Miscellaneous (e.g., Subcellular Parts Of Micro-organisms, Etc.) Patents (Class 435/317.1)
  • OUTER MEMBRANE VESICLES AND USES THEREOF
    Publication number: 20120039942
    Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
    Type: Application
    Filed: August 17, 2011
    Publication date: February 16, 2012
    Applicants: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: Martine Petronella Bos, Jan Poolman, Boris Tefson, Johannes Petrus Maria Tommassen
  • METHODS FOR ALTERING THE REACTIVITY OF PLANT CELL WALLS
    Publication number: 20120030844
    Abstract: Methods and means are provided for the modification of the reactivity of plant cell walls, particularly as they can be found in natural fibers of fiber producing plants by inclusion of positively charged oligosaccharides or polysaccharides into the cell wall. This can be conveniently achieved by expressing a chimeric gene encoding an N-acetylglucosamine transferase, particularly an N-acetylglucosamine transferase, capable of being targeted to the membranes of the Golgi apparatus in cells of a plant.
    Type: Application
    Filed: July 20, 2011
    Publication date: February 2, 2012
    Applicant: Bayer BioScience N.V.
    Inventors: Marc DE BLOCK, Frank Meulewaeter, Rainhard Koch, Bernd Essigmann
  • COMPOSITIONS FOR SOLUBILIZING TISSUE
    Publication number: 20120004592
    Abstract: Tissue solubilizing compositions are provided. The compositions comprise 3-(decyl dimethyl ammonio) propane sulfonate and polyethylene glycol dodecyl ether, such as tetraethylene glycol dodecyl ether. The compositions may be useful to solubilize tissue, including skin, mucosal membrane, and other tissue. The compositions may be further useful to preserve and recover analytes contained within the solubilized skin, mucosal membrane, and other tissue.
    Type: Application
    Filed: April 27, 2011
    Publication date: January 5, 2012
    Applicant: The Regents of the University of California
    Inventors: Samir Mitragotri, Sumit Pallwal, Makoto Ogura, Russell M. Lebovitz
  • Process for the Selective Production of Hydrocarbon Based Fuels from Algae Utilizing Water at Subcritical Conditions
    Publication number: 20110314881
    Abstract: Disclosed herein is the production of hydrocarbon based fuel from micro-organisms and algae that comprise algaenan without requiring prior removal of water, as well as the production of hydrocarbon based fuel directly from the algaenan itself. Also disclosed herein are feed material for the processes disclosed herein comprising modified algae and algaenan that selectively produce hydrocarbon of desired chain lengths, along with the process of modifying the algae and algaenan. Also disclosed herein is the production of both hydrocarbon and organic fertilizer from algae without the need to remove the water from the algae prior to processing.
    Type: Application
    Filed: April 28, 2011
    Publication date: December 29, 2011
    Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
    Inventors: Patrick G. Hatcher, Elodie Salmon
  • PLANT PLASTID TRANSFORMATION METHOD
    Publication number: 20110321187
    Abstract: Method for heterologous protein production in plant cell plastids comprising introducing into plant cells nucleic acid components that encode heterologous proteins under the control of promoters operative in plastids, vectors, host cells, plants and uses thereof.
    Type: Application
    Filed: November 25, 2009
    Publication date: December 29, 2011
    Applicant: Algentech SAS
    Inventors: Isabelle Malcuit, Alexander Sorokin
  • Adsorption agent for noble metal, method for manufacturing the same, and method for recovering noble metal
    Publication number: 20110308355
    Abstract: A noble metal adsorption agent includes algae or residue of algae having an amino group as a functional group. A noble metal is retrieved by a method including: adsorbing the noble metal on the noble metal adsorption agent; and retrieving the noble metal. The noble metal is solved in a liquid. Thus, by using the noble metal adsorption agent, the noble metal is selectively retrieved.
    Type: Application
    Filed: June 20, 2011
    Publication date: December 22, 2011
    Applicants: Saga University, DENSO CORPORATION
    Inventors: Hisaya Kato, Toshiyuki Morishita, Kinya Atsumi, Minoru Kurata, Katsutoshi Inoue, Hidetaka Kawakita, Keisuke Ohto
  • Plasma Membrane Isolation
    Publication number: 20110312056
    Abstract: The present invention relates to a population of monodisperse magnetic nanoparticles with a diameter between 1 and 100 nm which are coated with a layer with hydrophilic end groups. Herein the layer with hydrophilic end groups comprises an inner layer of monosaturated and/or monounsaturated fatty acids bound to said nanoparticles and bound to said fatty acids, an outer layer of a phospholipid conjugated to a monomethoxy polyethyleneglycol (PEG) comprising a hydrophilic end group, or comprises a covalently bound hydrophilic layer bound to said nanoparticles.
