Optical Result Patents (Class 436/164)
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Patent number: 8748159Abstract: A rapid method for the quantitation of various live cell types is described. This new cell fluorescence method correlates with other methods of enumerating cells such as the standard plate count, the methylene blue method and the slide viability technique. The method is particularly useful in several applications such as: a) quantitating bacteria in milk, yogurt, cheese, meat and other foods, b) quantitating yeast cells in brewing, fermentation and bread making, c) quantitating mammalian cells in research, food and clinical settings. The method is especially useful when both total and viable cell counts are required such as in the brewing industry. The method can also be employed to determine the metabolic activity of cells in a sample. The apparatus, device, and/or system used for cell quantitation is also disclosed.Type: GrantFiled: October 28, 2011Date of Patent: June 10, 2014Assignee: GenPrime, Inc.Inventors: James E. Fleming, Jason Buck Somes, Darby McLean, Jerad R. Holcomb
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Patent number: 8747773Abstract: Embodiments of the invention relate to portable detection apparatus, comprising one or more detector regions adapted to visually indicate the presence or amount of an analyte in a beverage. The detection apparatus is shaped substantially the same as a consumer product.Type: GrantFiled: August 11, 2011Date of Patent: June 10, 2014Inventor: Maryse Thomas
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Patent number: 8747779Abstract: A microfluidic cartridge including on-board dry reagents and microfluidic circuitry for determining a clinical analyte or analytes from a few microliters of liquid sample; with docking interface for use in a host workstation, the workstation including a pneumatic fluid controller and spectrophotometer for monitoring analytical reactions in the cartridge.Type: GrantFiled: October 13, 2011Date of Patent: June 10, 2014Assignee: Micronics, Inc.Inventors: Isaac Sprague, John E. Emswiler, C. Frederick Battrell, Joan Haab, Sean M. Pennell, Justin L. Kay, Zane B. Miller, Troy D. Daiber
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Patent number: 8748183Abstract: A method of continuously verifying proper sort calibration in a droplet sorting flow cytometer by selecting a fraction of droplets estimated to have substantially zero probability of containing a particle; applying one charge of a set of charges to the selected droplets in order to form a test stream out of the selected droplets; illuminating the droplets in the test stream; and detecting any light emitted or scattered by any particles in the selected droplets.Type: GrantFiled: February 7, 2013Date of Patent: June 10, 2014Assignee: Inguran, LLCInventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
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Patent number: 8748192Abstract: The present invention relates to an optical fluorescence dual sensor comprising a probe for sensing pH, a probe for sensing oxygen, an intra-reference probe and a matrix. The present invention also relates to methods of preparing an optical fluorescence dual sensor and methods of using them.Type: GrantFiled: October 24, 2012Date of Patent: June 10, 2014Assignee: Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State UniversityInventors: Yanqing Tian, Weiwen Zhang, Deirdre Meldrum, Hongguang Lu, Yuguang Jin, Mark Holl
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Patent number: 8747747Abstract: A reader for mechanical actuation of fluids within a test cartridge. The instrument interface including multiple independently-controlled plungers aligned to respective fluidic pouches on a test cartridge that is inserted into a testing apparatus embodying the instrument interface. The plungers include tips for applying mechanical force to the respective fluidic pouches.Type: GrantFiled: December 20, 2011Date of Patent: June 10, 2014Assignee: Abbott Point of Care Inc.Inventor: Seth Hunter
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Publication number: 20140154808Abstract: Compositions, devices and processes related to etching of a very thin layer or fine particles of a metal are disclosed for monitoring a variety of parameters, such as time, temperature, time-temperature, thawing, freezing, microwave, humidity, ionizing radiation, sterilization and chemicals. These devices have capabilities of producing a long and sharp induction period of an irreversible visual change. The devices are composed of an indicator comprising a very thin layer of a metal and an activator, e.g., a reactant, such as water, water vapor, an acid, a base, oxidizing agent or their precursors, which is capable of reacting with the said indicator. Ink formulations composed of a metal powder and a proper activator can be used for monitoring several sterilization processes, such as sterilization with steam. When water is used as an activator, a thin layer of metals, such as that of aluminum can be used as steam sterilization or humidity indicator.Type: ApplicationFiled: December 3, 2012Publication date: June 5, 2014Inventor: Gordhanbhai N. Patel
