Type: GrantFiled: January 26, 2010Date of Patent: April 10, 2012Assignee: MRCInventors: Philipp Holliger, Farid Ghadessy
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Publication number: 20120077263Abstract: This document relates to methods and materials involved in obtaining exosomes. For example, methods and materials for obtaining exosomes from biological samples such as urine samples are provided.Type: ApplicationFiled: June 4, 2010Publication date: March 29, 2012Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Christopher J. Ward, Marina Ramirez-Alvarado, Marie C. Hogan
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Patent number: 8143297Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.Type: GrantFiled: October 28, 2010Date of Patent: March 27, 2012Assignee: Vertex Pharmaceuticals IncorporatedInventors: Nicole Hilgraf, Peter Diederik Jan Grootenhuis, Mehdi Numa, Dean Stamos, Corey Anderson, Tara Whitney
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Patent number: 8143039Abstract: The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga cells, particularly in the chloroplast. Single enzymes or multiple enzymes may be produced by the methods disclosed. The methods disclosed herein allow for the production of biofuel, including ethanol.Type: GrantFiled: May 30, 2008Date of Patent: March 27, 2012Assignees: Sapphire Energy, Inc., The Scripps Research InstituteInventors: Stephen Mayfield, Bryan O'Neill, Michael Mendez, Yan Poon
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Publication number: 20120070848Abstract: The present invention relates to a method for diagnosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a sample of a subject by detecting oncogenic proteins in microvesicles, and to the use of an agent blocking exchange of microvesicles for treating cancer.Type: ApplicationFiled: August 8, 2008Publication date: March 22, 2012Applicants: The Royal Institution for the Advancement of Learning/McGill University, University of TorontoInventors: Janusz Rak, Khalid Al-Nedawi, Brian Meehan, Abhijit Guha
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Publication number: 20120052547Abstract: The embodiments described herein pertain to cells, and methods for preparing cells, that can be used as biocatalysts by altering enzymes that compete for a substrate or product of a pathway of interest such that the targeted enzyme is sensitive to a site-specific protease, which protease is expressed but relocated in the cell to a site where it is not in contact with the targeted enzyme in the intact cell. Upon cell lysis, the protease contacts the target enzyme, which is then inactivated by protease cleavage.Type: ApplicationFiled: August 31, 2011Publication date: March 1, 2012Inventor: James R. Swartz