    Type: Application
    Filed: May 19, 2011
    Publication date: December 22, 2011
    Applicants: KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D, IMEC
    Inventors: Deepak Balaji Thimiri Govinda Raj, Liesbet Lagae, Wim Annaert, Gustaaf Borghs
  • Tagged Ligands for Enrichment of Rare Analytes from a Mixed Sample
    Publication number: 20110300603
    Abstract: Method of enriching specific cells from cellular samples are disclosed, comprising contacting in solution a cellular sample with affinity-tagged ligands (ATLs) each comprising a first ligand linked to an affinity tag, wherein the ligand selectively binds a cellular marker of the rare cells and the affinity tag can be selectively captured by a capture moiety, wherein the affinity tags do not comprise a magnetic particle; and flowing the sample through a microfluidic device comprising the capture moiety to selectively retain ATL-bound cells. Methods for enriching circulating tumor cells, and devices for enriching specific cells from cellular samples are also disclosed.
    Type: Application
    Filed: July 13, 2011
    Publication date: December 8, 2011
    Applicant: On-Q-Ity
    Inventors: Allyn Forsyth, Helen Barnes
  • PLANT MITOCHONDRIA TRANSFORMATION METHOD
    Publication number: 20110296551
    Abstract: Method for heterologous RNA species and protein production in plant cell mitochondria comprising introducing into plant cells nucleic acid components that encode heterologous proteins/RNAS under the control of promoters operative in mitochondria, vectors, host cells, plants and uses thereof.
    Type: Application
    Filed: November 25, 2009
    Publication date: December 1, 2011
    Applicant: ALGENTECH SAS
    Inventors: Isabelle Malcuit, Alexander Sorokin
  • METHODS FOR ISOLATING BACTERIA
    Publication number: 20110294979
    Abstract: The present invention relates to compositions and methods to identify novel bacteria and metabolites derived therefrom. More specifically, the invention describes a novel method to isolate bacteria producing metabolites of interest from environmental samples. Particularly, the invention discloses a method to select rare antibiotic producing bacteria. The invention can be used from any sample and allows the isolation of bacteria having e.g., pharmaceutical or agrochemical interest.
    Type: Application
    Filed: January 18, 2010
    Publication date: December 1, 2011
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, DEINOVE
    Inventors: Jean-Paul Leonetti, Stephanie Texier
  • CELL WASHING
    Publication number: 20110294203
    Abstract: A cell cluster from which unwanted components are removed by efficiently washing the cell cluster is collected. Provided is a cell washing method including a centrifuging step (S1) of collecting a cell suspension in a centrifuge container having a washing fluid discharge port opposing a bottom part and centrifugally separating cells at the bottom part by rotating in such a manner that the bottom part faces outward in the radial direction; a supernatant ejecting step (S2) of ejecting a supernatant centrifugally separated in the centrifuging step (S1); and a washing step (S3) of discharging the washing fluid from the discharge port while rotating the centrifuge container while ejecting the supernatant in the supernatant ejecting step (S2).
    Type: Application
    Filed: June 17, 2011
    Publication date: December 1, 2011
    Applicants: CYTORI THERAPEUTICS, INC., OLYMPUS CORPORATION
    Inventors: Hiroki TSUCHIDA, Chisato KARASAWA, Kazuhiro YOSHIDA, Robert K. SHANAHAN, Lucas V. FORNACE
  • Method of reducing the activation of Th2 lymphocytes
    Patent number: 8057795
    Abstract: We previously reported that NKG2A, a key inhibitory ligand for HLA-E, is expressed on activated TH2, but not TH1, cells. Here we measured cytokine expression in ex vivo TH2 cells and in a mouse model of asthma upon activation with antiCD3/28 and challenge with an NKG2A-specific agonist. We show that signaling through NKG2A modulates Th2 cell effector function. This new molecular pathway data provides a novel explanation and treatment for respiratory virus-associated asthma. RSV and hMPV suppress IFN-? and HLA-E expression and therefore decrease NKG2A signaling in activated TH2 cells. This results in a relatively robust Th2 response and an unfavorable shift in Th1/Th2 balance. The data presented here suggest that increasing signaling via the NKG2A receptor suppresses Th2 effector function and could positively impact Th1/Th2 balance in asthma.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: November 15, 2011
    Assignee: Children's Research Institute
    Inventor: Robert J. Freishtat
  • CHIMERIC POLYNUCLEOTIDES AND POLYPEPTIDES ENABLING SECRETION OF A POLYPEPTIDE OF INTEREST IN ASSOCIATION WITH EXOSOMES AND USE THEREOF FOR THE PRODUCTION OF IMMUNOGENIC COMPOSITIONS
    Publication number: 20110268750
    Abstract: The present invention concerns a chimeric polypeptide comprising several polypeptide domains, which is capable of being secreted in association with membrane vesicles and in particular exosomes. The present invention also concerns a polypeptide constituted by one of said domains for the secretion of a peptide or polypeptide of interest in association with membrane vesicles and in particular exosomes. The invention also concerns the use of polypeptides of the invention and of polynucleotides coding for said polypeptides for the production of immunogenic compositions based on exosomes or based on DNA or for screening protein interactions.