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Patent number: 8741658Abstract: A method and devices analyze for the presence of cyanide in samples using colorimetric analysis of samples after contacting with cobinamide or monocyanocohinapmide.Type: GrantFiled: March 15, 2011Date of Patent: June 3, 2014Assignees: The Regents of the University of California, Board of Regents, The University of Texas SystemInventors: Gerry Boss, Vijay Sharma, Matthew Brenner, Purnendu K. Dasgupta, William Curt Blackledge
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Publication number: 20140147928Abstract: The invention is in the field of in vitro diagnostics and relates to a method for ascertaining a transmission value for a light signal that is pulsed at a frequency through a specimen in an automatic analysis appliance. It also relates to a transmission measurement apparatus for an automatic analysis appliance, comprising a light source that is pulsed at a frequency and a photodetector having a downstream A/D converter.Type: ApplicationFiled: November 25, 2013Publication date: May 29, 2014Applicant: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBHInventor: Wolfgang Steinebach
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Publication number: 20140147923Abstract: Methods and systems for testing fluid samples include a diffused air flotation (DAF) system and a jar. The jar includes a diffuser for injecting the diffused air into the jar and a tap for drawing a fluid out of the jar.Type: ApplicationFiled: November 19, 2013Publication date: May 29, 2014Applicant: BAKER HUGHES INCORPORATEDInventors: Stephen J. Wiacek, Bingbing Guo
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Patent number: 8734341Abstract: A hydration sensor or sensing element configured to measure the hydration level of a user is disclosed. The sensing element can include a water-permeable material positioned in between two water-impermeable material. The sensing element can be coupled to a bottle of fluid, or a carrier with a timer. The sensing element can be incorporated into a handheld device. The sensing element can be a disposable element, an element applicable for more than one-time use, or a re-usable element. The sensing element or sensor can be calibrated for a specific user or a group of users. One or more additional sensors that do not measure hydration level of the user can be coupled to a hydration sensing element to determine the amount of fluid consumption for the user in different conditions.Type: GrantFiled: November 2, 2006Date of Patent: May 27, 2014Assignee: IpVenture, Inc.Inventors: Thomas A. Howell, Angeline Hadiwidjaja, Peter P. Tong, C. Douglass Thomas
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Patent number: 8735161Abstract: The disclosure provides sensor for gas sensing including CO2 gas sensors comprising a porous framework sensing area for binding an analyte gas.Type: GrantFiled: July 8, 2013Date of Patent: May 27, 2014Assignees: The Regents of the University of California, BASF SEInventors: Omar M. Yaghi, Alexander U. Czaja, Bo Wang, Kosmas Galatsis, Kang L. Wang, Hiroyasu Furukawa
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Patent number: 8721990Abstract: Disclosed is an assay device for the determination of the presence and/or extent if an analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilizing a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilizing a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.Type: GrantFiled: April 9, 2008Date of Patent: May 13, 2014Assignee: Alere Switzerland GmbHInventors: Balbir Raj, Saji Eapen, Ezra Linley
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Patent number: 8722347Abstract: A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the cytosol of the cell, the cell further having a emitter molecule which, in response to the increased calcium concentration in the cytosol, emits a photon; (2) a liquid medium for receiving the antigen and in which the cell is immersed; and (3) an optical detector arranged for receiving the photon emitted from the cell.Type: GrantFiled: February 27, 2009Date of Patent: May 13, 2014Assignee: Massachusetts Institute of TechnologyInventors: Todd H. Rider, Laura Bortolin
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Patent number: 8722426Abstract: The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore.Type: GrantFiled: March 5, 2010Date of Patent: May 13, 2014Assignee: Quidel CorporationInventors: Paul Lambotte, Michael Cerrito, Cecille Ramirez
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Patent number: 8722417Abstract: An apparatus is provided for sensing an analyte in a fluid.Type: GrantFiled: January 20, 2007Date of Patent: May 13, 2014Assignee: Invoy Technologies, L.L.C.Inventor: Lubna Ahmad
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Patent number: 8721969Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.Type: GrantFiled: June 11, 2010Date of Patent: May 13, 2014Assignee: Industrial Technology Research InstituteInventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