    Type: Application
    Filed: March 18, 2009
    Publication date: November 3, 2011
    Applicants: Universite Montpellier 2 Sciences et Techniques, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Robert Zaine EI Abiddine Mamoun, Bernadette Nadine Trentin, Michel Vidal
  • RAB6KIFL/KIF20A EPITOPE PEPTIDE AND VACCINES CONTAINING THE SAME
    Publication number: 20110262471
    Abstract: The present invention provides oligopeptides comprising the amino acid sequence selected from the group consisting of SEQ ID NOs: 3, 4 and 5. The present invention also provides a pharmaceutical composition containing the amino acid sequence of selected from the group consisting of SEQ ID NOs: 3, 4 and 5 formulated for the treatment or prevention of cancer in a subject. Furthermore, the present invention provides a method of inducing immune response using such oligopeptides and pharmaceutical agents.
    Type: Application
    Filed: October 15, 2009
    Publication date: October 27, 2011
    Applicant: ONCOTHERAPY SCIENCE, INC.
    Inventors: Yasuharu Nishimura, Katsunori Imai, Yusuke Nakamura, Takuya Tsunoda
  • INCUBATOR DEVICE AND METHOD
    Publication number: 20110263010
    Abstract: The invention provides an incubation device, comprising an incubator chamber (12), a specimen carrier (15), which is designed to accommodate a specimen (14) and position it in the interior of the incubator chamber (12) at a specimen position (P), a heating arrangement (38, 40) with at least one heating element (38, 40), which is arranged inside the incubator chamber (12) and releases heat to the interior of the incubator chamber (12), a humidifier (16) for producing a humidifying fluid, and a passage opening (30) arranged between the humidifier (16) and the interior of the incubator chamber (12), through which the humidifying fluid may pass into the interior of the incubator chamber (12), wherein the interior of the incubator chamber (12) is substantially free of directed fluid flow at least at the specimen position (P).
    Type: Application
    Filed: October 29, 2009
    Publication date: October 27, 2011
    Inventor: Jürgen Tümpner
  • Transgenic plants with enhanced agronomic traits
    Publication number: 20110265221
    Abstract: This invention provides recombinant DNA constructs, transgenic plant nuclei and cells with such recombinant DNA construct for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: July 10, 2008
    Publication date: October 27, 2011
    Applicant: Monsanto Technology LLC
    Inventors: Mark Abad, Jeffrey E. Ahrens, Alice Clara Augustine, Erin Bell, Robert J. Bensen, Paolo Castiglioni, R. Eric Cerny, Shobha Char, Xianfeng Chen, Jaishree M. Chittoor-Vijayanath, Maureen Daley, Jill Deikman, Molian Deng, Todd Dezwaan, Stephen Duff, Michael D. Edgerton, Bradon J. Fabbri, Jason Fenner, Karen K. Gabbert, Meghan Galligan Donnarummo, Barry S. Goldman, Deborah J. Hawkins, Steve He, G. Richard Johnson, Balasulojini Karunanandaa, Garrett J. Lee, Paul Loida, Savitha Madappa, Robert J. Meister, Donald E. Nelson, Anand Pandravada, Obed Patty, Ming Peng, Marie Petracek, M.S. Rajani, Dhanalakshmi Ramachandra, Monica Ravanello, Thomas G. Ruff, Rick A. Sanders, Beth Savidge, Steven H. Schwartz, Padmini Sudarshana, Jindong Sun, Rebecca L. Thompson-Mize, Virginia Ursin, Dale L. Val, Srikanth Venkatachalayya, T.V. Venkatesh, K.R. Vidya, K. Vijayalakshmi, Todd C. Weber, Jingrui Wu, Zhidong Xie, Wei Zheng
  • GENE SEQUENCES AND USES THEREOF IN PLANTS
    Publication number: 20110258734
    Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: March 11, 2011
    Publication date: October 20, 2011
    Applicant: Monsanto Technology LLC
    Inventors: Thomas Adams, Ameeta K. Agarwa, Jeffrey Ahrens, James A. Ball, Amarjit Basra, Erin Bell, Terry L. Bradshaw, Paul S. Chomet, James H. Crowley, Jill Deikman, Molian Deng, Meghan Donnarummo, Kimberly Faye Zobrist Duff, Stephen Duff, Michael D. Edgerton, Banu Gopalan, Xiaoping He, Mackenzie Heal, Brendan S. Hinchey, Shihshieh Huang, Richard G. Johnson, Vincent Jung, Keith Kretzmer, Lucille B. Laccetti, Chao Qiang Lai, Garrett J. Lee, Michael H. Luethy, Timothy J. Leland, Jingdong Liu, Bin Lu, Adrian A. Lund, Linda L. Madson, Kathleen P. Malloy, Marcus Paul McNabnay, Manchikanti Padmavati, Thomas Ruff, William Start, Daniel Tennessen, Carl P. Urwin, Gabriela Vaduva, K.R. Vidya, Steven Thomas Voss, Christine Voyles, Zhango Xin, Nanfei Xu, Qingzhang Xu, Qiang Zhang, Yajuan Zhao, Li Zhou
  • GENES AND USES FOR PLANT ENHANCEMENT
    Publication number: 20110258735
    Abstract: The present invention discloses transgenic seeds for crops with enhanced agronomic traits are provided by trait-improving recombinant DNA in the nucleus of cells of the seed where plants grown from such transgenic seed exhibit one or more enhanced traits as compared to a control plant. Of particular interest are transgenic plants that have increased yield. The present invention also provides recombinant DNA molecules for expression of a protein, and recombinant DNA molecules for suppression of a protein.