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Patent number: 8722425Abstract: In a chromatography quantitative measuring apparatus according to the present invention, a beam applied from a light source to a chromatography test strip is formed into an elliptical shape by an optical means such as a cylindrical lens, a variation in absorbance that accompanies elution of a marker regent is detected while the elliptical beam is applied between a marker reagent hold part and a detection part, and a measurement is automatically started in a prescribed period of time since the detection of variation. According to the chromatography quantitative measuring apparatus so configured, non-uniform coloration is reduced by shaping the beam elliptically with the optical means, whereby the accuracy of quantitative analysis is enhanced, and the apparatus can be operated easily.Type: GrantFiled: December 18, 2009Date of Patent: May 13, 2014Assignee: Panasonic CorporationInventors: Koji Miyoshi, Masahiro Aga, Kaoru Shigematsu
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Patent number: 8715592Abstract: An integrated electronic-micro fluidic device an integrated electronic-micro fluidic device, comprising a semiconductor substrate on a first support, an electronic circuit on a first semiconductor-substrate side of the semiconductor substrate, and a signal interface structure to an external device. A micro fluidic structure is formed in the semiconductor substrate, and is configured to confine a fluid and to allow a flow of the fluid to and from the microfluidic structure only on a second semiconductor-substrate side that is opposite to the first semiconductor-substrate side and faces away from the first support.Type: GrantFiled: January 31, 2013Date of Patent: May 6, 2014Assignee: Koninklijke Philips N.V.Inventors: Ronald Dekker, Remco Henricus Wilhelmus Pijnenburg, Nicolaas Johannes Anthonius Van Veen
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Patent number: 8716028Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.Type: GrantFiled: December 31, 2012Date of Patent: May 6, 2014Assignee: Nalco CompanyInventors: Amy Tseng, Brian V. Jenkins, Robert M. Mack
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Patent number: 8709826Abstract: The invention relates to a device for determining an analyte in a liquid sample. The inventive device consists of: a capillary action means, involving lateral migration, defining a reference capillary action direction and comprising a liquid sample deposit area and an analytedetection area which is disposed downstream of the deposit area; a first analytespecific binding reagent which is conjugated to a visible and/or measurable marker and which is free to migrate when wet by means of capillary action in the abovementioned capillary actions means along the reference direction; and a second analytespecific binding reagent which is immobilized in the detection area. The invention is characterized in that the detection area comprises the analyte or an analogue of the analyte, which is immobilized and disposed at a distance from the second specific binding reagent.Type: GrantFiled: August 23, 2006Date of Patent: April 29, 2014Assignee: VedalabInventor: Raphael Donati
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Patent number: 8709356Abstract: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.Type: GrantFiled: April 12, 2010Date of Patent: April 29, 2014Assignee: Canon U.S. Life Sciences, Inc.Inventors: Brian Murphy, Scott Corey, Alex Flamm, Ben Lane, Conrad Laskowski, Chad Schneider
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Patent number: 8709355Abstract: The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210. Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of metal 150 deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon 110, immersion in a metal salt solution 130, drying and thermal decomposition of the metal salt 140 to form a metal deposit 150. In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates 210 with one or more metal salt solutions 130. Other embodiments of the invention concern apparatus and/or systems 400 for Raman detection of analytes, comprising metal-coated porous silicon substrates 110, 210 prepared by the disclosed methods.Type: GrantFiled: December 28, 2012Date of Patent: April 29, 2014Assignee: Intel CorporationInventors: Selena Chan, Sunghoon Kwon, Narayan Sundararajan
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Patent number: 8710437Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.Type: GrantFiled: September 11, 2013Date of Patent: April 29, 2014Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
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Patent number: 8713711Abstract: A disclosed chemical detection system for detecting a target material, such as an explosive material, can include a cantilevered probe, a probe heater coupled to the cantilevered probe, and a piezoelectric element disposed on the cantilevered probe. The piezoelectric element can be configured as a detector and/or an actuator. Detection can include, for example, detecting a movement of the cantilevered probe or a property of the cantilevered probe. The movement or a change in the property of the cantilevered probe can occur, for example, by adsorption of the target material, desorption of the target material, reaction of the target material and/or phase change of the target material. Examples of detectable movements and properties include temperature shifts, impedance shifts, and resonant frequency shifts of the cantilevered probe. The overall chemical detection system can be incorporated, for example, into a handheld explosive material detection system.Type: GrantFiled: March 15, 2013Date of Patent: April 29, 2014Assignee: Board of Regents of the Nevada System of Higher Education, on Behalf of the University of NevadaInventors: Jesse D. Adams, Todd A. Sulchek, Stuart C. Feigin