    Type: Application
    Filed: December 17, 2009
    Publication date: October 20, 2011
    Inventor: Marie Coffin
  • EPITOPE PEPTIDES DERIVED FROM VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 AND VACCINES CONTAINING THESE PEPTIDES
    Publication number: 20110250219
    Abstract: The present invention provides immunogenic peptides comprising the amino acid sequence of SEQ ID NO: 1, 2, 13, 32, and peptides comprising the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted or added, and having cytotoxic T cell inducibility, and also provides drugs for treating or preventing tumors comprising these peptides. The peptides of this invention can be used as vaccines.
    Type: Application
    Filed: March 3, 2011
    Publication date: October 13, 2011
    Applicant: Oncotherapy Science, Inc.
    Inventors: Hideaki Tahara, Takuya Tsunoda, Masabumi Shibuya, Shuichi Nakatsuru
  • PROTEIN AND NUCLEIC ACID DELIVERY VEHICLES, COMPONENTS AND MECHANISMS THEREOF
    Publication number: 20110250263
    Abstract: Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles.
    Type: Application
    Filed: April 8, 2011
    Publication date: October 13, 2011
    Applicant: The Catholic University of America
    Inventor: Venigalla B. RAO
  • VIABLE GRAM NEGATIVE BACTERIA LACKING OUTER MEMBRANE AGONISTS OF TLR4/MD-2
    Publication number: 20110224097
    Abstract: Viable Gram-negative bacteria or components thereof comprising outer membranes that substantially lack a ligand, such as Lipid A or 6-acyl lipidpolysaccharide, that acts as an agonist of TLR4/MD2. The bacteria may comprise reduced activity of arabinose-5-phosphate isomerases and one or more suppressor mutations, for example in a transporter thereby increasing the transporters capacity to transport Lipid IVA or in membrane protein YhjD. One or more genes (e.g., IpxL, IpxM, pagP, IpxP, and/or eptA) may be substantially deleted and/or one or more enzymes (e.g., LpxL, LpxM, PagP, LpxP, and/or EptA) may be substantially inactive. The bacteria may be competent to take up extracellular DNA, may be donor bacteria, or may be members of a library. The present invention also features methods of creating and utilizing such bacteria.
    Type: Application
    Filed: March 11, 2011
    Publication date: September 15, 2011
    Applicant: RESEARCH CORPORATION TECHNOLOGIES
    Inventors: David Bramhill, Uwe Mamat
  • MELK EPITOPE PEPTIDES AND VACCINES CONTAINING THE SAME
    Publication number: 20110212115
    Abstract: According to the present invention, peptides having the amino acid sequence of SEQ ID NOs: 14, 21, 23, 27, 36, 46, 57, 60 and 62 were demonstrated to have cytotoxic T lymphocyte (CTL) inducibility. Therefore, the present invention provides a peptide having the amino acid sequence selected from among SEQ ID NOs: 14, 21, 23, 27, 36, 46, 57, 60 and 62. The peptide can include one, two, or several amino acid substitutions, deletions, insertions, or additions so long as its CTL inducibility is retained. Furthermore, the present invention provides pharmaceutical agents for the treatment and/or prophylaxis of cancers, and/or prevention of postoperative recurrence thereof, which contain any of these peptides. Pharmaceutical agents of this invention include vaccines.
    Type: Application
    Filed: July 30, 2009
    Publication date: September 1, 2011
    Applicant: ONCOTHERAPY SCIENCE, INC.
    Inventors: Takuya Tsunoda, Ryuji Ohsawa
  • T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS
    Publication number: 20110201028
    Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.
    Type: Application
    Filed: February 8, 2011
    Publication date: August 18, 2011
    Applicant: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Sialoadhesin-related compositions and methods
    Patent number: 7998485
    Abstract: Methods of delivering a cargo moiety to a cell is provided according to embodiments of the present invention which includes contacting a cell expressing sialoadhesin with a conjugate including a sialoadhesin binding moiety and a cargo moiety. The sialoadhesin binding moiety binds to the sialoadhesin expressed by the cell and is internalized along with the cargo, delivering the cargo moiety to the cell. Particular methods provided by the present invention include induction or enhancement of sialoadhesin expression in a cell which naturally produces little or no sialoadhesin. Induction or enhancement of sialoadhesin expression includes transfection of a sialoadhesin expression construct and/or administration of an agent effective to induce or enhance sialoadhesin expression. Methods and compositions for stimulating an immune response in a subject are detailed. Particular methods and compositions for stimulating an immune response to a virus are provided by the present invention.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: August 16, 2011
    Assignee: Universiteit Gent
    Inventors: Hans Nauwynck, Peter Delputte
  • USE OF BACTERIA OF THE GENUS TENACIBACULUM FOR QUORUM QUENCHING
    Publication number: 20110195051
    Abstract: Use of bacterial cells of the genus Tenacibaculum, from the crude cellular extract or from its cultivation supernatants, capable of degrading N-acyl homoserine lactones, for quorum quenching, for treatment of infectious bacterial illnesses or to inhibit formation of biofilms.
    Type: Application
    Filed: July 23, 2009
    Publication date: August 11, 2011
    Applicant: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Ana Maria Otero Casal, Manuel Romero Bernárdez, Arturo Roca Rivada
  • Plants with Increased Yield (LT)
    Publication number: 20110195843
    Abstract: A method for producing a plant with increased yield as compared to a corresponding wild type plant comprising at least the following step: increasing or generating in a plant or a part thereof one or more activities selected from the group consisting of 3-phosphoglycerate dehydrogenase, Adenylate kinase, B2758-protein, Cyclic nucleotide phosphodiesterase, cysteine synthase, Exopolyphosphatase, geranylgeranyl reductase, Mating hormone A-factor precursor, mitochondrial succinate-fumarate transporter, modification methylase HemK family protein, Myo-inositol transporter, oxidoreductase subunit, peptidy-prolyl-cis-trans-isomerase, protein kinase, Ribose-5-phosphate isomerase, slr1293-protein, YDR049W-protein, YJL181W-protein, and YPL109C-protein-activity.
    Type: Application
    Filed: September 18, 2009
    Publication date: August 11, 2011
    Applicant: BASF Plant Science GmbH
    Inventors: Oliver Thimm, Gerhard Ritte, Hardy Schön, Oliver Bläsing
  • CELL BROTH CLARIFICATION AND HOST CELL PROTEIN REMOVAL
    Publication number: 20110184154
    Abstract: The present invention relates to a method for clarification of, and removal of host cell proteins from, a cell broth consisting essentially of viable cells, a culture medium and a secreted desired biological substance having an overall positive charge in the cell broth by contacting the cell broth with a particulate anion exchanger, allowing an adequate incubation time to result in formation of a cell pellet and a supernatant layer, separating the resulting cell pellet from the supernatant layer. The present invention further relates to a method for the recovery of a secreted desired biological substance from the cell broth by extracting the secreted desired biological substance from the supernatant layer.
    Type: Application
    Filed: April 9, 2011
    Publication date: July 28, 2011
    Applicant: PERCIVIA LLC
    Inventors: Grigorios Zarbis-Papastoitsis, Michael Christopher Kuczewski, Emily Belcher Schirmer
  • Pharmaceutical Proteins, Human Therapeutics, Human Serum Albumin Insulin, Native Cholera Toxin B Subunit on Transgenic Plastids
    Publication number: 20110179530
    Abstract: This invention relates in part to synthesizing high value pharmaceutical proteins in transgenic plants by chloroplast expression for pharmaceutical protein production. We use poly(GVGVP), for example, as a fusion protein to enable hyper-expression of insulin and to accomplish rapid one step purification of fusion peptides utilizing the inverse temperature transition properties of this polymer. We also use insulin-CTB fusion protein in chloroplasts of nicotine free edible tobacco (LAMD 605) for oral delivery. This invention includes expression of native cholera toxin B subunit gene as oligomers in transgenic tobacco chloroplasts which may be utilized in connection with large-scale production of purified CTB, as well as an edible vaccine if expressed in an edible plant, as a transmucosal carrier of peptides to which it is fused to enhance mucosal immunity, and/or to induce oral tolerance of the products of these peptides.