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Patent number: 8709823Abstract: A method for performing time resolved homogeneous assays using a long-lifetime luminescent dye as a donor. A reaction well containing a sample portion, donor reagent, and acceptor reagent and a matrix well containing a sample portion and donor reagent are excited and the resulting emission from each is measured at a single wavelength associated with the acceptor. The measurement obtained from the matrix well is used to provide a correction for the measurement obtained from the reaction well. The sample may be a biological fluid such as an oral fluid.Type: GrantFiled: July 19, 2010Date of Patent: April 29, 2014Assignee: Biophor Diagnostics, Inc.Inventor: Todd M. Corneillie
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Patent number: 8712699Abstract: The present invention provides an agglutination judgment method includes a first step of collecting data of a transmitted light intensity from each of measuring points included in a predetermined region of the reaction pattern, a second step of calculating a parameter representing the dispersion of a transmitted light intensity in the region, and a third step of judging the agglutination or non-agglutination by comparing the parameter thus calculated with a predetermined reference value.Type: GrantFiled: May 14, 2009Date of Patent: April 29, 2014Assignee: Beckman Coulter, Inc.Inventor: Tadashi Haga
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Publication number: 20140113383Abstract: The invention relates generally to both a method and apparatus for the creation of full resolution color digital images of diagnostic cassettes or objects of interest using a gray-scale digital camera or sensor combined with time sequential illumination using additive primary colors followed by post exposure digital processing. Such procedures and equipment is of significant economic value when employed in situations such as diagnostic clinical analyzers where space is limited and image quality requirements are high.Type: ApplicationFiled: October 18, 2012Publication date: April 24, 2014Applicant: Ortho-Clinical Diagnostics, Inc.Inventors: Jens H. Jorgensen, Michael W. LaCourt, Donald J. Moran, JR., David J. Hawks, Joseph Wycallis, Stephen C. Arnold
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Patent number: 8703070Abstract: Apparatus for immunoassay includes: a cartridge, including at least one test unit; a pin-film assembly, having a second sealing film, a plurality of pierce mechanisms, and a first actuation unit; a plurality of magnetic particles; at least one first magnetic unit; and at least one second magnetic unit. The test unit includes a plurality of fluid chambers, a plurality of pin chambers, a microchannel structure, a buffer chamber, a detection chamber and a waste chamber. The first actuation unit drives the pierce mechanisms to enable a working fluid to flow into the detection chamber storing the magnetic particles. As the second magnetic unit has a magnetic force larger than that of the first magnetic unit and can move reciprocatingly between a third position and a fourth position, the magnetic particles are driven to move reciprocatingly inside the detection chamber, thereby fully mixing the magnetic particles with the working fluid.Type: GrantFiled: November 2, 2012Date of Patent: April 22, 2014Assignee: Industrial Technology Research InstituteInventors: Shaw-Hwa Parng, Chih-Wen Yang, Yu-Yin Tsai, Yi-Chau Huang
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Patent number: 8703495Abstract: A blood coagulation detection device includes a micro channel unit, an optical signal unit, an opto-electronic conversion circuit, an amplifier circuit, and a filter circuit. The micro channel unit has a sample detection area. The optical signal unit transmits a reference light to the micro channel unit so as to form a message light. The opto-electronic conversion circuit receives the message light and converts the message light into an electrical signal. The amplifier circuit is electrically connected to the opto-electronic conversion circuit for amplifying the electrical signal. The filter circuit is electrically connected to the amplifier circuit for filtering the amplified electrical signal.Type: GrantFiled: July 6, 2012Date of Patent: April 22, 2014Assignee: National Cheng Kung UniversityInventors: Kung-Chia Young, Song-Jeng Huang, Chin-Lung Yang
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Patent number: 8704167Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.Type: GrantFiled: June 25, 2013Date of Patent: April 22, 2014Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
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Patent number: 8703494Abstract: Described herein are systems and methods for assaying a sample to quantitatively determine the percentage of glycated hemoglobin in the sample.Type: GrantFiled: May 20, 2010Date of Patent: April 22, 2014Assignee: Relia Diagnostic Systems, LLCInventors: William J. Rutter, Jang H. Han, Taewoo Kwon