    Type: Application
    Filed: January 11, 2008
    Publication date: July 21, 2011
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventor: Henry Daniell
  • BIO-ENGINEERED PHOTOSYSTEMS
    Publication number: 20110154541
    Abstract: The present invention relates to bio-engineered photosystems, specifically photosystem II (PSII) having an alternative electron transfer pathway that enables electron flow from PSII to a water-soluble protein electron carrier. The present invention further relates to methods and systems for electron transfer using the bio-engineered photosystems. Such photosystems may be utilized for electrical energy production, hydrogen production and/or reduction of carbon-based gases (for example, CO2 and CO) to liquid fuels.
    Type: Application
    Filed: November 24, 2010
    Publication date: June 23, 2011
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Noam ADIR, Gadi SCHUSTER, Shirley LAROM, Faris SALAMA
  • Novel Strain of Lactobacillus Paracasei Subspecies Paracasei Having Antimicrobial and Immunomodulatory Properties
    Publication number: 20110150852
    Abstract: The invention relates to a novel strain of Lactobacillus paracasei subspecies paracasei, having antimicrobial and immunomodulatory properties, and to compositions containing said strain.
    Type: Application
    Filed: April 16, 2009
    Publication date: June 23, 2011
    Inventors: Isabelle Chambaud, Artem Khlebnikov, Anne-Catherine Villain, Gianfranco Grompone, Thierry Saint Denis, Anne Druesne, Tamara Smokvina
  • Method for Isolating Nuclei
    Publication number: 20110136220
    Abstract: This invention relates to methods of isolating cell nuclei from the other cell components in cell samples, e.g., cell samples from cell cultures or tissue samples. The method does not comprise ultracentrifugation or super-centrifugation rather the method comprises centrifuging cell samples in a table-top conventional centrifuge or microfuge. The method also comprises the use of buffers that are substantially devoid of protease inhibitor or enzyme treatments. The methods facilitate separation of nuclei from nuclear outer membranes leaving the cellular structures and inner membranes of nuclei intact. The method also provides for rapid and consistent results.
    Type: Application
    Filed: December 6, 2010
    Publication date: June 9, 2011
    Inventor: Takako Nagata
  • METHODS AND COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS
    Publication number: 20110105383
    Abstract: Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a StIR polypeptide or peptide or fragment or derivative or analog thereof to the individual.
    Type: Application
    Filed: September 10, 2009
    Publication date: May 5, 2011
    Inventors: Magnus Hook, Dekai Zhang, Christi Gendron, Burton Dickey, Michael Tuvim, Scott Evans
  • HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS
    Publication number: 20110098328
    Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: October 28, 2010
    Publication date: April 28, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Nicole Hilgraf, Peter Diederik Jan Grootenhuis, Mehdi Numa, Dean Stamos, Corey Anderson, Tara Whitney
  • USE OF BIOLOGICAL PHOTORECEPTORS AS DIRECTLY LIGHT-ACTIVATED ION CHANNELS
    Publication number: 20110086421
    Abstract: Use of a biological photoreceptor as light-controlled ion channel for the alteration of the ion conductivity of a membrane by means of light. The photoreceptor used comprises an apoprotein and a light-sensitive polyene covalently bound to the apoprotein, said polyene interacting with the apoprotein and functioning as a light-sensitive gate.
    Type: Application
    Filed: May 18, 2010
    Publication date: April 14, 2011
    Applicant: MAX-PLANCK-GESEL.ZUR FOERDERUNG DER WISSEN. E.V.
    Inventors: Peter Hegemann, Georg Nagel, Ernst Bamberg
  • Hybrid Polypeptides Including Meningococcal fHBP Sequences
    Publication number: 20110076300
    Abstract: fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.
    Type: Application
    Filed: August 27, 2010
    Publication date: March 31, 2011
    Inventors: Mariagrazia Pizza, Maria Scarselli, Marzia Monica Giuliani, Maria Arico, Rino Rappuoli
  • VACCINE COMPOSITIONS COMPRISING L2 AND/OR L3 IMMUNOTYPE LIPOOLIGOSACCHARIDES FROM LGTB-NEISSERIA MENINGITIDIS
    Publication number: 20110033500
    Abstract: The present invention relates to the field of neisserial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to processes of making novel engineered meningococcal strains which are more suitable for the production of neisserial, in particular meningococcal, outer-membrane vesicle (or bleb) vaccines. Advantageous processes and vaccine products are also described based on the use of novel LOS subunit or meningococcal outer-membrane vesicle (or bleb) vaccines which have been rendered safer and/or more effective for use in human subjects. In particular combinations of gene downregulations are described such as PorA and OpA, PorA and OpC, OpA and OpC, and PorA and OpA and OpC. Alternatively, or in addition, lgtB? is shown to be an optimal mutation for effectively and safely using L3 and/or L2 LOS in Neisseria vaccine compositions.
    Type: Application
    Filed: October 21, 2010
    Publication date: February 10, 2011
    Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: Ralph Biemans, Philippe Denoel, Christiane Feron, Carine Goraj, Jan Poolman, Vincent Weynants
  • METHOD FOR MODIFYING LIGNIN STRUCTURE USING MONOLIGNOL FERULATE CONJUGATES
    Publication number: 20110003978
    Abstract: Described is an isolated lignified plant cell wall including lignin, wherein the lignin includes a ferulate residue incorporated therein, such as from coniferyl ferulate and/or sinapyl ferulate. Also described is a method to make the isolated lignified plant cell wall, and the lignin produced by the method.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 6, 2011
    Inventors: John Ralph, John H. Grabber, Ronald D. Hatfield, Fachuang Lu
  • MESENCHYMAL STEM CELL PARTICLES
    Publication number: 20110003008
    Abstract: We describe a particle secreted by a mesenchymal stem cell and comprising at least one biological property of a mesenchymal stem cell. The biological property may comprise a biological activity of a mesenchymal stem cell conditioned medium (MSC-CM) such as cardioprotection or reduction of infarct size. The particle may comprise a vesicle or an exosome.
    Type: Application
    Filed: February 21, 2009
    Publication date: January 6, 2011
    Applicant: Agency For Science, Technology And Research (A*STAR)
    Inventor: Sai Kiang Lim
  • SILICEOUS PARTICLES
    Publication number: 20100330658
    Abstract: Various aspects provide for extracting siliceous particles. Siliceous particles may include or be derived from diatoms. Certain embodiments provide for segregating suspensions into two or more segregation products. In some cases, a first product includes siliceous particles, and a second product may include hydrophobic species. Certain aspects provide for extracting non-siliceous biomass (e.g., lipids).
    Type: Application
    Filed: June 29, 2009
    Publication date: December 30, 2010
    Inventors: Daniel Fleischer, Andrew Thompson, Marko Jukic, Guido Radaelli
  • Non-Endogenous, Constitutively Activated Versions of Human G Protein Coupled Receptor: FSHR
    Publication number: 20100317046
    Abstract: The invention disclosed in this patent document relates to transmembrane receptors, particularly to a human G protein-coupled receptor, more particularly to a follicle stimulating hormone receptor (FSHR), and most particularly to mutated (non-endogenous) versions of the human FSHR for evidence of constitutive activity.
    Type: Application
    Filed: December 3, 2009
    Publication date: December 16, 2010
    Inventor: CHEN W. LIAW
  • Expression of Human Serum Albumin in Plastids
    Publication number: 20100304476
    Abstract: Human Serum Albumin (HSA) or an HSA fusion protein is expressed in plant plastids. A plastid transformation vector is made which contains an expression cassette that contains regulatory sequences, the coding region for HSA or an HSA fusion protein and a selectable marker coding sequence. The vector is used to transform a plant where the plant expresses the HSA or HSA fusion protein. HSA is isolated and purified from the plant. A preferred plant is tobacco.
    Type: Application
    Filed: May 18, 2010
    Publication date: December 2, 2010
    Inventor: Henry Daniell
  • Magnetosome Gene Expression in Eukaryotic Cells
    Publication number: 20100297022
    Abstract: The invention is the production of magnetosome-like structures in cells. The invention provides in vitro and in vivo diagnostic and therapeutic methods using eukaryotic cells expressing magnetosome-like structures that act as contrast agents.
    Type: Application
    Filed: June 8, 2007
    Publication date: November 25, 2010
    Applicant: MULTI-MAGNETICS INCORPORATED
    Inventors: Frank S. Prato, Donna E. Goldhawk, Cheryl R. McCreary, Rebecca McGirr, Savita Dhanvantari, Terry R. Thompson, Alex W. Thomas, David Hill
  • Novel Transporter Protein in Mammal and Utilization of the Same
    Publication number: 20100279331
    Abstract: The present invention provides a lipid membrane that contains a polypeptide consisting of the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, or 22. Use of the present invention enables screening for a chemical which regulates excretion of a chemical and/or a waste. Furthermore, use of the present invention enables an arbitrary chemical to be tested for nephrotoxicity and/or hepatotoxicity.
    Type: Application
    Filed: June 17, 2010
    Publication date: November 4, 2010
    Applicant: Genomembrane, Inc.