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Patent number: 8703504Abstract: A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources, such as scattered light and autofluorescence, is practically eliminated during detection. In addition, the phosphorescent labels may be encapsulated within particles to shield the labels from quenchers, such as oxygen or water, which might disrupt the phosphorescent signal.Type: GrantFiled: September 4, 2013Date of Patent: April 22, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventor: Xuedong Song
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Publication number: 20140106963Abstract: Color change compositions that transition from a first to second color state upon application of an applied stimulus are provided. Also provided are substrates having the compositions on a surface thereof, as well as methods of making and using the compositions.Type: ApplicationFiled: September 27, 2013Publication date: April 17, 2014Applicant: Segan Industries, Inc.Inventor: Hans O. Ribi
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Publication number: 20140106471Abstract: Provided herein is a method of detecting a biomolecule, which enhances a mass of the target biomolecule by irradiating light to a photocatalytic nanoparticle binding to the target biomolecule. Accordingly, the method can effectively detect a change in mass, and provide economical and rapid detection using a low-priced photocatalyst.Type: ApplicationFiled: December 16, 2013Publication date: April 17, 2014Applicants: Postech Academy Industry Foundation, Samsung Electronics Co., Ltd.Inventors: Sang Min JEON, Hye Jung Seo, Soo Suk Lee
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Patent number: 8697008Abstract: A method and device for periodically perturbing the flow field within a microfluidic device to provide regular droplet formation at high speed.Type: GrantFiled: March 9, 2010Date of Patent: April 15, 2014Assignee: Eastman Kodak CompanyInventors: Andrew Clarke, Nicholas J. Dartnell, Christopher B. Rider
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Patent number: 8696990Abstract: A device for the photometric examination of samples has a sample-holder apparatus for at least two sample vessels, and a measuring apparatus and a moveable apparatus. The sample-holder apparatus is designed to be stationary, and the measuring apparatus is arranged on the moveable apparatus such that it can be displaced by means of the moveable apparatus.Type: GrantFiled: September 7, 2010Date of Patent: April 15, 2014Assignee: Siemens Healthcare Diagnostics Products GmbHInventors: Paul Meller, Holger Pufahl
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Patent number: 8697449Abstract: An optical blood coagulation monitor and method. The monitor has a blood sample holder, a laser with its output light directed through the blood sample, a two-dimensional detector that is able to detect light at the laser light wavelength and that has a detector output, optics for imaging onto the detector laser light that is forward scattered by the blood, and a data analysis system, responsive to the detector output, that is adapted to analyze the detected light to provide information on time-resolved coagulation and clotting properties of the blood.Type: GrantFiled: March 30, 2012Date of Patent: April 15, 2014Assignee: Spectral Sciences, Inc.Inventors: Brian Gregor, Rama Bansil, Julian D. Spring
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Patent number: 8696992Abstract: Disclosed is a highly reliable optical fiber measurement device and measurement method having a simple and compact structure.Type: GrantFiled: August 5, 2010Date of Patent: April 15, 2014Assignee: Universal Bio Research Co., Ltd.Inventor: Hideji Tajima
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Patent number: 8697452Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.Type: GrantFiled: June 8, 2012Date of Patent: April 15, 2014Assignee: Life Technologies CorporationInventors: John Linton, Arrin Katz, Colin Brenan, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya Kanigan, Kristine Friesen, Thomas Morrison, Javier Garcia
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Publication number: 20140099731Abstract: A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.Type: ApplicationFiled: October 4, 2012Publication date: April 10, 2014Applicant: CLONDIAG GMBHInventors: Thomas Kaiser, Klaus-Peter Möbius, Torsten Schulz, Thomas Uhlig, Alexander Von Schenk Zu Schweinsberg, Eugen Ermantraut, Jens Tuchscheerer
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Patent number: 8691151Abstract: This invention provides an apparatus for particle sorting, particle patterning, and methods of using the same. The sorting or patterning is opto-fluidics based, in that particles are applied to individual chambers in the device, detection and/or analysis of the particles is carried out, such that a cell or population whose removal or conveyance is desired is defined, and the cell or population is removed or conveyed via application of an optical force and flow-mediated conveyance or removal of the part.Type: GrantFiled: August 27, 2007Date of Patent: April 8, 2014Assignee: Massachusetts Institute of TechnologyInventors: Joseph Kovac, Joel Voldman
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Patent number: 8691595Abstract: The subject of this invention is a process for detection of analytes from biological samples comprising the following process steps: a) Preparation of a reversible binding partner 1 that is immobilized on a solid phase, to which an analyte binder is reversibly bonded via a reversible binding partner 2 that is bonded to the analyte binder, whereby the analyte binder is immobilized by binding between the reversible binding partners 1 and 2, b) Addition of the biological sample and binding of the analyte to the reversible immobilized analyte binder in the case that the biological sample contains the analytes, c) Separation of the biological sample, d) Addition of a dissolving buffer, which dissolves the binding between the reversible binding partners 1 and 2, whereby the binding of the analyte to the analyte binder remains optional, and e) Detection of the analyte in the dissolving buffer in the case that the biological sample contains the analytes and determination of the absence of the analyte in the case tType: GrantFiled: June 20, 2008Date of Patent: April 8, 2014Assignee: B.R.A.H.M.S. GmbHInventors: Andreas Bergmann, Joachim Struck
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Patent number: 8691591Abstract: Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.Type: GrantFiled: March 25, 2013Date of Patent: April 8, 2014Assignee: Trustees of Tufts CollegeInventors: David R. Walt, Todd A. Dickinson
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Patent number: 8691594Abstract: A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations.Type: GrantFiled: October 31, 2012Date of Patent: April 8, 2014Assignee: Bioarray Solutions, Ltd.Inventor: Michael Seul
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Patent number: 8691135Abstract: A tetrazolium bromide dye, e.g., 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), to be used as a high dose solution dosimeter is disclosed. The dose response of MTT solution dosimeter increases strongly with increase of absorbed dose up to 1 kGy. In order to increase the dose range and for ease of handling the present dosimeter as routine dosimeter, MTT-polyvinyl alcohol (PVA) film dosimeter is used. The dose response of MTT-PVA film dosimeters increases strongly with increase of absorbed dose up to 25 kGy. Polyvinyl butyral (PVB) as a polymer for making a film provides more stability at higher temperatures and humidity levels and less calibration is required. The dose response of MTT-PVB film dosimeters is effective with absorbed dose of up to 100 kGy.Type: GrantFiled: June 6, 2011Date of Patent: April 8, 2014Assignee: King Abdulaziz City for Science and Technology (KACST)Inventors: Ahmed A Basfar, Khalid A Raba'eh
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Patent number: 8691589Abstract: The method of the present disclosure determines whether a target DNA forms a G-quadruplex using a phenomenon in which thioflavin T generates a strong fluorescence when reacted with the G-quadruplex in the presence of potassium ions.Type: GrantFiled: May 22, 2013Date of Patent: April 8, 2014Assignee: Panasonic CorporationInventor: Daisuke Miyoshi
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Patent number: 8691584Abstract: A method of analyzing particles in a fluid stream including focusing a generally elliptical beam spot to a width less than the size of the particles. As particles pass through the beam spot electromagnetic radiation from the particles which is then detected and converted into electrical signals indicative of characteristics of the particles. The electrical signals may be digitally sampled to provide digital information which may be analyzed to extract information and to classify the particles.Type: GrantFiled: February 25, 2013Date of Patent: April 8, 2014Assignee: Inguran, LLCInventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
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Publication number: 20140093896Abstract: A point-of-care, screening kit for use by a heath care worker to create custom test strips for screening the bodily fluids of an individual for various, medical conditions includes: (a) a plurality of reagents (12), (b) a substrate (18) configured to: i) receive one of the reagents and react with it so as to cause it to acquire a first characteristic color, and, ii) upon the addition of the individual's bodily fluid to the substrate, acquire, as a result of the formulation of each of the reagents, a second, dichotomous characteristic color when the individual has a specific one of the various, medical conditions.Type: ApplicationFiled: May 7, 2012Publication date: April 3, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Sean Mongale, Shishira Nagesh, Ezra Taylor, Mary O'Grady, Thembi Mdluli, Peter Truskey, Sherri Hall, James Waring, III, Britni Crocker, Harshard Sanghvi, Elaine Yang, Soumyadipta Acharya, Maxim Budyansky, Matthew Means
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Patent number: 8685745Abstract: A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.Type: GrantFiled: October 26, 2011Date of Patent: April 1, 2014Assignee: Polestar Technologies, Inc.Inventor: James A. Kane