    Inventors: Yoshinori Moriyama, Hiroshi Omote, Masato Otsuka, Takuya Matsumoto, Miki Hiasa
  • MicroRNA Expression in Human Peripheral Blood Microvesicles and Uses Thereof
    Publication number: 20100279292
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of disorders by examining samples containing microvesicles and miRs therein.
    Type: Application
    Filed: September 12, 2008
    Publication date: November 4, 2010
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Clay B. Marsh, Melissa G. Piper, Noura Ismail
  • Viable non-toxic gram-negative bacteria
    Publication number: 20100272758
    Abstract: The present invention provides non-toxic Gram-negative bacteria. In particular, the present invention provides viable Gram-negative bacteria (e.g., E. coli) substantially lacking lipopolysaccharide (LPS, endotoxin) within the outer membrane. The present invention further provides methods of generating viable non-toxic Gram-negative bacteria and uses thereof. The present invention also provides compositions and methods for inducing immune responses and for researching and developing therapeutic agents.
    Type: Application
    Filed: January 19, 2007
    Publication date: October 28, 2010
    Applicant: Regents of the University of Michigan
    Inventors: Ronald Wesley Woodard, Timothy Charles Meredith, Parag Aggarwal
  • Kits for flurotometric analyses
    Patent number: 7820783
    Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Grant
    Filed: October 6, 2008
    Date of Patent: October 26, 2010
    Assignee: AnaSpec Incorporated
    Inventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
  • Bionanomaterials and their synthesis
    Patent number: 7820426
    Abstract: The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like layer are generally disclosed. Porous gels having controllable pore size through the use of virus particles are also disclosed.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: October 26, 2010
    Assignee: University of South Carolina
    Inventors: Qian Wang, Zhongwei Niu
  • MEMBRANE VESICLE FISSION SYSTEM
    Publication number: 20100248354
    Abstract: A membrane vesicle fission system is disclosed. The membrane vesicle fission system includes: a membrane vesicle having a lipid bi-layer membrane including a cationic lipid; and a unit which applies, to the membrane vesicle, an anionic material having a hydrophobic group.
    Type: Application
    Filed: March 9, 2010
    Publication date: September 30, 2010
    Applicants: NTT DoCoMo, Inc, NAT'L UNIV. CORP.NARA INST. OF SCIENCE AND TECH.
    Inventors: Yuki MORITANI, Satoshi Hiyama, Junichi Kikuchi, Kazuma Yasuhara
  • USE OF MICROVESICLES (MVS) FOR PREPARING A MEDICAMENT HAVING ADJUVANT ACTIVITY ON ENDOTHELIAL CELL TRANSPLANTATION, PARTICULARLY IN THE TREATMENT OF DIABETES BY PANCREATIC ISLET TRANSPLANTATION, AND RELATED METHOD
    Publication number: 20100233216
    Abstract: The invention relates to the use of microvesicles derived from cells of the endothelial cell lineage, preferably from endothelial progenitor cells, as an adjuvant agent in endothelial cell-pancreatic islet transplantation, particularly in the treatment of type I or type II diabetes by pancreatic islet transplantation. The adjuvant effect of the microvesicles consists in the improvement of survival and functionality of the transplanted islets. The adjuvant effect of the microvesicles is maintained even when the recipient is subjected to rapamycin-based immunosuppression.
    Type: Application
    Filed: October 15, 2007
    Publication date: September 16, 2010
    Inventors: Vincenzo Cantaluppi, Maria Chiara Armilde Deregibus, Giovanni Camussi
  • NOVEL PEPTIDES AND METHODS FOR PRODUCING THEM
    Publication number: 20100196524
    Abstract: The present invention relates to the fields of life sciences and food, feed or pharmaceutical industry. Specifically, the invention relates to novel peptides, pilus structures, polynucleotides as well as vectors, host cells, products and pharmaceutical compositions comprising the polynucleotides, peptides or pilus structures. The invention also relates to gene clusters and antibodies. Furthermore, the present invention relates to methods for producing the peptides or pilus structures or producing the products comprising the peptides or pilus structures. Furthermore, the present invention relates to treatments as well as uses and methods for screening bacterial strains, for reducing or inhibiting the adhesion of pathogenic bacteria, promoting the adhesion of bacterial cells to the mucus and for modifying immune response in a subject. Still, the present invention relates to methods for detecting probiotic bacterial strains or pathogen strains.
    Type: Application
    Filed: February 2, 2009
    Publication date: August 5, 2010
    Applicant: VALIO LTD.
    Inventors: Willem MEINDERT DE VOS, Airi Palva, Ilkka Palva, Justus Reunanen, Ingemar Von Ossowski, Reetta Satokari, Satu Vesterlund, Matti Kankainen, Tuomas Salusjarvi, Soile Tynkkynen